Composition of ginsenosides Rg3 and Rg5 and medicine use such as anti-tumor use of composition

A technology of ginsenoside and composition, which is applied in the field of composition preparation, can solve the problems of unidentified content, etc., and achieve the effects of improving immunity, antidepressant effect, and reducing toxic and side effects

Pending Publication Date: 2021-01-22
富力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the present inventors found that the prior art either takes one or several purified ginsenosides as the research object to conduct pharmacological research, wherein the dosages of ginsenoside Rg3 and ginsenoside Rg5 are ofte...

Method used

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  • Composition of ginsenosides Rg3 and Rg5 and medicine use such as anti-tumor use of composition
  • Composition of ginsenosides Rg3 and Rg5 and medicine use such as anti-tumor use of composition
  • Composition of ginsenosides Rg3 and Rg5 and medicine use such as anti-tumor use of composition

Examples

Experimental program
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Effect test

Embodiment 1-9

[0055] The preparation of the composition of embodiment 1-9 ginsenoside Rg3 and ginsenoside Rg5

[0056] The specific process route is: decoct three times with water, combine the water and liquid, combine and concentrate to the crude drug: the water ratio is 1:5, keep the temperature at 60-80°C, add ZTC1+1-II clarifier (available from Wuhan Zhengtiancheng Biotechnology Co., Ltd.) to a final concentration of 500ppm, stir evenly, stand still, filter, dry the filtrate, add ethanol solution to dissolve at 60°C, cool down after filtering, precipitate in an ice-water bath, collect the precipitate, and dry it. The content of each component was detected by high performance liquid chromatography.

[0057] Ginseng and various crude drugs were weighed according to the weights in Table 1, and mixed and extracted with the parameters in Table 2 according to the above process route, and prepared. The test data of the finished product is shown in Table 3.

[0058] The raw material ratio of ...

Embodiment 181-198

[0081] Example 181-198 Preparation of ginsenoside Rg3 and ginsenoside Rg5 composition and cyclodextrin composition

[0082] Take the ginsenoside Rg3 and ginsenoside Rg5 compositions prepared in Example 1-198, and prepare the composition according to the following method with the weight ratio described in Table 4: (1) directly add to the cyclodextrin solution, or (2) directly Add to the cyclodextrin solution and stir thoroughly for 1-24h, (3) directly add to the cyclodextrin solution and heat for 10-120 minutes, (4) directly add to the cyclodextrin solution and sonicate for 10-120 minutes, (5) Grinding directly with cyclodextrin powder for 10-120 minutes, (6) mixing ginsenoside Rg3 and ginsenoside Rg5 with the cyclodextrin powder evenly, and sieving; (7) directly adding cyclodextrin to derivatize solution, or (8) directly added to the solution of cyclodextrin derivatives and fully stirred for 1-24h, (9) directly added to the solution of cyclodextrin derivatives and heated for 1...

Embodiment 199

[0086] The preparation of embodiment 199 ginsenoside Rg3 and ginsenoside Rg5 composition tablet

[0087] Prepare the tablet of ginsenoside Rg3 and ginsenoside Rg5 composition according to the following ratio:

[0088]

[0089] According to the above ratio, take the ginsenoside Rg3 and ginsenoside Rg5 compositions prepared by the process route in Example 1-198 and mix them evenly with starch, make granules, add talcum powder and magnesium stearate, mix evenly, and press into 10,000 tablets .

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Abstract

The invention discloses a composition of ginsenoside Rg3 and ginsenoside Rg5, a preparation method of the composition, and application of the composition to medicines, foods and health-care products for improving immunity, resisting tumors, resisting medicine resistance of tumor targeted medicines, relieving chemoradiotherapy toxic and side effects, resisting fatigue and resisting depression. Thecomposition can quickly take effect, has small toxic and side effects, can be taken for a long time, belongs to a safe, efficient and stable medicine and health care food with a simple preparation process, is suitable for industrial production, and can be easily popularized. The invention provides a novel raw material and production process for medicines and foods for improving immunity, resistingtumors, resisting medicine resistance of tumor targeted medicines, relieving chemoradiotherapy toxic and side effects, resisting fatigue and resisting depression.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry. Specifically, the invention relates to a preparation method of a composition of ginsenoside Rg3 and ginsenoside Rg5, and its role in improving immunity, anti-tumor, and drug resistance of anti-tumor targeted drugs, alleviating Toxic and side effects of radiotherapy and chemotherapy, anti-fatigue, anti-depression drugs, food and health care products. Background technique [0002] Ginseng is a plant belonging to the genus Panax in the Araliaceae family. It has been widely used in China, Korea, and Japan for more than 2,000 years, mainly for the purpose of preventing diseases and prolonging life. According to "Shen Nong's Materia Medica", ginseng has the functions of "replenishing the five internal organs, calming the nerves, calming the soul, relieving palpitations, eliminating evil spirits, improving the mind, and long-term use to lighten the body and prolong life". Modern medical research show...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K36/484A61K36/8966A61K36/185A61K36/8964A61K36/808A61K36/899A61P37/04A61P35/00A61P39/00A61P25/24A23L33/10A23L33/105A23C9/152A23G3/36A23F3/14A21D13/06A21D2/34A21D2/36C12G3/055
CPCA61K31/704A61K36/484A61K36/8966A61K36/185A61K36/8964A61K36/808A61K36/899A61P37/04A61P35/00A61P39/00A61P25/24A23L33/10A23L33/105A23C9/152A23G3/364A23F3/14A21D13/06A21D2/34A21D2/36A21D2/362A21D2/366C12G3/055A23V2002/00A61K2300/00A23V2200/324A23V2200/308A23V2200/322A23V2200/30A23V2250/204A23V2250/21A23V2250/2124A61K31/517A61K31/506A23G3/48A61K2236/39A61K2236/37A61K36/9066A61K36/904A61K36/287A61K36/285A61K36/79A61K36/902A61K36/284A61K36/47A61K36/39A61K36/756A61K36/258A61K45/06A61P25/26A61K2236/331A61K2236/333A61K2236/51A61K2236/53
Inventor 富力柳洋鲁明明惠敏刘国友王硕
Owner 富力
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