Medicine compounds for treating hypertension

A composition and high blood pressure technology, applied in the direction of drug combination, heterocyclic compound active ingredients, pharmaceutical formulations, etc., can solve the problems of reducing the survival rate of patients, the survival rate of hypertensive patients cannot be improved, and the loss of antihypertensive treatment, etc. Reduced incidence and severity of adverse reactions, reduced cardiac arrest and fatal and non-fatal stroke, effect of dose reduction

Active Publication Date: 2008-07-30
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Now for the treatment of hypertension, it is more important to improve the long-term survival rate of patients. Otherwise, the blood pressure will be lowered, and the survival rate of hypertensive patients cannot be improved or even reduced, which also makes blood pressure reduction. Treatment loses its most fundamental meaning
It can be said that among the existing antihypertensive drugs, there is no ideal drug that meets the current concept of hypertension treatment.

Method used

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  • Medicine compounds for treating hypertension
  • Medicine compounds for treating hypertension
  • Medicine compounds for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 hypertension compound tablet

[0023] Simvastatin 20g

[0024] Amlodipine 2.5g

[0025] Pioglitazone 20g

[0026] The rest of the pharmaceutical excipients are commonly used excipients for preparing tablets.

[0027] Preparation process: Prepared according to the conventional preparation process of photographic agent.

Embodiment 2

[0028] Embodiment 2 Hypertension Compound Capsules

[0029] Atorvastatin 10g

[0030] Enalapril 10g

[0031] Pioglitazone 20g

[0032] All the other pharmaceutical excipients are commonly used excipients for preparing capsules.

[0033] Preparation process: It is prepared according to the conventional preparation process of capsules.

Embodiment 3

[0034] Embodiment 3 hypertensive compound bilayer tablet

[0035] Simvastatin 10g

[0036] Mannitol 10g

[0037] Lactose 40g

[0038] Microcrystalline Cellulose 20g

[0039] 6% PVP in 95% ethanol solution 120g

[0040] Magnesium stearate 2g

[0041] Preparation process: Simvastatin passes through a 100-mesh sieve, mannitol, lactose, and microcrystalline cellulose pass through a 80-mesh sieve, weighs the prescribed amount of niacin and mixes them evenly with mannitol, lactose, and microcrystalline cellulose, and adds 6% PVP Appropriate amount of 95% ethanol solution is granulated, dried at 60° C., sieved with 16 meshes to dry the granules, and adding the prescribed amount of magnesium stearate to the dry granules.

[0042] Nifedipine 30g

[0043] Rosiglitazone 8g

[0044] Pregelatinized starch 50g

[0045] Mannitol 50g

[0046] 6% PVP in 95% ethanol solution 100g

[0047] Micronized silica gel 5g

[0048] Preparation process: Nifedipine and rosiglitazone pass through a...

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PUM

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Abstract

The invention provides a medical composite for treating hypertension and a preparation thereof. The medical composite comprises antihypertensive drug, HMGCoA reductase inhibitor and insulin sensitizer. The medical composite of the invention not only can effectively reduce blood pressure, but also has good effect on the treatment and prevention of hypertension complications. The long term survival of patients can be improved obviously.

Description

Technical field [0001] The invention is a pharmaceutical composition for treating hypertension. Background technique [0002] People with high blood pressure have increasingly become a major health killer for modern urbanites, and we must pay attention to it. Hypertension mainly damages the human blood. It can promote the hardening of the arterial wall and the narrowing of the lumen-that is, "arteriosclerosis" as it is usually called. If hypertension is combined with diabetes, it will accelerate and aggravate the damage of blood vessels and make the condition worsen rapidly. It should be actively treated. [0003] At present, there are many drugs for the treatment of hypertension. What they have in common is that they can all lower blood pressure. The difference is that the mechanism of action and links are different, and the therapeutic effects on hypertension caused by different reasons are different. Some antihypertensive drugs have protective effects on target organs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/4422A61K31/47A61K31/4709A61K31/55A61K31/551A61K47/32A61K47/36A61K47/38A61P9/12
Inventor 赵志全姚景春
Owner LUNAN PHARMA GROUP CORPORATION
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