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Medicinal composition for preventing and treating diabetic nerve pathology

A neuropathy and composition technology, applied in the field of pharmaceutical compositions for preventing and treating diabetic neuropathy, can solve problems such as lack of diabetic neuropathy

Inactive Publication Date: 2012-03-14
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since diabetic neuropathy involves many factors, and these drugs often have relatively large toxic and side effects, there is still a lack of drugs or methods that can effectively prevent and treat diabetic neuropathy.

Method used

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  • Medicinal composition for preventing and treating diabetic nerve pathology
  • Medicinal composition for preventing and treating diabetic nerve pathology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Grind 50g of total saponins of Anemarrhena, 500g of total flavonoids of Epimedium, and 500g of total phenolic acid of salvia miltiorrhiza that are commercially available, grind and mix them, add them to the PEG-6000 melt, stir and mix them, and make 1 Ten thousand drop pills, that is, the corresponding pill-type medicine.

Embodiment 2

[0015] Grind 500g of total saponins of Anemarrhena, 50g of total flavonoids of Epimedium, and 50g of total phenolic acid of Salvia miltiorrhiza, which are commercially available, and mix them evenly. g, is the corresponding capsule dosage form drug.

Embodiment 3

[0017] Add 200g of commercially available total saponins of Anemarrhena, 200g of total flavonoids of Epimedium, and 200g of total salvianolic acid, add appropriate amount of pharmaceutical excipients, mix evenly, granulate and compress into tablets, each weighing 0.3g, to obtain the corresponding tablet form drug.

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PUM

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Abstract

The invention provides a medicinal composition for preventing and treating diabetic nerve pathology, the medicinal composition is composed of effective medical components of total timosaponin, epimeddium total flavonoids and total salvianolic acid as well as auxiliary components which are acceptable in pharmacy. The weight ratio of total timosaponin to epimeddium total flavonoids to total salvianolic acid in the effective medical components is (0.1-1): (0.1-1): (0.1-1), the weight of the optimized effective medical components is equal quantity or basically equal quantity. The effective medical components and the auxiliary components which are acceptable in pharmacy are combined for preparing an oral pharmaceutical preparation. The medicinal composition has obvious efficacy and function for preventing and treating diabetic chronic complication, particularly for the diabetes nerve pathology such as diabetic peripheral neuropathy, diabetic impotence, diabetic gastroparesis, diabetic cerebrosis and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition which can be used for preventing and treating chronic complications of diabetes, especially for preventing and treating diabetic neuropathy. Background technique [0002] Diabetes is a common and multiple disease, and its harm to human health is mainly manifested in a variety of chronic complications, including diabetic nephropathy, diabetic eye disease, diabetic heart disease, diabetic neuropathy and other microvascular diseases, etc. . Among them, diabetic neuropathy is a frequently-occurring disease, a common disease, and the incidence rate is about 70%. At present, there is no effective drug specifically for diabetic neuropathy. The clinical prevention and treatment mainly uses hypoglycemic drugs such as insulin and metformin plus aldose reductase inhibitors (AR Is) such as Fidarestat and epalrestat. (Epalrestat) or α-lipoic acid (Antioxidant α-lipoic acid), methylcobalamin, angiotensin conver...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P3/10A61P25/00
Inventor 谭正怀易进海熊静月刘玉华唐大轩
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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