39 results about "Tissue Degeneration" patented technology

The present invention relates to the use of one or more natural or modified oxygen carriers, devoid of plasma or cellular membrane constituents, for the production of an agent for the external treatment of open wounds, particularly chronic wounds. Hemoglobin or myoglobin of human or animal origin are suitable as oxygen carriers. The oxygen carriers can also preferably be modified. Suitable modifications are cross-linking, reaction with polyalkylene oxides, chemically reactive or chemically non-reactive effectors, or combinations. The agent is applied to the wound area particularly by means of spraying on an aqueous solution containing the oxygen carrier(s). The oxygen carriers can be used in particularly effective manner in the case of chronic wounds resulting from tissue degeneration, particularly diabetic tissue degeneration.

An apparatus and method for treating superficial skin conditions with radio frequency energy. The apparatus includes a probe that is coupled to a radio frequency console. The probe has at least one tip that can be inserted into skin tissue. Radio frequency energy can be delivered to the skin tissue through the tip. The radio frequency energy denatures tissue to cause tissue shrinkage. The tissue shrinkage can reduce or remove wrinkles, or reduce or eliminate the visual appearance of blood carrying tissue such as facial spider veins.

An apparatus that is used to perform a medical procedure on a cornea. The apparatus may include a ring that can be placed on a cornea and a probe that can deliver energy to denature corneal tissue. The probe can be moved about the ring and cornea by a first actuator. A second actuator may move the probe into contact with the cornea to deliver energy and denature tissue. The process of moving the probe and delivering energy can be repeated to create a circular pattern of denatured areas. The circular pattern of denatured areas may correct for hyperopia. The actuators may be controlled by a controller that operates in accordance with a program to move the probe and create the circular pattern of denatured areas in an automated process.

The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.

Biomarkers for diagnosis and monitoring of vascular aneurysms are described in the context of the use of assays to measure a plurality of these biomarkers. Tissue degeneration, particularly elastin and/or collagen degradation, can be monitored within patient blood (serum) and/or urine to diagnose the presence, the progression, or the likelihood of rupture of aneurismal disease. Additionally, enzymes responsible for this degradation and other biomarkers responsible for the activation or inhibition of these enzymes can be monitored additionally or alternatively. Prompt diagnosis can provide the opportunity for intervention and potentially increase the health of patients by tempering the development of debilitating and life-threatening vascular aneurysms.

Methods of preventing and reversing stem cell aging including the step of activating the mitochondrial unfolded protein response in a stem cell are described. Further described are methods of promoting stem cell maintenance and methods of preventing and/or reversing tissue degeneration or injury including the step of activating the mitochondrial unfolded protein response.

This invention relates to novel anthraquinone compounds useful in the treatment of allergic, inflammatory conditions, antioxidant, tumor condition, stem cell application, tissue engineering, applied in treating age-associate tissue degeneration, reverse organ failure in chronic high-turnover disease and therapeutic compositions containing such compounds. The compounds of the present invention are 1,4-, 1,5- and 1,8-difunctionalized anthraquinones or analogs thereof. According to the practice of the invention, there are provided bis-symmetrical substituted anthraquinone compounds according to formula I:

wherein R1, R2, R3 and R4 present a straight, aminoalkylamino side chains or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R5, or R1, R2, R3 and R4 present phenyl or benzyl which may be substituted with one or two groups of R6; wherein R5 is selected from the group consisting of halogen, —RNH₂, —RNH₂R, —ROH, —NO₂, —OCH₃, —OCH₂CH₃, and —OCH₂CH₂CH₃; and wherein R6 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, —RNH₂, —RNH₂R, —ROH, —NO₂, —OCH₃, —OCH₂CH₃, —OCH₂CH₂CH₃, —CH₂Br, —CH₂Cl, —CH₂OH, —C(CH₃)₃, —(CH₂)₂0H, —(CH₂)₃OH, —(CH₂)₄OH, —CH₂NH₂, —(CH₂)₂NH₂, —(CH₂)₃NH₂, —(CH₂)₄NH₂, —(CH₂)₅NH₂, —CH₂N(CH₃)₂, —(CH₂)₂N(CH₃)₂, —(CH₂)₂NH(CH₂)₂OH, —(CH₂)₃NH(CH₂)₂OH, —(CH₂)₂NHCH₂OH, —(CH₂)₃NHCH₂OH, —CH₂CH(CH₃)₂, —CHCl₂, —CH(CH₃)Cl, —(CH₂)₂Cl, —(CH₂)₃Cl, —(CH₂)₃Br, —(CH₂)₄Br, and —(CH₂)₄Cl.

Chart 1. Activation of hTERT promoter-driven SEAP expression by c-Myc. About 1×10⁷ hTERT-BJ1 cells were transfected with 13.5 μg each of plasmid pSEAP or pPhTERT-SEAP and of plasmid pMT2T or pMT2T-cMyc by electroporation. After 24 h, viable cells were harvested, and reinoculated at a density of 3×10⁵/mL, and the SEAP activity after 24 h at 37 □. The transfection efficiency of each experiment was determined by cotransfection with 1.5 μg of plasmid pCMVβ. The values were determined from three experiments. P<0.05 is presented by an asterisk.

The invention relates to the technical field of microorganisms, relates to application of bifidobacterium lactis MN-Gup to improvement of obesity and characteristic intestinal flora, and discloses bifidobacterium lactis MN-Gup and a microecological preparation thereof, which have the effects of regulating obesity characteristic intestinal flora and improving and restoring health of the intestinal flora, and have the effects that obesity characteristic intestinal flora are regulated; obesity characteristic intestinal flora are improved and regulated in a targeted manner, the abundance of beneficial bacteria related to obesity is improved, the abundance of harmful bacteria related to obesity is reduced, and the health of the intestinal flora is improved and recovered; inflammatory factors IL-1beta, TNF-alpha, IL-6 and INF-gamma are inhibited, and obesity-related inflammatory reactions are improved; triglyceride, cholesterol and/or low-density lipoprotein are reduced, high-density lipoprotein is increased, and the purposes of reducing blood fat and inhibiting fat accumulation are achieved; the adipose tissue degeneration is inhibited; and obesity or weight gain is comprehensively prevented, relieved or improved through the mechanisms.

Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration, regeneration, or aging in a patient including inflammatory joint disease or age-related disorders.

The invention relates to a tulasnella fungus and an application thereof in promoting germination of paphiopedilum spicerianum seeds to form seedlings. The fungus is a tulasnella strain which is Tulasnella sp. GYBQ01, and the preservation number of the fungus in China Center for Type Culture Collection is CCTCC NO: M 2020129. The invention provides morphology and physiological and biochemical characteristics of the strain. Morphology, physiology, biochemistry and nucleotide sequence analysis results show that Tulasnella sp. GYBQ01 belongs to a tulasnellaceae tulasnella fungus, can be used for promoting germination of the paphiopedilum spicerianum seeds to form seedlings, and has higher specificity, high-quality symbiotic seedlings can be obtained through inoculating the paphiopedilum spicerianum seeds with the strain, efficient seed and seedling breeding of symbiotic germination can be realized, and the Tulasnella sp. GYBQ01 can be used for seedling culture in nurseries or field fungusseed dressing and direct sowing. Compared with tissue culture, the tulasnella fungus has the advantages of being low in cost, high in field cultivation survival rate, free of tissue degeneration and the like, and lays a foundation for carrying out bionic cultivation, species regression and population reconstruction of the paphiopedilum spicerianum.

The invention provides a Hirsutella sinensis fermented powder extract. The heavy metal content of the extract is lower than that in the international food hygiene standard, the extract does not have pesticide residue, can be completely dissolved in water or ethanol and does not contain culture medium residue, and the product is difficultly oxidized, difficultly generates smell of mutton, and has long retention period. The extract has obvious activity of resisting renal failure, 0.2 to 1.0g/Kg extract can obviously reduce serum creatinine (SCr) and blood urea nitrogen (BUN) content of a rat with renal failure, improves nephridial tissue degeneration caused by gentamicin, inverses renal tubular epithelial cell proliferation inhibition caused by aristolochic acid, reduces mRNA expression of renal failure key factors (TGF beta 1, TIMP-1, PAI-1 and ET) and has other effects; and compared with that of Hirsutella sinensis fermented powder, the effect of the Hirsutella sinensis fermented powder extract is improved by 2 to 10 times, the dosage can be greatly reduced, and the Hirsutella sinensis fermented powder extract is conveniently used by the patient and can be applied to preventing and treating renal failure disease. The Hirsutella sinensis fermented powder extract can serve as an active ingredient to be mixed with pharmaceutic excipients so as to prepare granules, capsules, tablets, buccal tablets, oral solution, tinctures and other formulations.

The invention relates to the field of probiotic dairy products, in particular to fermented milk of bifidobacterium lactis MN-Gup for relieving obesity and a preparation method. The dairy product has the effects of relieving obesity and regulating obesity characteristic intestinal flora, and has the following action mechanisms that the obesity characteristic intestinal flora are improved and regulated in a targeted manner, and the abundance of beneficial bacteria related to obesity is increased; the abundance of harmful bacteria related to obesity is reduced, and the health of intestinal flora is improved and recovered; inflammatory factors IL-1beta, TNF-alpha, IL-6 and INF-gamma are inhibited, and obesity-related inflammatory reactions are improved; triglyceride, cholesterol and/or low-density lipoprotein are reduced, high-density lipoprotein is increased, and the purposes of reducing blood fat and inhibiting fat accumulation are achieved; the adipose tissue degeneration is inhibited; and obesity or weight gain is comprehensively prevented, relieved or improved through the mechanisms.

The present invention relates to a portable, affordable and user-friendly mobile RF radiation detection device. The device is composed of three major parts, namely, a sensor arrangement, a processing 5 unit, and a power supply. The sensor arrangement consists of a flexible sensor and an associated circuit element having few passive electrical components. The substrate of the sensor was made of nanoparticle treated flexible material preferably paper treated with the gold nanoparticles (AuNPs). The electrically conducting patches made 10 of conductive materials preferably silver pastes on the substrate are the key component in detecting the RF radiation from the mobile. The electrical signal generated by the RF sensor is sent to the processing unit, which further transmitted the signal to a mobile android application for displaying the result. The device is useful for detecting 15 harmful mobile radiations to generate alarm in order to save people from deadly diseases such as cell or tissue denaturation, depression, tumor formation, and above all malignancy of tumors.

The present invention is concerned with a composition and in vitro method for generating a desired cell type and/or tissue type from hair follicular stem cells. The composition and in vitro method are particularly suitable for generating an autologous desired cell type and/or tissue type. Furthermore, the composition and method are especially efficient and suitable for use in the context of cosmetic cell and/or tissue transplantation in recipient areas of a subject experiencing cell and/or tissue loss caused by, for example, a wound, scar, burn injury, tissue degeneration, and aging. The composition and in vitro method are also suitable to circumvent complications related to infections and/or immune rejection of a cosmetic cell and/or tissue implant or graft.

A comestible composition with anti-diabetic property which is effective in lowering the blood glucose and help reduce oxidative stress in diabetics and have anti-diabetic properties that protect against diabetic complications, retarding diabetes related organ degeneration and effective to hinder or prevent ailments or conditions resulting from, or exacerbated by, a chronic increase in blood sugar including: tissue degeneration, cardiovascular disease, kidney degeneration, loss of cognitive function, weight loss, visual impairment, and vasomotor symptoms which contains extract from palm leaf.