41 results about "Diabetic gastroparesis" patented technology

The invention discloses a medicinal composition for treating diabetes. The medicinal composition consists of astragalus, gardenia, Szechuan lovage rhizome, siberian solomonseal rhizome, finger citron, root of red-rooted salvia, cinnamomvine, swordlike atractylodes rhizome, white paeony root, perilla fruit, kudzuvine root, fragrant solomonseal rhizome, oyster shell, rehmannia root, Chinese angelica, common anemarrhena rhizome, honeysuckle flower, heartleaf houttuynia herb, fresh imperata root, Chinese caterpillar fungus, semen nelumbinis, siberian solomonseal rhizome, cornus fruit, prepared rehmannia root, villous amomum fruit, liquoric root, medlar, asparagus, black sesame, tuckahoe, cherokee rose fruit, cistanche deserticola, angelica dahurica, adenophora, dark plum fruit, complanate astragalus seed, cassia seed, mulberry leaf, fresh reed rhizome, mint, oriental waterplantain rhizome, wrinkled gianthyssop herb and parslane herb. The medicinal composition can control the blood sugar level of various patients who suffer from the diabetes and improve the clinical symptoms of diabetes complications effectively. Therefore the medicinal composition can be used for treating the diabetesand the diabetes complications such as diabetic gastroparesis, diabetic nephroma, diabetic foot, diabetic neuropathy, diabetic eye diseases and diabetic pruritus and the like.

The invention relates to conformation-constrained entirely-synthetic macrocyclic compounds. A conformation-constrained, space-defined 12-30-member macrocyclic system (I) which is as shown in the description comprises three different constitution units: an aromatic template a, a confor1ation regulator b and a spaced part c, which are illustrated in the description and the claims. The macrocyclic compounds (I) can be easily prepared according to a parallel synthesis method or a combinatorial chemistry method, and are designed for realizing interaction with a specific biological target. Particularly, the compounds show agonistic or antagonistic activity to the following matters: a motilin receptor (MR), a 5-hydroxytryptamine receptor (5-HT2B receptor) of a subtype 5-HT2B, and a prostaglandin F2alpha receptor (FP receptor). Thus, the compounds are effectively used for treating gastrointestinal tract hypomotility disorder such as diabetic gastroparesis and constipation-predominant irritable bowel syndrome, CNS-related diseases such as migraine, schizophrenia, psychosis and depression, ocular hypertension such as glaucoma-related ocular hypertension, and premature delivery.

The invention belongs to the field of traditional Chinese medicines for treating diabetes mellitus, and provides a traditional Chinese medicine for treating diabetic gastroparesis, aiming at achieving good efficacy and rapid onset of action. The traditional Chinese medicine is prepared by nutgrass galingale rhizome, Szechuan lovage rhizome, sanchi, swordlike atractylodes rhizome, cape jasmine fruit, lucid ganoderma, Chinese thorowax root, turmeric root-tuber, Chinese angelica and other raw materials and has the effects of banking up root by strengthening vital qi, dispersing stagnated liver qi for relieving qi stagnation, regulating qi-flowing for eliminating mass, promoting blood circulation for removing blood stasis and relieving pain. The traditional Chinese medicine has good effect and rapid onset of action and is characterized by significant effect, exact efficacy and rapid onset of action.

There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.

The invention relates to an orally-taken alpha-glycosidase inhibitor for treating diabetes and diabetic gastroparesis. The composition comprises at least one of the alpha-glycosidase inhibitor and a rhizoma atractylodis extractive at a ratio of (1:1)-(1:10) in parts by weight, and preferably the ratio is 1:3. Through clinical and pharmacological serendipitous discoveries, the composition provided by the invention has multiple effects of inhibiting and reducing postprandial blood sugar through glycosidase, enhancing gastric emptying, helping to improve infection of helicobacter pylori and the like. When the composition disclosed by the invention is designed to be an oral chewable tablet, the rhizoma atractylodis and mulberry chewable tablet can partially act on the oral cavity to remove the helicobacter pylori from the oral cavity and is helpful for cutting off the in-vivo reinfection way of the helicobacter pylori so as to realize the aim of radical treatment on the helicobacter pylori.

The invention provides a medicinal composition for preventing and treating diabetic nerve pathology, the medicinal composition is composed of effective medical components of total timosaponin, epimeddium total flavonoids and total salvianolic acid as well as auxiliary components which are acceptable in pharmacy. The weight ratio of total timosaponin to epimeddium total flavonoids to total salvianolic acid in the effective medical components is (0.1-1): (0.1-1): (0.1-1), the weight of the optimized effective medical components is equal quantity or basically equal quantity. The effective medical components and the auxiliary components which are acceptable in pharmacy are combined for preparing an oral pharmaceutical preparation. The medicinal composition has obvious efficacy and function for preventing and treating diabetic chronic complication, particularly for the diabetes nerve pathology such as diabetic peripheral neuropathy, diabetic impotence, diabetic gastroparesis, diabetic cerebrosis and the like.

The invention discloses a pressure measuring device for stomach pressure method examination of a diabetic gastroparesis patient, which comprises a main body bin serving as a main frame of the pressure measuring device for stomach pressure method examination, a positioning rotating shaft connected to the upper side of the rear surface of the main body bin, and a sealing plate connected to the outer side of the positioning rotating shaft, meanwhile, a positioning buckle is fixed to the front surface of the sealing plate, the detection pipe is arranged on the outer side of the detection end in a sleeving and sealing mode, the tail end of the detection pipe is connected with a pressure detection module, and the pressure detection module is electrically connected with the display control panel; and the signal conversion module is arranged at the central position of the front surface of the detection bin. The pressure measuring device for stomach pressure method examination of the diabetic gastroparesis patient is simple in overall structure and convenient to disassemble and assemble, the gastrointestinal contraction function of the patient can be detected, information can be intelligently stored and recorded, and follow-up comparison of medical staff can be facilitated.

The invention belongs to the technical field of preparation of a medicine preparation, and particularly relates to an itopride hydrochloride medicine composition and a preparation method thereof. Theitopride hydrochloride medicine composition is prepared from the following ingredients in parts by weight: 50 to 150 parts of itopride hydrochloride, 20 to 80 parts of croscarmellose sodium, 20 to 80parts of dimeticone, 5 to 20 parts of fumed silica, 10 to 40 parts of starch, 20 to 80 parts of lactose, 4 to 10 parts of hydroxypropyl cellulose and 1 to 5 parts of magnesium stearate. The prepared itopride hydrochloride medicine composition is a composition prepared from the itopride hydrochloride and the dimeticone; the itopride hydrochloride and the dimeticone have different pharmacological actions and achieve respective effects, but the harmonious synergistic effect is achieved; the gastrointestinal peristalsis is enhanced; meanwhile, the flatulence of the gastrointestinal tract is eliminated; the gastric emptying time of a diabetic gastroparesis rat is obviously shortened; and the mucosa of the gastrointestinal tract is protected.

The invention discloses a constraint type stomach massager for the diabetic gastroparesis patient, which comprises a body and a massage frame; a constraint belt is connected to the lower side of the body, a positioning clamping groove is formed in the outer side of the body, a positioning protruding block is fixed to the inner side of the positioning clamping groove, and a splicing assembling block is connected to the outer side of the positioning protruding block; positioning sliding grooves are formed in the inner sides of the splicing assembling blocks, buffer bins are fixed to the inner sides of the splicing assembling blocks, positioning springs are arranged in the buffer bins, adjusting plates are arranged on the inner sides of the positioning springs, the massage frame is arranged on the inner sides of the positioning sliding grooves, and massage bins are arranged on the inner side of the massage frame. According to the invention, multiple groups of splicing assembly blocks canbe communicated through the arranged positioning sliding grooves, so that the subsequent massage frame can slide conveniently, the normal use of the device is facilitated, the friction force between the splicing assembly blocks and the massage frame can be reduced through the arranged balls, and the service life of the massage frame can be prolonged.

The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.

The invention relates to a traditional Chinese medicine with the characteristics of good and fast effect on treating diabetic gastroparesis, which belongs to the field of traditional Chinese medicine for treating diabetes. The tranditional Chinese medicine is prepared by using ash bark, ganoderma, pseudo-ginseng, Chinese angelica, magnolia cortex, pinellia ternate and radish seed as raw materials. The above medicine, which has a fast, certain and obvious effect on treating diabetic gastroparesis, has the advantages of reinforcing the vital energy, consolidating the constitution, replenishing qi and blood, activating blood, dissolving stasis, dissipating heat, drying the damp and relieving distension to eliminate abdominal mass.

The invention discloses a pressure measurer for stomach pressure method examination of diabetic gastroparesis patients, which comprises a recorder, a display screen is embedded in the front surface of the recorder, a control box is mounted below the recorder, and the right side of the control box is slidably connected with a telescopic plate; the telescopic adjuster is fixed to the upper surface of the right end of the telescopic plate, a shaping hose is installed on the right side of the telescopic adjuster, a threaded connector is in threaded connection with the outer side of the lower end of the shaping hose, a detection sleeve is integrally connected to the lower end of the threaded connector, and a positioning balloon is installed on the outer side of the lower end of the detection sleeve. A detection inner pipe is installed in the lower end of the detection sleeve in a telescopic mode, and a detection window is formed in the outer side of the lower end of the detection inner pipe. The pressure measuring catheter is provided with the detection sleeve and the detection inner tube, the detection inner tube can be telescopically adjusted relative to the detection sleeve, the problem that the nasal cavity of a patient is rubbed due to the fact that the pressure measuring catheter is integrally telescoped is effectively solved, and damage to the interiors of the noses of the patient can be reduced.

The invention provides application of a composition in preparation of a medicine for treating diabetic gastroparesis. The composition comprises coptis chinensis, mangnolia officinalis, radix aucklandiae and rhizoma zingiberis. The composition can be prepared into anti-diarrheal dropping pills for application. For a DGP rat model, the curative effect of single use of the Huang-Thick antidiarrheal dropping pill is obviously superior to that of dry ginger, scutellaria baicalensis, coptis chinensis and ginseng soup, and is not inferior to that of single use of mosapride; and the improvement degree of the combination of the yellow and thick mosapride on the model animal is obviously higher than that of the combination of the berberine hydrochloride and the mosapride.

The invention provides a traditional Chinese medicine for treating diabetic gastroparesis. The traditional Chinese medicine for treating diabetic gastroparesis is prepared from fructus aurantii immaturus, semen euryales, ginseng, fiveleaf gynostemma herb, radix adenophorae, medicago falcata, mosla scabra, cortex magnoliae officinalis, rheum rhaponticum, rhizoma galangae, fructus crataegi, rhizoma acori calami, abrus herb, fructus gardeniae, persimmon calyx, rhizoma polygonati, semen coicis, fructus citrus sarcodactylis and rhizoma sparganii. Compared with western medicines, the traditional Chinese medicine for treating diabetic gastroparesis has the advantage that symptoms of abdominal distention, early satiety, nausea, emesis and the like of patients suffering from diabetic gastroparesis can be better relieved. In addition, the traditional Chinese medicine for treating diabetic gastroparesis is excellent in treatment effect, high in tolerance, available for discontinuous or long-term administration, especially suitable for patients intolerant of gastrointestinal excitomotor medicines and worthy of clinical popularization and application, and clinical efficacy is improved.