Hemostatic anti-adhesive membrane and preparation method thereof

Abstract

The invention relates to a hemostatic anti-adhesive membrane and a preparation method of the hemostatic anti-adhesive membrane. The preparation method of the hemostatic anti-adhesive membrane comprises the following steps: dissolving chitosan in acetic acid aqueous solution, carrying out electrostatic spinning, thus obtaining a chitosan fibrous membrane, removing residual acid in the chitosan fibrous membrane, immersing the chitosan fibrous membrane in acid polysaccharide aqueous solution, thus obtaining a compound fibrous membrane, and finally, carrying out aftertreatment on the compound fibrous membrane, thus obtaining the hemostatic anti-adhesive membrane. The finally obtained hemostatic anti-adhesive membrane is mainly composed of the chitosan fibrous membrane and acid polysaccharose, wherein the content of the acid polysaccharose is 5-80 wt%, the acid polysaccharose is polysaccharose containing carboxylate radical ions, the acid polysaccharose is bonded to chitosan through amido bonds, and thus the chitosan fibers realize covalent cross-linking. The finally prepared hemostatic anti-adhesive membrane is high in tenacity, good in fitting performance, and high in biocompatibility, can completely degrade in the body, and belongs to the ideal hemostatic anti-adhesive material.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a hemostatic and anti-adhesion film and a preparation method thereof. Background technique [0002] In the clinical field, adhesions are abnormal structures formed by fibrous bands of connective tissue joined together with adjacent tissues or organs. Postoperative adverse adhesions can cause pain or dysfunction of biological tissues, and in severe cases, additional surgery is required to strip the adverse adhesions. Clinically, an anti-adhesion film is generally used as a physical barrier to prevent adhesions from occurring. [0003] At present, there are two kinds of anti-adhesion films commonly used in the market. One is polylactic acid anti-adhesion film. Hard and brittle, and this type of product has poor adhesion, often requires surgical sutures to fix, and there is a risk of re-adhesion, so the use is greatly restricted; the other is chitosan anti-adhesion film, mainly carbox...

AI Technical Summary

Problems solved by technology

[Xinying Gen, Electrospinning of chitosan dissolved in concentrated acetic acid solution.Biomaterials.] proposed the method of electrospinning chitosan acetic acid solution, but the mechanical properties of the fiber membrane produced by electrospinning are very poor, which is not enough for clinical application

Patent CN 103691006A discloses a method for preparing an anti-adhesion film after neurosurgery. First, chitosan nanofibers are prepared by electrospinning, and genipin ethanol solution is used to cross-link the fibers, and then the shell is coated with hyaluronic acid. Polysaccharide nanofibers obtained postoperative anti-adhesion film, although to a certain extent prevented postoperative adhesion, but the use of genipin ethanol solution will bring some toxicity, there is a safety hazard for implantable medical devices, and chitosan After the electrospun membrane is cross-linked with genipin ethanol solution, the structure between the chitosan fibers is solidified, and the softness and adhesive performance of the chitosan electrospun membrane become poor, which affects the performance of the final product

Images