130 results about "Diabetes Complication" patented technology

Disclosed is a novel food product characterized by a low glucose or glucose free content, a balanced functional fat content, and a proactive agent aimed for the diabetic and diabetic-prone populations. The food product of the invention is a functional food which may be used clinically to lower the lipid level in people suffering from an imbalanced lipid profile and which may progress towards diabetes complications and coronary vascular disorders. In particular embodiments the proactive agent can be any of a naturally occurring lipid, a synthetic or mimetic lipid which is not digestible by humans and interferes with body weight gain/loss, plant extracts and substances derived therefrom, antioxidants, animal-derived substances, minerals and pharmaceuticals, and any mixture thereof.

The invention discloses a medicinal composition for treating diabetes. The medicinal composition consists of astragalus, gardenia, Szechuan lovage rhizome, siberian solomonseal rhizome, finger citron, root of red-rooted salvia, cinnamomvine, swordlike atractylodes rhizome, white paeony root, perilla fruit, kudzuvine root, fragrant solomonseal rhizome, oyster shell, rehmannia root, Chinese angelica, common anemarrhena rhizome, honeysuckle flower, heartleaf houttuynia herb, fresh imperata root, Chinese caterpillar fungus, semen nelumbinis, siberian solomonseal rhizome, cornus fruit, prepared rehmannia root, villous amomum fruit, liquoric root, medlar, asparagus, black sesame, tuckahoe, cherokee rose fruit, cistanche deserticola, angelica dahurica, adenophora, dark plum fruit, complanate astragalus seed, cassia seed, mulberry leaf, fresh reed rhizome, mint, oriental waterplantain rhizome, wrinkled gianthyssop herb and parslane herb. The medicinal composition can control the blood sugar level of various patients who suffer from the diabetes and improve the clinical symptoms of diabetes complications effectively. Therefore the medicinal composition can be used for treating the diabetesand the diabetes complications such as diabetic gastroparesis, diabetic nephroma, diabetic foot, diabetic neuropathy, diabetic eye diseases and diabetic pruritus and the like.

The invention relates to a drug for reducing blood glucose, regulating blood lipid and treating diabetes mellitus combined with hyperlipidemia and other chronic vascular complications and a preparation method thereof. The drug is total alkaloids which are extracted from traditional Chinese medicine golden thread. The preparation method of the drug comprises the following steps: 1) the golden thread herbal medicine is crushed into coarse powder; 2) 5-10 times of the amount of 60-80 percent ethanol is used for carrying out the reflux extraction of the golden thread coarse powder for 1-3 times by 1-2h/time, the filtration is carried out by times, and filtrates are merged. Golden thread extract is obtained by pressure reduction concentration and drying; 3) the golden thread extract is added in 5 times of the amount of 0.5 percent sulfuric acid for dissolution and filtration, the filtrates are respectively regulated to pH9 by lime milk, filtrated and respectively regulated to pH1-2 by hydrochloric acid, sodium chloride is added to allow the salt content to be 10 percent, and the total alkaloids of the golden thread are obtained by even shaking and still placement. Or the golden thread extract is used for separating and purifying the total alkaloids of the golden thread by macroporous resin method. The drying is carried out, and the total alkaloids of the golden thread are prepared into oral formulation or injection formulation. The drug has prominent efficacy for the diabetes mellitus combined with hyperlipidemia and other chronic vascular complications.

The invention provides mutual ternary salts of metformin, lipoic acid and acidic amino acids such as aspartic acid and glutamic acid. The invention further provides treatment of prediabetes, diabetes, diabetic complications and/or other conditions in mammals in a method that comprises administering an effective amount of one or more of the foregoing compositions to a mammal in need of such treatment.

The invention relates to a prescription for curing type II diabetes and complications and a preparation technology thereof. The prescription for curing the type II diabetes is prepared by defining, quantifying, extracting, separating or manually synthesizing traditional Chinese medicinal materials, such as radix puerariae, radix astragali, red sage roots, and the like and adding a chemical medicine of gliclazide by a solid dispersion technology. The prescription for curing the type II diabetes is a compound preparation by compounding Chinese and Western medicines and chemical medicines, can be prepared into preparation formulations of tablets, granules, capsules, dripping pills, and the like, can effectively cure the type II diabetes, improves the body immunity and can effectively delay the occurrence and the development of the diabetes complications. The preparation technology of the compound preparation has short technological flow, low production cost, rapid effectual action, unique prescription and preparation method thereof and remarkable treatment effect.

A levo-potassium magnesium aspartate freeze-dried powder injection consists of levo-potassium aspartate, levo-magnesium aspartate, freeze-dried power supporting agent and pH regulator. it is a kind of electrolyte extender, contains no crystal water, and has pH value of 5-11.5, large dosage, physical stability not affected by temperature and no pollution. It has wide application range, and is suitable for intravenously guttae to treat arrhythmia caused by various causes, chronic alcoholism fremitus, myocardiopathy as diabetes complication, etc. and application in heart operation. It is also suitable for acute and chronic hepatitis, intrahepatic cholestasis, and diseases of respiratory system, nerve system and metabolic system.

The invention relates to a newly-developed medicine compound for diabetes which contains sulfonylureas drug for diabetes or a bioactive metabolite of the sulfonylureas drug for diabetes or pharmaceutical salt of the sulfonylureas drug for diabetes, and thiazolidinedione drug for diabetes or pharmaceutical salt and vitamin B of the thiazolidinedione drug for diabetes. The compound contains the sulfonylureas drug for diabetes of therapy dose or the bioactive metabolite of the sulfonylureas drug for diabetes or the pharmaceutical salt of the sulfonylureas drug for diabetes, the thiazolidinedione drug for diabetes of therapy dose or the pharmaceutical salt and therapy dose of vitamin B of the thiazolidinedione drug for diabetes or compound which is related to the thiazolidinedione drug for diabetes and has similar bioactivity and pharmaceutical carrier or excipient. The invention also relates to the purpose of the compound in preparation of drug for treating diabetes or preventing diabetes complication, belonging to the pharmaceutical field.

The bitter gourd tea is composed of 45-50% of bitter gourd powder, 15-20% of mulberry leaves, 10-15% of astragalus root, 10-15% of green tea and 5-10% of black tea by weight. The production process is as follows: 1) high-quality fresh bitter gourd is chosen as raw material and produced into bitter gourd powder after dehydration by cryogenic technique; 2) well-chosen mulberry leaves, astragalus root, green tea and black tea are purified, cleaned, dried and grinded into powder; 3) the above-mentioned powders are evenly mixed according to the weight percentage, sealed in bags or cans. In the bitter gourd tea, the bitter gourd as the main raw material contains charantin which is a hypoglycemic component, proteinoid active substance and multiple amino acids, so has health-care functions of blood sugar regulation, diabetes complication prevention and cure and alcoholism prevention. The bitter gourd tea has advantages of coordinated ingredients, amalgamated taste, convenient eating and no toxic and side effects.

The invention provides formulations and methods of use of furopyridine-based compositions alone and in combination with one or more various second therapeutic agents for the treatment of human disease. The furopyridine composition may include one or more furopyridine species, of which cicletanine is an example. The furopyridines may take various enantiomeric forms, ranging from pure (−) through (−)-dominant, racemic and (+)-dominant to pure (+). Second agents may be any drug useful in combination with a furopyridine in the treatment of diseases such as, cardiovascular disease (hypertension, restenosis, etc.), diabetes, diabetes complications, and polycystic ovarian syndrome. Some of these diseases are associated with endothelial dysfunction and imbalances of prostacyclin or of reactive oxygen species (ROS) or reactive nitrogen species (RNS).

The invention relates to a novel application of a traditional Chinese medicinal composition in the preparation of a medicament for controlling diabetes complications. The prescription contains, by weight, 100 parts of red ginseng, 250 parts of epimeddium, 750 parts of brine-heated Psoralea corylifolia, 250 parts of wolfberry, 250 parts of ephedra stem, 50 parts of Asarum Herb, 375 parts of red sage root and 250 parts of leech. The dosage form comprises pills, a particulate agent, hard capsules, soft capsules, tablets, dropping pills or an oral liquid. The invention aims to provide a novel treatment application of the pharmaceutical composition, enlarge the clinic application range of the pharmaceutical composition and avoid waste of good drug resources.

The invention relates to the prediction of sulfonylureas drug effect by measuring polymorphism site genetype of sulfonylureas recepted gene, and the method. It predicts the effect of sulfonylureas drug in reducing blood sugar, improving and restoring Langer-hans' insula beta cell function and/ or intensifying insulin sensitive function by measuring polymorphism site genetype of sulfonylureas recepted gene; and predicts the effect of sulfonylureas drug in reducing blood sugar, improving and restoring Langer-hans' insula beta cell function and/ or intensifying insulin sensitive function by making use of polymorphism parting oligonucleotide to detect polymorphism site genetype of sulfonylureas recepted gene in biological sample. The invention can indicate doctor to choose medicine according to individual gentic difference, increase the effective rate of clinical medicine treating and safty of clinical midicine usage, reduce toxic and side effect of medicine and economical load, and reduce diabetes complication generation.

The invention discloses a marine organism type enteral nutrition preparation for diabetes patients, a preparation method of the marine organism type enteral nutrition preparation and application. The nutrition preparation includes, by weight, from 3 to 15 parts of algal polysaccharides, from 1 to 5 parts of marine edible animal protein peptide powder, from 3 to 5 parts of microalgae oil, from 0.3to 2 parts of spirulina powder, from0.1 to 1 part of taurine, from 40 to 45 parts of balsam pear polysaccharide or pumpkin polysaccharide, from 10 to 15 parts of soybean protein isolate powder, from 7 to 10 parts of medium chain triglyceride, from 3 to 8 parts of konjac dietary fibers, from 1 to 5 parts of fruit and vegetable powder, from 0.1 to 0.5 part of wheat bran, from 0.1 to 0.5 part of alpha-lipoic acid and a trace of trace element additives. Marine active functional matters with unique pharmacologic bioactivity are reasonably compounded according to needs of nutrition and metabolism of the diabetes patients, and the personal enteral nutrition preparation for the diabetes patients is developed, provides balanced nutrition for the diabetes patients and former diabetes patients, effectively relieves malnutrition, prevents diabetes, assists in regulating blood sugar level, can effectively prevent diabetes complications, and is favorable for increasing the quality of life of the patients and promoting rehabilitation.

The invention discloses a method for extracting cactus polysaccharide, which comprises following steps: extracting with water to remove foreign matter, disintegrating cactus stalk, centrifuging and getting supernatant, filtering, purifying and condensing the supernatant with super filtering membrane, depositing condensed solution to get polysaccharide at ethanol solution with different concentrations, removing protein through Sevag method, and de-coloring with active carbon. The invention is characterized by temperate reaction condition, little polysaccharide loss, fast super-filtering speed, short process, and saved energy consumption. The product is oxidation-inhibitive for diabetes complication, and it can be used to prepare diabetes anti-oxidation medicine. The invention provides a mew way for wild cactus utilization.

The invention relates to the bio-fermentation and medicine field, relating to a method for preparing a zymotic fluid of a coprinus comatus liquid converted mulberry leaf, and a drug or a health product which is obtained by the method and contains the zymotic fluid. The coprinus comatus is taken as a starting strain, the mulberry leaf is taken as a converting target, and fluid shaking culture, primary seed culture and fermenting culture are performed so as to prepare the coprinus comatus deep level zymotic fluid after the mulberry leaf is converted. The zymotic fluid becomes brown from yellow and contains amylase up to 1.5 to 2.5 percent and phenolic compound up to 0.6 to 1.3 percent. The zymotic fluid has the functions of various medicines and can be applied to preparing a drug or a health drink for preventing and treating diabetes and diabetes complications. The method not only provides a novel method for deeply exploiting and utilizing the coprinus comatus and increasing the traditional Chinese medicine function but also provides a traditional Chinese medicine formulation which is safe, effective, and easy to control the manufacture process for preventing and treating diabetes.

The invention provides a diabetes detection device. The diabetes detection device comprises a detection module and a data acquisition module, wherein the detection module comprises an electrochemical sensor, a first analog-digital converter, a hematokrit and oxygen partial pressure fitting curve correction submodule, a color sensor, a second analog-digital converter and a standard color correction submodule, and the data acquisition module comprises a classification submodule, a memory, a medical language conversion submodule and a wireless transmission submodule. According to the diabetes detection device provided by the invention, blood glucose and various urine indexes can be obtained by detecting blood and urine, and are subjected to classified and cross-over analysis so as to be converted into corresponding medical indexes, so that the diabetes detection device can be used for discovering diabetes and diabetes complications more effectively and timely than similar products in the current market, and realizing the daily household detection on the diabetes and the diabetes complications.

The invention discloses a method for producing a nutritious soybean milk which is made from major ingredients including soybean, vitamin B12, vitamin D, taurine and calcium and adjuvant ingredients including pueraria root, cinnamon bark, folic acid, beta-cyclodextrin and flavoring agent. The method comprises the following steps: soaking soybean and draining or soaking soybean, dehulling and draining; freezing at low temperature; mixing with other ingredients; blending to obtain a slurry with bean cake particle size less than or equal to 50 micrometers and protein content more than or equal to 2%; homogenizing; boiling to obtain nutritious soybean milk; and optionally further concentrating and drying to obtain nutritious soybean milk powder. The product can relieve the adverse effect of hypoglycemic drugs and prevent diabetes complications.

A leveo-potassium magnesium aspartate infusion injection consists of levo-potassium aspartate, levo-magnesium asparatate, osmotic pressure regulator and pH regulator. It is a kind of electrolyte extender for infusion, and has pH value of 5-11.5, high concentration, large dosage, high stability and no pollution. it has wide application range, and is suitable for intravenously guttae to treat arrhythmia caused by various causes, chronic alcoholism fremitus, myocardiopathy as diabetes complication, etc. and applicaltion in heart operation. It is also suitable for acute and chronic hepatitis, intrahepatic cholestasis, and disease of respiratory system, nerve system and metabolic system.

The invention provides a traditional Chinese medicine composition for treating diabetes and a preparation method thereof. The traditional Chinese medicine composition for treating diabetes has the advantages of obvious effect and small toxic or side effect, has the functions of preventing, controlling, relieving and curing diabetes, and can prevent the generation and development of diabetes complications. The traditional Chinese medicine composition for treating diabetes is characterized by comprising 2-8g of ginseng, 6-15g of radix astragali, 4-10g of cornel, 2-6% of angelica, 4-9g of wolfberry fruit, 8-10g of kudzu root, 4-8g of polygonatum, 2-8g of pupae, 30-50g of balsam pear and 1-6g of licorice root. The preparation method is characterized by comprising the following steps: extracting volatile oil from angelica, and extracting ginseng with alcohol; merging decoction dregs of angelica and ginseng with radix astragali, cornel, wolfberry fruit, kudzu root, polygonatum, pupae, balsam pear and licorice root; adding 10 times of water, extracting twice (two hours a time), and filtering; merging the two filtrates; concentrating the merged filtrate under reduced pressure at 60 DEG C until the relative density reaches about 1.15-1.20, adding 3 times of 75% ethanol, standing for 24 hours, and taking the supernatant for later use; drying the supernatant, and screening; and taking the undersize, mixing with the volatile oil of angelica for 30 minutes, granulating by a dry process, and finishing the granules.

The invention discloses a chronic non-alcoholic steatohepatitis (NASH) non-human primate model, a method for building the same and application of the chronic non-alcoholic steatohepatitis non-human primate model. The chronic non-alcoholic steatohepatitis non-human primate model, the method and the application have the advantages that the chronic non-alcoholic steatohepatitis non-human primate model built by the aid of the method further can be accompanied by pathological characteristics of chronic hepatic fibrosis and hepatic cirrhosis, can be used for research and development of medicines forpreventing or treating chronic non-alcoholic steatohepatitis, the chronic hepatic fibrosis and the hepatic cirrhosis and can be used as an animal model for research on chronic fatty livers, steatohepatitis, the hepatic fibrosis, the hepatic cirrhosis, hepatocellular carcinoma, metabolic diseases, diabetes mellitus and diabetes complications, and accordingly the chronic non-alcoholic steatohepatitis non-human primate model and the method have extremely high application values.

The invention discloses a medicine composition for preventing and/or treating diabetes and complication of diabetes. The medicine composition is prepared from Chinese herbaceous peony and cassia bark in a weight ratio of (10-1) to 1. The medicine composition comprises the following effective components in parts by weight: 50-150 parts of a pinane monoterpene glycoside compound in Chinese herbaceous peony, and 1-5 parts of a cinnamic acid/aldehyde compound. The medicine composition not only has a good and stable blood sugar reduction and weight loss function, but also can effectively prevent and treat multiple diabetes complications, such as fatty liver, diabetic cardiomyopathy, diabetes peripheral neuritis, diabetes eye diseases and diabetic nephropathy. The composition is low in toxicity, small in side effect, low in cost and safe to use.

The invention discloses a health sock. The health sock comprises a welt, a leg, a surface, a bottom, a heel and a toe, wherein a manually-outwards-linked structure is adopted between the toe and the surface. The invention further discloses a production method for the health sock. The production method comprises the following steps: integrally compounding three bamboo fibres yarns with a chinlon high-elastic yarn, weaving the outer layers of the welt and the leg, and serially connecting and weaving a Lycra elastic yarn to the inner side of each outer layer; integrally compounding three bamboo fibres yarns with a spandex elastic yarn, and weaving the surface and the bottom; integrally compounding three bamboo fibres yarns, a chinlon high-elastic yarn and a spandex elastic yarn, and weaving the heel and the toe; externally sewing the toe and the surface together. The health sock disclosed by the invention is simple in structure, good in breathability, and capable of inhibiting bacteria and diminishing inflammation, and promoting blood circulation; the toe and the surface are in seamless junction, the interior of a sock body is smooth and prevents the skin from being worn; the occurrence of diabetes complications can be prevented; moreover, the production method is simple and convenient to operate.

The invention provides a medicine composition for preventing and treating diabetes and diabetes complications. The medicine composition for preventing and treating the diabetes and diabetes complications comprises the following components in parts by weight: 40-120 parts of panax notoginseng extract, 60-180 parts of American ginseng extract, 0.2-0.6 parts of chromium picolinate and 10-70 parts of momordica charantia extract. The medicine composition can be used for reducing blood sugar and effectively inhibiting a non-enzyme glycosylation reaction of protein, so that diabetes complications of atherosclerosis, diabetic nephropathy, diabetes cardiovascular diseases, diabetes retinal diseases and the like which are caused by non-enzyme glycosylation of the protein can be effectively prevented and treated. The invention also provides a preparation which is prepared from the medicine composition and is used for preventing and treating the diabetes and diabetes complications.

The invention relates to a method for producing sea cucumber bio-alcohol. The method has the following characteristics that: sea cucumber is soaked in water, the produced soak is centrifugally filtered and concentrated, the produced concentrated solution is cooled, fucoidan hydrolytic enzyme is added to enzymatically hydrolyze the fucoidan in the concentrated solution, the temperature is increased to 80 DEG C to 90 DEG C, so that the fucoidan hydrolytic enzyme is inactivated, the produced enzymatically hydrolyzed solution is filtered, edible alcohol and auxiliary materials are added and blended, and the produced sea cucumber bio-alcohol is filtered by diatomite, filled, sterilized and packed. The sea cucumber bio-alcohol can increase the pH value of the acidic body fluid of the human body, enhance the activity of insulin, repair islet cells injured by the acidic constitution, recover the normal functions of islet cells and effectively reduce postprandial plasma glucose; and the sea cucumber bio-alcohol can strengthen metabolism, improve the acidic constitution, stabilize blood pressure, reduce blood sugar, blood fat, blood viscosity and the like, prevent and improve diabetes complication, notably reduce the activity of liver-injuring serum alanine aminotransferase and aspartate aminotransferase, increase the activity of liver SOD and reduce the content of MDA, thus having the function of protecting the liver.

The present invention discloses a kind of diabetes treating medicine composition, which consists of flavone compound extracted from kudzu vine root and red sage polyphenolate extracted from red sage in certain ratio. Of the composition, the kudzu vine root extract contains kudzu vine root flavonid in 50-95 wt%, and the red sage extract contains magnesium red sage acetate in 50-95 wt% and polyphenolate approaching 100 wt%. The medicine composition has the synergistic effect of the components in treating diabetes and diabetes complications and may be used as the medicine for treating diabetes and diabetes complications. The present invention also provides the preparation process of kudzu vine root flavonid and red sage polyphenolate.

The present invention provides drugs containing chymase inhibitors as active ingredients for improving glucose intolerance or preventing and/or treating diseases caused by glucose intolerance. The diseases caused by glucose intolerance are diabetes and/or diabetes complications, wherein the diabetes complications include diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, hyperinsulinism, insulin resistance syndrome, arteriosclerosis, acute coronary syndrome, arteriosclerosis obliterans, angitis, stroke, hypertension, renal insufficiency, nephropathy, nephritis, renal artery aneurysm, renal infarction, obesity and the like.

The present invention relates to recombinant protein of hypoglycemic peptide and human lysozyme and its use. The hypoglycemic peptide in the fusion protein is GLP-1 or its analog and has amino acid sequence of one of those shown in SEQ ID Nos. 1-5; and the human lysozyme has amino acid sequence as shown in SEQ ID No. 6. The hypoglycemic peptide and the human lysozyme are connected in one of the following four connection modes: hypoglycemic peptide-connecting peptide-human lysozyme, hypoglycemic peptide-human lysozyme, human lysozyme-connecting peptide-hypoglycemic peptide and human lysozyme-hypoglycemic peptide. The fusion protein has the hypoglycemic activity of GLP-1 maintained, prolonged half life, as well as anti-infective activity and AGE level-lowering function of human lysozyme, and may be used in preparing medicine for treating diabetes and diabetes complication.