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Growth factor compound dressing capable of adhering tissue fissure and preparation method thereof

A growth factor and fissure technology, used in medical science, bandages, absorbent pads, etc., can solve the problems of complex preparation process, inconvenience for patients, multiple drug components, etc., and achieve good biocompatibility, reduce pain, and improve microcosm. The effect of the environment

Inactive Publication Date: 2015-11-18
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN10302788A reports a kind of absorbable medical dressing and its preparation method, the growth factors are added in its medicinal ingredients, but its preparation process is relatively complicated; Patent CN102671231A reports a preparation method of a marine source composite dressing, using marine fish A dressing prepared by extracting collagen from the epidermis and adding growth factors and related functional components, but the dressing contains many medicinal ingredients and has certain toxic and side effects; similar patent reports on growth factors include CN102078636A, CN103007339A, CN102397585A and CN104288828A Wait
However, for operations or deep wounds with fissures, it is still necessary to rely on sutures, which brings unconsciousness and pain to patients.

Method used

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  • Growth factor compound dressing capable of adhering tissue fissure and preparation method thereof

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Effect test

Embodiment 1

[0037] A growth factor composite dressing capable of bonding tissue fissures, comprising an alginate gel layer and a non-woven fabric layer, the main components of the alginate gel layer include: sodium alginate, calcium carbonate, gluconolactone, Glycerin, sodium carboxymethylcellulose, allantoin, alpha-cyanoacrylate, cell growth factor, protective agent.

[0038] A preparation method of a growth factor composite dressing capable of bonding tissue fissures is as follows:

[0039] (1) Add 40 parts of sodium alginate, 12.5 parts of calcium carbonate, 20 parts of gluconolactone, 6 parts of glycerin, and 3 parts of sodium carboxymethylcellulose into 75 parts of deionized water and stir evenly to form a mixed solution A;

[0040] (2) Add 0.05 parts of allantoin, 4 parts of α-cyanoacrylate, 0.1 part of cell growth factor and 0.2 part of protective agent into 100 parts of deionized water and stir evenly to form a mixed solution B. The cell growth factor is epidermal growth factor, ...

Embodiment 2

[0045] A growth factor composite dressing capable of bonding tissue fissures, comprising an alginate gel layer and a non-woven fabric layer, the main components of the alginate gel layer include: sodium alginate, calcium carbonate, gluconolactone, Glycerin, sodium carboxymethylcellulose, allantoin, alpha-cyanoacrylate, cell growth factor, protective agent.

[0046] A preparation method of a growth factor composite dressing capable of bonding tissue fissures is as follows:

[0047] (1) Add 50 parts of sodium alginate, 20 parts of calcium carbonate, 30 parts of gluconolactone, 2 parts of glycerin, and 1 part of sodium carboxymethylcellulose into 50 parts of deionized water and stir evenly to form a mixed solution A;

[0048] (2) Add 0.2 part of allantoin, 1 part of α-cyanoacrylate, 0.08 part of cell growth factor and 0.1 part of protective agent into 70 parts of deionized water and stir evenly to form a mixed solution B. The cell growth factor is Epidermal growth factor and fib...

Embodiment 3

[0053] A growth factor composite dressing capable of bonding tissue fissures, comprising an alginate gel layer and a non-woven fabric layer, the main components of the alginate gel layer include: sodium alginate, calcium carbonate, gluconolactone, Glycerin, sodium carboxymethylcellulose, allantoin, alpha-cyanoacrylate, cell growth factor, protective agent.

[0054] A preparation method of a growth factor composite dressing capable of bonding tissue fissures is as follows:

[0055] (1) Add 30 parts of sodium alginate, 5 parts of calcium carbonate, 10 parts of gluconolactone, 10 parts of glycerin, and 5 parts of sodium carboxymethylcellulose into 100 parts of deionized water and stir evenly to form a mixed solution A;

[0056] (2) Add 0.1 part of allantoin, 5 parts of α-cyanoacrylate, 0.05 part of cell growth factor and 0.05 part of protective agent into 50 parts of deionized water and stir evenly to form a mixed solution B. The cell growth factor is Epidermal growth factor and...

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Abstract

The invention discloses a growth factor compound dressing capable of adhering a tissue fissure and a preparation method thereof. The compound dressing comprises an alginate gel layer and a non-woven fabric layer, wherein the alginate gel layer is prepared from sodium alginate, calcium carbonate, glucolactone, glycerinum, sodium carboxymethyl cellulose, allantoin, alpha-cyanoacrylate, cell growth factors and a protective agent. The dressing can be used for replacing a suture line to a certain extent, radically effectively promoting wound healing to prevent pains of surgical suturing for patients with relatively deep wounds, and effectively reducing generation of scars.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a growth factor composite dressing capable of bonding tissue fissures and a preparation method thereof. Background technique [0002] After the skin has been damaged or cut, the normal healing response leads to the formation of scars. The healing process of damaged skin consists of three phases—an inflammatory phase, a granulation phase, and a remodeling phase of the matrix. In the phase of inflammatory response, a series of biochemical reactions such as changes in vascular dynamics, increased vascular permeability, and swelling at the injured site appear. Local tissue degeneration, exudation, and proliferation are used to eliminate and repel foreign lethal cells, laying the foundation for the mission. During the granulation stage, fibroblasts secrete a large amount of collagen, elastin and fibronectin, etc., and form a large number of collagen fibers, but collagenase continue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/20A61L15/44C08J3/075
Inventor 韦加娜陈锦涛熊亮何立彬
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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