Itopride hydrochloride medicine composition and preparation method thereof

A technology of itopride hydrochloride and its composition, which is applied in the field of itopride hydrochloride pharmaceutical composition and its preparation, can solve the problems that there is no development and application of itopride hydrochloride and simethicone composition, and achieve protection Gastrointestinal mucous membrane, elimination of gastrointestinal flatulence, and shortening of gastric emptying time

Active Publication Date: 2020-02-14
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new formulation for making medications called tioprostat was developed through advanced technical techniques that improve its performance or reduce side-effects caused from previous drugs used alone. These improvements lead to improved patient outcomes when compared to existing treatments such as metformin or sulfonylurea tablets.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing new compositions containing both drugs that have similar effects but without causing side effects such as sedative or neurological related issues like constipomimepirophylaxis syndrome.

Method used

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  • Itopride hydrochloride medicine composition and preparation method thereof
  • Itopride hydrochloride medicine composition and preparation method thereof
  • Itopride hydrochloride medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Itopride hydrochloride pharmaceutical composition formula is as shown in table 1 below:

[0038] Table 1

[0039] name mass (mg) Percentage, % Itopride Hydrochloride 50 38.5 Croscarmellose Sodium 20 15.4 Simethicone 20 15.4 fumed silica 5 3.8 starch 10 7.6 lactose 20 15.4 Hypromellose (EF or ELF) 4 3.1 Magnesium stearate 1 0.8

[0040] The preparation method of itopride hydrochloride pharmaceutical composition comprises the following steps:

[0041] A: Preparation of mixture of itopride hydrochloride and croscarmellose sodium

[0042] Itopride hydrochloride and croscarmellose sodium were grinded 4 times in a mass ratio of 2.5:1 with a planetary grinder (Model-PMRetsch Haan) at a speed of 200 rpm for 30 minutes each time, Collect and reserve;

[0043] B: Preparation of mixture of simethicone and fumed silica

[0044] Stir and mix simethicone and fumed silica at a mass ratio of 4:1 at 80°C to 150...

Embodiment 2

[0053] Itopride hydrochloride pharmaceutical composition formula is as shown in table 2 below:

[0054] Table 2

[0055] name mass (mg) Percentage, % Itopride Hydrochloride 100 38.5 Croscarmellose Sodium 40 15.4 Simethicone 40 15.4 fumed silica 10 3.8 starch 20 7.6 lactose 40 15.4 Hypromellose (EF or ELF) 8 3.1 Magnesium stearate 2 0.8

[0056] The preparation method of itopride hydrochloride pharmaceutical composition comprises the following steps:

[0057] A: Preparation of mixture of itopride hydrochloride and croscarmellose sodium

[0058] Itopride hydrochloride and croscarmellose sodium were grinded 4 times in a mass ratio of 2.5:1 with a planetary grinder (Model-PMRetsch Haan) at a speed of 200 rpm for 30 minutes each time, Collect and reserve;

[0059] B: Preparation of mixture of simethicone and fumed silica

[0060] Stir and mix simethicone and fumed silica at a mass ratio of 4:1 at 80°C to 1...

Embodiment 3

[0069] Itopride hydrochloride pharmaceutical composition formula is as shown in table 3 below:

[0070] table 3

[0071] name mass (mg) Percentage, % Itopride Hydrochloride 150 33.1 Croscarmellose Sodium 75 16.6 Simethicone 80 17.6 fumed silica 20 4.4 starch 40 8.8 lactose 75 16.6 Hypromellose (EF or ELF) 10 2.2 Magnesium stearate 3 0.7

[0072] The preparation method of itopride hydrochloride pharmaceutical composition comprises the following steps:

[0073] A: Preparation of mixture of itopride hydrochloride and croscarmellose sodium

[0074] Itopride hydrochloride and croscarmellose sodium were grinded 4 times in a mass ratio of 2:1 with a planetary grinder (Model-PMRetsch Haan) at a speed of 200 rpm for 30 minutes each time, Collect and reserve;

[0075] B: Preparation of mixture of simethicone and fumed silica

[0076] Stir and mix simethicone and fumed silica at a mass ratio of 4.4:1 at 80°C to ...

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Abstract

The invention belongs to the technical field of preparation of a medicine preparation, and particularly relates to an itopride hydrochloride medicine composition and a preparation method thereof. Theitopride hydrochloride medicine composition is prepared from the following ingredients in parts by weight: 50 to 150 parts of itopride hydrochloride, 20 to 80 parts of croscarmellose sodium, 20 to 80parts of dimeticone, 5 to 20 parts of fumed silica, 10 to 40 parts of starch, 20 to 80 parts of lactose, 4 to 10 parts of hydroxypropyl cellulose and 1 to 5 parts of magnesium stearate. The prepared itopride hydrochloride medicine composition is a composition prepared from the itopride hydrochloride and the dimeticone; the itopride hydrochloride and the dimeticone have different pharmacological actions and achieve respective effects, but the harmonious synergistic effect is achieved; the gastrointestinal peristalsis is enhanced; meanwhile, the flatulence of the gastrointestinal tract is eliminated; the gastric emptying time of a diabetic gastroparesis rat is obviously shortened; and the mucosa of the gastrointestinal tract is protected.

Description

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Claims

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Application Information

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Owner CHENGDU HENGRUI PHARMA
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