41 results about "Tissue Degeneration" patented technology

The present invention provides isolated or essentially pure diterpenoic tetrahydropyran, such as steviol-19-glucuronide, steviol, stevioside and rebaudioside processes for obtaining the same and methods for obtaining stable pharmaceutically acceptable salts of the same for use of such compounds or compositions in a treatment of cardiovascular disorders or vascular disease or for the manufacture of medicaments to treat a condition of a cardiovascular disorder or vascular disease.

Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Superficial-partial thickness and deep-partial thickness burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The disclosed method uses spatial frequency domain imaging (SFDI) far noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity is developed and applied to 17 rats. SFDI data is acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity is verified using hematoxylin and eosin histology. Changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) are statistically significant measures, which are used to differentiate superficial partial-thickness burns from deep-partial thickness burns.

The present invention relates to the use of one or more natural or modified oxygen carriers, devoid of plasma or cellular membrane constituents, for the production of an agent for the external treatment of open wounds, particularly chronic wounds. Hemoglobin or myoglobin of human or animal origin are suitable as oxygen carriers. The oxygen carriers can also preferably be modified. Suitable modifications are cross-linking, reaction with polyalkylene oxides, chemically reactive or chemically non-reactive effectors, or combinations. The agent is applied to the wound area particularly by means of spraying on an aqueous solution containing the oxygen carrier(s). The oxygen carriers can be used in particularly effective manner in the case of chronic wounds resulting from tissue degeneration, particularly diabetic tissue degeneration.

An apparatus and method for treating superficial skin conditions with radio frequency energy. The apparatus includes a probe that is coupled to a radio frequency console. The probe has at least one tip that can be inserted into skin tissue. Radio frequency energy can be delivered to the skin tissue through the tip. The radio frequency energy denatures tissue to cause tissue shrinkage. The tissue shrinkage can reduce or remove wrinkles, or reduce or eliminate the visual appearance of blood carrying tissue such as facial spider veins.

An apparatus that is used to perform a medical procedure on a cornea. The apparatus may include a ring that can be placed on a cornea and a probe that can deliver energy to denature corneal tissue. The probe can be moved about the ring and cornea by a first actuator. A second actuator may move the probe into contact with the cornea to deliver energy and denature tissue. The process of moving the probe and delivering energy can be repeated to create a circular pattern of denatured areas. The circular pattern of denatured areas may correct for hyperopia. The actuators may be controlled by a controller that operates in accordance with a program to move the probe and create the circular pattern of denatured areas in an automated process.

The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.

NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and / or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl / cho and cho / carb, are readily acquired and analyzed to predict degree of tissue degeneration and / or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3 T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3 T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and / or pain.

Biomarkers for diagnosis and monitoring of vascular aneurysms are described in the context of the use of assays to measure a plurality of these biomarkers. Tissue degeneration, particularly elastin and / or collagen degradation, can be monitored within patient blood (serum) and / or urine to diagnose the presence, the progression, or the likelihood of rupture of aneurismal disease. Additionally, enzymes responsible for this degradation and other biomarkers responsible for the activation or inhibition of these enzymes can be monitored additionally or alternatively. Prompt diagnosis can provide the opportunity for intervention and potentially increase the health of patients by tempering the development of debilitating and life-threatening vascular aneurysms.

Methods of preventing and reversing stem cell aging including the step of activating the mitochondrial unfolded protein response in a stem cell are described. Further described are methods of promoting stem cell maintenance and methods of preventing and / or reversing tissue degeneration or injury including the step of activating the mitochondrial unfolded protein response.

The present invention provides methods for regulating the growth and / or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem / progenitor cells, for producing differentiated cells and for isolating / purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods. Also provided are methods for diagnosing tumors, for assessing the efficacy of therapy to treat tumors and for assessing the prognosis of a subject who has a neural tumor. Finally, the present invention provides a kits for use in detecting and treating tumors.

This invention relates to novel anthraquinone compounds useful in the treatment of allergic, inflammatory conditions, antioxidant, tumor condition, stem cell application, tissue engineering, applied in treating age-associate tissue degeneration, reverse organ failure in chronic high-turnover disease and therapeutic compositions containing such compounds. The compounds of the present invention are 1,4-, 1,5- and 1,8-difunctionalized anthraquinones or analogs thereof. According to the practice of the invention, there are provided bis-symmetrical substituted anthraquinone compounds according to formula I: wherein R1, R2, R3 and R4 present a straight, aminoalkylamino side chains or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R5, or R1, R2, R3 and R4 present phenyl or benzyl which may be substituted with one or two groups of R6; wherein R5 is selected from the group consisting of halogen, —RNH2, —RNH2R, —ROH, —NO2, —OCH3, —OCH2CH3, and —OCH2CH2CH3; and wherein R6 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, —RNH2, —RNH2R, —ROH, —NO2, —OCH3, —OCH2CH3, —OCH2CH2CH3, —CH2Br, —CH2Cl, —CH2OH, —C(CH3)3, —(CH2)20H, —(CH2)3OH, —(CH2)4OH, —CH2NH2, —(CH2)2NH2, —(CH2)3NH2, —(CH2)4NH2, —(CH2)5NH2, —CH2N(CH3)2, —(CH2)2N(CH3)2, —(CH2)2NH(CH2)2OH, —(CH2)3NH(CH2)2OH, —(CH2)2NHCH2OH, —(CH2)3NHCH2OH, —CH2CH(CH3)2, —CHCl2, —CH(CH3)Cl, —(CH2)2Cl, —(CH2)3Cl, —(CH2)3Br, —(CH2)4Br, and —(CH2)4Cl. Chart 1. Activation of hTERT promoter-driven SEAP expression by c-Myc. About 1×107 hTERT-BJ1 cells were transfected with 13.5 μg each of plasmid pSEAP or pPhTERT-SEAP and of plasmid pMT2T or pMT2T-cMyc by electroporation. After 24 h, viable cells were harvested, and reinoculated at a density of 3×105 / mL, and the SEAP activity after 24 h at 37 □. The transfection efficiency of each experiment was determined by cotransfection with 1.5 μg of plasmid pCMVβ. The values were determined from three experiments. P<0.05 is presented by an asterisk.

The invention relates to the technical field of microorganisms, relates to application of bifidobacterium lactis MN-Gup to improvement of obesity and characteristic intestinal flora, and discloses bifidobacterium lactis MN-Gup and a microecological preparation thereof, which have the effects of regulating obesity characteristic intestinal flora and improving and restoring health of the intestinal flora, and have the effects that obesity characteristic intestinal flora are regulated; obesity characteristic intestinal flora are improved and regulated in a targeted manner, the abundance of beneficial bacteria related to obesity is improved, the abundance of harmful bacteria related to obesity is reduced, and the health of the intestinal flora is improved and recovered; inflammatory factors IL-1beta, TNF-alpha, IL-6 and INF-gamma are inhibited, and obesity-related inflammatory reactions are improved; triglyceride, cholesterol and / or low-density lipoprotein are reduced, high-density lipoprotein is increased, and the purposes of reducing blood fat and inhibiting fat accumulation are achieved; the adipose tissue degeneration is inhibited; and obesity or weight gain is comprehensively prevented, relieved or improved through the mechanisms.

Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and / or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration, regeneration, or aging in a patient including inflammatory joint disease or age-related disorders.

The present invention provides methods for regulating the growth and / or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem / progenitor cells, for producing differentiated cells and for isolating / purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods. Also provided are methods for diagnosing tumors, for assessing the efficacy of therapy to treat tumors and for assessing the prognosis of a subject who has a neural tumor. Finally, the present invention provides a kits for use in detecting and treating tumors.

The invention relates to a tulasnella fungus and an application thereof in promoting germination of paphiopedilum spicerianum seeds to form seedlings. The fungus is a tulasnella strain which is Tulasnella sp. GYBQ01, and the preservation number of the fungus in China Center for Type Culture Collection is CCTCC NO: M 2020129. The invention provides morphology and physiological and biochemical characteristics of the strain. Morphology, physiology, biochemistry and nucleotide sequence analysis results show that Tulasnella sp. GYBQ01 belongs to a tulasnellaceae tulasnella fungus, can be used for promoting germination of the paphiopedilum spicerianum seeds to form seedlings, and has higher specificity, high-quality symbiotic seedlings can be obtained through inoculating the paphiopedilum spicerianum seeds with the strain, efficient seed and seedling breeding of symbiotic germination can be realized, and the Tulasnella sp. GYBQ01 can be used for seedling culture in nurseries or field fungusseed dressing and direct sowing. Compared with tissue culture, the tulasnella fungus has the advantages of being low in cost, high in field cultivation survival rate, free of tissue degeneration and the like, and lays a foundation for carrying out bionic cultivation, species regression and population reconstruction of the paphiopedilum spicerianum.

The invention relates to the identification and visualization of the spatial distribution of particular tissue states in histological tissue sections from mass spectrometric signals acquired with spatial resolution. The invention proposes a method by means of which regions of the tissue with similar mass spectra are found automatically, and it is further proposed that mass spectra of these regions are summed in order to improve the spectral quality to such an extent that known markers for tissue degenerations can be identified with increased certainty. Regions of similar mass spectra can be interconnected on a large scale, but can also be isolated from each other on a small scale.

The present disclosure relates to an image processing device, an image processing method, and a surgical system with which more accurate surgical resection can be performed in a shorter time.An identifying unit identifies the type of tissue degeneration in a mid-surgery image. In accordance with the identified type of the tissue degeneration, a drawing unit draws auxiliary information for the operator, the auxiliary information being to be superimposed on the mid-surgery image. The present disclosure can be applied to an endoscopic surgical system or the like that includes a display device, a camera control unit (CCU), a light source device, a treatment tool device, a pneumoperitoneum apparatus, a recorder, a printer, an endoscope, an energetic treatment tool, forceps, trocars, a foot switch, and a patient's bed, for example.

The invention provides a Hirsutella sinensis fermented powder extract. The heavy metal content of the extract is lower than that in the international food hygiene standard, the extract does not have pesticide residue, can be completely dissolved in water or ethanol and does not contain culture medium residue, and the product is difficultly oxidized, difficultly generates smell of mutton, and has long retention period. The extract has obvious activity of resisting renal failure, 0.2 to 1.0g / Kg extract can obviously reduce serum creatinine (SCr) and blood urea nitrogen (BUN) content of a rat with renal failure, improves nephridial tissue degeneration caused by gentamicin, inverses renal tubular epithelial cell proliferation inhibition caused by aristolochic acid, reduces mRNA expression of renal failure key factors (TGF beta 1, TIMP-1, PAI-1 and ET) and has other effects; and compared with that of Hirsutella sinensis fermented powder, the effect of the Hirsutella sinensis fermented powder extract is improved by 2 to 10 times, the dosage can be greatly reduced, and the Hirsutella sinensis fermented powder extract is conveniently used by the patient and can be applied to preventing and treating renal failure disease. The Hirsutella sinensis fermented powder extract can serve as an active ingredient to be mixed with pharmaceutic excipients so as to prepare granules, capsules, tablets, buccal tablets, oral solution, tinctures and other formulations.

The invention discloses a repeated annealing and spheroidizing method of flake alpha in a similar alpha titanium alloy hybrid structure. The method comprises the following steps: heating a resistance furnace to 50-60 DEG C below a phase transformation point of titanium alloy; putting near alpha titanium alloy sample with a hybrid structure into the resistance furnace to carry out high-temperature annealing heat-preservation treatment, wherein the heat preservation time is 15+ / -0.5min / mm*D, and D is the minimal boundary dimension of the sample; taking out the sample to cool in air after heat preservation is ended; finishing annealing for the first time; and repeating the annealing process for 2-5 times, so that the equiaxial alpha content is increased to 5-20%. The defects that the flake alpha two-phase area deformation spheroidizing technology of the near alpha titanium alloy is complicated in process and high in cost are overcome by repeated annealing, and the method is applicable to a formed member and a flake alpha spheroidizing member in the near alpha titanium alloy hybrid structure.

The present invention teaches novel methods of diagnosing and prognosing conditions associated with tissue degeneration and / or pain, including intervertebral disc degeneration, discogenic pain, osteoarthritis, rheumatoid arthritis, and articular cartilage injury. Using the inventive noninvasive imaging methods, the diagnosis and prognosis of back pain and related conditions can be quickly and accurately determined by detecting one or more biomarkers disclosed herein.

The present disclosure relates to an image processing device, an image processing method, and a surgical system with which more accurate surgical resection can be performed in a shorter time.An identifying unit identifies the type of tissue degeneration in a mid-surgery image. In accordance with the identified type of the tissue degeneration, a drawing unit draws auxiliary information for the operator, the auxiliary information being to be superimposed on the mid-surgery image. The present disclosure can be applied to an endoscopic surgical system or the like that includes a display device, a camera control unit (CCU), a light source device, a treatment tool device, a pneumoperitoneum apparatus, a recorder, a printer, an endoscope, an energetic treatment tool, forceps, trocars, a foot switch, and a patient's bed, for example.

The invention relates to the field of probiotic dairy products, in particular to fermented milk of bifidobacterium lactis MN-Gup for relieving obesity and a preparation method. The dairy product has the effects of relieving obesity and regulating obesity characteristic intestinal flora, and has the following action mechanisms that the obesity characteristic intestinal flora are improved and regulated in a targeted manner, and the abundance of beneficial bacteria related to obesity is increased; the abundance of harmful bacteria related to obesity is reduced, and the health of intestinal flora is improved and recovered; inflammatory factors IL-1beta, TNF-alpha, IL-6 and INF-gamma are inhibited, and obesity-related inflammatory reactions are improved; triglyceride, cholesterol and / or low-density lipoprotein are reduced, high-density lipoprotein is increased, and the purposes of reducing blood fat and inhibiting fat accumulation are achieved; the adipose tissue degeneration is inhibited; and obesity or weight gain is comprehensively prevented, relieved or improved through the mechanisms.

Disclosed herein are methods and compositions for treating skin conditions (e.g., damaged skin barrier, acne, wrinkles, hyperpigmentation / insufficiency, dryness, elastic tissue degeneration), increasing skin volume, and preventing or treating baldness and related conditions, the compositions comprise placental adherent stromal cells, conditioned media derived from cultured placental ASC, lysates thereof, and fractions thereof.

The present invention provides methods for promoting generation of heart tissue, and for treating and preventing heurt tissue degeneration. Additionally, the present invention provides a therapeutic composition comprising a cyclin-associated agent, and a kit comprising the composition. The present invention further provides a heart tissue tell, a sidepopulation progenitor tell, and a stem tell in which cyclin is augmented. Also provided are tell lins comprising these tells, screening methods using the tell lins, and drugs identified by these methods. The present invention further provides in vitro systems for use in screening candidate drugs for at least one cardiotoxic effect and / or for synergy with cyclin in the treatment and prevention of heart tissue degeneration. Finally, the present invention provides use of a cyclin-associated agent in the generation of heart tissue, and use of a cyclin associated agent in the treatment or prevention of heart tissue degeneration.

The present invention relates to a portable, affordable and user-friendly mobile RF radiation detection device. The device is composed of three major parts, namely, a sensor arrangement, a processing 5 unit, and a power supply. The sensor arrangement consists of a flexible sensor and an associated circuit element having few passive electrical components. The substrate of the sensor was made of nanoparticle treated flexible material preferably paper treated with the gold nanoparticles (AuNPs). The electrically conducting patches made 10 of conductive materials preferably silver pastes on the substrate are the key component in detecting the RF radiation from the mobile. The electrical signal generated by the RF sensor is sent to the processing unit, which further transmitted the signal to a mobile android application for displaying the result. The device is useful for detecting 15 harmful mobile radiations to generate alarm in order to save people from deadly diseases such as cell or tissue denaturation, depression, tumor formation, and above all malignancy of tumors.

The present invention is concerned with a composition and in vitro method for generating a desired cell type and / or tissue type from hair follicular stem cells. The composition and in vitro method are particularly suitable for generating an autologous desired cell type and / or tissue type. Furthermore, the composition and method are especially efficient and suitable for use in the context of cosmetic cell and / or tissue transplantation in recipient areas of a subject experiencing cell and / or tissue loss caused by, for example, a wound, scar, burn injury, tissue degeneration, and aging. The composition and in vitro method are also suitable to circumvent complications related to infections and / or immune rejection of a cosmetic cell and / or tissue implant or graft.

A comestible composition with anti-diabetic property which is effective in lowering the blood glucose and help reduce oxidative stress in diabetics and have anti-diabetic properties that protect against diabetic complications, retarding diabetes related organ degeneration and effective to hinder or prevent ailments or conditions resulting from, or exacerbated by, a chronic increase in blood sugar including: tissue degeneration, cardiovascular disease, kidney degeneration, loss of cognitive function, weight loss, visual impairment, and vasomotor symptoms which contains extract from palm leaf.

The invention discloses a method of carrying out denaturation ablation on a target tissue selectively. The method comprises the following steps: S1, a high frequency radiofrequency radiation energy source is provided, and a target tissue which needs to be ablated is selected; S2, the high frequency radiofrequency energy is applied to the target tissue, the generated heat raises the temperature ofthe target tissue by 1 to 2 DEG, and thus, denaturation of the target tissue is stimulated; and S3, the target tissue after denaturation is gradually absorbed by white blood cells in a body, and ablation of the target tissue is realized. A device which can provide the high frequency radiofrequency radiation source is used, in a local noninvasive environment, the electrothermal principle of the radiofrequency and the temperature differences between different tissues of the human body are used, through high-frequency selective heating effects, ablation temperature is achieved at a mammary glandhyperplasia part, fibrous nodules are defused, the health structure of the breast is restored, the process is safe and noninvasive, the effects are stable and reliable, and the health preserving effects of hyperplasia ablation and mammary gland opening are achieved.

Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and / or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or monitoring joint tissue degeneration, regeneration, or aging in a patient including inflammatory joint disease or age-related disorders.