A traditional Chinese medicine preparation for assisting acupuncture in treating diabetic gastroparesis and its preparation method and application

Abstract

The invention discloses a traditional Chinese medicine preparation for assisting acupuncture in treating diabetic gastroparesis and its preparation method and application. 8‑10 parts, Amomum 3‑6 parts, Citrus aurantium 6‑8 parts, Salvia miltiorrhiza 6‑8 parts, Gallus chinensis 6‑8 parts. The traditional Chinese medicine preparation is prepared by decocting raw medicinal materials with water, extracting them, and concentrating them. Pharmacodynamic experiments have proved that the auxiliary acupuncture treatment of diabetic gastroparesis traditional Chinese medicine preparation of the present invention has no obvious adverse reactions, is safe and reliable; can promote the increase in body weight, food intake and defecation volume of diabetic gastroparesis mice, and can better improve The disorder of gastric electrical activity and the ultrastructure of ICC in gastric antrum tissue can not only enhance the expression of c-kit-positive ICC and SP-positive substances in gastric antrum, but also down-regulate the expression of nNOS-positive; Transduction function has a good improvement effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for assisting acupuncture in treating diabetic gastroparesis, a preparation method and application thereof. Background technique [0002] Diabetic gastroparesis is a common and important gastrointestinal complication of diabetes, mainly manifested as gastrointestinal motility dysfunction and slow emptying of gastric contents. Studies have found that 30% to 50% of patients with type 1 or type 2 diabetes have delayed gastric emptying. At present, it is believed that the mechanism of motility disorder that causes the extreme delay of gastric emptying in diabetic gastroparesis includes gastric electrical rhythm disorder, decreased gastric body tone, weakened gastric antrum contraction propulsion, abnormal pyloric tightening, and gastric antrum to duodenal segment motility However, recent studies have shown t...

AI Technical Summary

Problems solved by technology

At present, metoclopramide, domperidone, cisapride and other treatments are commonly used in western medicine, but the curative effect is found to be unsatisfactory through clinical application and lacks long-term satisfactory curative effect

At present, the published inventions of traditional Chinese medicine preparations for the treatment of this disease have defects such as complicated prescriptions, unclear basis for prescriptions, failure to reflect the characteristics of TCM syndrome differentiation and treatment, difficult digestion and absorption of medicines, inaccurate curative effects, and unclear mechanisms.

Images