Alpha-glycosidase inhibitor and application thereof
A technology of glycosidase inhibitor and composition, applied in the field of alpha-glycosidase inhibitor, can solve problems such as insufficient theoretical explanation and effective prescription, reduce gastrointestinal adverse reactions, and assist in improving Helicobacter pylori infection and resistance. The effect of interrupting the reinfection pathway in vivo
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0071] This kind of traditional Chinese medicine composition for treating diabetes for oral administration, the raw material of making active ingredient is by following weight:
[0072] Cut 1000g of mulberry leaves and 500g of atractylodes into coarse grains, decoct them in water, add 8-12 times the amount of water, heat at 60-100°C, stir for 1-2 hours, filter, and the filtrate is centrifuged at high speed, filtered with a polysulfoneamide membrane, and the filtrate Under the condition of temperature 60~110℃ and vacuum degree 0.08~0.09MPa, concentrate under reduced pressure to a clear paste with a relative density of about 0.8~1.5 (60℃), add appropriate amount of auxiliary materials, material drying temperature 75~100℃, atomization pressure 0.06 ~0.09MPa, spray frequency and speed 30~40kg / h, and spray dry to obtain the extract of mulberry leaves-Atractylodes atractylodes, and the extract solution can be used for gavage administration to animals in pharmacological experiments. ...
Embodiment 2
[0074] Get the leaf 2kg of Moraceae plant mulberry, remove impurity, pulverize after low-temperature drying, add the sherwood oil of 3 times of volumes and extract, remove fat-soluble component, then filter, get filter residue, filter residue evaporates organic solvent, gets mulberry powder residue. The mulberry powder residue is extracted by adding 5 times the volume of hot water, filtered, and the residue is removed to obtain the liquid. Add ethanol to the filtrate to make the concentration 40%, precipitate, and filter to obtain supernatant and precipitate.
[0075] The supernatant was first purified with cation exchange resin, eluted with 0.4M ammonia water, the eluate was collected, concentrated, then purified with anion exchange resin, and eluted with aqueous solution. The eluate was concentrated and dried to obtain mulberry leaf alkaloids, wherein the content of 1-deoxynojirimycin (1-Deoxynojirimycin) was not less than 50%.
[0076] The precipitate was dissolved in wate...
Embodiment 3
[0080] This kind of traditional Chinese medicine composition for treating diabetes for oral administration, the raw material of making active ingredient is by following weight:
[0081] The invention provides a preparation method of a traditional Chinese medicine composition for treating diabetes, which comprises cutting 1000 g of mulberry leaves and 500 g of herb atractylodes into coarse grains, decocting them in water, adding 8 to 12 times the amount of water, heating at 60 to 100 ° C, and stirring for 1 to 2 hours , filtered, after the filtrate is centrifuged at high speed, filtered by a polysulfoneamide filter membrane, the filtrate is concentrated under reduced pressure at a temperature of 60-110°C and a vacuum of 0.08-0.09MPa to a clear paste with a relative density of about 0.8-1.5 (60°C), Add appropriate amount of auxiliary materials, dry the material at a temperature of 75-100°C, atomize at a pressure of 0.06-0.09 MPa, spray at a frequency of 30-40 kg / h, and spray dry ...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com