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Bifidobacterium lactis MN-Gup fermented milk for relieving obesity and preparation method thereof

A Bifidobacterium lactis and obesity technology, applied in the field of probiotic dairy products, can solve the problems of inability to specifically regulate obesity-related intestinal flora to restore healthy intestinal flora, affecting product efficacy, and single mechanism of action, etc. The effect of reducing the abundance of harmful bacteria, increasing the abundance of beneficial bacteria, and inhibiting fat accumulation

Active Publication Date: 2021-08-06
INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]Therefore, the technical problem to be solved by the present invention is to overcome the relatively single mechanism of action of existing probiotic products, which cannot specifically regulate obesity-related intestinal flora and restore health Defects such as intestinal flora, thereby affecting the efficacy of the product, thereby providing the use of Bifidobacterium lactis MN-Gup in the preparation of dairy products that improve obesity and regulate the intestinal flora of obesity characteristics, dairy products and preparation methods

Method used

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  • Bifidobacterium lactis MN-Gup fermented milk for relieving obesity and preparation method thereof
  • Bifidobacterium lactis MN-Gup fermented milk for relieving obesity and preparation method thereof
  • Bifidobacterium lactis MN-Gup fermented milk for relieving obesity and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0031] The preparation of embodiment 1 bifidobacterium lactis MN-Gup bacterium powder

[0032] (1) Inoculate Bifidobacterium lactis MN-Gup into the MRS medium for activation culture, and culture it statically at 37°C for 16 hours until it reaches the logarithmic phase, and the number of viable bacteria reaches 10 9 More than cfu / mL;

[0033] (2) Bifidobacterium lactis MN-Gup was centrifuged at 10,000rpm to collect the bacteria, and the protective agent was lactose. The mass ratio of the added amount of the freeze-drying protective agent to the collected bacteria was 0.8:1, and the bacteria were collected under vacuum at -50°C. Dried to obtain MN-Gup powder, the number of bacteria is greater than 4×10 11 cfu / g.

Embodiment 2

[0034] The preparation of embodiment 2 Bifidobacterium lactis MN-Gup bacterium powder

[0035] (1) Inoculate Bifidobacterium lactis MN-Gup into the MRS medium for activation culture, and culture it statically at 37°C for 20 hours, and cultivate it to the logarithmic phase, and the number of viable bacteria reaches 10 9 More than cfu / mL;

[0036] (2) Bifidobacterium lactis MN-Gup was centrifuged at 12,000rpm to collect the bacteria, and the protective agent was lactose. The mass ratio of the added amount of the freeze-drying protective agent to the collected bacteria was 0.7:1, and the bacteria were collected under vacuum at -55°C. Dried to obtain MN-Gup bacteria powder, the number of bacteria is greater than 5×10 11 cfu / g.

Embodiment 3

[0037] The preparation of embodiment 3 Bifidobacterium lactis MN-Gup bacterium powder

[0038] (1) Inoculate Bifidobacterium lactis MN-Gup into MRS medium for activation culture, and culture it statically at 37°C for 18 hours, and cultivate it to the logarithmic phase, and the number of viable bacteria reaches 10 9 More than cfu / mL;

[0039](2) Bifidobacterium lactis MN-Gup was centrifuged at 11,000rpm to collect the bacteria, and the protective agent was maltodextrin. The mass ratio of the amount of the freeze-drying protective agent to the collected bacteria was 0.6:1, and the bacteria were collected at -50°C Under vacuum drying, MN-Gup bacteria powder was obtained, and the number of bacteria was greater than 6×10 11 cfu / g.

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Abstract

The invention relates to the field of probiotic dairy products, in particular to fermented milk of bifidobacterium lactis MN-Gup for relieving obesity and a preparation method. The dairy product has the effects of relieving obesity and regulating obesity characteristic intestinal flora, and has the following action mechanisms that the obesity characteristic intestinal flora are improved and regulated in a targeted manner, and the abundance of beneficial bacteria related to obesity is increased; the abundance of harmful bacteria related to obesity is reduced, and the health of intestinal flora is improved and recovered; inflammatory factors IL-1beta, TNF-alpha, IL-6 and INF-gamma are inhibited, and obesity-related inflammatory reactions are improved; triglyceride, cholesterol and / or low-density lipoprotein are reduced, high-density lipoprotein is increased, and the purposes of reducing blood fat and inhibiting fat accumulation are achieved; the adipose tissue degeneration is inhibited; and obesity or weight gain is comprehensively prevented, relieved or improved through the mechanisms.

Description

technical field [0001] The invention relates to the field of probiotic milk products, in particular to a Bifidobacterium lactis MN-Gup fermented milk for improving obesity and a preparation method thereof. Background technique [0002] Obesity is a global problem that threatens public health. It not only causes many diseases including type 2 diabetes, coronary heart disease, hypertension, and osteoarthritis, but also imposes a serious economic burden on society. As the "invisible organ" carrying the "second gene" of the human body, the intestinal flora participates in the metabolism of nutrition and energy in the human body, and mediates the occurrence and development of obesity through the intestinal flora-intestine-target organ axis. The gut microbiota diversity and Bacteroides / Firmicutes ratio were decreased in obese patients compared with normal population. In addition, the products and metabolites of intestinal flora can also act on remote organs to affect the pathophy...

Claims

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Application Information

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IPC IPC(8): A23C9/123
CPCA23C9/1234
Inventor 陈建国康小红孙健栾少萌赵红峰孙二娜韩雨婷
Owner INNER MONGOLIA MENGNIU DAIRY IND (GRP) CO LTD
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