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Composite hemostatic anti-adhesion dressing and preparation method and application thereof

An anti-adhesion and mixed solution technology, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problems of poor hemostatic effect and anti-adhesion effect, and achieve the effect of good hemostatic performance, no toxic side effects, and low skin irritation.

Inactive Publication Date: 2019-06-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a composite hemostatic and anti-adhesion dressing and its preparation method and application, so as to overcome the defects of poor hemostatic effect and anti-adhesion effect of the hemostatic dressing in the prior art

Method used

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  • Composite hemostatic anti-adhesion dressing and preparation method and application thereof
  • Composite hemostatic anti-adhesion dressing and preparation method and application thereof
  • Composite hemostatic anti-adhesion dressing and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Prepare a mixed solution of 2g / L sodium hydroxide and 2g / L isomeric tridecyl alcohol polyoxyethylene ether 1305, and soak the knitted cotton in the mixed solution, react at a temperature of 90°C for 30min, and the liquor ratio is 1:30. The resulting fabric was washed with a large amount of deionized water, and dried in an oven at 60-80°C.

[0037] (2) Soak the knitted cotton treated in step (1) in 40g / L sodium hydroxide ethanol aqueous solution (85wt%), react at 10°C for 30min, and the bath ratio is 1:30.

[0038] (3) Add a certain amount of 20 g / L monochloroacetic acid ethanol aqueous solution (85 wt%) into the reaction system of step (2), mix well, and react at a temperature of 70° C. for 3 h. The volume ratio of the ethanol aqueous solution (85wt%) of the added monochloroacetic acid to the ethanol aqueous solution (85wt%) of sodium hydroxide in step (2) is 3:5. Adjust pH to neutral with 0.5 mol / L hydrochloric acid solution, and then wash with ethanol aqueous so...

Embodiment 2

[0044](1) Prepare a mixed solution of 3g / L sodium hydroxide and 3g / L isomeric tridecyl alcohol polyoxyethylene ether 1305, and soak the knitted cotton in the mixed solution, react at a temperature of 95°C for 45min, and the liquor ratio is 1:40. The resulting fabric was washed with a large amount of deionized water, and dried in an oven at 60-80°C.

[0045] (2) Soak the knitted cotton treated in step (1) in 35g / L sodium hydroxide ethanol aqueous solution (85wt%), and react at a temperature of 15°C for 40min with a bath ratio of 1:30.

[0046] (3) Add a certain amount of 30 g / L monochloroacetic acid ethanol aqueous solution (85 wt%) into the reaction system of step (2), mix well, and react at a temperature of 65° C. for 3.5 h. The volume ratio of the ethanol aqueous solution (85wt%) of the added monochloroacetic acid to the ethanol aqueous solution (85wt%) of sodium hydroxide in step (2) is 2.5:5. Adjust pH to neutral with 0.5 mol / L hydrochloric acid solution, and then wash w...

Embodiment 3

[0051] (1) Prepare a mixed solution of 8g / L sodium hydroxide and 2g / L isomeric tridecyl alcohol polyoxyethylene ether 1305, and immerse the knitted cotton in the mixed solution, react at a temperature of 85°C for 30min, and the bath ratio is 1:30. The resulting fabric was washed with a large amount of deionized water, and dried in an oven at 60-80°C.

[0052] (2) Soak the knitted cotton treated in step (1) in 42g / L sodium hydroxide ethanol aqueous solution (85wt%) and react at 13°C for 30min with a bath ratio of 1:30.

[0053] (3) Add a certain amount of 34g / L monochloroacetic acid ethanol aqueous solution (85wt%) into the reaction system of step (2), mix well, and react at a temperature of 65°C for 3h. The volume ratio of the ethanol aqueous solution (85wt%) of the added monochloroacetic acid to the ethanol aqueous solution (85wt%) of sodium hydroxide in step (2) is 3:5. Adjust pH to neutral with 0.5 mol / L hydrochloric acid solution, and then wash with ethanol aqueous solut...

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Abstract

The invention relates to a composite hemostatic anti-adhesion dressing and a preparation method and application thereof. The dressing is obtained by coating a mixture of chitosan particles and a sodium carboxymethylcellulose solution on a carboxymethylated cotton fabric. The method comprises alkalizing the pretreated knitted cotton and then performing etherification treatment to obtain the carboxymethylated cotton fabric; dispersing the chitosan particles in the sodium carboxymethylcellulose solution to obtain a mixed solution, coating the mixed solution on the obtained carboxymethylated cotton fabric and drying. The dressing has good water absorption, excellent hemostatic properties and gelation performance.

Description

technical field [0001] The invention belongs to the field of hemostatic dressing and its preparation and application, in particular to a composite hemostatic and anti-adhesion dressing and its preparation method and application. Background technique [0002] Hemorrhagic shock is a common cause of death in medical trauma, traffic accidents, and combat injuries. Uncontrolled blood loss accounts for more than 30% of trauma deaths worldwide. The existing dressing is easy to adhere to the wound, and it is easy to cause secondary damage to the wound when it is removed, which increases the pain of the patient. Therefore, it is of great significance to develop effective hemostatic and anti-adhesion dressings. [0003] Chitosan is derived from the deacetylation of chitin. It is non-toxic and has various physiological activities such as good biocompatibility, biodegradability, antibacterial properties, hemostasis and wound healing. Carboxymethylcellulose sodium is a polysaccharide ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42
Inventor 徐红王雅梅毛志平周培文肖冬冬朱元昭张琳萍钟毅陈支泽隋晓锋王碧佳冯雪凌
Owner DONGHUA UNIV
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