Alpha-glycosidase inhibitor and application thereof

A technology of glycosidase inhibitor and composition, applied in the field of alpha-glycosidase inhibitor, can solve problems such as insufficient theoretical explanation and effective prescription, reduce gastrointestinal adverse reactions, and assist in improving Helicobacter pylori infection and resistance. The effect of interrupting the reinfection pathway in vivo

Inactive Publication Date: 2014-05-21
北京博泽德润医药科技开发有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

"However, in the field of traditional Chinese medicine, there are no sufficient theoretical explanations and effe...

Method used

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  • Alpha-glycosidase inhibitor and application thereof

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Experimental program
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Effect test

Embodiment 1

[0071] This kind of traditional Chinese medicine composition for treating diabetes for oral administration, the raw material of making active ingredient is by following weight:

[0072] Cut 1000g of mulberry leaves and 500g of atractylodes into coarse grains, decoct them in water, add 8-12 times the amount of water, heat at 60-100°C, stir for 1-2 hours, filter, and the filtrate is centrifuged at high speed, filtered with a polysulfoneamide membrane, and the filtrate Under the condition of temperature 60~110℃ and vacuum degree 0.08~0.09MPa, concentrate under reduced pressure to a clear paste with a relative density of about 0.8~1.5 (60℃), add appropriate amount of auxiliary materials, material drying temperature 75~100℃, atomization pressure 0.06 ~0.09MPa, spray frequency and speed 30~40kg / h, and spray dry to obtain the extract of mulberry leaves-Atractylodes atractylodes, and the extract solution can be used for gavage administration to animals in pharmacological experiments. ...

Embodiment 2

[0074] Get the leaf 2kg of Moraceae plant mulberry, remove impurity, pulverize after low-temperature drying, add the sherwood oil of 3 times of volumes and extract, remove fat-soluble component, then filter, get filter residue, filter residue evaporates organic solvent, gets mulberry powder residue. The mulberry powder residue is extracted by adding 5 times the volume of hot water, filtered, and the residue is removed to obtain the liquid. Add ethanol to the filtrate to make the concentration 40%, precipitate, and filter to obtain supernatant and precipitate.

[0075] The supernatant was first purified with cation exchange resin, eluted with 0.4M ammonia water, the eluate was collected, concentrated, then purified with anion exchange resin, and eluted with aqueous solution. The eluate was concentrated and dried to obtain mulberry leaf alkaloids, wherein the content of 1-deoxynojirimycin (1-Deoxynojirimycin) was not less than 50%.

[0076] The precipitate was dissolved in wate...

Embodiment 3

[0080] This kind of traditional Chinese medicine composition for treating diabetes for oral administration, the raw material of making active ingredient is by following weight:

[0081] The invention provides a preparation method of a traditional Chinese medicine composition for treating diabetes, which comprises cutting 1000 g of mulberry leaves and 500 g of herb atractylodes into coarse grains, decocting them in water, adding 8 to 12 times the amount of water, heating at 60 to 100 ° C, and stirring for 1 to 2 hours , filtered, after the filtrate is centrifuged at high speed, filtered by a polysulfoneamide filter membrane, the filtrate is concentrated under reduced pressure at a temperature of 60-110°C and a vacuum of 0.08-0.09MPa to a clear paste with a relative density of about 0.8-1.5 (60°C), Add appropriate amount of auxiliary materials, dry the material at a temperature of 75-100°C, atomize at a pressure of 0.06-0.09 MPa, spray at a frequency of 30-40 kg / h, and spray dry ...

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Abstract

The invention relates to an orally-taken alpha-glycosidase inhibitor for treating diabetes and diabetic gastroparesis. The composition comprises at least one of the alpha-glycosidase inhibitor and a rhizoma atractylodis extractive at a ratio of (1:1)-(1:10) in parts by weight, and preferably the ratio is 1:3. Through clinical and pharmacological serendipitous discoveries, the composition provided by the invention has multiple effects of inhibiting and reducing postprandial blood sugar through glycosidase, enhancing gastric emptying, helping to improve infection of helicobacter pylori and the like. When the composition disclosed by the invention is designed to be an oral chewable tablet, the rhizoma atractylodis and mulberry chewable tablet can partially act on the oral cavity to remove the helicobacter pylori from the oral cavity and is helpful for cutting off the in-vivo reinfection way of the helicobacter pylori so as to realize the aim of radical treatment on the helicobacter pylori.

Description

technical field [0001] The invention relates to an alpha-glucosidase inhibitor for oral treatment of diabetes and diabetic gastroparesis, belonging to the field of natural medicines. Background technique [0002] Diabetes has become a major disease that seriously endangers people's life and health. Diabetes mellitus is a syndrome characterized by persistent hyperglycemia as its basic biochemical feature. Various reasons lead to insufficient supply of insulin or the failure of insulin to play a normal physiological role in the target cells, which makes the metabolism of sugar, protein and fat in the body disordered, and diabetes occurs. The etiology of diabetes is very complex, basically can be divided into absolute or relative lack of insulin, or insulin resistance. Therefore, any problem in any of the three steps of insulin production by β cells, insulin delivery by the blood circulatory system, and target cells receiving insulin and exerting physiological effects can cau...

Claims

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Application Information

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IPC IPC(8): A61K36/284A61K36/605A61K36/62A61P3/10A61P1/14A61P31/04A23L1/29A23L1/30A23L2/52A23L33/10A23L33/105
Inventor 宋春光张荣立程璇张天可
Owner 北京博泽德润医药科技开发有限公司
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