Chitosan-iodine composite biological medical film and preparation method thereof

A biomedical, shell iodine technology, applied in the field of medical materials, can solve the problems such as the introduction of biological dressings that have not yet been discovered, and achieve superior hemostatic function, improve the microenvironment, and protect the wound surface

Active Publication Date: 2013-11-13
ZHEJIANG SANCHUANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many manufacturers at home and abroad have launched silver-containing dres

Method used

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  • Chitosan-iodine composite biological medical film and preparation method thereof
  • Chitosan-iodine composite biological medical film and preparation method thereof
  • Chitosan-iodine composite biological medical film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] 1. The chitosan polyvinyl alcohol foam layer is composed of gelatin, chitosan and polyvinyl alcohol, and is prepared according to the following steps:

[0070] Ⅰ. Prepare 1.0wt% gelatin solution, heat in a water bath at 50°C until completely dissolved;

[0071] Ⅱ. Add 1.0wt% polyvinyl alcohol to the above solution, and heat in a water bath at 90°C until completely dissolved;

[0072] Ⅲ. Add 0.6wt% chitosan, heat until completely dissolved

[0073] IV. Add 1.0wt% foaming agent and stir for 1h at a speed of 1000r / min or more;

[0074] V. Add 0.8wt% glycerin and mix well;

[0075] VI. Add 0.01wt% glutaraldehyde and mix thoroughly;

[0076] VII. Gained chitosan polyvinyl alcohol foam is tiled on a tetrafluoroethylene plate, and vacuum freeze-dried;

[0077] Ⅷ. Vacuum freeze-drying to obtain a molded foam, wash off unreacted glutaraldehyde, vacuum freeze-drying again, and obtain chitosan polyvinyl alcohol foam after drying;

[0078] Shell iodine, polyvinyl alcoho...

Embodiment 2

[0094] 1. The chitosan polyvinyl alcohol foam layer is composed of gelatin, chitosan and polyvinyl alcohol, and is prepared according to the following steps:

[0095] Ⅰ. Prepare 3.0wt% gelatin solution, heat in a water bath at 50°C until completely dissolved;

[0096] Ⅱ. Add 5.0wt% polyvinyl alcohol to the above solution, and heat in a water bath at 90°C until completely dissolved;

[0097] Ⅲ. Add 0.8wt% chitosan, heat until completely dissolved

[0098] IV. Add 3.0wt% foaming agent and stir for 1 hour at a speed above 1000r / min;

[0099] V. Add 2.0wt% glycerin and mix thoroughly;

[0100] VI. Add 0.1wt% glutaraldehyde and mix thoroughly;

[0101] VII. Gained chitosan polyvinyl alcohol foam 0.3mm thickness is tiled on the tetrafluoroethylene plate, vacuum freeze-drying;

[0102] Ⅷ. Vacuum freeze-drying to obtain a molded foam, wash off unreacted glutaraldehyde, vacuum freeze-drying again, and obtain chitosan polyvinyl alcohol foam after drying;

[0103] Shell iodi...

Embodiment 3

[0119] The shell-iodine composite biomedical film (that is, the shell-iodine polyvinyl alcohol-polyvinyl alcohol-chitosan polyvinyl alcohol foam-polyglutamic acid network gel composite material) will be prepared, and the experimental group of 30 cases of the General Hospital of Chengdu Military Region The clinical trial with 30 cases of control groups proves that the shell iodine composite biomedical film with the shell iodine polyvinyl alcohol layer and the gel layer as the matrix provided by the present invention is used for wound dressings such as trauma wounds, surgical wounds, and burn wounds. Compared with the product prepared with application number 201310010441.5, it has more functions of protecting wound surface, absorbing exudate, stopping bleeding, preventing and controlling wound infection, and promoting wound healing, etc. It is safe and effective in clinical use.

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Abstract

A chitosan-iodine composite biological medical film and a preparation method thereof are disclosed. The chitosan-iodine composite biological medical film is formed by compounding a chitosan-iodine polyvinyl-alcohol layer, a polyvinyl alcohol layer, a chitosan polyvinyl-alcohol foam layer and a hydrophilic polyglutamic acid net-shaped gel layer , and the chitosan polyvinyl-alcohol foam layer is compounded between the polyvinyl alcohol layer and the hydrophilic polyglutamic acid net-shaped gel layer . The four layers have different effects: the chitosan-iodine polyvinyl-alcohol layer has the effects of killing bacteria, moisturizing and promoting healing; the polyvinyl alcohol layer has the effects of moisturizing and promoting healing; the chitosan polyvinyl-alcohol foam layer has the effects of dewatering, absorbing seepage and moisturizing; and the hydrophilic polyglutamic acid net-shaped gel layer has the effects of stopping bleeding, adsorbing the wound and converting the adsorbed seepage to the chitosan polyvinyl-alcohol foam layer. According to the chitosan-iodine composite biological medical film, the chitosan-iodine polyvinyl-alcohol layer and the polyvinyl alcohol layer are heated in a microwave mode, so that a polar medium can be rapidly heated, the reaction temperature is rapidly reached, and the reaction time is shortened; and the chitosan polyvinyl-alcohol foam layer is dried by a vacuum freeze-drying method.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to an iodine-shell (antibacterial) wet biocomposite functional dressing, in particular to an improved product of the second part of the iodine-shell composite biomedical film (paste) and a preparation method thereof. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. With the aging of the population and the increase of chronic ulcer wounds, the biomaterials closely related to wound repair involve various dressings and coverings on the wound surface, and the market value of medical dressings is becoming more and more important. [0003] The characteristics that an ideal dressing should have include: good biocompatibility, control and absorption of wound exudate, prevention of bacterial invasion and a...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/28A61L15/32A61L15/26A61L15/44C08J5/18
Inventor 杨玉民
Owner ZHEJIANG SANCHUANG BIOTECHNOLOGY CO LTD
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