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Quality detection method of musk pain relieving cream

A quality inspection method and a pain-relieving technology of musk, applied in the fields of pharmacy and analytical chemistry, can solve problems such as inability to accurately measure the active ingredients, and achieve the effects of qualitative and quantitative, improved purity, and increased sample volume.

Active Publication Date: 2015-04-08
浙江康恩贝中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a quality detection method of musk pain relief ointment, specifically adopt steam distillation to extract the target component, organic solvent dissolves the target component to be tested, and gas chromatography detects the target component; Simultaneously accurate measurement of the content of multiple medicinal ingredients in Musk Jietong plasters

Method used

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  • Quality detection method of musk pain relieving cream
  • Quality detection method of musk pain relieving cream
  • Quality detection method of musk pain relieving cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: the investigation of preparation method of test sample (extraction solvent and its consumption, extraction time)

[0061] (1) Preparation of internal standard solution

[0062] Take naphthalene as the internal standard, dissolve with organic solvents screened according to orthogonal tables 1 and 2, respectively, to make a 0.5 mg / ml internal standard solution;

[0063] (2) Preparation of the test solution: according to figure 1 Install the distillation extraction device, take 50 pieces of musk pain relief ointment, remove the lining cover, weigh, cut into pieces to about 0.5cm*0.5cm, mix well, take the weight equivalent to 4 pieces, a total of 9 parts, accurately weighed, Put the round bottom flask in the distillation extraction device, add 10-40ml of distilled water to soak, the amount of distilled water should cover the ointment completely, add an appropriate amount of organic solvent into the U-shaped tube, and then heat, distill and extract the musk wi...

Embodiment 2

[0080] Embodiment 2: the single factor investigation (extraction solvent) of need testing sample solution preparation method

[0081] (1) Preparation of internal standard solution

[0082] Taking naphthalene as the internal standard, dissolve it with the organic solvent selected according to Table 4 respectively to make a 0.5mg / ml internal standard solution;

[0083] (2) preparation of need testing solution

[0084] according to figure 1 Install the distillation extraction device, take 50 pieces of musk pain relief ointment, remove the lining cover, weigh, cut into pieces to about 0.5cm*0.5cm, mix well, take the weight equivalent to 4 pieces, a total of 9 parts, accurately weighed, Put the round bottom flask in the distillation extraction device, add 10-40ml of distilled water to soak, the amount of distilled water should cover the ointment completely, add an appropriate amount of organic solvent into the U-shaped tube, and then heat, distill and extract the musk with an elect...

Embodiment 3

[0094] Embodiment 3: chromatographic column investigation

[0095] (1) Preparation of internal standard solution

[0096] Use naphthalene as the internal standard and dissolve it in n-hexane to make a 0.5mg / ml internal standard solution;

[0097] (2) preparation of need testing solution

[0098] according to figure 1 Install the distillation extraction device, take 50 pieces of musk pain relief ointment, remove the lining cover, weigh, cut into pieces to about 0.5cm*0.5cm, mix well, take the weight equivalent to 4 pieces, a total of 9 parts, accurately weighed, Put the round bottom flask in the distillation extraction device, add 10-40ml of distilled water to soak, the amount of distilled water is preferably to completely cover the paste, add 40ml of n-hexane into the U-shaped tube, and then heat with an electric heating mantle for 4h, distill and extract Muscone and other volatile components: move the above extract to a funnel, separate the organic layer, filter it with a ...

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Abstract

The invention aims to provide a method for detecting main medicinal components of musk pain relieving cream. Specifically, a target product is extracted by distillation of water steam, and to-be-detected target components are dissolved by an organic solvent and are detected by a gas chromatographic method. According to the method, special distillation extraction equipment and the organic solvent are used for distillation extraction so as to realize accurate extraction of the to-be-detected target components such as ultralow-content musk ketone; the content of the musk ketone, camphor, menthol, borneol, cinnamaldehyde and eugenol can be simultaneously accurately detected by one step; the method disclosed by the invention has the advantages of providing an extraction and measurement method for the low-content musk ketone, solving the problem of specificity of a method for simultaneously extracting and detecting other volatile components, being simple and convenient to operate and having a good application value.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and analytical chemistry, and in particular relates to a quality detection method of musk pain relief ointment. Background technique [0002] Musk pain relief ointment has the functions of promoting blood circulation, expelling cold, and relieving pain. It is used for sprains, joint pains, etc. [0003] [0004] Preparation method: according to the prescription, take raw aconite, clove, calamus, safflower, Xu Changqing, rhubarb, sweet pine, and chuanxiong from the above thirteen herbs and grind them into coarse powder, reflux three times with 90% ethanol, each time for 1 hour, filter After that, the combined filtrates were concentrated under reduced pressure to a liquid extract with a relative density of about 1.05 (20°C); the musk was impregnated twice with ether, each time with 18ml of ether for 48 hours, and then with ether-ethanol (1:2) Mix 15ml, soak for 48 hours, combine the extracts, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 吴华铃金汉台何厚洪印晓红陈卿姚建标王建方闵会胡江宁吕丽丽
Owner 浙江康恩贝中药有限公司
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