Application of external-use plaster composition in preparation of drug used for preventing, relieving and/or treating inflammatory diseases

An inflammatory disease and composition technology, applied in the field of external medicine, can solve problems such as patients who are not suitable for acute gastroenteritis, and achieve the effects of unique effects, easy use and pain relief.

Inactive Publication Date: 2014-11-05
吕刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these agents are not indicated for the treatment of patients with acute gastroenteritis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] The traditional Chinese medicine ointment for external use prepared in Example 1 is made into a plaster for external use and pasted on the affected part, one paste each time, once a day.

[0124] Positive control drug: indomethacin ointment, Shenyang Xingqi Pharmaceutical Co., Ltd., specification 1%, for external use, take an appropriate amount and apply it to the affected area.

[0125] 3.2 Experimental method

[0126] Take 60 rats and divide them into 6 groups at random, namely blank control group, model control group (apply with deionized water 5mL / kg), high (10g crude drug / kg) and medium (5g crude drug / kg) compositions of the present invention. , low (2g crude drug / kg) dose group, positive drug control group, 10 rats in each group. Apply deionized water, external ointment of the present invention, and indomethacin ointment on both sides of the right ear of rats, twice a day, after 7 days of continuous administration, and 30 minutes after the last administration, ex...

Embodiment 2

[0214] 1) Weigh the raw materials according to the following ratio (unit: ×100g)

[0215] Rehmannia 20, Radix Radix 30, Rhizoma Drynaria 30, Panax notoginseng 40, Peach Kernel 20, Rehmannia Rehmanniae 15, Bletilla striata 20, Guangui 30, Angelica dahurica 35, Angelica 30, Radix Paeoniae Rubra 45, Notopterygium 20, Sophora flavescens 30, Licorice 25, Duhuo 20. Yuanshen 15, Rhubarb 25, Turtle Turtle 35, Huang Dan 20, Cucumber Seed 10, Leek Seed 30, Grape Seed 30, Green Peel 30

[0216] Among them, Shengdi, Baishui, Drynaria, Panax notoginseng, peach kernel, Rehmannia glutinosa, Bletilla striata, Guangui, Baizhi, Angelica, Chishao, Qianghuo, Sophora flavescens, licorice, Duhuo, Yuanshen, rhubarb, and Turtle are crushed into fine powder , the particle size of the fine powder is 200-300 mesh, mix evenly, and prepare the first fine powder mixture for later use;

[0217] Grinding the raw materials cucumber seeds, leek seeds, grape seeds and green peels into fine powder respectively ...

Embodiment 3

[0224] 1) Weigh the raw materials according to the following ratio (unit: ×100g)

[0225] Rehmannia 30, Radix Radix 35, Rhizoma Drynaria 20, Panax notoginseng 60, Peach Kernel 30, Rehmannia Rehmanniae 10, Bletilla striata 35, Guangui 20, Angelica dahurica 20, Angelica 35, Radix Paeoniae Rubra 30, Notopterygium 15, Sophora flavescens 15, Licorice 15, Duhuo 30. Yuanshen 35, Rhubarb 10, Turtle 45, Huang Dan 40, Cucumber Seed 15, Leek Seed 20, Grape Seed 20, Green Peel 40

[0226] Among them, the raw ground, white pomegranate, drynaria, notoginseng, peach kernel, rehmannia, bletilla striata, official osmanthus, angelica, angelica, red peony root, notopterygium, flavescens, licorice, lovage, root ginseng, rhubarb, and soft-shelled turtle are crushed into fine Powder, fine powder particle size is 200-300 mesh, mix evenly, make the first fine powder mixture and set aside;

[0227] Grinding the raw materials cucumber seeds, leek seeds, grape seeds and green peels into fine powder res...

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PUM

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Abstract

The invention discloses an application of an external-use plaster composition in preparation of a drug used for preventing, relieving and / or treating inflammatory diseases. A experiment proves that the external-use plaster composition is significant in effects on treatment of inflammatory diseases, is quick in the effects, is slight in toxic and side effects, is simple in the preparation method, is a drug used for treating inflammatory diseases safely, high-efficiently and stably, is suitable for industrial production, is easy to popularize. The invention provides a new drug source for preventing and treating the inflammatory diseases.

Description

technical field [0001] The invention relates to an external medicine and its application, in particular to a traditional Chinese medicine external medicine ointment composition and its application in the preparation of medicines for preventing, alleviating and / or treating inflammatory diseases. Background technique [0002] Medicines for external use are applied on the body surface or certain mucous membranes, and have the functions of killing insects and relieving itching, reducing swelling and dissipating stagnation, removing putrefaction and discharging pus, promoting granulation and closing the mouth, astringent and hemostasis. External treatment prescriptions include ointment, pill, water, wine, powder, medicinal thread (yaoding) and other dosage forms, and are used directly on the affected part. Usage includes plastering, painting, applying, blending, fumigation, washing, soaking, bathing, eyedropping, ear filling, nose dripping, throat blowing and medicine insertion i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P29/00
Inventor 吕刚佟玉兰
Owner 吕刚
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