Rapidly effectual aluminum magnesium carbonate preparation and technique of preparing the same

A technology of aluminum magnesium carbonate and preparation, which is applied in the directions of non-active ingredients medical preparations, pill delivery, aluminum/calcium/magnesium active ingredients, etc., can solve the problems of reducing production cost, long time, and drug onset after 30 minutes, etc. , to achieve the effect of low manufacturing cost, no toxic side effects and adverse reactions, and easy to collapse

Inactive Publication Date: 2008-07-16
游洪涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the hydrochloric magnesium carbonate preparation of the prior art has better clinical curative effect, but the disintegration time is long after the medicine is taken, and the medicine takes effect after 30 minutes. Disintegration time and dispersion uniformity are used as indicators to screen the type and components of fillers, optimize the process parameters of the preparation, and reduce production costs at the same time

Method used

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  • Rapidly effectual aluminum magnesium carbonate preparation and technique of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 prepares 1000 aluminum magnesium carbonate sheets

[0020] a. prepare the superfine powder of aluminum magnesium carbonate and mannitol

[0021] Aluminum magnesium carbonate and mannitol are made into ultra-fine powder with a particle size of 0.5 μm, ready for use, process conditions: air consumption 40M 3 / min, working pressure 0.75Mpa, feed particle size 60 mesh

[0022] b. wet granulation

[0023] According to 1000 preparation units, take aluminum magnesium carbonate powder 0.45kg, mannitol 0.18kg and carboxymethyl starch sodium 12g and add in the wet granulator, start the wet granulator and stir at a low speed (1000r / min) for 3 minutes to make it Mix well; dissolve 0.5g of cyclamate in about 0.5Kg of purified water, start the wet granulator to stir at a low speed of 1000r / min and cut at a low speed of 1500r / min for 1 minute, so that the solution of cyclamate is mixed in the wet granulator , then change the low-speed cutting to 3000r / min high-speed cu...

Embodiment 2

[0028] Embodiment 2 prepares 1000 aluminum magnesium carbonate sheets

[0029] a. prepare the superfine powder of aluminum magnesium carbonate and mannitol

[0030] Aluminum magnesium carbonate and mannitol are made into superfine powder with a particle size of 3 μm, ready for use, process conditions: air consumption 40M 3 / min, working pressure 0.8Mpa, feed particle size 100 mesh

[0031] b. wet granulation

[0032] According to 1000 preparation units, take aluminum magnesium carbonate powder 0.5kg, mannitol 0.20kg and carboxymethyl starch sodium 15g and add in the wet granulator, start the wet granulator and stir at a low speed (1000r / min) for 4 minutes to make it Mix evenly; dissolve 0.75g of cyclamate in about 0.5Kg of purified water, start the wet granulator to stir at a low speed of 1000r / min and cut at a low speed of 1500r / min for 1 minute, so that the solution of cyclamate is mixed in the wet granulator Evenly, then change the low-speed cutting to 3000r / min high-spe...

Embodiment 3

[0037] Embodiment 3 prepares 1000 aluminum magnesium carbonate sheets

[0038] a. prepare the superfine powder of aluminum magnesium carbonate and mannitol

[0039] Aluminum magnesium carbonate and mannitol are made into superfine powder with a particle size of 15 μm, ready for use, process conditions: air consumption 40M 3 / min, working pressure 0.85Mpa, feed particle size 300 mesh

[0040] b. wet granulation

[0041] According to 1000 preparation units, take aluminum magnesium carbonate powder 0.55kg, mannitol 0.25kg and carboxymethyl starch sodium 18g and add in the wet granulator, start the wet granulator and stir at a low speed (1000r / min) for 5 minutes to make it Mix evenly; dissolve 1.0g cyclamate in about 0.5Kg purified water, start the wet granulator to stir at a low speed of 1000r / min and cut at a low speed of 1500r / min for 1 minute, so that the solution of cyclamate is mixed in the wet granulator , then change the low-speed cutting to 3000r / min high-speed cutting...

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Abstract

The invention relates to hydrotalcite preparation with rapid efficiency and a preparation process thereof, which belong to the biopharmaceuticals field. Every 1000 hydrotalcite units of the invention comprise the following constituents: 0.45-0.55kg of hydrotalcite, 0.18-0.25kg of mannitol, 12-18g of carboxymethyl starch sodium, 8.0-15.0g of magnesium stearate, 0.5-1.0g of sodium cyclamate, 0.3-0.9ml of peppermint flavor, 0.378kg-0.462kg of pre-gelatinized starch paste (12 percent by mass specific concentration) and 0.504kg-0.616kg of pre-gelatinized starch paste (5 percent by mass specific concentration). The preparation process of the invention comprises the following steps: hydrotalcite and mannitol are prepared into super-fine powder with grain diameter of 5-15um, which are blended with carboxymethyl starch sodium, sodium cyclamate and pre-gelatinized starch paste, wet granulated, sieved by a sieve with 12-16 meshes, totally mixed, packaged or tabletted to prepare finished product of hydrotalcite preparation; the hydrotalcite preparation prepared by adopting the method of the invention has fast effectiveness, good effect with low toxicity, small side-effects, pleasant taste and high suffer compliance, which is an ideal clinical antiacid.

Description

technical field [0001] The invention relates to an antacid drug for treating gastric diseases, in particular to a rapidly effective aluminum magnesium carbonate preparation and a preparation method thereof. Background technique [0002] Aluminum magnesium carbonate is a natural mineral whose structural formula is AI 2 Mg 6 (OH) 16 CO 3 4H 2 O; the chemical name is hexadecyl hydroxy dialuminum hexamagnesium carbonate tetrahydrate. It was first discovered in 1942 by Feitknecht et al. In the process of studying its structure and properties, people have found that aluminum magnesium carbonate has many excellent properties, such as being a high-efficiency, low-toxic, and smoke-free material as a flame retardant, but the most extensive and main use is as a new Antacids are used to treat gastric ulcer, duodenal ulcer, hyperacidity and gastritis, etc. It was first developed by Shionogi Pharmaceutical Company in Japan and launched in 1970. It is currently produced in Japan, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/20A61K47/36A61P1/04
Inventor 游洪涛王瑛苏跃进陈海红
Owner 游洪涛
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