Traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis and preparation method and applications thereof

Abstract

The invention discloses a traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis and a preparation method and applications thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 8-10 parts of astragalus membranaceus, 8-10 parts of codonopsis pilosula, 8-10 parts of atractylodes macrocephala koidz, 3-6 parts of fructus amomi, 6-8 parts of hovenia dulcis, 6-8 parts of salvia miltiorrhiza and 6-8 parts of endothelium corneum gigeriae galli. The traditional Chinese medicine preparation is prepared by decocting raw herbal materials with water, then extracting and concentrating. Pharmacodynamic experiments show that the traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis has no obvious adverse reaction, and is safe and reliable; the preparation can be used for promoting the increase of body mass, food intake and stool quantity of mice with diabetic gastroparesis, relieving the gastric electrical activity confusion and improving the gastric antrum ICC ultrastructure very well, so that the expression of positive ICC and SP positive materials of gastric antrum c-kit can be enhanced, and the positive expression of nNOS can be lowered; and the preparation has a good improvement effect on the number increasing, form and signal transduction function of ICC.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for assisting acupuncture in treating diabetic gastroparesis, a preparation method and application thereof. Background technique [0002] Diabetic gastroparesis is a common and important gastrointestinal complication of diabetes, mainly manifested as gastrointestinal motility dysfunction and slow emptying of gastric contents. Studies have found that 30% to 50% of patients with type 1 or type 2 diabetes have delayed gastric emptying. At present, it is believed that the mechanism of motility disorder that causes the extreme delay of gastric emptying in diabetic gastroparesis includes gastric electrical rhythm disorder, decreased gastric body tone, weakened gastric antrum contraction propulsion, abnormal pyloric tightening, and gastric antrum to duodenal segment motility However, recent studies have shown t...

AI Technical Summary

Problems solved by technology

At present, metoclopramide, domperidone, cisapride and other treatments are commonly used in western medicine, but the curative effect is found to be unsatisfactory through clinical application and lacks long-term satisfactory curative effect

At present, the published inventions of traditional Chinese medicine preparations for the treatment of this disease have defects such as complicated prescriptions, unclear basis for prescriptions, failure to reflect the characteristics of TCM syndrome differentiation and treatment, difficult digestion and absorption of medicines, inaccurate curative effects, and unclear mechanisms.

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