41 results about "Diabetic gastroparesis" patented technology

There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.

The invention discloses a medicinal composition for treating diabetes. The medicinal composition consists of astragalus, gardenia, Szechuan lovage rhizome, siberian solomonseal rhizome, finger citron, root of red-rooted salvia, cinnamomvine, swordlike atractylodes rhizome, white paeony root, perilla fruit, kudzuvine root, fragrant solomonseal rhizome, oyster shell, rehmannia root, Chinese angelica, common anemarrhena rhizome, honeysuckle flower, heartleaf houttuynia herb, fresh imperata root, Chinese caterpillar fungus, semen nelumbinis, siberian solomonseal rhizome, cornus fruit, prepared rehmannia root, villous amomum fruit, liquoric root, medlar, asparagus, black sesame, tuckahoe, cherokee rose fruit, cistanche deserticola, angelica dahurica, adenophora, dark plum fruit, complanate astragalus seed, cassia seed, mulberry leaf, fresh reed rhizome, mint, oriental waterplantain rhizome, wrinkled gianthyssop herb and parslane herb. The medicinal composition can control the blood sugar level of various patients who suffer from the diabetes and improve the clinical symptoms of diabetes complications effectively. Therefore the medicinal composition can be used for treating the diabetesand the diabetes complications such as diabetic gastroparesis, diabetic nephroma, diabetic foot, diabetic neuropathy, diabetic eye diseases and diabetic pruritus and the like.

The invention relates to conformation-constrained entirely-synthetic macrocyclic compounds. A conformation-constrained, space-defined 12-30-member macrocyclic system (I) which is as shown in the description comprises three different constitution units: an aromatic template a, a confor1ation regulator b and a spaced part c, which are illustrated in the description and the claims. The macrocyclic compounds (I) can be easily prepared according to a parallel synthesis method or a combinatorial chemistry method, and are designed for realizing interaction with a specific biological target. Particularly, the compounds show agonistic or antagonistic activity to the following matters: a motilin receptor (MR), a 5-hydroxytryptamine receptor (5-HT2B receptor) of a subtype 5-HT2B, and a prostaglandin F2alpha receptor (FP receptor). Thus, the compounds are effectively used for treating gastrointestinal tract hypomotility disorder such as diabetic gastroparesis and constipation-predominant irritable bowel syndrome, CNS-related diseases such as migraine, schizophrenia, psychosis and depression, ocular hypertension such as glaucoma-related ocular hypertension, and premature delivery.

The invention discloses a traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis and a preparation method and applications thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 8-10 parts of astragalus membranaceus, 8-10 parts of codonopsis pilosula, 8-10 parts of atractylodes macrocephala koidz, 3-6 parts of fructus amomi, 6-8 parts of hovenia dulcis, 6-8 parts of salvia miltiorrhiza and 6-8 parts of endothelium corneum gigeriae galli. The traditional Chinese medicine preparation is prepared by decocting raw herbal materials with water, then extracting and concentrating. Pharmacodynamic experiments show that the traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis has no obvious adverse reaction, and is safe and reliable; the preparation can be used for promoting the increase of body mass, food intake and stool quantity of mice with diabetic gastroparesis, relieving the gastric electrical activity confusion and improving the gastric antrum ICC ultrastructure very well, so that the expression of positive ICC and SP positive materials of gastric antrum c-kit can be enhanced, and the positive expression of nNOS can be lowered; and the preparation has a good improvement effect on the number increasing, form and signal transduction function of ICC.

The purpose of the present invention is to provide a traditional Chinese medicine for treating chronic atrophic gastritis and a preparation method thereof, wherein the traditional Chinese medicine includes cassia twig, red ginseng, poria, amomum fruit, alpinia fruit, baked ginger, ginger, cardamom, and prepared pinellia. The traditional Chinese medicine of the present invention has good reversal, alleviating or eliminating effect to intestinal metaplasia pathological changes of chronic atrophic gastritis, and currently, no obvious adverse reactions and side effects are found, so the medicine is safe and reliable. The traditional Chinese medicine of the present invention has good gastric motility promoting effect, and can also be applied to the treatment of patients having functional gastrointestinal disorders with poor gastrointestinal motility, such as the gastroesophageal reflux disease, bile reflux gastritis, functional dyspepsia, diabetic gastroparesis and functional constipation.

The invention discloses a traditional Chinese medicine for treating diabetic gastroparesis, belonging to the technical field of pure traditional Chinese medicine. The traditional Chinese medicine for treating diabetic gastroparesis comprises pseudostellaria root, Radix Astragali, Chinese yam, bighead atractylodes rhizome, cuttlefish bone, calcined clam shell, hedgehog skin, mutmeg, Hindu daturae flower, immature orange fruit, perilla stem, banksia rose, medicinal evodia fruit, bitter orange, officinal magnolia bark, finger citron, toosendan fruit, silktree albizia bark, vine of tuber fleeceflower, Chinese thorowax root, nutgrass galingale rhizome, radish seed, ginger, pinellia tuber, rehmannia root and hemp seed. A dose of the traditional Chinese medicine is taken each day and decocted twice; 350 to 450 ml of the obtained decoction is extracted and divided into two parts which are respectively taken after meal. Through combination of the above-mentioned bulk drugs, the traditional Chinese medicine exerts spleen-invigorating, qi-benefiting, blood circulation-promoting, blood stasis-dispelling, qi-rectifying, pain-relieving, stomach-harmonizing and adverse-rising energy-claming effects. The traditional Chinese medicine is better than the western medicine--cisapride, has the advantages of small side effects, flexibility in usage, suitability for long-term treatment and a treatment effective rate of more than 93% and is worth popularization and application.

The invention belongs to the field of traditional Chinese medicines for treating diabetes mellitus, and provides a traditional Chinese medicine for treating diabetic gastroparesis, aiming at achieving good efficacy and rapid onset of action. The traditional Chinese medicine is prepared by nutgrass galingale rhizome, Szechuan lovage rhizome, sanchi, swordlike atractylodes rhizome, cape jasmine fruit, lucid ganoderma, Chinese thorowax root, turmeric root-tuber, Chinese angelica and other raw materials and has the effects of banking up root by strengthening vital qi, dispersing stagnated liver qi for relieving qi stagnation, regulating qi-flowing for eliminating mass, promoting blood circulation for removing blood stasis and relieving pain. The traditional Chinese medicine has good effect and rapid onset of action and is characterized by significant effect, exact efficacy and rapid onset of action.

The invention relates to a traditional Chinese medicine composition for treating diabetic gastroparesis. The traditional Chinese medicine composition is prepared from active pharmaceutical ingredientsincluding fructus citri sarcodactylis, fructus citri, rhizoma cyperi, inula flowers, ochre, radix linderae, pericarpium citri reticulatae, radix pseudostellariae and rhizoma pinelliae. The traditional Chinese medicine composition can be used for obviously relieving relevant symptoms of diabetic gastroparesis patients. The total effectiveness rate reaches 93.3 percent.

The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.

There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.

The invention relates to an orally-taken alpha-glycosidase inhibitor for treating diabetes and diabetic gastroparesis. The composition comprises at least one of the alpha-glycosidase inhibitor and a rhizoma atractylodis extractive at a ratio of (1:1)-(1:10) in parts by weight, and preferably the ratio is 1:3. Through clinical and pharmacological serendipitous discoveries, the composition provided by the invention has multiple effects of inhibiting and reducing postprandial blood sugar through glycosidase, enhancing gastric emptying, helping to improve infection of helicobacter pylori and the like. When the composition disclosed by the invention is designed to be an oral chewable tablet, the rhizoma atractylodis and mulberry chewable tablet can partially act on the oral cavity to remove the helicobacter pylori from the oral cavity and is helpful for cutting off the in-vivo reinfection way of the helicobacter pylori so as to realize the aim of radical treatment on the helicobacter pylori.

The invention provides a medicinal composition for preventing and treating diabetic nerve pathology, the medicinal composition is composed of effective medical components of total timosaponin, epimeddium total flavonoids and total salvianolic acid as well as auxiliary components which are acceptable in pharmacy. The weight ratio of total timosaponin to epimeddium total flavonoids to total salvianolic acid in the effective medical components is (0.1-1): (0.1-1): (0.1-1), the weight of the optimized effective medical components is equal quantity or basically equal quantity. The effective medical components and the auxiliary components which are acceptable in pharmacy are combined for preparing an oral pharmaceutical preparation. The medicinal composition has obvious efficacy and function for preventing and treating diabetic chronic complication, particularly for the diabetes nerve pathology such as diabetic peripheral neuropathy, diabetic impotence, diabetic gastroparesis, diabetic cerebrosis and the like.

The invention discloses a Chinese herbal granule for treating diabetes gastroparesis, and relates to a Chinese herbal preparation. The Chinese herbal granule for treating the diabetes gastroparesis is characterized by being prepared by, by mass, the following traditional Chinese medicine raw materials of 7.2-8.8% of radix trichosanthis, 6-7.4% of rhizoma phragmitis, 5.4-6.6% of moutan bark, 3.6-4.4% of wahlenbergia marginata, 5.4-6.6% of malt sugar, 6-7.4% of paederia scandens, 7.2-8.8% of rice sprouts, 5.4-6.6% of agilawood, 5.9-7.3% of rhizoma cyperi, 7.2-8.8% of pericarpium citri reticulatae viride, 7.2-8.8% of lotus petiole, 7.2-8.8% of verbena officinalis, 5.4-6.6% of rhizoma curcumae longae, 5.4-6.6% of rhizoma curcumae and 5.4-6.6% of semen lablab album. The Chinese herbal granule has the effects of discharging liver and regulating qi, promoting circulation and removing stasis, clearing heat and promoting fluid, promoting digestion and tonifying spleen, reducing blood sugar and quenching thirsty, strengthening gastric motility and promoting gastrointestinal motility and is convenient to take, good in symptomatic property, rapid to display effects and good in treatment effect, and the cure rate is 90.32 percent.

There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinson's disease, MS, Alzheimer's Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-Clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-Clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinson's disease, MS, Alzheimer's Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-Clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-Clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.

The invention discloses a pressure measuring device for stomach pressure method examination of a diabetic gastroparesis patient, which comprises a main body bin serving as a main frame of the pressure measuring device for stomach pressure method examination, a positioning rotating shaft connected to the upper side of the rear surface of the main body bin, and a sealing plate connected to the outer side of the positioning rotating shaft, meanwhile, a positioning buckle is fixed to the front surface of the sealing plate, the detection pipe is arranged on the outer side of the detection end in a sleeving and sealing mode, the tail end of the detection pipe is connected with a pressure detection module, and the pressure detection module is electrically connected with the display control panel; and the signal conversion module is arranged at the central position of the front surface of the detection bin. The pressure measuring device for stomach pressure method examination of the diabetic gastroparesis patient is simple in overall structure and convenient to disassemble and assemble, the gastrointestinal contraction function of the patient can be detected, information can be intelligently stored and recorded, and follow-up comparison of medical staff can be facilitated.

The invention provides a traditional Chinese medicine (TCM) for treating diabetic gastroparesis, belonging to the field of TCMs for treating diabetes. The TCM has good effect and quick effect. The TCM is prepared from the following raw materials: weeping forsythia capsule, lucid ganoderma, pseudo-ginseng, angelica, officinal magnolia bark, pinellia ternata, radish seed and the like, has the functions of strengthening the body resistance, invigorating qi and nourishing blood, activating blood circulation to dissipate blood stasis, clearing away heat and drying dampness and relieving and eliminating mass and has the advantages of obvious effect, definite efficacy and quicker effect.

The invention discloses a constraint type stomach massager for the diabetic gastroparesis patient, which comprises a body and a massage frame; a constraint belt is connected to the lower side of the body, a positioning clamping groove is formed in the outer side of the body, a positioning protruding block is fixed to the inner side of the positioning clamping groove, and a splicing assembling block is connected to the outer side of the positioning protruding block; positioning sliding grooves are formed in the inner sides of the splicing assembling blocks, buffer bins are fixed to the inner sides of the splicing assembling blocks, positioning springs are arranged in the buffer bins, adjusting plates are arranged on the inner sides of the positioning springs, the massage frame is arranged on the inner sides of the positioning sliding grooves, and massage bins are arranged on the inner side of the massage frame. According to the invention, multiple groups of splicing assembly blocks canbe communicated through the arranged positioning sliding grooves, so that the subsequent massage frame can slide conveniently, the normal use of the device is facilitated, the friction force between the splicing assembly blocks and the massage frame can be reduced through the arranged balls, and the service life of the massage frame can be prolonged.

The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and GTPCH1 levels and thus, are more susceptible to develop diabetic gastroparesis. The use of tetrahydrobiopterin and its derivatives and sex steroid hormones as disclosed herein provides a novel strategy for therapeutic intervention of diabetic gastroparesis and any other gut-related diseases. Additionally, the present invention also discloses methods to determine risk of developing gastroparesis in an individual that are drawn to detecting variations in the activity and levels of GCH gene and in gene encoding sex steroid hormone receptor.

The invention relates to a traditional Chinese medicine with the characteristics of good and fast effect on treating diabetic gastroparesis, which belongs to the field of traditional Chinese medicine for treating diabetes. The tranditional Chinese medicine is prepared by using ash bark, ganoderma, pseudo-ginseng, Chinese angelica, magnolia cortex, pinellia ternate and radish seed as raw materials. The above medicine, which has a fast, certain and obvious effect on treating diabetic gastroparesis, has the advantages of reinforcing the vital energy, consolidating the constitution, replenishing qi and blood, activating blood, dissolving stasis, dissipating heat, drying the damp and relieving distension to eliminate abdominal mass.

The invention discloses a pressure measurer for stomach pressure method examination of diabetic gastroparesis patients, which comprises a recorder, a display screen is embedded in the front surface of the recorder, a control box is mounted below the recorder, and the right side of the control box is slidably connected with a telescopic plate; the telescopic adjuster is fixed to the upper surface of the right end of the telescopic plate, a shaping hose is installed on the right side of the telescopic adjuster, a threaded connector is in threaded connection with the outer side of the lower end of the shaping hose, a detection sleeve is integrally connected to the lower end of the threaded connector, and a positioning balloon is installed on the outer side of the lower end of the detection sleeve. A detection inner pipe is installed in the lower end of the detection sleeve in a telescopic mode, and a detection window is formed in the outer side of the lower end of the detection inner pipe. The pressure measuring catheter is provided with the detection sleeve and the detection inner tube, the detection inner tube can be telescopically adjusted relative to the detection sleeve, the problem that the nasal cavity of a patient is rubbed due to the fact that the pressure measuring catheter is integrally telescoped is effectively solved, and damage to the interiors of the noses of the patient can be reduced.

The invention provides application of a composition in preparation of a medicine for treating diabetic gastroparesis. The composition comprises coptis chinensis, mangnolia officinalis, radix aucklandiae and rhizoma zingiberis. The composition can be prepared into anti-diarrheal dropping pills for application. For a DGP rat model, the curative effect of single use of the Huang-Thick antidiarrheal dropping pill is obviously superior to that of dry ginger, scutellaria baicalensis, coptis chinensis and ginseng soup, and is not inferior to that of single use of mosapride; and the improvement degree of the combination of the yellow and thick mosapride on the model animal is obviously higher than that of the combination of the berberine hydrochloride and the mosapride.

The invention provides a traditional Chinese medicine for external application capable of treating diabetes gastroparesis. The traditional Chinese medicine is prepared from the following raw materials: garden balsam stem, rhizoma atractylodis, betel nut, rheum officinale, clove, folium artemisiae argyi, fructus aurantii and the like. The traditional Chinese medicine has the effects of regulation qi and removing stasis and allowing the drug effect to reach the whole body, can be clinically used for effectively relieving the gastroparesis symptom of diabetics, and has the characteristics of obvious effects, exact drug effect, safety in use and the like.

The invention belongs to the field of traditional Chinese medicine application, and particularly discloses a composition for treating diabetic gastroparesis and an application thereof. The composition contains ginseng, bighead atractylodes rhizome, colla corii asini, polygonum multiflorum, fructus lycii, semen cassiae, aloe and fructus aurantii immaturus. The traditional Chinese medicine adopts pure traditional Chinese medicine raw materials, is complete in monarch, minister, assistant and guide, and is suitable for cases. The clinical medication feedback shows that the composition can effectively treat gastroparesis syndrome, especially diabetic gastroparesis, and is short in treatment course and good in effect; and animal experiments show that the effective rate of the medicine for treatment is 95% or above. The traditional Chinese medicine composition can be added into health-care products and food according to a certain proportion to prepare products with the same curative effect.

The invention provides a traditional Chinese medicine for treating diabetic gastroparesis. The traditional Chinese medicine for treating diabetic gastroparesis is prepared from fructus aurantii immaturus, semen euryales, ginseng, fiveleaf gynostemma herb, radix adenophorae, medicago falcata, mosla scabra, cortex magnoliae officinalis, rheum rhaponticum, rhizoma galangae, fructus crataegi, rhizoma acori calami, abrus herb, fructus gardeniae, persimmon calyx, rhizoma polygonati, semen coicis, fructus citrus sarcodactylis and rhizoma sparganii. Compared with western medicines, the traditional Chinese medicine for treating diabetic gastroparesis has the advantage that symptoms of abdominal distention, early satiety, nausea, emesis and the like of patients suffering from diabetic gastroparesis can be better relieved. In addition, the traditional Chinese medicine for treating diabetic gastroparesis is excellent in treatment effect, high in tolerance, available for discontinuous or long-term administration, especially suitable for patients intolerant of gastrointestinal excitomotor medicines and worthy of clinical popularization and application, and clinical efficacy is improved.