The invention discloses a sterile packaging method for small-volume injection. The sterile packaging method includes steps of (1) weighing injection raw and auxiliary materials under a negative-pressure weighing cover according to the technical proportion, sequentially adding the weighed injection raw and auxiliary materials into a dosing pot which is sterilized in advance, adding injection-used water to dilute and uniformly mix; (2) replenishing injection-used water to the total dosing amount according to the technical proportion by the aid of a weighing
system of the dosing pot, adjusting the pH (potential of
hydrogen) value of a
drug liquor, and filtering and sterilizing the
drug liquor through a 0.22-
micrometer sterilizing level filter of a redundant
filter system; and (3) injecting the filtered sterile
drug liquor into an integrated
plastic bottle blowing and filling and sealing
machine through a sterile pipeline
system, and obtaining a finished product after completing
bottle blowing, filling and sealing under protection of an A-level laminar flow cover. The sterile packaging method has the advantages that
terminal sterilization is omitted, original chemical characteristics of the injection are guaranteed, and further plastic ampoules are used for
package, so that no craps are generated during use,
embolism of blood vessels is avoided as well, and strong guarantee is provided for safety in clinical use.