The invention discloses an anti-fatigue and heart-protecting American ginseng preparation and a preparation method thereof, which are characterized in that the active ingredients are made of American ginseng, Sanqi and Rhodiola rosea, and are also made of fresh American ginseng as raw materials. American ginseng extract, combined with Panax notoginseng extract and Rhodiola rosea extract, mixed, granulated, dried, granulated, then added magnesium stearate and mixed evenly, then filled into capsules, polished, packaged, and irradiated to sterilize Made into capsule preparations. The present invention adopts processing technologies such as the combination of pure physical means and heating ultrasonic hydrolysis treatment, so that the obtained product has high yield and good activity, helps to improve the nutritional value of the product, promotes the digestion and absorption of nutrients, and helps to improve the immune system. At the same time, it promotes the release of cell content and improves the effective utilization of American ginseng. The product has strong human immune function, anti-fatigue and anti-aging, and heart protection. It can be widely promoted and produced.