513results about How to "Safe for clinical use" patented technology

An anticancer high-molecular precursor medicine C-Spacer-P, where P is high- molecular pectin, C is an anticancer medicine containing amino radical or hydroxy radical, and Spacer is the spacing radical, is prepared by bonding the amino or hydroxy of an anticancer medicine with the hydroxy, carboxy, or hydroxymethyl of high- molecular pectin via spacing radical. It is an injection suitable for the solid cancer, and cancerous ascites or hydrothorax.

The invention discloses a traditional Chinese medicine composition for treating chronic pharyngitis or tonsillitis and a preparation method thereof. The traditional Chinese medicine composition for treating chronic pharyngitis or tonsillitis comprises 20 to 40 parts of radix sophorae tonkinensis, 20 to 40 parts of fragrant solomonseal rhizome, 15 to 35 parts of root of straight ladybell, 15 to 35 parts of lasiosphaera seu calvatia, 15 to 25 parts of hyacinth bean, 12 to 25 parts of great burdock achene, 12 to 25 parts of mulberry leaf, 12 to 25 parts of blackberry lily rhizome, 12 to 25 parts of platycodon root, 4 to 15 parts of mint, 4 to 15 parts of isatis root, 3 to 12 parts of dandelion, 3 to 12 parts of Tokyo violet herb, 4 to 15 parts of honey-suckle bud and flower, 3 to 12 parts of weeping forsythia capsule, 3 to 12 parts of common andrographis herb, 2 to 10 parts of common bletilla rubber and 1 to 8 parts of liquorice root. The traditional Chinese medicine composition has effects of clearing heat and removing toxins, moistening lung and relieving a cough, and relieving sore throat and dissipating binds, has clear effects of treating chronic pharyngitis and tonsillitis, realizes simultaneous treatment of principal and subordinate symptoms, is safe in clinical application, and has no toxic and side effect.

The invention discloses a Chinese medicinal composition for treating arthritis, osteoproliferation and disc protrusion, which comprises the following raw material constituents (by weight ratio): large-leaf gentian root, ledebouriella root, Ligusticum wallichii, Clematis chinensis, achyranthes and cyathula root, root of herbaceous peony, prepared rehmannia root, Chinese angelica root, eucommia bark, Cinnamomum cassia, wolferry fruit, morinda root, dipsacus root, poria cocos, Chinese ephedra, Loranthus mulberry mistletoe, cassia twig, corydalis tuber, notoginseng, notopterygium root, root of red rooted saliva, tetrandra root, spatholobus stem, dried orange peel, licorice root, pangolin scales, buthus martensi karsch, earthworm, wood louse, dragon's blood resin, wasp's nest and drynaria.

The invention relates to a method for navigating and positioning a multi-joint arm mechanical sensing type ultrasonic image, which mainly comprises a mechanical sensing component combining method, and a navigating and positioning method, wherein the method adopts a six-joint arm with a sensor to directly measure the real-time position of an ultrasonic probe; the multi-joint arm adopts the combination form that rotating shafts of two electric joints and four passive joints are mutually perpendicular; the x-direction displacement only depends on the intersection angle of the electric joint group and is unrelated to the intersection angle of the passive joint group when the probe position is measured and controlled; and the y-direction displacement of a probe pedestal only depends on the intersection angle of the passive joint group and is unrelated to the intersection angle of the electric joint group. The method adopts a semi-active structure mode that the electric joint group is matched with the passive joint group mutually. The method has the advantages of simple and compact structure, safety and stability.

The invention discloses a Chinese medicinal composition for treating gout and a preparation method thereof. The Chinese medicinal composition comprises more than forty Chinese medicinal components such as angelica, gentiana macrophylla, peach seeds, ground beetle, earthworm, poria cocos, glabrous greenbrier rhizome, yam rhizome, clematis root, white atractylodes rhizome, atractylodes, cortex phellodendri, raw coix seeds, eupatorium lindleyanum, polygonum cuspidatum, cyathula root, rhizoma alismatis, honeysuckle stem, astragalus root, loosestrife herb and red peony root. The Chinese medicinal composition facilitates pharmacy and administration, is specially used for treating the gout, is safe in clinical application, and treats both symptoms and root causes. Through reasonable compatibility of each component, the treatment effect is improved, the medicinal properties are changed or alleviated, and the toxicity and side effects of medicaments are eliminated. The medicaments with strong properties and flavors are alleviated, the treatment effect is significant, many active ingredients are absorbed, and the composition has a good effect of treating or relieving the symptoms of the gout.

The invention relates to a pharmaceutical compound and a preparation method and a preparation thereof, in particular to a pharmaceutical compound for curing prostatitis and prostate hyperplasia and a preparation method and a preparation thereof. The pharmaceutical compound is prepared by the following traditional Chinese medicine raw materials according to the parts by weight: 60-100 parts of wuling powder, 20-80 parts of zedoary, 20-80 parts of fritillaria thunbergii and 20-40 parts of alisma orientale. The invention also discloses the preparation method and the preparation of the pharmaceutical compound. The pharmaceutical compound and the preparation thereof have good curative effects to prostatitis and prostate hyperplasia without side effects.

The invention relates to a carboxymethyl chitosan microsphere embolization agent. The embolization agent takes carboxymethyl chitosan as raw materials; the carboxymethyl chitosan is subjected to pretreatment, emulsification, cross-linking and dehydration drying to prepare microspheres with three-dimensional network structures. After the microspheres absorb water, the microspheres are smooth in surface and are rich in elasticity, have good biocompatibility and biodegradablity and is suitable for non-permanent vascular embolization.

The invention provides a Chinese medicine composition for treating haemorrhoids. The prescription is consisted of fumigating-washing medicine and oral medicine, wherein the fumigating-washing medicine is consisted of Saposhnikovia divaricata, schizonepeta, talc, dandelion, phellodendron, peach seed, angelica dahuricae, glabrous Greenbrier Rhizome, cimicifuga, pagodatree flowers and pagodatree pod; the oral medicine is consisted of dark plum fruit, Sophora flavescens, Blackberrykiky Rhizome, Chinese gall, scorpion, Scutellaria baicalensis, clam, Cacumen biotae, Chinese torreya seed, water spinach, rock tripe, Agrimonia pilosa, bitter orange, white muscardine silkworm and Fructus Cannabis. The invention provides a Chinese medicine composition for treating haemorrhoids, wherein the compatibility of each drug can play the effects of removing pathogenic heat from blood, hemostasis and convergence and blood circulation. In the invention, the Chinese medicine composition can address both symptoms and root causes to all kinds of symptoms, and the curative effect is exactly reliable and true proved by clinical curative effect observation. The Chinese medicine preparation provided by the invention is non-toxic, harmless and safe and reliable, does not have an adverse effect after administration and is safe in clinical use.

The invention provides traditional Chinese medicine lotion for treating hemorrhoids. The traditional Chinese medicine lotion for treating the hemorrhoid is prepared from the following traditional Chinese medicine materials: gallnut, sophora flower, cortex lycii radices, alum, Momordica cochinchinensis, folium artemisiae argyi, loranthus parasiticus, pepper, plantain seed, radix angelicae, Ailanthus altissima Swingle, fructus aurantii, honeysuckle, cimicifugae foetidae, smoked plum, radix sophorae flavescentis, blackberry lily, fructus cannabis, Scutellaria baicalensis, Ammannia baccifera, hedgehog hide, rheum officinale, hairyvein agrimony, pagoda tree fruit, Cacumen biotae, peach kernel, herba portulacae, cinnabar, Ligusticum wallichii, bezoar, safflower carthamus, leech, Polygonum cuspidatum, borneol, duckweed and mongolian oak leaf. The traditional Chinese medicine lotion for treating the hemorrhoids has effects of removing heat to cool blood, stopping bleeding and astringing and promoting blood circulation to remove blood stasis by the compatibility of all the traditional Chinese medicines. Symptoms and root causes of the hemorrhoids with various symptoms can be treated by the traditional Chinese medicine composition. Proved by observation, a clinical effect is exact, reliable and real. The traditional Chinese medicine lotion provided by the invention is non-toxic and harmless, is safe and reliable and is safe in clinical use, and no adverse reaction is generated after fumigation and washing.

Disclosed is a Blonanserin-contained oral preparation for treating schizophrenia, using a 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine as ingredient, and one or more pharmaceutically acceptable excipients. The preparation method comprises the steps of mixing the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine and the alternative thinner, adhesive, disintegrant, abhesive and lubricant with an appropriate amount of humectants to prepare soft wood, sieving to prepare wet granules, drying the wet granules, sieving and integrating the granules to prepare oral preparation, wherein, the Blonanserin is 0.1-30 per cent of the preparation by weight. The preparation is applicable to administrate 1-2 times per day in 1-2 preparation units each time, and used for controlling the concentration of the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine in the plasma of human body, thus enabling the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine to play a role in treatment.

The invention discloses a composition of ginsenoside Rg3 and ginsenoside Rg5, a preparation method of the composition, and application of the composition to medicines, foods and health-care products for improving immunity, resisting tumors, resisting medicine resistance of tumor targeted medicines, relieving chemoradiotherapy toxic and side effects, resisting fatigue and resisting depression. Thecomposition can quickly take effect, has small toxic and side effects, can be taken for a long time, belongs to a safe, efficient and stable medicine and health care food with a simple preparation process, is suitable for industrial production, and can be easily popularized. The invention provides a novel raw material and production process for medicines and foods for improving immunity, resistingtumors, resisting medicine resistance of tumor targeted medicines, relieving chemoradiotherapy toxic and side effects, resisting fatigue and resisting depression.

The invention aims to provide a method for detecting main medicinal components of musk pain relieving cream. Specifically, a target product is extracted by distillation of water steam, and to-be-detected target components are dissolved by an organic solvent and are detected by a gas chromatographic method. According to the method, special distillation extraction equipment and the organic solvent are used for distillation extraction so as to realize accurate extraction of the to-be-detected target components such as ultralow-content musk ketone; the content of the musk ketone, camphor, menthol, borneol, cinnamaldehyde and eugenol can be simultaneously accurately detected by one step; the method disclosed by the invention has the advantages of providing an extraction and measurement method for the low-content musk ketone, solving the problem of specificity of a method for simultaneously extracting and detecting other volatile components, being simple and convenient to operate and having a good application value.

The invention relates to a polymer composition loaded with a sirolimus compound or its derivative. The composition can have diversified forms. A necessary link includes preparing the sirolimus compound or its derivative and a polymer carrier into a micelle. Then according to needs, the micelle can be further prepared into a freeze-dried composition by a freeze-drying technology, or the micelle and other polymer and carrier can be prepared into a solid or semi-solid preparation. The polymer composition can be used for treating tumors, reducing rejection reactions after organ and tissue transplantation, promoting cell regeneration and repair, preventing excessive scar tissue growth after injury and preventing vascular restenosis and blood coagulation embolism, treating or inhibiting autoimmune diseases, and treating or inhibiting inflammation, etc.

The invention discloses a novel application of albiflorin in preparing medicines for preventing and treating the Parkinson's disease. Tests prove that albiflorin has a distinct antiparkinsonian effect, quick action and low toxic and adverse effects. Albiflorin as a medicine for treating the Parkinson's disease, is safe, efficient and stable, has a simple preparation process, is suitable for industrial production, and is easy for generalization. The invention provides a new source of medicines for preventing and treating the Parkinson's disease.

The invention discloses a traditional Chinese medicine composition for treating hemorrhoids and a preparation method thereof. The traditional Chinese medicine composition comprises the following ingredients in parts by weight: 10 to 25 parts of cimicifuga foetida, 8 to 16 parts of radix bupleuri, 10 to 20 parts of radix scutellariae, 4 to 10 parts of rhubarb, 4 to 10 parts of angelica, 2 to 8 parts of sanguisorba, 2 to 8 parts of glabrous sarcandra herb, 1 to 6 parts of yerbadetajo herba ecliptae and 1 to 6 parts of liquorice. The traditional Chinese medicine composition can be prepared into any one clinically acceptable oral medicine preparation according to the conventional preparation method of the traditional Chinese medicine preparation, has the effects of removing pathogenic heat from blood, stopping bleeding for convergence and activating blood circulation to dissipate blood stasis, can fast realize the hemostasis convergence on various haemorrhoids such as internal hemorrhoids, external hemorrhoids, mixed hemorrhoids and the like, has exact and reliable curative effect, treats both the secondary and primary symptoms, is safe in clinical application and has no any toxic or side effect.

The invention relates to a traditional Chinese medicine composition, particularly a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition for treating rheumatoid arthritis is prepared from glabrous greenbrier rhizome, radix clematidis, homalomena rhizoma, schizophragma integrifolium, club moss, spatholobus stem, orienavine, futokadsura stem, Trachelospermum jasminoides, ephedra, folium artemisiae argyi, black-tail snake, frankincense, myrrh, angelica, notopterygium root, heracleum hemsleyanum michaux, radix cyathulae, angelica, radix sileris, cassia twig, papaya, kudzu root, ant, radix astragali, rhizoma atractylodis, cherokee rose, licorice and ground beetle. By properly compounding the multiple medicines, the mutually synergic or resisting effects are utilized to lower or eliminate the toxic and side effects of the medicines, reduce the untoward reaction and enhance the curative effect; the traditional Chinese medicine composition is safe for clinical application, does not stimulate the viscera when being taken orally, is convenient to make and take, ensures the cleanliness of the medicines, is easy for storage, has the advantages of obvious curative effect, many absorbable effective components and favorable drug effect taking, and can treat both the symptoms and root causes; and the total effective rate is up to 96%.

The invention discloses a traditional Chinese medicine composition for treating seborrheic dermatitis and acne and a preparation method thereof. The traditional Chinese medicine composition comprises 16 to 35 parts of honeysuckle, 16 to 35 parts of Chinese honeylocust spine, 16 to 35 parts of divaricate saposhnikovia root, 12 to 28 parts of dahurian angelica root, 12 to 28 parts of tendrilleaf fritillary bulb, 12 to 28 parts of garden sorrel, 10 to 25 parts of semiaquilegia adoxoides, 10 to 25 parts of akebia stem, 10 to 25 parts of dandelion, 10 to 25 parts of Tokyo violet herb, 8 to 15 parts of spanishneedles herb, 8 to 15 parts of weeping forsythia capsule, 8 to 15 parts of Chinese wolfberry root-bark, 6 to 12 parts of sarcandra, 6 to 12 parts of elephants-foot, 5 to 10 parts of poria cocos, 5 to 10 parts of paniculate swallowwort root, 5 to 10 parts of Chinese clematis root, 5 to 10 parts of great burdock achene, 5 to 10 parts of kudzuvine root, 5 to 10 parts of wilford granesbill herb, 4 to 8 parts of snakegourd root, 4 to 8 parts of pangolin scales, 4 to 8 parts of dried orange peel, 3 to 8 parts of haw and 2 to 6 parts of licorice. The traditional Chinese medicine composition has obvious effects of treating seborrheic dermatitis and acne and is safe in clinical application.

The invention discloses ganciclovir for injection and a preparation method thereof. The preparation is formed by regulating the pH of a solution containing ganciclovir and sodium chloride to 10.0-11.5 by adopting a pH regulator, and freezing and drying repetitively. The freeze-dried powder injection of the ganciclovir for injection has the advantages of high yield, good re-dissolubility, more stable quality and the like; change of related substances during the period of accelerated test is not obvious; and the ganciclovir for injection is safer for clinical application.

The invention discloses a traditional Chinese medicine composite for treating mammitis and lobular hyperplasia of mammary gland and a preparation method thereof. The traditional Chinese medicine composite comprises the following components in parts by weight: 3-10 parts of radix bupleuri, 12-25 parts of fructus toosendan, 10-20 parts of radix clematidis, 6-12 parts of curcuma zedoary, 2-8 parts of oyster, 10-20 parts of garden balsam, 12-25 parts of pericarpium citri reticulatae viride, 4-12 parts of cornu cervi degelatinatum, 10-20 parts of dandelion, 12-25 parts of vegetable sponge and 1-6 parts of liquorice. The traditional Chinese medicine composite can be prepared into any one clinically acceptable oral medicine preparation according to a traditional Chinese preparation method. The traditional Chinese medicine composite treats both principal and secondary aspects of the mammitis and the lobular hyperplasia of mammary gland. Proved by clinical effect observation, the traditional Chinese medicine composite takes the obvious curative effects on the mammitis and the lobular hyperplasia of mammary gland. The traditional Chinese medicine composite has no toxin or harm, is safe and reliable, cannot generate adverse reaction after being orally taken and is safe in clinical application.

The invention relates to hydrotalcite preparation with rapid efficiency and a preparation process thereof, which belong to the biopharmaceuticals field. Every 1000 hydrotalcite units of the invention comprise the following constituents: 0.45-0.55kg of hydrotalcite, 0.18-0.25kg of mannitol, 12-18g of carboxymethyl starch sodium, 8.0-15.0g of magnesium stearate, 0.5-1.0g of sodium cyclamate, 0.3-0.9ml of peppermint flavor, 0.378kg-0.462kg of pre-gelatinized starch paste (12 percent by mass specific concentration) and 0.504kg-0.616kg of pre-gelatinized starch paste (5 percent by mass specific concentration). The preparation process of the invention comprises the following steps: hydrotalcite and mannitol are prepared into super-fine powder with grain diameter of 5-15um, which are blended with carboxymethyl starch sodium, sodium cyclamate and pre-gelatinized starch paste, wet granulated, sieved by a sieve with 12-16 meshes, totally mixed, packaged or tabletted to prepare finished product of hydrotalcite preparation; the hydrotalcite preparation prepared by adopting the method of the invention has fast effectiveness, good effect with low toxicity, small side-effects, pleasant taste and high suffer compliance, which is an ideal clinical antiacid.

The invention relates to a flurbiprofen acetaminophen resin lipid microsphere injection, a freeze-drying lipid microsphere injection and a preparation method. Through a reasonable composition proportion and a preparation process with controllable parameters, good stability and strong operability, the flurbiprofen acetaminophen resin which is an indissolvable drug is wrapped in an oil phase and an interfacial film of a lipid microsphere, so that not only is the solubility of the drug remarkably strengthened, but also precipitation and oxidation do not occur easily, the physical and chemical stabilities of the drug are greatly improved, the devitrification phenomenon is avoided in the use and storage processes, a slow release effect is exerted and the action time of the drug in the blood plasma is prolonged, meanwhile, as the lipid microsphere targets to an inflammation part, the toxicity and the vessel stimulation during injection are remarkably reduced, the clinical application of the injections is safer, the treatment effect is more remarkable, and the injections and the methods are suitable for industrialized production and clinical application.

The invention discloses an application of an external-use plaster composition in preparation of a drug used for preventing, relieving and / or treating inflammatory diseases. A experiment proves that the external-use plaster composition is significant in effects on treatment of inflammatory diseases, is quick in the effects, is slight in toxic and side effects, is simple in the preparation method, is a drug used for treating inflammatory diseases safely, high-efficiently and stably, is suitable for industrial production, is easy to popularize. The invention provides a new drug source for preventing and treating the inflammatory diseases.

The present invention relates to a culture system and method for amplifying hematopoietic stem cells and / or hematopoietic progenitor cells, hematopoietic stem cells, and hematopoietic progenitor cells. The culture system comprises: a basal medium suitable for stem cell expansion; and a JNK signaling pathway inhibitor. The culture system provided by the invention can expand hematopoietic stem cellsin vitro, and the amplification effect thereof is obvious, and the CD34+CD45RA-labeled hematopoietic stem cells can be amplified nearly 100 times.

The invention relates to a ropivacaine mesylate freeze-dried powder injection which consists of ropivacaine mesylate and a PH regulator and is prepared by using the following freeze drying method: (1) a section quick-freezing stage: keeping bulked ropivacaine mesylate solution at the temperature of 0 DEG C for 10-30 minutes, and then keeping the bulked ropivacaine mesylate solution at the temperature of minus 35 DEG C-minus 45 DEG C for 1-2 hours; (2) a lyophilization stage: heating to 0 DEG C under the vacuum degree of 10-20 Pa and at the speed of 2-10 DEG C / h, and then keeping the temperature for 1-3 hours; and (3) a desorption drying stage: heating to 30 DEG C under the vacuum degree of 0-10 Pa and at the speed of 5-10 DEG C / h and keeping the temperature for 2-5 hours. The freeze-dried powder injection provided by the invention has the advantages of high yield, good re-dissolubility, more stable quality and the like.

The present invention discloses a new type medicine target slowly-releasing carrier material and its preparation process. Said medicine target slowly-releasing carrier material is made up by utilizing attapulgite and Fe3O4. Its principle lies in that it utilizes the large specific surface area and adsorbability of ultrafine high-purity attapulgite and uses it as carrier material of medicine to prolong action time of medicine in interior of human body, raise concentration of local medicine, raise therapeutic effect of medicine and reduce toxic side effect of the medicine, and utilizes magnetization treatment so as to attain the goal of making target administration and controlling release of medicine.

The invention provides a cladded nuclide labeled protein microsphere, comprising the following bulk pharmaceutical chemicals and auxiliary materials in parts by weight: 1-5 parts of Na131I, 1-5 parts of Na125I, 300-1000 parts of chitosan, 100-500 parts of sodium alginate and 300-800 parts of gelatin, wherein, the specific radioactivity concentrations of the Na131I and the Na125I are both 37GBq / ml. The invention also provides a preparation method and applications of the cladded nuclide labeled protein microsphere; the cladded nuclide labeled protein microsphere adopts the inclusion of the chitosan and the sodium alginate; the actual half-life period of the cladded nuclide microsphere in the bodies of animals is longer, and is close to the half-life period of the nuclide; and the blood gamma counts and urine gamma counts of two microspheres are compared to discover that the nuclide released by the cladded nuclide microsphere is more stable than the nuclide released by the uncladded nuclide microsphere, thereby reliving the effect of the explosive release, thus the cladding can protect the nuclide microsphere, reduce the label peeling, and prolong the degrading time of the microsphere in the bodies.

The invention relates to a complex traditional Chinese medicine preparation for treating upper respiratory tract infection and a preparation method thereof. The complex traditional Chinese medicine preparation comprises the following raw materials: 10-25 parts of picria felterrae lour, 5-15 parts of herba sarcandrae, 5-15 parts of senecio, 5-13 parts of pubescent holly root and 1-5 parts of liquorice. The preparation method comprises the following steps: pulverizing a proper amount of picria felterrae lour into fine powders; adding water into residual picria felterrae lour, the herba sarcandrae, the senecio, and the like and extracting to obtain extracts; adding alcohol into the extracts to carry out alcohol deposition, filtration and concentration to form thick paste; uniformly mixing, drying and pulverizing the thick paste and the picria felterrae lour fine powder to form fine powders; and adding a proper number of auxiliary materials and uniformly mixing to prepare particles or adding general preparation auxiliary materials to prepare general solid oral administration preparation. According to clinical observation for many years, the traditional Chinese medicine preparation benzyrin tablet has the obvious treating effects on a patient with upper respiratory tract infection diseases, such as upper respiratory tract inflammation, bronchitis, rhinitis, pharyngolaryngitis, tonsillitis, and the like.

The invention discloses a pharmaceutical composition for preventing and treating warm-heat diseases of livestock and poultry and a preparation method thereof. The mix proportion by weight of a variety of traditional Chinese medicines calculated by raw plant drugs and dressings in 1500ml of liquid medicine is as follows: 350-450g of fructus forsythiae, 150-250g of indigowoad root, 150-250g of honeysuckle flower, 150-250g of baical skullcap root, 150-250g of golden thread, 150-250g of commelina communis, 75-125g of liquoric root, 2-3g of benzyl alcohol and the balance of distilled water. The preparation method of the pharmaceutical composition comprises three steps of water extraction, ethanol precipitation and preparation of the liquid medicine, thereby preparing an injection. A large number of clinical uses prove that the medicine has the effects of anti-virus, anti-bacteria, anti-inflammation, clearing heat-toxin and enhancing immunity and excellent treatment effect on warm diseases which are mainly characterized by fever, and the applications thereof can play the positive role of promoting the development of the livestock and poultry industry in China.

The invention discloses a Chinese medicinal ointment, in particular a Chinese medicinal ointment for treating intervertebral disc hyperosteogeny and a preparation method thereof. The Chinese medicinal ointment for treating the intervertebral disc hyperosteogeny is characterized by being prepared from the following components: Chinese angelica root, notopterygium, pubescent angelica root, clematis root, earthworm, suberect spatholobus stem, insects, white mustard seed, garter snake, drynaria, Chinese honeylocust spine, garden balsam stem, medicinal cyathula root, cassia twig, papaya, eucommia bark, divaricate saposhnikovia root, ephedra, acanthopanax bark, Chinese taxillus twig, pangolin scales, frankincense, myrrh, dragon's blood, musk and plum borneol. The Chinese medicinal ointment is specially used for treating the intervertebral disc hyperosteogeny, and by using the Chinese medicinal ointment, the concentration of the medicament applied into local tissues is significantly higher than the blood concentration, so the Chinese medicinal ointment is brought into full play, the local curative effect is obviously superior to internal treatment, and the Chinese medicinal ointment takes effect rapidly, has wide adaptation diseases, is safe to use, and has less toxic or side effect. 690 cases using the Chinese medicinal ointment for treatment show that the total effective rate reaches 96 percent.

The invention discloses a chimeric antigen receptor targeting CD22 and an application for the chimeric antigen receptor. The chimeric antigen receptor has a sequence selected from one of the followingtwo structures: a first structure, which comprises a CD22 antigen binding domain and a constant domain of a T cell receptor (TCR); and a second structure, which comprises a transmembrane protein signal peptide, a CD22 antigen binding structural domain, a CD8 protein molecule hinge region, a transmembrane region, a 4-1BB costimulatory structural domain and a CD3<zeta> intracellular signal transduction structural domain which are sequentially connected in series. Compared with a traditional CD28, 4-1BB costimulatory structural domain, the chimeric antigen receptor provided by the invention shows more persistent anti-tumor activity, can be combined with CD19 chimeric antigen receptor T cells for sequential application, improves the coverage rate of CART cells on tumor cells, or is applied totreatment of leukemia negative recurrence by being combined with the CD19 chimeric antigen receptor T cells, and has good application prospect in treatment of blood and lymphatic system malignant tumors.