94 results about "Long term survival" patented technology

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

The present invention is directed to the identification of predictive markers that can be used to determine whether patients with cancer are expected to demonstrate long term or short term survival times. In particular, the present invention is directed to the use of certain individual and / or combinations of predictive markers, wherein the expression of the predictive markers correlates with expected short term or long term survival. Thus, by examining the expression levels of individual predictive markers and / or predictive markers comprising a marker set, it is possible to determine predicted patient survival.

Normal tissue complications limit curative broadbeam radiotherapy to tumors including lung cancer. Radiation retinitis causing blindness limits quality of life and long term survival for patients with ocular melanoma. This invention pertains to alternative, normal tissue sparing 100 to 1,000 Gy microbeam radiations with least normal tissue complications and concomitant radio-immunotherapy by innate immune response of epidermis and dermis to low dose radiation with 50 kV X-rays. Total body skin radiation with former airport passenger screening machines with 50 kV X-ray is disclosed. Microbeams are generated without contaminating scatter and neutron radiations from collinear gamma ray and electron beam produced by inverse Compton interaction with high energy laser and electron beam and from proton and carbon ion beams in tissue equivalent cylindrical collimators. Extracorporeal immunotherapy and chemotherapy and apheresis of mutated subcellular particles released into circulation in response to cancer-therapies are by clinical continuous flow ultracentrifugation combined chromatography.

This invention relates to methods and compositions for determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as gastric or colorectal cancer, based on cell proliferation signatures. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a personalized genomics profile for a cancer patient, among other methods as well as kits and devices for carrying out these methods.

This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer, based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods.

Methods are taught for culturing mammalian cells, preferably human cells, to improve production of proteins, recombinant or endogenous. Methods are also provided for the growth and long-term survival of cell lines, particularly cell lines established from primary culture. Cell culture media are also provided, contained varying levels of selected amino acids, supplemented with various growth factors and trace elements. In additionally, the media are optionally serum-free, and preferably use an energy source other than glucose. The media are particularly suitable for the primary culture and long-term culture of human fetal cells.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.

The invention discloses a concrete water storage and retention type vegetation base material and a preparation method thereof. According to the invention, continuously superposed round integrated holes are formed at the whole body of the vegetation base material; diameters of big holes are 2-15mm; small holes with the diameters of 0.5-3mm are bestrewed at the center and the periphery of each big hole; and holes are mutually communicated to ensure that internal pipelines and cumulative containers for water storage and water drainage for plant growth are formed. The concrete water storage and retention type vegetation base material disclosed by the invention is of a porous structure, longer in water retention time, suitable for long-term survival and growth of plants and capable of beautifying the cities, purifying the air and improving the environment and has the advantages that the water storage and retention rate is about 50% of self weight of the base material; strength and plasticity are endowed; living space conditions of the plants are satisfied; water and soil loss problem does not exist; the water storage and retention mechanism of the vegetation base material is also beneficial to increasing the humidity and purifying the environment; and the whole-body hole structure is adopted to ensure that the base material is capable of absorbing the sound and lowering the noise.

The invention provides a medical composite for treating hypertension and a preparation thereof. The medical composite comprises antihypertensive drug, HMGCoA reductase inhibitor and insulin sensitizer. The medical composite of the invention not only can effectively reduce blood pressure, but also has good effect on the treatment and prevention of hypertension complications. The long term survival of patients can be improved obviously.

The invention discloses a novel aging mulberry rejuvenation and improvement method capable of allowing the yield to be increased in the same year after the half-year grafting time, and belongs to the technical field of gardening mulberry cultivation. The method is characterized in that ear buds are inserted in the same direction; winter bud grafting and spring bud grafting are used simultaneously; and sawed pile multi-bud grafting is performed. An improved spring sawed pile bud grafting (ear bud inserting in the same direction and multi-bud grafting) is applied by the method, and a winter skin cutting and bud grafting method is successfully applied to winter and early spring sawed pile bud grafting by using a method of skiving a rough bark of a stock, so that the grafting time is prolonged to half a year during which ear strips are not required to be stored; the number of grafted ear buds of each mulberry is increased from 2-3 to 5-10 by adopting the multi-bud grafting, so that the yield can be increased by 50-200% in the same grafting year, and mulberry tree type cultivation can be accomplished on time; and a grafting body and a stock tree body can be healed tightly and firmly by adopting the ear bud inserting in the same direction, so that the long-term survival rate of the graft body is high. According to the method, the ear bud survival rate is not less than 97%; the mulberry survival rate is not less than 99%; and the method can be widely applied to renewal rejuvenation and variety improvement of aging trees of various mulberry fields, four-edge mulberries, daxing mulberries, coriaria sinia and arbor mulberries.

One example embodiment includes a method of preparing a personalized genomics profile for a patient with colorectal cancer. The method includes assaying an expression level of an RNA transcript in a biological sample. The biological sample includes a colorectal cancer cell obtained from a patient. The method also includes determining a normalized expression level of the RNA transcript, wherein the normalized expression level of the RNA transcript correlates with an increased likelihood of colorectal cancer recurrence in the patient. The method further includes creating a report. The report summarizes the data obtained from the normalized expression level and includes an estimate of likelihood of long-term survival without colorectal cancer recurrence in said patient.

The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tolerance inducing treatment regimen, used optionally with adjunct immunosuppressive agents, prevents pancreatic islet cell rejection while maintaining long term islet cell function following xenogeneic and allogeneic pancreatic islet cell transplantation. Thus, the methods of the present invention provide a means for treating diabetes, wherein the need for exogenous insulin or immunosuppressive agents is decreased or eliminated. Also provided is a method of inhibiting a rejection response of a transplant recipient, comprising administering an immunotoxin during the peritransplant period, thereby transiently reducing the number of T-cell lymphocytes and promoting long-term survival of the transplant.

The invention provides a method for predicting the clinical response to a cancer vaccine in a patient having cancer, a method for determining the immune response to a cancer vaccine in a patient having cancer who has been administered a cancer vaccine, a method for determining the long-term survival in a patient having cancer, corresponding kits therefor, as well as methods of for improving the efficacy of a virus-based vaccine.

The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.

The invention discloses a spacecraft capsule space farm. The spacecraft capsule space farm comprises a spacecraft, a connector A, a connector B, a working capsule and a planting capsule. The spacecraft capsule space farm is characterized in that the spacecraft capsule space farm is connected and fixed to the spacecraft through the connector A and the connector B, the spacecraft capsule space farm is provided with the working capsule with large space and the planting capsule with large space after being unfolded, and a cyclic ecosphere divided into different environments and conditions for production, utilization, processing and reutilization is constructed. Compared with the prior art, a systematic and comprehensive ecological cycle system with a wide range and a large scale can support excellent environments and conditions needed by long-term survival and life of spacecraft garrison personnel and provide new products, new techniques, experience and material support for the earth and migration to other planets in future.

The invention discloses a tissue engineering bionic liver lobe structure based on 3D printing of living cells and a preparation method thereof. Firstly, biological information of human body liver lobes is collected, and inputted into a computer for high biomimetic modeling; then, material separated printing and material-cell mixed printing output are performed with a hydrogel material and cells for constructing liver, bile duct epithelium, blood vessel endothelium, smooth muscle and fibroblast and the like required for the human liver lobes by a biological 3D printer, wherein a hollow part inblood vessels and bile ducts is printed by a casting agent; after all the hydrogel materials are solidified, the casting agent in the blood vessels and bile ducts are removed by means of enzymes or chelating reactions or temperature control or illumination and the like, and a vascular system and a bile duct system in the artificial bile duct-containing liver lobes are constructed. The circulationfeeding of the vascular system of the bionic liver lobes and gas exchange are achieved by connection of main blood vessels at two ends of the vascular system and a delivery pipe of a culture solution.The long-term survival and biological function of the bionic liver lobes in vitro and in vivo are achieved.

The invention discloses an indoor feeding device for odontotermes. The indoor feeding device comprises a main nest box (1), a water supply box (2), a draining box (3) and a feeding box (4) which are provided with connecting holes, and is characterized in that: the main nest box (1) is connected with the water supply box (2), the draining box (3) and the feeding box (4) respectively through connection pipes (5) which are connected to the connecting holes; and a main nest expansion box can be arranged for meeting the requirement of ant colony breeding. The invention further discloses an indoor feeding method for odontotermes. According to the feeding device for odontotermes, the feeding space is separable, so that a feeding area, a water supply area, a draining area and a nest area are separated from each other. Wood scrap which is processed is taken as a feed of odontotermeswhite ants. Through a feeding technology, odontotermes colonies can be fed indoors for a long time, and the long-term survival rate is over 80 percent.

This invention is the discovery of novel specific epitopes and antibodies associated with long term survival of HIV-1 infections. These epitopes and antibodies have use in preparing vaccines for preventing HIV-1 infection or for controlling progression to AIDS.

The invention discloses a kit for constructing forecasting NSCLC (non-small-cell lung cancer) patient prognosis and guiding clinic application of zoledronic acid and application of osteopontin (OPN) acting as a specific marker of M2 type macrophage; the application of the kit provided by the invention is evaluation of the NSCLC patient prognosis by using the expression of OPN in an immunofluorescence double standard technology detection tissue chip in TAMs and tumor cells, and comprehensive measures are taken in real time to interfere aiming at the detection result of the kit, so that the long-term survival rate of patients is increased, and the prognosis is improved; the method is simple and convenient and can be widely applied to clinic.

The invention discloses a method for constructing a biomimetic vascular net in a large-volume tissue engineering tissue organ. Firstly, biological information of a large-volume tissue of a human bodyis collected, and inputted into a computer for high biomimetic modeling; then, material separated printing and material-cell mixed printing output are performed with a hydrogel material and a varietyof amplified cells from the tissue by a high-precision biological 3D printer, wherein a hollow part in blood vessels is printed by a controllable degradable hydrogel; after all the hydrogel materialsare solidified, the controllable degradable hydrogel in the blood vessels are removed by means of specific enzymes or chelating reactions or temperature control or illumination and the like, and the vascular net in the large-volume artificial tissue is constructed. The circulation feeding of the vascular net and gas exchange in the large-volume artificial tissue are achieved by connection of mainblood vessels at two ends of the vascular net and a delivery pipe of a culture solution. The central feeding problem of the large-volume tissue is solved, so as to realize the long-term survival and biological function of the large-volume artificial tissue in vitro.

The invention relates to a vascularized tissue engineering bone and a preparation method thereof. The vascularized tissue engineering bone is composed of a support composed of poly-L-lysine (PLL) modified coralline hydroxyapatite (CHA) as well as a vascular endothelium dermatoblast patch and a bone formation cell patch which are sequentially wrapped at the inner layer of the support. According to the invention, an exogenous support obtained by virtue of the PLL modified CHA is beneficial to crawling ingrowth of blood vessels, and vascularization is realized finally, so that a precondition is provided for long term survival of cells in the tissue engineering bone, and organism immune rejection and inflammatory response are also reduced; adipose mesenchymal stem cells are selected for preparing a double cell patch, endothelial cells different in sources do not need to be added, cells are rich in resources and easy to separate and acquire, a trauma on a donor is minimal, ethical principles are not violated, and culture requirements are low. The vascularized tissue engineering bone provided by the invention is simple in preparation method and mild in preparation conditions, has good bone formation and vascularization properties, is consistent with in vivo application requirements, and has good application prospects as a novel vascularized tissue engineering bone.

The invention discloses high-activity essence, and relates to a biotechnology, a cosmetic and a health-care product. The essence is prepared from 0.4 to 0.8 percent of hyaluronic acid, 0.3 to 0.7 percent of water-soluble natural vitamin E, 0.4 to 0.8 percent of co-ferment, 0.09 to 0.2 percent of lauric acid modifier, 3 to 7 percent of propylene glycol, 8 to 12 percent of glycerol and 83.2 percent of deionized water. An independent sealed disposable package is adopted in the essence, greatly reduces the contact of the essence and the air during use, is not easily broken, is safe in materials, convenient to use and safe to transport, is not easily damaged, and effectively solves the problem of long-term survival of the natural active ingredients in the essence. When the essence is used on the skin, the effective time is prolonged, the absorption rate is increased, and the concentration and the activity of the active enzyme are high; and the quality guarantee period of the essence is prolonged by over one and half years compared with other like products.

The invention discloses a dry powder cylinder device for blood purification. An inlet of a liquid inlet passage of the middle-upper part of a first fixed seat is connected with a liquid inlet pipe, and an outlet of the liquid inlet passage is communicated with the top of the cavity of the first fixed seat; a first cut head is arranged in the cavity of the first fixed seat; the lower end of the first cut head is connected with a liquid inlet joint on the top of a dry powder cylinder; a liquid outlet joint at the bottom of the dry powder cylinder is connected with the upper end of a second cut head; the second cut head is arranged in the cavity on the upper part of a second fixed seat; the middle-lower part of the second fixed seat is provided with a liquid outlet passage; and an inlet of the liquid outlet passage is communicated with the bottom of the cavity of the second fixed seat, and an outlet of the liquid outlet passage is connected with a liquid outlet pipe. In the invention, a closed sterile dry powder device is utilized, and prepared dialyzate is sterile, so that the dialysis quality and the long-term survival rate of a patient are greatly improved; and a B concentrate pump is difficult to block, so that the failure rate of dialysis equipment is greatly reduced.

The present invention provides agricultural wettable composition containing microbe with high long term survival rate and excellent physical property for applying as effective component and its long term stable storage method. The wettable composition has mold fungus spore as effective component and moisture absorbent with water absorbing capacity and in the amount of 1 mass%. The present invention provides the preparation process of the wettable composition and the method of sealing the composition into airtight film for storage.

The invention relates to a natural pharmaceutical composition as well as a traditional Chinese medicine composition containing the same and application of the natural pharmaceutical composition. The natural composition comprises the following raw materials in weight ratio: 40 to 200 parts of paeoniflorin, 1 to 20 parts of ferulic acid, 10 to 50 parts of hydroxysafflor yellow and 1 to 20 parts of protocatechuic aldehyde. The traditional Chinese medicine composition is a composition containing the natural pharmaceutical. The natural pharmaceutical composition and the traditional Chinese medicinecomposition have anti-aGvHD and anti-fungal infection effects, and are of great significance to improve the success rate of transplantation, improve the prognosis of patients, and increase the long-term survival rate of patients with hematological diseases, recipients of allogeneic hematopoietic stem cells and patients with fungal sepsis.

The invention discloses an SNP marker composition related to onset risk of brain radiation injury caused by tumor radiotherapy and application thereof. The SNP marker composition comprises 15 SNP loci. Meanwhile, a kit for predicating the onset risk of brain radiation injury caused by tumor radiotherapy is prepared, the kit is adopted to detect types of SNP markers, and the onset risk of onset risk of patients suffering from nasopharyngeal carcinoma can be more comprehensively and accurately detected estimated through clinic information of the patients. Through the adoption of the SNP marker composition to clinical applications, and adoption of protective measures in advance to high-risk patients, the SNP marker composition is beneficial to implementation of individualized treatment to thepatients, and improves the long-term survival quality of the patients suffering from nasopharyngeal carcinoma. Meanwhile, the SNP marker composition can provide a method and tactical reference for the predication of risk of normal tissue injury caused by other radiotherapies.