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Medicine composite containing aspirin and application thereof

An aspirin and composition technology, which is applied in the field of pharmaceutical compositions containing low-dose aspirin, can solve the problems of not preventing or treating hypertension complications and the like, and achieves good sympathomimetic activity, good antihypertensive effect, and prevents smooth muscle cell proliferation. Effect

Active Publication Date: 2013-09-18
BEIJING FRESENIUS KABI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no report on the combined application of carvedilol and aspirin in the prior art, especially there is no report on the prevention or treatment of hypertensive complications after the combined application of the two

Method used

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  • Medicine composite containing aspirin and application thereof
  • Medicine composite containing aspirin and application thereof
  • Medicine composite containing aspirin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 carvedilol / aspirin compound tablet

[0022] Prescription composition:

[0023]

[0024]

[0025] Preparation Process:

[0026] Take carvedilol and aspirin according to the prescription quantity, take microcrystalline cellulose and starch as fillers, croscarmellose sodium and crospovidone as disintegrants, and 5% PVP 60% ethanol solution is Adhesive, magnesium stearate as lubricant, one-step granulation with fluidized bed, and then compressed into tablets, to obtain.

Embodiment 2

[0027] The preparation of embodiment 2 carvedilol / aspirin compound capsules

[0028] Prescription composition:

[0029]

[0030] Preparation process: pass the carvedilol, aspirin, pregelatinized starch, microcrystalline cellulose and sodium carboxymethyl starch in the prescription through a 100-mesh sieve, weigh according to the prescription amount, mix well, add 10% starch slurry in an appropriate amount Granulate, dry below 55°C, sieve through a 18-mesh sieve, and fill the capsules.

Embodiment 3

[0031] Example 3 Curative Effect Study of Carvedilol Combined with Aspirin on Hypertensive Rats

[0032] Spontaneous hereditary hypertensive rats (SHR) were purchased from Shanghai Slack Experimental Animal Co., Ltd. Grouping of animals: 60 SHR rats of 200-250 g were randomly divided into 4 groups according to blood pressure level, 15 rats in each group. Followed by model control group, carvedilol group, aspirin group and combined drug group. Another 10 SD rats were used as normal blood pressure control group. Rats in each group were intragastrically administered once a day in the morning and evening, and given the corresponding test substances according to the dosage in Table 1.

[0033] Table 1. Grouping and administration of experimental animals

[0034]

[0035]

[0036] After 15 weeks of intragastric administration to the rats in each group, the urine of the rats was inoculated with metabolic cages, and the microalbumin content in the urine of the rats in each gr...

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PUM

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Abstract

The invention relates to a medicine composite containing aspirin and application thereof. An active ingredient of the medicine composite containing aspirin comprises carvedilol and aspirin, and preferably the weight ratio of the carvedilol to the aspirin is 1:0.25-1.25. The medicine composite provided by the invention can be used for efficiently preventing various complications of hypertensives in a cooperative mode and enhancing the long-term survival rate of patients, and meanwhile, and has a favorable preventive effect to the renal injury of the hypertensives.

Description

technical field [0001] The invention relates to a western medicine compound, in particular to a pharmaceutical composition containing low-dose aspirin and its use, and belongs to the technical field of western medicine compound. Background technique [0002] In the population of hypertensive patients, diastolic blood pressure (DBP) is easier to control (≤90mmHg), and systolic blood pressure (SBP) is more difficult to control (≤140mmHg). In the traditional treatment of hypertension, diastolic blood pressure is regarded as an important goal of blood pressure control, which now seems to be incorrect. A new breakthrough in the concept. However, in the current clinical treatment, there is no ideal drug that has a good effect on systolic blood pressure and pulse pressure. For many hypertensive patients, the diastolic blood pressure is often easy to control, but the systolic blood pressure cannot be well controlled. For these hypertensive patients, as a result of traditional ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/616A61K31/403A61P9/12A61P13/12
Inventor 张超
Owner BEIJING FRESENIUS KABI PHARM CO LTD
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