Novel anti-microbial and hemostatic gauze and preparation method thereof

A hemostatic gauze, a new type of technology, applied in the field of medical devices, can solve the problems of antibacterial drug resistance, hemostatic materials are difficult to have antibacterial function and other problems, and achieve the effect of no toxic side effects and good biocompatibility

Inactive Publication Date: 2017-03-08
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It is generally difficult for existing hemostatic materials to have antibacterial functions. In order to have antibacterial

Method used

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  • Novel anti-microbial and hemostatic gauze and preparation method thereof
  • Novel anti-microbial and hemostatic gauze and preparation method thereof
  • Novel anti-microbial and hemostatic gauze and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of novel antibacterial hemostatic gauze, comprising the following steps:

[0022] S1: pretreatment: soak medical absorbent cotton gauze with absolute ethanol for 45min;

[0023] S2: Alkalization treatment: Soak the medical absorbent cotton gauze treated by S1 in a mixed solution of ethanol and alkali (v / v=1:1) for alkalization reaction, at a temperature of 25°C with a mass ratio of 3:50 Under reaction 60min; Wherein, the mixed solution of ethanol and alkali is the ethanol that volume concentration is 90% and the sodium hydroxide solution that concentration is 15wt% configures with the volume ratio of 1:1;

[0024] S3: Etherification treatment: After the alkalinization treatment step of S2, chloroacetic acid ethanol solution (wherein the chloroacetic acid in the chloroacetic acid ethanol solution and the sodium hydroxide in the mixed solution of ethanol and alkali described in S2 are added to the reaction system) The molar ratio is 2:1) for etherifi...

Embodiment 2

[0029] A preparation method of novel antibacterial hemostatic gauze, comprising the following steps:

[0030] S1: pretreatment: soak medical absorbent cotton gauze with absolute ethanol for 60min;

[0031] S2: Alkalization treatment: Soak the medical absorbent cotton gauze treated by S1 in a mixed solution of ethanol and alkali (v / v=1:1) for alkalization reaction, with a mass ratio of 3:100 at a temperature of 27°C Under reaction 40min; Wherein, the mixed solution of ethanol and alkali is that volume concentration is the ethanol of 95% and the sodium hydroxide solution that concentration is 35wt% configures with the volume ratio of 1:1;

[0032] S3: Etherification treatment: After the alkalinization treatment step of S2, chloroacetic acid ethanol solution (wherein the chloroacetic acid in the chloroacetic acid ethanol solution and the sodium hydroxide in the mixed solution of ethanol and alkali described in S2 are added to the reaction system) The molar ratio is 4:1) for ethe...

Embodiment 3

[0041] A preparation method of novel antibacterial hemostatic gauze, comprising the following steps:

[0042] S1: pretreatment: soak medical absorbent cotton gauze with absolute ethanol for 30min;

[0043] S2: Alkalization treatment: Soak the medical absorbent cotton gauze treated by S1 in a mixed solution of ethanol and alkali (v / v=1:1) for alkalization reaction, with a mass ratio of 3:70 at a temperature of 30°C Under reaction 30min; Wherein, the mixed solution of ethanol and alkali is the ethanol that volume concentration is 98% and the sodium hydroxide solution that concentration is 25wt% configures with the volume ratio of 1:1;

[0044] S3: Etherification treatment: After the alkalinization treatment step of S2, chloroacetic acid ethanol solution (wherein the chloroacetic acid in the chloroacetic acid ethanol solution and the sodium hydroxide in the mixed solution of ethanol and alkali described in S2 are added to the reaction system) The molar ratio is 3:1) for etherifi...

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Abstract

The invention specifically relates to novel anti-microbial and hemostatic gauze and a preparation method of the novel anti-microbial and hemostatic gauze. The preparation method comprises the following steps: carrying out modified treatment including alkalization, etherification, neutralization, ethanol washing and the like on medical degreasing cotton gauze, thus obtaining sodium carboxymethylcellulose gauze; and carrying out a certain synthetic process (ion exchange) on the sodium carboxymethylcellulose gauze, thus obtaining the sodium carboxymethylcellulose gauze. The prepared carboxymethylcellulose metal salt gauze has the hemostasis function and also has the excellent anti-microbial property, the purposes of stopping bleeding and diminishing inflammation can be rapidly realized without adding of any medicines, meanwhile, the surgical adhesion can be prevented, and finally, the product is decomposed into monosaccharide in the body so as to be absorbed by the human body.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a novel antibacterial hemostatic gauze and a preparation method thereof. Background technique [0002] According to statistics, the main cause of death on the battlefield is excessive blood loss, accounting for about 50% of the total, while in peacetime, 39% of people who died due to trauma died from excessive blood loss. Hemorrhage that has not been effectively controlled is already The second leading cause of traumatic death. Even if the bleeding can be gradually controlled over a long period of time, excessive blood loss usually leads to serious consequences such as wound infection, hypothermia, coagulopathy or multiple organ failure. [0003] It is generally difficult for existing hemostatic materials to have antibacterial functions. Most of the hemostatic materials generally add antibacterial drugs in order to have antibacterial functions, but there is a problem of antimicrob...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/46
CPCA61L15/28A61L15/44A61L15/46A61L2300/102A61L2300/404A61L2300/412A61L2300/604C08L1/286
Inventor 卢亢庄壮辉吴帅
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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