43 results about "Bone augmentation" patented technology

The invention discloses a magnetoelectric stent for realizing bone repair under external field driving and a preparation method and application thereof.The stent comprises a stent body based on a triple-period minimal curved surface structure and a magnetoelectric nano-particle coating, and the stent body comprises a convoluted and / or through hole structure; and the magnetoelectric nanoparticle coating is loaded on the inner surface of at least part of the pore structure. The magnetoelectric stent is suitable for providing better mechanical support for the early stage of bone repair of large-area bone defects, meanwhile, under the synergistic effect of magnetoelectric stimulation, osteogenesis and angiogenesis coupling can be promoted, and bone defect repair under the complex conditions of oral clinical alveolar bone vertical bone increment and systemic diseases such as inflammation and the like is achieved.

The present invention is applicable to the technical field of bone defect repair, and provides a preparation method and application of a collateral-modified Gelma hydrogel. The present invention performs collateral modification on the Gelma hydrogel by Fibrinogen, successfully improving the mechanical properties and cell adhesion of the hydrogel scaffold. At the same time, the loading of NELL‑1 protein significantly improves the scaffold's ability to repair bone defects. The Fibrinogen‑Gelma / NELL‑1 hydrogel scaffold constructed by the present invention has shown ideal mechanical properties in relevant characterizations, and has been shown to play a key role in the repair of bone tissue defects in in vitro and in vivo experiments, and has greatly promoted the expression of osteogenesis-related genes. Therefore, the present invention is expected to be applied to clinical treatments related to bone defect repair, such as maxillary sinus bone augmentation and guided bone regeneration (GBR), in the future.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

The utility model discloses an oral implant which comprises a bone surface supporting structure, the appearance of the bone surface supporting structure is attached to an upper jaw alveolar bone surface or a lower jaw alveolar bone surface, and a net-shaped through hole is formed in the bone surface supporting structure and corresponds to the alveolar bone surface; a plurality of base tables protruding out of the surface are arranged on the surface of one side of the bone surface supporting structure, and the base tables are used for fixedly connecting the oral implant with a prosthesis; one end, connected to the bone surface supporting structure, of the abutment is provided with an intraosseous implant implanted into the jaw bone. According to the utility model, the traditional subperiosteal implant is improved, the subperiosteal implant is designed in the area with insufficient bone mass of the jaw bone, and the novel stent-shaped implant is formed by combining the subperiosteal implant with the intraosseous implant in the area with sufficient bone mass of the jaw bone, so that independent bone increment operation is not needed, and the implant can be implanted only by one operation; and the clinical problem that a patient with serious atrophy of the alveolar ridge is difficult to implant and repair is effectively solved.

An electroactive titanium support-reinforced composite film includes a titanium support and a film material coating the titanium support. The titanium support has a structure designed according to securing sites. The electroactive titanium support-reinforced composite film of the present invention can be bent and shaped for a close fit with a hard tissue, has excellent mechanical performance and a stable electroactive bending strength of bionic magnitude, and can prevent the collapse of surrounding tissues and tissue adhesion, effectively maintain a three-dimensional space for bone osteanagenesis and effectively promote bone injury healing, featuring ease and convenience of clinical operation and capability of promoting bone marrow mesenchymal stem cell adhesion, cytoskeleton rearrangement and induced osteogenic differentiation. The support-reinforced composite film is suitable for mandible or cranium injury repair in different ranges and has significant efficacy for clinical indications such as alveolar bone vertical bone augmentation and alveolar ridge preservation after tooth extraction.

The present invention provides a method for preparing bone augmentation and reduction, and belongs to the technical field of traditional Chinese medicine preparations. The raw materials of the bone augmentation and reduction include: Radix Rehmanniae Preparata, Rhizoma Epimedii, Caulis Spatholobi, Cibotium Barbarum, Rhizoma Drynariae, Cynomorium Songaricum, Dipsacus Asper, Fructus Lycii and Semen Raphani; the method includes: choline salt, 1-octyl-3-methylimidazolium bromide and acid hydrogen bond donor or alcohol hydrogen bond donor are heated and mixed to prepare multi-component deep eutectic solvent A or multi-component deep eutectic solvent B; Radix Rehmanniae Preparata powder, multi-component deep eutectic solvent A and water are evenly mixed, and microwave heating is performed to obtain Radix Rehmanniae Preparata extract and Radix Rehmanniae solid residue; the Radix Rehmanniae solid residue after drying, the remaining raw material powder and the multi-component deep eutectic solvent B are mixed with the alcohol solution, and an extraction supernatant is obtained by short-term multiple ultrasonic-assisted extraction; the Radix Rehmanniae Preparata extract and the extraction supernatant are combined and concentrated to obtain a bone augmentation and reduction stock solution; and a bone augmentation and reduction preparation is prepared. The present invention can quickly and efficiently extract the effective active ingredients of each raw material of bone augmentation and reduction, and the conditions are mild and the time consumption is short.

The utility model discloses a 3D (three-dimensional) printing implant for oral implantation in the technical field of medical equipment, which comprises an implant structure, the implant structure comprises an implant body, the implant body is of a gradient pore net structure, a bioactive layer is arranged on the outer side of the implant body, and the bioactive layer is made of a transparent material. A bone meal attaching and guiding structure is arranged on the inner wall of a mesh hole of the implant body, a surface fixing structure is arranged on the surface of the implant body, and a bottom fixing structure is arranged at the bottom of the implant body. According to the utility model, the implant body is arranged into the net-shaped structure, and the bone meal attachment and guide structure is matched, so that the bone meal can be guided to directionally grow along the net-shaped pores, the traditional osteogenesis waiting stage is skipped, the implant implantation and bone increment are synchronously completed, and the damage to soft tissues caused by repeated bone meal filling and pressing operation is avoided.

The utility model relates to the technical field of dental nails, in particular to a degradable biological tent nail for increasing dental implant bone, which is made of biodegradable materials and comprises a threaded portion, a tent cap and a self-tapping tip, the tent cap and the self-tapping tip are arranged on different sides of the threaded portion, and the self-tapping tip is connected to the end of the threaded portion. The thread part is connected with the tent cap through a connecting part, a hollow part is reserved in the tent cap for filling and observing the height of bone meal, and an assembling groove is reserved in the tent cap for screwing operation of a screwing screw part. According to the degradable biological tent nail for increasing the dental implant bone, the degradable polylactic acid bone nail does not need to be taken out after the dental implant bone is increased and healed in clinical use, so that the operation cost is reduced; the hollowed-out design of the top of the tent nail facilitates observation of the height of bone meal, and the clinical operation efficiency is improved.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

The utility model discloses an oral cavity bone increment operation barrier membrane nail planting fixing auxiliary device which comprises a handle portion, a fixing portion and a fixing portion. The bent clamping end comprises two arc-shaped cranks, the rear ends of the two cranks are connected with the front ends of the two grab handles through connecting pivots respectively, and separation and reunion of the two cranks are controlled through tightness clamping of the two grab handles; the sides, close to each other, of the front ends of the two cranks are detachably provided with the chuck parts used for clamping the barrier film in the folded state. According to the scheme, the barrier film is clamped and positioned through the modularized chuck part, the barrier film can be clamped and stabilized in a non-contact mode through operation optimization of the scissor-type and lever-type mechanical handles, and an unshielded nailing operation space can be provided; the problems that in a traditional oral cavity bone increment surgery, a membrane nail is difficult to fix and position, tired to operate and poor in adaptation are systematically solved.

The present invention discloses a SLM-molded titanium mesh and a surface treatment method thereof, belonging to the technical field of biomedical implantable metal materials; the surface treatment method provided by the present invention comprises laser remelting, pickling, anodizing treatment, and hydrophobic treatment. The surface treatment method of the SLM-molded titanium mesh provided by the present invention combines the steps of laser remelting, pickling, anodizing treatment, and hydrophobic treatment, thereby obtaining an SLM-molded titanium mesh with high strength and strong hydrophobicity, which can be easily removed after bone augmentation is completed in subsequent applications. In addition, the surface treatment method provided by the present invention is simple to operate, has low equipment requirements, and is suitable for practical use.

The invention discloses an operation guide plate for periodontal auxiliary accelerated osteogenesis orthodontic treatment and a manufacturing method thereof. The manufacturing method comprises the following steps: designing a retention structure model covering the surfaces of dental crowns of all target teeth and adjacent teeth on dentition data after undercut filling according to full-mouth dentition tooth root three-dimensional data; respectively designing a first positioning structure model and a second positioning structure model which are connected with the retention structure model on the buccal bone surface of the jaw three-dimensional data; designing a linear opening area on the first positioning structure model according to the full-mouth dentition tooth root three-dimensional data, obtaining a bone cortex incision line positioning structure model, and obtaining bone cortex incision limiting guide plate data and bone increment limiting guide plate data; printing is conducted based on the bone cortex incision limiting guide plate data and the bone increment limiting guide plate data, and the bone cortex incision limiting guide plate and the bone increment limiting guide plate are obtained. The positioning accuracy of the operation area can be improved, and the operation difficulty is reduced.

A method for dispensing a bone reinforcement composition into an intervertebral spacer and at least one adjacent vertebra can help retain the implant in situ. A cannula guide is inserted into a first vertebra guided by a live imaging system. A curved directional composition delivery cannula is inserted through a tubular body of the guide; then positioning the delivery cannula along a desired path, positioning an end using a curved end as a steering mechanism. The delivery cannula passes through a first vertebra, into the intervertebral spacer, and optionally into a second vertebra. A volume of reinforcement composition is dispensed using cyclical steps incrementally withdrawing the delivery cannula and dispensing of the reinforcement composition until the desired path is filled with reinforcement composition stabilizing the respective vertebrae and / or interbody devices relative to each other. In an alternate arrangement, the cannula is inserted through a guide integrated into the intervertebral spacer.

The application relates to a dental shielding film shaping device which comprises a bottom plate, a lower mold mounting frame, an upper mold mounting frame, a guide rod and a pressing rod; the lower mold mounting frame is mounted at the top end of the bottom plate, and the top end of the lower mold mounting frame is provided with a lower mold body; the guide rod is mounted at the top end of the bottom plate, the upper mold mounting frame is limitingly and slidingly mounted on the guide rod, and the bottom end of the upper mold mounting frame is provided with an upper mold body; the top end of the lower mold body and the bottom end of the upper mold body are respectively provided with a corresponding shaping protrusion and a shaping cavity; the shape of the shaping protrusion and the shape of the shaping cavity are matched with the shape of the alveolar bone of a patient; one end of the pressing rod is hinged to one end of the bottom plate, and the pressing rod is arranged to press the upper mold body on the lower mold body, so that the shielding film body is shaped through the shaping protrusion and the shaping cavity. The application can reduce the labor cost, improve the bone augmentation operation efficiency, and make the shielding film body accurately fit the shape of the alveolar bone of the patient.

The application belongs to the technical field of auxiliary medical treatment, and particularly relates to a digital bone augmentation design method and system with real-time visual implant position. The method comprises the following steps: ideal prosthesis design of tooth loss site is performed; CBCT data, intraoral scanning data and ideal prosthesis data are fitted, and the position of the implant is planned; implant guide plate data is imported into MAGICS software, and a virtual implant model is constructed; the virtual implant and the implant guide plate are grouped, and the spatial relative position of the two is locked; the grouped data of the jawbone model, the intraoral scanning data, the virtual implant and the implant guide plate are input into a bone augmentation design software, and the accurate position of the virtual implant in the jawbone is fitted; in the bone augmentation design software, real-time visual virtual bone augmentation painting operation is performed according to the accurate position of the virtual implant in the jawbone, and the bone augmentation design is accurately completed. The design method and system of the application are more convenient and accurate, and have a good application prospect.

1. Name of the design product: Bone extruder (bone expansion and bone augmentation). 2. Use of the design product: Used as a surgical instrument after jaw bone atrophy. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Stereogram.

The invention belongs to the technical field related to medical image processing, and particularly relates to a maxillary sinus bone increment evaluation method based on CBCT image analysis, which comprises the following steps of preoperative maxillary sinus three-dimensional segmentation, double-stage maxillary bone segmentation processing, double-stage maxillary bone space registration, bone increment volume calculation, implant space positioning analysis and bone increment morphological parameter measurement. According to the method provided by the invention, the image segmentation precision, the measurement precision and the registration efficiency can be improved.

A method for dispensing a bone reinforcement composition into an intervertebral spacer and at least one adjacent vertebra can help retain the implant in situ. A cannula guide is inserted into a first vertebra guided by a live imaging system. A curved directional composition delivery cannula is inserted through a tubular body of the guide; then positioning the delivery cannula along a desired path, positioning an end using a curved end as a steering mechanism. The delivery cannula passes through a first vertebra, into the intervertebral spacer, and optionally into a second vertebra. A volume of reinforcement composition is dispensed using cyclical steps of incrementally withdrawing the delivery cannula and dispensing of the reinforcement composition until the path is filled with reinforcement composition stabilizing the respective vertebrae and / or interbody devices relative to each other. In an alternate arrangement, the cannula is inserted through a guide integrated into the spacer.

The application provides a polytetrafluoroethylene barrier film and its application and preparation method, and belongs to the technical field of biomedical materials. The polytetrafluoroethylene barrier film comprises a film body and a bioactive layer on the surface of the film body; wherein the material of the film body comprises polytetrafluoroethylene, and the outer surface of the film body has a polar group; the material of the bioactive layer comprises a hydrophilic bioactive molecule. In the polytetrafluoroethylene barrier film provided by the application, the polar group on the outer surface of the polytetrafluoroethylene film body interacts with and effectively combines with the hydrophilic bioactive molecule, the combination stability between the film body and the bioactive layer is improved, the adhesion and growth of osteoblasts can be realized, and then the new bone mass during the bone augmentation surgery using the polytetrafluoroethylene barrier film is improved. In addition, the hydrophilic bioactive molecule can also endow the polytetrafluoroethylene barrier film with multifunctionality due to its characteristics.

The application is a kind of periodontitis treatment before and after bone increment quantitative evaluation method based on curved surface tomography, which firstly extracts the tooth feature point pair of the evaluated part in the oral curved surface tomography obtained twice before and after treatment, automatically extracts the feature point of the edge point, matches the feature point of the edge point in the two images; a registration model is constructed to transform the post-treatment oral curved surface tomography; according to the position of the feature point pair, the post-treatment oral curved surface tomography after registration is locally sliced to obtain the registered slice, and the image gray of the registered slice is segmented to obtain a plurality of consistent connected regions, the alveolar bone change target position is automatically selected, and the alveolar bone increment area is calculated by using the number of region pixels and the real resolution of the curved surface tomography. The application can accurately transform the post-treatment picture to the locally aligned position with the pre-treatment picture, automatically extract the change area, and then obtain the accurate alveolar bone increment area.

The present invention relates to the technical field of dental implants, and in particular to a double-cortical bone anchored bone augmentation system and method. The double-cortical bone anchored bone augmentation system includes an anchorage screw, a first nut, and a second nut. The first nut is disposed at one end of the anchorage screw, and the second nut is disposed at the other end of the anchorage screw. The second nut includes a connecting portion and a plurality of umbrella-shaped pieces. The connecting portion is used to connect the anchorage screw, and the plurality of umbrella-shaped pieces are disposed on the side wall of the connecting portion. The umbrella-shaped pieces are arc-shaped, and the umbrella-shaped pieces expand after being squeezed. The present invention rigidly supports the periosteum through the first nut and the second nut, greatly improving the stability of the periosteum.

The invention belongs to the technical field of periodontal repair medical instruments, and particularly relates to a pair of three-dimensional viscous bone forming forceps for periodontal tissue regeneration, which comprises two forceps handles, a hinge piece and locking structures arranged at the tail ends of the forceps handles, the working ends of the two forceps handles are provided with detachable lip side viscous bone forming structures or tongue side forming structures. Each lip side viscous bone forming structure comprises a first arc-shaped concave block, a second arc-shaped concave block and a third arc-shaped concave block, wherein the first arc-shaped concave block is fixed to the end of one forceps handle through a screw; the first arc-shaped convex block is fixed to the end of the other clamp handle through a screw, the outer convex face of the first arc-shaped convex block is matched with the arc face of the first arc-shaped concave block in an inserted mode, and a first working groove and the like are formed in the face, close to the first arc-shaped convex block, of the first arc-shaped convex block. According to the three-dimensional-configuration viscous bone forming forceps, through physical property improvement (viscosity solidification) and shape presetting (dissecting to be matched with a groove type) of a bone grafting material, the three major pain points of bone meal collapse, insufficient increment of key sites and operation dependence on experience in a traditional PAOO operation are solved, and the bone increment accuracy and long-term stability are remarkably improved.

Various embodiments of a novel glenoid implant base plate are disclosed. A prosthesis for attachment to the glenoid is provided, the prosthesis including a monolithic metal structure incorporating a distal surface and a proximal surface, a base plate body, a post extending from the proximal surface, and features associated with the post capable of providing orientation stability for a modular bone augment. Also disclosed is a prosthesis for attachment to the glenoid, including a base plate body that is a monolithic metal structure incorporating an integrally formed metal bone augment.

The utility model provides a titanium mesh for oral implantation, which not only can be conveniently taken out in sections, but also can reduce the risks of displacement and breakage during placement, and relates to the technical field of oral implantation. The oral implant titanium mesh comprises a bent arch-shaped titanium mesh body, the titanium mesh body comprises a titanium mesh edge and a pore structure arranged in the titanium mesh edge, a weak structure easy to break is arranged on the side face of one side of the titanium mesh body, and the weak structure easy to break comprises a groove body extending from one end of the titanium mesh body to the other end of the titanium mesh body. At least one supporting rod group is arranged in the groove body; the supporting rod set is composed of two supporting rods which incline towards the two sides of the width direction of the groove body respectively and intersect in an X mode, and the two ends of each supporting rod are connected with the inner walls of the two sides of the groove body respectively. A fracture guide groove is formed in the intersection position of the two supporting rods of the supporting rod set. According to the utility model, the flap turning area when the titanium mesh is taken out in the later period can be reduced, and the treatment effect of the bone increment surgery can be better ensured.

An apparatus and methods for delivery of reinforcing materials to a weakened or fractured bone is disclosed. An apparatus for delivering a reinforcing mixture to a bone including a tube having a proximal end, a distal end, and a longitudinal axis therebetween, wherein the tube has at least one inner lumen capable of allowing a bone reinforcing mixture to pass therethrough; a balloon engaging the tube wherein the balloon expands from a substantially deflated state to a substantially inflated state upon the bone reinforcing mixture entering the balloon; and at least one light guide extending through the tube into the balloon to guide a light into the balloon.

The invention relates to the technical field of medical instruments, in particular to an alveolar bone increment barrier membrane and a preparation method thereof. The alveolar bone increment barrier film provided by the invention comprises a zirconium oxide film prepared by a 3D printing technology; the alveolar bone increment barrier membrane comprises an alveolar ridge surface, a lip side surface and a tongue side surface, wherein the lip side surface and the tongue side surface are positioned on two opposite sides of the alveolar ridge surface; fixing holes are formed in the lip side surface and / or the tongue side surface, and the total number of the fixing holes is at least two; air holes are formed in the alveolar ridge surface. The alveolar bone increment barrier membrane disclosed by the invention has excellent mechanical property and biocompatibility and low tissue viscosity; the device can be better attached to the defect of the alveolar bone of a patient.

A stent is an expansion system formed by compounding various materials to expand a bone increment space, comprises a bag body, is of a porous structure, is made of materials such as silk fibroin, gelatin, chitosan, silk, PET, PP, PE, PGA, PLL, PLA and PLGA, and expands after absorbing liquid to provide the bone increment space. The stent is suitable for minimally invasive surgery. When the stent is used, large-area soft tissue incision in an operation area is avoided, the stent can be implanted in a minimally invasive mode in advance in a remote incision and tunnel separation mode, and the stent needs to be placed between a bone wall and the soft tissue. After being delivered to a target increment part, the stent expands due to imbibition, so that the volume is increased, the stent is integrated with tissues, and bone increment is finally realized by inducing osteogenic differentiation.

The invention relates to the technical field of biomedical materials, in particular to a medical oral cavity bone increment barrier film and a preparation method thereof. In order to solve the problems of an existing barrier membrane, the novel medical oral cavity bone increment barrier membrane is provided, a magnesium membrane is adopted as a main body, a supporting area and a blocking area are designed, the supporting area is used for providing a mechanical supporting and stabilizing bone repair material, the retention of the bone repair material is enhanced through the design of claw parts, and the bone repair material is more stable. The osteogenesis failure caused by micro motion is reduced; the blocking area is used for blocking invasion of soft tissues; in addition, thickness distribution is optimized through finite element analysis, gradient design is carried out on the thickness of the supporting area and the thickness of the blocking area, and the space maintaining capacity is improved. Furthermore, a ceramic coating is arranged on the surface of the magnesium membrane, initial protection is provided for the magnesium membrane, and cooperative regulation and control of the degradation rate of the magnesium membrane body and the ceramic coating are achieved in the later period, so that the osteogenesis cycle is matched.

The present invention provides methods of distributing agents into bone and the maintenance of those agents within bone. These methods include mechanical, rheological, pharmacological, and other methods. By maintaining injectates within a targeted location in bone and increasing their distribution in bone, the methods are useful for purposes including but not limited to increasing local concentration, improving therapeutic effectiveness, increasing duration of action, and decreasing systemic toxicity. These same methods can displace the contents of bone toward a harvesting instrument for purposes of collection with similar and complimentary methods. The methods are useful for controlling the rate of egress of intraosseous distribution of agents or cells for a variety of purposes, including but not limited to: augmenting stem cell recovery in bone marrow aspiration, chemotherapy, medication delivery, treatment of infection, bone augmentation, and the like.

Biodegradable 3D printed structure for bone augmentation (1) comprises an outer structure (100) and an inner structure (200) that are printed from polylactide (PLA), wherein the inner structure (200) is filled with a chitosan and hydroxyapatite gel and the outer structure (100) is coated with a chitosan and hydroxyapatite composite. The outer structure (100) has a tunnel-like shape resembling an elongated projection of the letter "U" rotated 180 degrees in depth. Implants made in the form of a biodegradable 3D-printed structure for bone augmentation as disclosed in the present invention can be adapted to each individual patient and each individual situation, which will optimize the dentist's time required for the procedure and treatment, and will also facilitate the recovery of the patient due to the reduction of the invasiveness of the procedure. This makes the entire procedure faster, simpler, and painless, but also financially acceptable for patients.