The invention provides a pharmaceutical preparation for treating chronic urticaria. The pharmaceutical preparation comprises the following raw medicines: ephedra, centipeda minima, notopterygium root, cynanchum paniculatum, schisandra chinensis, rhizoma corydalis, sappanwood, poria cocos, radix clematidis, houttuynia cordata, polygonum cuspidatum, dandelion, schizonepeta, salvia miltiorrhiza, concretio silicea bambusae, sealwort, caulis polygoni multiflori, dendrobe, semen cuscutae, jasmine, folium eriobotryae, peach kernel, agastache rugosus, astragalus membranaceus, purslane, rhizoma anemarrhenae, moutan bark, conyza japonica, rhaponticum, fructus ziziphi jujubae, and honeysuckle stem. The pharmaceutical preparation shows obvious treatment effect, does not generate any side effects like dizzy giddy, drowsiness and weak caused by use of Western medicines, and is of great significance for relieving pain of a patient with chronic urticaria and preventing chronic urticaria.