5 results about "Cementum" patented technology

The invention discloses a standardized three-dimensional periodontal attachment quantification system and method, and relates to the technical field of digital oral medicine, and the method comprises the following steps: calibrating a cementum-enamel boundary, dividing a tooth model into a dental crown and a tooth root, and determining the total surface area of the tooth root; performing sensitivity analysis by using the candidate threshold sequence, and determining an optimal diagnosis threshold in combination with a surface integrity criterion; based on the optimal diagnostic threshold, an absolute adhesion area and a relative adhesion area ratio are calculated and output. The invention provides a quantitative method capable of truly, comprehensively and accurately reflecting the three-dimensional pathological change of the periodontal tissue, and the accuracy of a measurement result is ensured through standardized crown root segmentation and accurate geometric judgment; through data-driven parameter optimization, uncertainty caused by manual intervention is eradicated, and objectivity and repeatability of a measurement result are ensured.

This invention provides a biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold, its preparation method, and its application, relating to the technical field of tissue engineering scaffolds. The biomimetic periodontal complex multilayer hydrogel tissue engineering scaffold comprises, from the inside out, a cementum repair layer, a periodontal ligament repair layer, and an alveolar bone repair layer; the cementum repair layer and the alveolar bone repair layer include a mineralized hydrogel layer; wherein the raw materials for preparing the mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and hydroxyapatite; the alveolar bone repair layer includes a non-mineralized hydrogel layer; wherein the raw materials for preparing the non-mineralized hydrogel layer include modified hyaluronic acid, methacrylamide type I collagen, and fibrin I. This invention precisely matches the mechanical and biological requirements of each layer of the periodontal complex through a three-layer structure, a reversibly hydrazone-regulated viscoelastic gradient, and a differentiated biochemical microenvironment of nHAp / FBN1.

The invention provides a periodontal disease tooth root regeneration treatment method and a multi-modal implant system, and relates to the technical field of stomatology and tissue engineering, and the method comprises the following steps: S1, minimally invasive extraction of autologous hDPSCs, CD146 + sorting, co-culture of the autologous hDPSCs, a gradient scaffold and growth factor-loaded microspheres in a dynamic culture device to form an ECM membrane-scaffold complex; s2, minimally invasive implantation of the complex under the guidance of a navigation guide plate, wherein the initial torsion resistance of the magnesium alloy retention nail is larger than or equal to 25 N.cm; s3, zirconium oxide all-ceramic crown repair is carried out 6 months after operation, an adhesive contains 20wt% of nano ZrO, dynamic culture parameters are as follows: 1Hz compressive strain, a double-channel perfusion flow rate ratio is (1: 2)-(1: 4), a culture medium contains 25-50ng / mL of BMP-2 and 5-8ng / mL of USAG-1, and the gradient scaffold has a three-layer pore structure: the porosity of an alveolar bone contact layer is 85 + / -3%. According to the system, a functional periodontal membrane is formed, and collagen fiber bundles are vertically inserted into cementum / bone tissue; the vascularization time is shortened by 50%, and the CD31 + vascular density reaches 28.3 + / -4.7 pieces / mm < 2 > in 14 days after operation.

A method for measuring periodontal disease and treating diseases associated therewith includes: obtaining B-mode ultrasound images of a dentition and periodontium of a patient; identifying gingival margin (GM), alveolar bone crest (ABC), cementoenamel junction (CEJ), periodontal ligament (PDL), and gingival edge (GE) biomarkers on the B-mode ultrasound images, the GE biomarker being a part of periodontal soft tissue most distal from a tooth surface; evaluating a metric associated with periodontal disease using one or more of the GM, ABC, CEJ, PDL and GE biomarkers and based at least in part on the evaluating, performing an act that implements and / or adjusts a therapeutic treatment of a periodontal disease.

The present invention provides a dental composition comprising BMP9 to be used in regenerating dental tissue or periodontal tissue, or a method for regenerating dental tissue or periodontal tissue, comprising administering BMP9 to a subject requiring the regeneration of dental tissue or periodontal tissue. The dental tissue can be dentin, and the periodontal tissue can be cementum, alveolar bone, or periodontal ligament. BMP9 according to the present invention is effective, as exhibited by experimental results, in promoting dentin regeneration and periodontal tissue regeneration for teeth.