Application of albiflorin in resisting Parkinson's disease

A technology of paeonifloride glycosides and herba peony, which is applied in the field of anti-Parkinson's disease of paeonifloride glycosides, to achieve the effect of shortening the climbing time, reducing the number of rotations, and safe clinical use

Inactive Publication Date: 2011-07-20
张作光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the application of paeonifloride in the preparation of drugs for the prevention, alleviation and treatment of Parkinson's disease

Method used

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  • Application of albiflorin in resisting Parkinson's disease
  • Application of albiflorin in resisting Parkinson's disease
  • Application of albiflorin in resisting Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0068] Experimental Example 1 Effect of paeonifloride glycosides on rat striatum DA and DOPAC

[0069] 1.1 Experimental materials

[0070] Wistar rats, male, weighing 210±20 g, were provided by the Weitong Lihua Animal Experiment Center.

[0071] Paeonifloride (purity > 96.77%), purchased from Shanghai Eternal Biotechnology Co., Ltd.;

[0072] Dopamine (Dapamine, DA), 3,4 dihydroxyphenylacetic acid (3,4 dihydroxyphenylacetic acid, DOPAC) and other reference substances were purchased from Sigma;

[0073] Acetonitrile and methanol (both chromatographically pure, Fisher Scientific).

[0074] Waters510 pump, M464 electrochemical detector DL-822 chromatographic workstation (chromatographic center of Dalian Institute of Chemical Physics), MSE150 ultrasonic pulverizer.

[0075] 1.2 Experimental method

[0076] 1.2.1 Administration in groups

[0077] The rats were randomly divided into 8 groups, 5 in each group, namely two groups of normal saline blank control group, three groups...

experiment example 2

[0088] Experimental example 2 Effect of paeonifloride glycosides on rotation behavior of striatal 6-OHDA directional lesion model rats

[0089] The disappearance and degeneration of cytochrome in the substantia nigra are the main pathological changes of Parkinson's disease (PD), and 6-hydroxydopamine (6-OHDA) can selectively damage dopaminergic neurons. The damage caused by unilateral injection of 6-hydroxydopamine in the nigrostriatum of the rat brain can cause asymmetry in the two hemispheres of the animal and hypersensitivity of the dopamine receptor (DA-R). Apomorphine is a post-synaptic membrane D 2 Receptor agonists, when the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) exceeds 90%, hypersensitivity of the postsynaptic membrane will appear, and apomorphine can induce the rotation behavior of the model mice to the healthy side, and its The number of rotations was inversely proportional to the number of tyrosine hydroxylase positive neurons in...

experiment example 3

[0105] Experimental example 3 Effect of paeonifloride glycosides on pole climbing time of MPTP-induced Parkinson's disease model mice

[0106] MPTP is an inhibitor of complex I of the mitochondrial respiratory chain. After injection into the body, it can be catalyzed by midbrain monoamine oxidase B to generate MPP + , the latter is a selective neurotoxin that can specifically damage dopaminergic neurons in the substantia nigra. C57BL mice can produce pathological and neurophysiological changes very similar to those of clinical PD patients after application of a large dose of MPTP, so it is a better animal model. The pole climbing time reflects the coordinated movement ability of animals. Animals with good motor coordination will need less time to climb the pole, and those with poor coordination will have longer time to climb the pole.

[0107] 3.1 Materials

[0108] Animals: C57BL mice.

[0109] Equipment: self-made stainless steel measuring rod.

[0110] Drugs and reagen...

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Abstract

The invention discloses a novel application of albiflorin in preparing medicines for preventing and treating the Parkinson's disease. Tests prove that albiflorin has a distinct antiparkinsonian effect, quick action and low toxic and adverse effects. Albiflorin as a medicine for treating the Parkinson's disease, is safe, efficient and stable, has a simple preparation process, is suitable for industrial production, and is easy for generalization. The invention provides a new source of medicines for preventing and treating the Parkinson's disease.

Description

technical field [0001] The invention relates to a medicine or health food for preventing, alleviating and / or treating neurodegenerative diseases, in particular to a medicine or health food for anti-Parkinson's disease. Background technique [0002] Parkinson's Disease (PD) is the main type of neurodegenerative diseases, and it is an age-related neurodegenerative disease, with decreased movement, increased muscle tone and tremor as the main symptoms. [0003] Parkinson's disease is basically a disease of middle-aged and elderly people; its incidence rate increases with age; the prevalence rate of people over 60 years old is 1%. The onset of Parkinson's disease is very slow, often preceded by motor symptoms, such as tremor, which may be asymmetrical on both sides. Later, some patients will develop mental symptoms, such as depression, dementia, and personality changes. The survival time of untreated patients ranges from 1 to 30 years, mostly 8 to 10 years. The main lesions o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/16A61K31/365A23L1/29A23L33/00
CPCA61K31/343A61K31/7048A61P25/16A61P25/28
Inventor 张作光
Owner 张作光
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