Blonanserin-contained oral preparation for treating schizophrenia
A technology for schizophrenia and oral preparations, which is applied in the field of pharmaceutical preparations, can solve problems such as no production, and achieve the effects of good solubility, low dosage, and simple preparation process
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Embodiment 1
[0035] Composition and preparation method of compressed tablet with active ingredient 2 mg
[0036] Mix 2.0g of active ingredients, 20.0g of microcrystalline cellulose, 15.0g of pregelatinized starch, 36.0g of lactose, 6.0g of croscarmellose sodium, and 4.0g of hydroxypropylmethylcellulose, and mix them evenly, and use 50wt % ethanol aqueous solution is the soft material made of wetting agent, granulated with a 30-mesh screen, ventilated and dried at 55°C, granulated, added with 0.5g of micro-powdered silica gel and mixed evenly, pressed into about 1000 round tablets, each containing 2mg of active ingredient, namely Have to compress the tablet.
Embodiment 2
[0038] Composition and method of preparation of compressed tablet with active ingredient 4 mg
[0039] Mix 4.0g of active ingredients, 40.0g of microcrystalline cellulose, 20.0g of pregelatinized starch, 66.0g of lactose, 8.0g of croscarmellose sodium, and 8.0g of hydroxypropylmethylcellulose, and mix them evenly, and mix them with 50wt % ethanol water solution is the soft material made of wetting agent, granulated with a 30-mesh screen, ventilated and dried at 55°C, granulated, added with 1g of magnesium stearate and 1g of micro-powdered silica gel, mixed evenly, and pressed into about 1000 round tablets, each containing Active ingredient 4mg, that is, compressed tablets.
Embodiment 3
[0041] Composition and method of preparation of compressed tablet with 8 mg active ingredient
[0042] Mix 8.0 g of active ingredients, 60.0 g of microcrystalline cellulose, 30.0 g of pregelatinized starch, 100.0 g of lactose, and 12.0 g of croscarmellose sodium, and use 3 wt % hydroxypropyl methylcellulose aqueous solution as Soft material made of wetting agent, granulated with 30-mesh screen, ventilated and dried at 55°C, granulated, added with 2g of magnesium stearate and 1g of micro-powdered silica gel, mixed evenly, pressed into about 1000 round tablets, each containing 8mg of active ingredient, A compressed tablet is obtained.
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