Nano antibacterial agent and preparation method thereof

A nano-antibacterial agent and antibiotic technology, applied in the field of antibacterial agents and their preparation, can solve the problems of non-targeting, poor biocompatibility in the antibacterial field, and low utilization rate of antibiotics, and achieve simple and low-cost raw materials and energy-saving synthesis methods Simplicity and the effect of improving the effective utilization rate

Active Publication Date: 2018-11-20
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of poor biocompatibility, non-targetability and low utilization rate of antibiotics in the antibacterial field of existing nanomaterial modified antibiotics, and provide a nano antibacterial agent and its preparation method

Method used

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  • Nano antibacterial agent and preparation method thereof
  • Nano antibacterial agent and preparation method thereof
  • Nano antibacterial agent and preparation method thereof

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specific Embodiment approach 1

[0038] Specific embodiment 1: This embodiment is a nano-antibacterial agent that is sodium hyaluronate to modify the surface of the MOF and antibiotic synergistic system; the MOF and antibiotic synergistic system is antibiotic encapsulated in zeolite imidazole ester framework structure material ZIF -8 in.

specific Embodiment approach 2

[0039] Specific embodiment two: this embodiment is different from the specific embodiment one in that the zeolite imidazole ester framework structure material ZIF-8 is made of Zn(NO) 3 ·6H 2 O provides metal ions, 2-methylimidazole is used as a ligand, and deionized water is used as a dispersion medium, which is formed by cross-linking interaction at room temperature. The other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0040] Specific embodiment three: this embodiment is different from specific embodiment one or two in that the antibiotics are tetracycline antibiotics, aminoglycoside antibiotics, lactam antibiotics or polypeptide antibiotics. The other steps are the same as the first or second embodiment.

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Abstract

The invention discloses a nano antibacterial agent and a preparation method thereof and relates to an antibacterial agent and a preparation method thereof. The invention aims to solve the problems that the conventional nanometer material modified antibiotics applied to the antibacterial field have poor biocompatibility and do not have targeting property and the utilization rate of the antibioticsis low. The nano antibacterial agent is prepared by performing surface modification on a synergetic system of MOF and antibiotics with sodium hyaluronate, wherein the synergetic system of the MOF andantibiotics with sodium hyaluronate is formed by encapsulating the antibiotics in a zeolite imidazate framework structure material ZIF-8. The method comprises the following steps: 1, preparing the synergetic system of the MOF and antibiotics; 2, performing surface modification on the prepared synergetic system of the MOF and antibiotics with a sodium hyaluronate solution, and performing vacuum drying, thereby obtaining the nano antibacterial agent. According to the preparation method disclosed by the invention, the nano antibacterial agent can be obtained.

Description

Technical field [0001] The invention relates to an antibacterial agent and a preparation method thereof. Background technique [0002] Antibiotics were once known as "magic drugs" and have met many urgent medical needs for a long time. Unfortunately, excessive and inappropriate use has led to a sharp increase in the resistance of bacteria to conventional antibiotics. This phenomenon has always been the focus of attention and research hotspots at home and abroad, and the World Health Organization (WHO) has also listed it as the century. One of the biggest public safety issues. [0003] Intracellular bacteria refer to pathogenic bacteria that can invade host cells and colonize and multiply inside the cells. Intracellular pathogenic bacteria can not only escape the attack of the host immune system, but can also be protected from the toxic effects of antibiotics and other anti-infective drugs to a certain extent, resulting in an increase in bacterial resistance, and the formation of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/61A61K45/00A61K31/65A61P31/04
CPCA61K31/65A61K45/00A61K47/61A61K47/6923A61P31/04
Inventor 王建龙张旭刘立志黄伦杰张文涛汪蓉王宗汉
Owner NORTHWEST A & F UNIV
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