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Cured aspirin phospholipid composition and preparation method and medicinal preparation thereof

A technology of aspirin phospholipid and aspirin, which can be applied to drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems of salicylic acid poisoning, inconvenient medication, gastric mucosal damage, etc., achieves less environmental pollution, and improves medication compliance. Sexual, release-reducing effects

Active Publication Date: 2018-09-18
ZHEJIANG JIANFENG HANSHENG BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although people have improved the dosage form, such as adding suppositories to avoid contact between the drug and the gastrointestinal tract, it is extremely inconvenient to use the drug; Some of the tablets will leak, which will stimulate the stomach and cause damage to the gastric mucosa; if the content of free salicylic acid in the enteric-coated tablets is high, it will cause salicylic acid poisoning, which has not been fundamentally solved question

Method used

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  • Cured aspirin phospholipid composition and preparation method and medicinal preparation thereof
  • Cured aspirin phospholipid composition and preparation method and medicinal preparation thereof
  • Cured aspirin phospholipid composition and preparation method and medicinal preparation thereof

Examples

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Effect test

Embodiment 1

[0038] A kind of aspirin phospholipid solidification composition, it is made by aspirin, liquid phospholipid, adsorbent, viscosity modifier and hydrolysis inhibitor, wherein aspirin 810g, liquid phospholipid 810g, adsorbent 940g, viscosity regulator 179.9g, hydrolysis inhibitor 74.8 g;

[0039] The liquid phospholipid is phosal 35SB, the content of phosphatidylcholine in the liquid phospholipid is 50wt%, the adsorbent is silicon dioxide, the viscosity regulator is glycerol tricaprylate, and the hydrolysis inhibitor is citric acid.

[0040] A preparation method of aspirin phospholipid solidified composition, prepared by the following steps:

[0041] a) Crush aspirin to its D 90 20μm, spare;

[0042] b) Put the liquid phospholipid in a container, heat and stir in a water bath, and vacuumize and degas at the same time; after the degassing is completed, add a hydrolysis inhibitor, a viscosity modifier and aspirin in a water bath and vacuumize the environment, and then stir evenl...

Embodiment 2

[0046] A kind of aspirin phospholipid solidification composition, it is made by aspirin, liquid phospholipid, adsorbent, viscosity modifier and hydrolysis inhibitor, wherein aspirin 270g, liquid phospholipid 810g, adsorbent 540g, viscosity regulator 79.9g, hydrolysis inhibitor 44.8 g; the liquid phospholipid is phosal 35SB, the content of phosphatidylcholine in the liquid phospholipid is 50wt%, the adsorbent is made of amino-modified mesoporous silica, the viscosity modifier is glycerol tricaprylate, and the hydrolysis inhibitor is citron acid;

[0047] Amino-modified mesoporous silica is prepared by the following method, prepare 80 parts by weight of ammonium nitrate aqueous solution with a pH value of 6.0, dissolve 0.6 parts by weight of cetyltrimethylammonium bromide in aqueous ammonium nitrate solution, dissolve and stir After defoaming naturally, then the above solution is preheated to 80°C, followed by adding 4 parts by weight of tetraethyl orthosilicate and stirring at ...

Embodiment 3

[0054] A kind of aspirin phospholipid solidification composition, it is made by aspirin, liquid phospholipid, adsorbent, viscosity modifier and hydrolysis inhibitor, wherein aspirin 810g, liquid phospholipid 810g, adsorbent 940g, viscosity regulator 259.8g, hydrolysis inhibitor 74.8 g;

[0055] The liquid phospholipid is a mixture of phosal 35SB and phosal 53MCT in a weight ratio of 1:1, the content of phosphatidylcholine in the liquid phospholipid is 50wt%, the adsorbent is silicon dioxide, the viscosity regulator is glycerol tricaprylate, hydrolyzed The inhibitor is citric acid.

[0056] A preparation method of aspirin phospholipid solidified composition, prepared by the following steps:

[0057] a) Crush aspirin to its D 90 20μm, spare;

[0058] b) Put the liquid phospholipid in a container, heat and stir in a water bath, and vacuumize and degas at the same time; after the degassing is completed, add a hydrolysis inhibitor, a viscosity modifier and aspirin in a water bat...

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Abstract

The invention belongs to the technical field of medicinal preparations, and discloses a cured aspirin phospholipid composition and a preparation method and a medicinal preparation thereof. The cured aspirin phospholipid composition is prepared from aspirin, phospholipid, an adsorbent, a viscosity regulator, and a hydrolysis inhibitor. The invention discloses a preparation method of the cured aspirin phospholipid composition. The preparation method comprises following steps: grinding aspirin, preparing a mixture, and curing the mixture. The invention also discloses a medicinal preparation of the cured aspirin phospholipid composition. The medicinal preparation can be a tablet, a capsule, or a granule prepared from the cured aspirin phospholipid composition. After aspirin and phospholipid are compounded, the amount of aspirin released in the stomach is reduced, the adverse effects of gastro-intestinal tracts are obviously reduced, the medication adherence is improved, furthermore, the solubility is increased, the absorption is enhanced, the bioavailability is increased, the adverse reactions are reduced; the preparation method of the cured aspirin phospholipid composition has the advantages of simple production and good repeatability, and commercial production can be realized.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an aspirin phospholipid solidification composition, a preparation method thereof and a pharmaceutical composition. Background technique [0002] Aspirin, also known as acetylsalicylic acid, is one of the three classic drugs in history. As an antipyretic and analgesic with a long history, its effect is obviously low and it is still the most widely used antipyretic analgesic. It is an anti-inflammatory drug for pain and is a standard preparation for comparing and evaluating other drugs. Since the 1960s, pharmacological studies have shown that aspirin persistently inactivates COX-1 activity, inhibits platelet function, has no dose-related effect, and can quickly achieve the inhibitory effect at a very low concentration (nmol / L), that is, it has a clear anticoagulant effect. Blood effect, so it can be used as a drug to prevent blood clots. The Chinese Expert Con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K47/24A61P29/00A61P7/02A61P19/02
CPCA61K31/616A61K47/24A61P7/02A61P19/02A61P29/00
Inventor 姜双瑜陈传千徐松琳赵孝斌
Owner ZHEJIANG JIANFENG HANSHENG BIOSCI
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