Uniformly degradable orthopedic implant magnesium alloy material

A magnesium alloy and orthopedic technology, applied in the field of degradable biomedical alloy materials, can solve the problems of magnesium alloys that cannot meet clinical requirements, uneven local degradation, poor osteoinductive ability, etc., achieve ideal in vivo degradation performance, and avoid premature failure , the effect of good comprehensive mechanical properties

Inactive Publication Date: 2013-04-03
JIANGSU KONSUNG MEDICAL EQUIPMENT CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the rapid degradation rate of magnesium, uneven local degradation, and poor osteoinductive ability, magnesium alloys cannot meet clinical requirements at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The gravity casting method is used to prepare Mg-Gd-Nd-Sr-Zn-Zr magnesium alloy ingots, and its components and weight percentages are Gd 1%, Nd 2%, Sr 0.1%, Zn 0.1, Zr 0.5, The remainder is Mg. The purity of magnesium in the raw material is 99.95%, the purity of Zn is 99.999%, and the addition of Gd, Nd, Sr and Zr is based on Mg-30%Gd, Mg-30%Nd, Mg-25%Sr and Mg-30%Zr respectively Added in the form of binary master alloy, their purity is more than 99.95%. The degradation rate of the as-cast alloy in simulated body fluid containing glucose was 0.25 mm / year, and the degradation was uniform. Cytotoxicity results showed that the alloy had no cytotoxicity to osteoblasts. After solution treatment (540 ℃, 10 h) and extrusion deformation processing (extrusion temperature 270 ℃, extrusion ratio 9, extrusion speed 2 mm / min) of the alloy, its tensile strength at room temperature can be Up to 410 Mpa, the elongation rate is 9%.

Embodiment 2

[0016] The Mg-Gd-Nd-Sr-Zn-Zr magnesium alloy ingot is prepared by gravity casting, and its components and weight percentages are Gd0.5%, Nd1.5%, Sr0.5%, Zn0.2, Zr0 .3, the rest is Mg. The purity of magnesium in the raw material is 99.95%, the purity of Zn is 99.999%, and the addition of Gd, Nd, Sr and Zr is based on Mg-30%Gd, Mg-30%Nd, Mg-25%Sr and Mg-30%Zr respectively Added in the form of binary master alloy, the purity is greater than 99.95%. The degradation rate of the as-cast alloy in the simulated body fluid containing glucose was 0.28 mm / year, and the degradation was uniform. Cytotoxicity results showed that the alloy had no cytotoxicity to osteoblasts. After solution treatment (540 ℃, 10h) and extrusion deformation processing (extrusion temperature 380 ℃, extrusion ratio 9, extrusion speed 8 mm / min) of the alloy, its tensile strength at room temperature can reach 280Mpa, the elongation rate is 20%.

Embodiment 3

[0018] The Mg-Nd-Sr-Zn-Zr magnesium alloy ingot is prepared by gravity casting, and its components and weight percentages are Nd5%, Sr2%, Zn0.3, Zr1, and the rest is Mg. The purity of magnesium in the raw material is 99.95%, the purity of Zn is 99.999%, and the addition of Nd, Sr and Zr is added in the form of Mg-30%Nd, Mg-25%Sr and Mg-30%Zr binary master alloys respectively, The purity is greater than 99.95%. The degradation rate of the as-cast alloy in simulated body fluid containing glucose was 0.35 mm / year, and the degradation was uniform. Cytotoxicity results showed that the alloy had no cytotoxicity to osteoblasts. After solution treatment (540 ℃, 10h) and extrusion deformation processing (extrusion temperature 320 ℃, extrusion ratio 9, extrusion speed 8 mm / min) of the alloy, its tensile strength at room temperature can reach 300Mpa, the elongation rate is 28%.

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Abstract

The invention relates to a medical alloy material, in particular to a uniformly degradable orthopedic implant magnesium alloy material. The orthopedic implant magnesium alloy material comprises the following components in percentage by weight: 0-5% of Gd, 1-5% of Nd, more than 0-2% of Sr, 0-0.5% of Zn, more than 0-1% of Zr and the balance of Mg. Due to the addition of magnesium alloy elements Gd and Nd, the strength and the corrosion resistance of the magnesium alloy are improved. In addition, a small amount of Gd and Nd are better in bio-safety; Sr has the effect of inducing growth of osteoblasts; Zn is a human necessary micronutrient element, and the ductility and the corrosion resistance of the alloy can be improved due to the addition of the Zn; and Zr has the effects of refining crystal grains and improving the strength and the corrosion resistance of the alloy and can enable the magnesium degrading speed to be more uniform, and no cell toxicity exists after a small amount of Zr is added.

Description

technical field [0001] The invention relates to a degradable biomedical alloy material, in particular to a magnesium alloy material suitable for orthopedic implants, which has uniform degradation characteristics and induces bone cell growth. Background technique [0002] At present, the orthopedic implant materials in clinical application are mainly stainless steel and titanium alloy materials. However, stainless steel and titanium alloys are biologically inert materials, which are not degradable in the body and are prone to produce soluble ions, which can easily cause biotoxicity, local allergies or inflammation; after bone healing, a second operation is required to remove the implant material, which increases the pain of the patient , psychological and economic burdens. In addition, the elastic modulus of stainless steel and titanium alloy is much higher than that of human bone, which has a great "stress shielding" effect on local bone tissue, which may lead to the possib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/00C22C23/06A61L31/02
Inventor 王强章晓波王章忠巴志新
Owner JIANGSU KONSUNG MEDICAL EQUIPMENT CO LTD
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