Chinese toon leaf decocting pieces assisting in blood glucose reduction and preparation method of decocting pieces

A Chinese toon leaf and blood sugar-lowering technology, which is applied in the field of Chinese toon leaf-assisted blood sugar-lowering decoction pieces and its preparation, can solve the problems of low extraction rate, achieve the effects of increasing extraction rate, lowering blood sugar, and preventing lipid metabolism disorders in diabetes

Inactive Publication Date: 2016-08-10
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the extraction methods of flavonoids and other active substances in Toona sinensis mainly include enzymatic hydrolysis, ultrasonic method, microwave method, semi-bionic method, dipping method, etc., but there is a problem of low extraction rate.

Method used

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  • Chinese toon leaf decocting pieces assisting in blood glucose reduction and preparation method of decocting pieces
  • Chinese toon leaf decocting pieces assisting in blood glucose reduction and preparation method of decocting pieces
  • Chinese toon leaf decocting pieces assisting in blood glucose reduction and preparation method of decocting pieces

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Take 10kg of old leaves of Toona sinensis and dry them in the shade, add edible alcohol with a concentration of 55% according to the ratio of material to liquid 1:10, soak at room temperature for 4 hours, then soak at -35°C for 1 hour, stand at room temperature for 1 hour, and then perform ultrasonic extraction , the ultrasonic power was 175 W, the temperature was 45°C, the extraction time was 35 min, filtered, and the obtained filtrate was evaporated under reduced pressure at 0.01MPa and 46°C until alcohol-free, and then dried at 45°C to constant weight. Toon leaf crude extract was obtained.

[0023] (2) Dissolve the crude extract obtained in step (1) in water, and use NKA-9 macroporous resin to separate and purify. The conditions are: 70 mL of Toona sinensis leaf crude extract with a mass concentration of 7 mg / mL, and the loading speed is 2 BV / h, use 80 mL 60% edible alcohol as the eluent, elute at a flow rate of 2 BV / h, collect the eluate, evaporate under reduced...

Embodiment 2

[0027] (1) Take 10kg of old leaves of Toona sinensis and dry them in the shade, add edible alcohol with a concentration of 60% according to the ratio of material to liquid 1:15, soak at room temperature for 6 hours, then soak at -20°C for 2 hours, stand at room temperature for 1.5 hours, and then perform ultrasound Extraction, ultrasonic power is 175 W, temperature is 50°C, extraction time is 40 min, filtered, the obtained filtrate is evaporated under reduced pressure at 0.01MPa, 46°C until alcohol-free, and then dried at 45°C to constant weight , to obtain the crude extract of Chinese toon leaves.

[0028] (2) Dissolve the crude extract of Toona sinensis leaves obtained in step (1) in water, and use NKA-9 macroporous resin to separate and purify. Speed ​​2 BV / h, use 80 mL 60% edible alcohol as the eluent, elute at a flow rate of 2 BV / h, collect the eluate, evaporate under reduced pressure at 0.01MPa, 46°C until alcohol-free, Then it was dried to constant weight under the con...

Embodiment 3

[0032] (1) Take 10kg old leaves of Toona sinensis and dry them in the shade, add edible alcohol with a concentration of 65% according to the ratio of material to liquid 1:20, soak at room temperature for 8 hours, then soak at -5°C for 3 hours, let stand at room temperature for 2 hours, and use an ultrasonic power of 175 W, temperature 60°C, extraction time 50min, filter, the obtained filtrate is evaporated under reduced pressure at 0.01MPa and 46°C until alcohol-free, and then dried at 45°C to constant weight to obtain the crude extract of Chinese toon leaves .

[0033] (2) Dissolve the crude extract of Toona sinensis leaves obtained in step (1) in water, and use NKA-9 macroporous resin to separate and purify. Speed ​​2 BV / h, use 80 mL 60% edible alcohol as the eluent, elute at a flow rate of 2 BV / h, collect the eluate, evaporate under reduced pressure at 0.01MPa, 46°C until alcohol-free, Then it was dried to constant weight under the condition of 45° C. to obtain Toona sinen...

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Abstract

The invention relates to Chinese toon leaf decocting pieces assisting in blood glucose reduction and a preparation method of the decocting pieces, and belongs to the field of a medical health-care product. The decocting pieces comprise the following components, by mass, 6-9% of a toon leaf extract, 12-14% of maltodextrin, and 0.5-0.75% of a lubricant, with the balance being a filling agent. The decocting pieces are prepared by performing room-temperature soaking, low-temperature soaking, room-temperature standing, ultrasonic extraction, and purification to old Chinese toon leaves to obtain the toon leaf extract; uniformly mixing the toon leaf extract, maltodextrin, and the filling agent, and carrying out sieving, soft material preparation, granulation, drying, addition of the lubrication and tabletting. Through the method, the general flavones extraction ratio is high, and active components of the extract can be effectively kept. Meanwhile, old Chinese toon leaves are subjected to reasonable exploitation and utilization, thereby increasing the use ratio and additional value of Chinese toon resources. The provided decocting pieces are convenient to eat, have an obvious effect on assisting blood glucose reduction, and can effectively prevent diabetic complications.

Description

technical field [0001] The invention belongs to the field of medicine and health care products, and in particular relates to Chinese toon leaf auxiliary blood sugar-lowering decoction pieces and a preparation method thereof. Background technique [0002] Toona sinensis is a deciduous tree belonging to the Meliaceae family. It is widely distributed in the Yellow River and Yangtze River basins. It has been cultivated in my country for more than 2,000 years. Toona sinensis buds and young leaves are rich in aroma and unique in taste. They are unique woody vegetables in my country and are deeply loved by people. Chinese toon is not only nutritious, but also can be used as medicine. The old leaves of Toona sinensis are rich in active substances such as polyphenols, flavonoids and saponins. Flavonoids can resist oxidation, resist viruses, soften blood vessels, enhance blood vessel tension, and improve blood circulation, so they have a good preventive effect on diabetic complicati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/58A61K9/20A61K47/36A61P3/10A61P9/00A61K127/00
CPCA61K9/2059A61K36/58A61K2236/333A61K2236/51A61K2236/55
Inventor 张京芳苗修港张雅利余翔张贝贝
Owner NORTHWEST A & F UNIV
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