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Fluvastatin tablet containing antiflatulent agent

A technology of fluvastatin and flatulence, which is applied in the field of biopharmaceuticals, and can solve problems such as the appropriate ratio and application of fluvastatin and anti-flatulence agents that have not been mentioned

Inactive Publication Date: 2011-09-21
SHANGHAI TIANLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned publications do not mention the appropriate ratio and application of fluvastatin and anti-flatulent agent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Granule prescription

[0026] Fluvastatin Sodium 84g

[0027] Poloxamer 188 20g

[0028] PEG6000 60g

[0029] Preparation: Weigh fluvastatin sodium, poloxamer and PEG6000 according to the prescription amount, pulverize fluvastatin sodium through an 80-mesh sieve for later use; pulverize the poloxamer and PEG6000 through a 40-mesh sieve, heat in a water bath at 80-90°C Melt, slowly add fluvastatin sodium, stir until the drug powder completely disappears, put the molten drug-containing liquid in a freezer at 4°C for 24 hours, pulverize to obtain fluvastatin sodium particles.

[0030] tablet prescription

[0031] Simethicone 20g

[0032] Microcrystalline Cellulose 20g

[0033] Fluvastatin sodium granules (equivalent to fluvastatin sodium 84g)

[0034] Microcrystalline Fiber Yarn 145g

[0035] Hydroxyethyl Cellulose 50g

[0036] Magnesium Stearate 4g

[0037] Preparation: Disperse simethicone in microcrystalline cellulose, mix evenly with other materials in the ...

Embodiment 2

[0039] Granule prescription

[0040] Fluvastatin Sodium 84g

[0041] Mannitol 80g

[0042] Preparation: Weigh fluvastatin sodium and mannitol according to the prescription amount, pulverize fluvastatin sodium through an 80-mesh sieve, dissolve in mannitol ethanol solution, freeze and spray to obtain fluvastatin sodium granules.

[0043] tablet prescription

[0044] Fluvastatin sodium granules (equivalent to fluvastatin sodium 84g)

[0045] Simethicone 40g

[0046] Microcrystalline Cellulose 145g

[0047] Sodium carboxymethyl starch 50g

[0048] Magnesium Stearate 4g

[0049]Preparation: Disperse simethicone in microcrystalline cellulose, mix evenly with other materials in the prescription, add magnesium stearate, and compress into tablets.

Embodiment 3

[0051] Granule prescription

[0052] Fluvastatin Sodium 84g

[0053] PVP k30 60g

[0054] PVPP xl 20g

[0055] Preparation: Take fluvastatin sodium, PVP k30 and PVPPxl according to the prescription quantity, pulverize fluvastatin sodium through an 80 mesh sieve, dissolve in the acetone:ethanol (1:2) solution of PVP k30 and PVPPxl, freeze and spray to obtain Fluvastatin Sodium Granules.

[0056] tablet prescription

[0057] Fluvastatin sodium granules (equivalent to fluvastatin sodium 84g)

[0058] Simethicone 60g

[0059] Microcrystalline Fiber Yarn 145g

[0060] Low-substituted hypromellose 30g

[0061] Magnesium Stearate 4g

[0062] Preparation: Disperse simethicone in microcrystalline cellulose, mix evenly with other materials in the prescription, add magnesium stearate, and compress into tablets.

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PUM

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Abstract

The invention provides a fluvastatin tablet containing an antiflatulent agent which is selected from dimeticone or simethicone. The fluvastatin tablet is characterized in that fluvastatin is dispersed on pharmaceutically applicable polymer carriers to achieve the aim of stabilization; and the polymer carriers are selected from one or more of polyethylene glycols, polyvidones, surfactants containing polyoxyethylene groups, water-soluble cellulose derivatives, organic acids, saccharides and alcohols. The fluvastatin tablet can effectively remove flatulence and symptom disorder caused by oral administration of fluvastatin.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and in particular relates to a fluvastatin tablet containing an antiflatulent agent, and also relates to a preparation method thereof. Background technique [0002] Statins (ie, HMG-CoA reductase inhibitors) are currently the main class of drugs clinically used to lower cholesterol. Currently clinically used statins include lovastatin, fluvastatin, rosuvastatin, pravastatin, atorvastatin and simvastatin. The most prominent and common side effect of statins is flatulence, which causes not only discomfort but also confusion of symptoms because its symptoms are similar to some symptoms of coronary heart disease. [0003] Antifoaming agents can be used to reduce flatulence, such as simethicone and simethicone, which can be used to treat flatulence and gas in the abdomen. Pharmaceutical compositions comprising an H2 antagonist such as famotidine, alginate and optionally an anti-flatulent amount of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/80A61K31/405A61P3/06A61P1/14
Inventor 张相革
Owner SHANGHAI TIANLONG PHARMA
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