External preparations for skin containing calcium receptor active compounds

A technology for external preparations and calcium receptors, which can be used in medical preparations containing active ingredients, medical preparations without active ingredients, and organic active ingredients, etc. Difficulty and other problems, to achieve the effect of drug treatment, reduce the number of doses, and facilitate use

Active Publication Date: 2020-02-18
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most commonly used formulation for transdermal drug delivery is a patch, which is easy to use and has a relatively simple preparation process, but the drug loading of the patch is small and the gas permeability is poor, and most patients will have allergic reactions
With the continuous development of the preparation process, the gel ointment has attracted more and more attention. The gel ointment has a large drug loading capacity, its water content is as high as 40%-70%, and it has good air permeability. It will not cause allergies after long-term use. Good compliance, but due to its technical difficulty, so far there is no report on the relevant information about Xi'an Kasai Hydrochloride Gel Cream

Method used

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  • External preparations for skin containing calcium receptor active compounds
  • External preparations for skin containing calcium receptor active compounds
  • External preparations for skin containing calcium receptor active compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] materials Weight (g) proportion% Cinacalcet hydrochloride 2.5 1.25 Polyacrylic acid 6.0 3.00 Povidone 61.0 30.50 sodium hydroxymethyl cellulose 40.6 20.30 gelatin 19.0 9.50 glycerin 30.0 15.00 Sorbitol 10.5 5.25 Azone 14.0 7.00 Menthol 6.0 3.00 Kaolin 10.0 5.00 Aluminum glycylate 0.4 0.20 purified water Appropriate amount batch 100 stickers

[0028] Preparation process: mix cinacalcet hydrochloride, azone, and menthol in prescribed amounts, stir, and disperse evenly; mix polyacrylic acid, povidone, sodium hydroxymethylcellulose, kaolin, aluminum glycolate, and sorbitol with glycerin Disperse and stir evenly; mix gelatin with an appropriate amount of water to form a gelatin aqueous solution; mix the above three mixed solutions, continue to stir evenly, apply the paste prepared above evenly on the backing layer, cover the protective layer, and cut to Specify the...

Embodiment 2

[0030] materials Weight (g) proportion% Cinacalcet hydrochloride 5.0 2.50 Polyacrylic acid 20.0 10.00 Polyvinylpyrrolidone 38.5 19.25 Povidone 22.5 11.25 gelatin 28.0 14.00 glycerin 71.0 35.50 Azone 8.0 4.00 Oleic acid 4.0 2.00 kaolin 2.8 1.40 Aluminum glycylate 0.2 0.10 purified water Appropriate amount batch 100 stickers

[0031] Preparation process: Mix the prescribed amount of cinacalcet hydrochloride, azone, and oleic acid evenly to obtain the main drug mixture; disperse polyvinylpyrrolidone, povidone, kaolin, and glycol with glycerin, and stir evenly; gelatin Mix evenly with water to obtain gelatin aqueous solution; mix the above three mixed solutions, continue to stir evenly, apply the paste prepared above evenly on the backing layer, cover the protective layer, and cut to the specified size as required.

Embodiment 3

[0033] materials Weight (g) proportion% Cinacalcet hydrochloride 7.5 3.75 carbomer 14.0 7.00 polyethylene glycol 20.0 10.00 gelatin 20.0 10.00 sodium alginate 20.0 10.00 glycerin 100.1 50.05 N-Methylpyrrolidone 10.0 5.00 kaolin 7.8 3.90 Aluminum Glycinate 0.6 0.30 purified water Appropriate amount batch 100 stickers

[0034] Preparation process: Mix the prescribed amount of cinacalcet hydrochloride and N-methylpyrrolidone to obtain the main drug solution; disperse carbomer, polyethylene glycol, sodium alginate, kaolin, and aluminum glycinate evenly with glycerin; gelatin Mix evenly with water to get gelatin aqueous solution; mix the above three mixed solutions, stir evenly, apply the paste prepared above evenly on the backing layer, cover the protective layer, and cut to the specified size as required.

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Abstract

The invention discloses a skin external use preparation containing a calcium receptor activity compound. The preparation avoids hepatic first pass effect and gastrointestinal adverse reactions of an oral preparation. The preparation comprises a medicine active component, a high-molecular gel skeleton, a tackifier, a moisturizer, and other pharmaceutically acceptable excipients. The preparation has high drug load and is free of problems of irritation and allergy, has no crystallization phenomenon, has better stability and is more safe and convenient to use.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an external skin preparation containing a calcium receptor active compound. Background technique [0002] Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Chronic kidney disease leads to abnormal mineral and bone metabolism in patients, and its severity mainly leads to cardiovascular calcification. closely related to survival. Active vitamin D drugs used in the clinical treatment of secondary hyperparathyroidism are often accompanied by hypercalcemia and hyperphosphatemia, which increase the risk of cardiovascular calcification. Most patients with secondary hyperparathyroidism who do not respond to medical treatment can only receive parathyroidectomy. The advent of calcium receptor active compounds has changed the risk of surgery in patients with secondary hyperparathyroidism, making most patients with severe secondary hyp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61K31/593A61K9/06A61K9/70A61K47/32A61P5/16
CPCA61K9/06A61K9/7023A61K31/137A61K31/593A61K47/32A61K2300/00
Inventor 赵焰平周丽莹卢迪肖萱刘亚男
Owner BEIJING TIDE PHARMA
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