201 results about "Common St. Johnswort" patented technology

The use of extracts from the plant Hypericum perforatum in the preparation of pharmaceutical compositions for the treatment of hepatitis C, chronic hepatitis C and related viruses, said pharmaceutical compositions comprising at least one extract of the plant Hypericum perforatum and optionally in addition, one or more pharmaceutically acceptable inactive components, selected from, carriers, coatings, diluents and adjuvants.

An anti-aging composition is provided that contains high potency retinol along with anti-irritant properties. In particular, an anti-aging composition includes a base, from about 0.001% to 20.0 vol % retinol, at least one anti-irritant agent, at least one antioxidant, at least one anti-inflammatory agent, and a moisturizing complex. In one non-limiting illustration, the anti-aging composition contains about 1.0 vol % retinol, plantago lanceolata, hypericum perforatum leaf extract, phytosphingosine, leontopodium alpinum extract, glycyrriza glabra root extract, sambucus nigra flower extract, nordihydrognaiaretic acid, oleanolic acid, spiraea ulmaria flower extract, evodia rutaecarpa fruit extract, boswellia serrata extract, and additives.

The present invention provides a composition for topical treatment of skin and mucosal membrane lesions comprising a synergistic combination of copper compound and hypericum perforatum extract.

This invention relates to a method for producing Hypericum perforatum hyperoside and hypericin. This invention comprehensively utilizes Hypericum perforatum fruits which are rich in our country to produce both hyperoside and hypericin pharmaceutical active components with high recovery rate, high product purity, and low cost. During the producing process, it achieves the recovery and cycling use of many solvents like ethanol and ethyl ether, and also achieves the regeneration and cycling use of micelle reextracting agent and absorption resin. The plant biological active compounds produced by this invention can be broadly used in heat-clearing and detoxifying, astringing to arrest bleeding and promote diuresis, and antidepressant drug.

This invention discloses a method of use for a topical herbal formulation alone or in combination with oral administration of niacin (preferably a flush preparation) to prevent and/or treat dyshidrosis (pompholyx) and related skin diseases. The formulation may also be used to treat contact dermatitis, eczema, palmoplantar pustulosis and skin infections incurred by invasive pathogens such as mold, fungus and bacteria. The formulation is comprised of plant extracts and niacin, that when combined yield an effective multi-faceted pharmaceutical approach to treating dry skin disorders. The active ingredients within the formula include a combination of dry, aqueous, acid and alcohol extracts of black walnut hull (Juglans nigra), wormwood (Artemisia absinthium), tumeric rhizome (Curcuma longa), garlic (Allium sativum), two or more herbal antibacterial agents from the group consisting of chamomile (Matricaria Chamomile), licorice root (Glycyrrhiza glabra), St Johns wort (Hypericum perforatum), clove (Syzygium aromaticum), nutmeg (Myristica fragans), ginger (Zingiber officinale), frankincense (Boswellia carteri) and myrrh (Commiphora molmol), further combined with aloe vera and niacin.

A topical herbal formulation for preventing and/or treating dyshidrosis (pompholyx), non-responsive to topical steroids. The formulation may also be used to treat contact dermatitis, eczema, palmoplantar pustulosis and skin infections incurred by invasive pathogens such as mold, fungus and bacteria. The formulation is comprised of plant extracts and niacin, that when combined yield an effective multi-faceted pharmaceutical approach to treating dry skin disorders. The active ingredients within the formula include a combination of dry, aqueous, acid and alcohol extracts of black walnut hull (Juglans Nigra), wormwood (Artemisia Absinthium), tumeric rhizome (Curcuma Longa), garlic (Allium sativum), chamomile (Matricaria Chamomile), licorice root (Glycyrrhiza Glabra), St Johns wort (Hypericum perforatum), aloe vera, niacin and herbal anti-bacterial agents.

The invention relates to a biological preparation method of a Hypericum perforatum L extractive, providing a preparation method which can utilize medicinal material resources adequately, has simple process, is suitable for large-scale production and can prepare the Hypericum perforatum L extractive in accordance with or higher than international standards. The method comprises the following steps of: drying the Hypericum perforatum L firstly and smashing into Hypericum perforatum L powder, then weighing enzyme, adding warm water in the enzyme to dissolve the enzyme, activating enzyme solution by water bath, mixing the Hypericum perforatum L powder with water, performing water bath, soaking, cooling, adjusting pH with hydrochloric acid, stirirng uniformly, heating by water bath, adding the actived enzyme solution, mixing uniformly, performing enzymolysis, filtering, abandoning the filter to obtain medicinal material powder after enzymolysis, adding ethanol and fluxing for extraction, filtering, combining the filtrate, condensing under reduced pressure, recycling ethanol, and drying to obtain the Hypericum perforatum L extractive. The invention improves the content of hypericin in the extractive and the abandoned filtrate after enzymolysis takes away a large amount of water-soluble impurities so that the moisture of the extractive is not needed to absorb again. The biological method is safe, pollution free and has simple operation and is easy for industrialized application.

The invention discloses compound plant essential oil for refreshing, restoring consciousness, diminishing swelling and relieving itching and a preparation method of the compound plant essential oil. The compound plant essential oil is prepared by mixing the following components in parts by weight: 30-80 parts of simmondsia chinensis seed oil, 10-20 parts of peppermint leaf oil, 1-10 parts of eucalyptus globulus leaf oil, 1-10 parts of lavender oil, 1-10 parts of citrus aurantium bergamia fruit oil, 1-10 parts of hypericum perforatum oil, 1-10 parts of patchouli oil, 5-20 parts of natural menthol, 1-10 parts of borneol, 0.5-5 parts of tocopherol, 0.5-5 parts of natural bisabolol and 0.1-2 parts of aloe gel lyophilized powder. The compound plant essential oil has fresh and pleasant fragrance, is safe and mild, and is capable of refreshing, restoring consciousness, quickly diminishing swelling and relieving itching, and is an ideal product in summer.

The use of extracts from the plant Hypericum perforatum in the preparation of pharmaceutical compositions for the treatment of hepatitis C, chronic hepatitis C and related viruses, said pharmaceutical compositions comprising at least one extract of the plant Hypericum perforatum and optionally in addition, one or more pharmaceutically acceptable inactive components, selected from, carriers, coatings, diluents and adjuvants.

The invention discloses a traditional Chinese medicinal composition for preventing or treating common cold and/or flu. The Chinese medicinal composition is characterized by being prepared from the following raw materials: honeysuckle flower, weeping forsythia, mint, herba schizonepeta or schizonepetaspike, hypericum perforatum, burdock fruit, balloonflower, henon bamboo leaf and liquorice. The Chinese medicinal composition has the effects of dispelling wind, relieving exterior syndrome, clearing away heat and detoxicating, resisting H1N1 influenza virus and inhibiting avian influenza virus H9N2, and can be used for treating common cold and flu, particularly relieving the symptoms of fever headache, whole body pain, cough, throat pain, algidity, fatigue and the like. The preparation prepared by the method has obvious curative effect, is safety, non-toxic, convenient for taking and suitable for clinical application.

The invention discloses a Chinese medicinal herb preparation for poultry. The effective constituents of a Chinese medicinal herb product disclosed by the invention are made up of echinacea purpurea, honeysuckle, hypericum perforatum, glycyrrhiza, folium isatidis, platycodon grandiflorum, lophatherum gracile, mint and hypericin. The Chinese medicinal herb preparation disclosed by the invention can relieve the exterior syndrome with drugs pungent in flavor and cool in property and clear away heat and toxic materials; and the main therapeutical effects include strengthening vital Qi and eliminating pathogens, balancing Yin and Yang, and improving non-specific immunity of organisms. The Chinese medicinal herb preparation for poultry has significant therapeutical effect for depressed spirit of poultry, feed intake decrease, egg laying reduction, eyelid swelling of poultry caused by unknown viruses, respiratory inflammation, yellow-green dung, weight increment decline, soft-shelled eggs, and death rate increment, etc.; furthermore, the Chinese medicinal herb preparation for poultry can be utilized to prevent the diseases of untypical Newcastle disease and avian influenza etc. and treat the relevant mixed infection, secondary infection, untypical diseases and chronic cases; and finally, the Chinese medicinal herb preparation for poultry well promotes the recovery of production performance after the poultry is healed.

Disclosed is a Hypericum perforatum flavones extract, its preparation and use. the content of the flavones in the extract is 80-95%, the flavone-containing ingredients include birutan 5.0-50.0%, hyperoside 6.0-70.0%, isoquercitrin 3.0-10.0%, quercetin-3-O-alpha-L-arabinoside 0.5-5.0%, quercetin 0.5-5.0%, meletin 0.1-1.0%, and other balancing flavones components.

The invention relates to an extraction method of hyperin and application thereof in medicament preparation. The extraction method of the hyperin comprises the following steps: placing Turpinia formosana leaves or Hypericum perforatum in 30%-90% ethanol of 5-15 times, carrying out reflux extraction for 1-3 times, and filtering, wherein the reflux extraction of each time is carried out for 1-3 hours; merging the filtrates, recovering the ethanol, eluting the aqueous solution with a macroporous adsorption resin column, collecting eluted parts, carrying out depressurized concentration, and drying to obtain mixed total glycoside of the hyperin; and carrying silicagel column chromatography and Sephadex LH-20 column chromatography separation, merging hyperin fractions, and crystallizing to obtain the pure hyperin product. The hyperin can be used as a neuraminidase inhibitor for preventing and treating flu, and can be prepared into pharmaceutically acceptable dosage forms.

The invention discloses a total flavonoid from hypericum perforatum, a preparation method of a preparation thereof and a quality test method thereof. The preparation method of the invention mainly adopts the steps of degreasing, extracting ethyl acetate, and the like, which has the advantages of less loss of heat sensitivity components, stable content of effective component and better guarantee for product yield and quality compared with the prior art. The quality test method of the invention can successfully control the quality of the product and ensure the relevant efficacy of the product. The total flavonoid from hypericum perforatum and the preparation thereof have better efficacy on treating depression.

The present invention relates to the preparation process of extract containing three active components including hypericin, Hyperforin and flavones in the total content not less than 50% from hypericum perforatum or other congeneric plant. The three active components are separated from the polar solvent extracted liquid via biphase extraction with non-polar solvent selected based on their difference in polarity. They are then purified separately based on their difference in acid-base property to obtain the extract A with high hypericin and flavones content and extract B with high Hyperforin content. The two extracts are merged through dissolution to obtain hypericum perforatum extract with total active component content not less than 50%. The extract has the obvious activity of resisting depression and may be used as the material of depression treating medicine or functional food.

St. John's Wort products which have enhanced bioactivity in a serotonin re-uptake assay and enhanced stability and bioavailability are formulated and manufactured from hyperforin-enriched Hypericum fractions made by supercritical and near critical fluids with and without polar cosolvents. These fluids are used to fractionate the biomass materials in several sequential steps. In each step, the biomass is subjected to a multiplicity of supercritical or near critical fluid extraction steps, with different solvation conditions used for each fraction. Thus, fractionation of the biomass is effected and the St. John's Wort products are manufactured. In addition to excellent overall yield, the bioactivity and stability of the St. John's Wort products manufactured from Hypericum perforatum biomass with supercritical and near critical fluids with and without polar cosolvents are significantly higher than that obtained by conventional organic phase extraction. The advanced formulation of the hyperforin-enriched Hypericum fractions includes antioxidants as oxygen scavengers to improve stability and emulsifiers such as lecithin to improve bioavailability.

The invention relates to a compound antivirus immune intensifier of Chinese herbal medicine, comprising a main material, a solubilizer Tween -80 and a stabilizer vitamin C, wherein the main material of the antivirus immune intensifier comprises honeysuckle, forsythia, houttuynia, hypericum perforatum and the like. The compound antivirus immune intensifier of Chinese herbal medicine has the functions of resisting viruses, inhibiting bacteria and intensifying immunity, is taken by oral administration and injection, innovatively uses a spray method for stirring the material, effectively solves the problem of difficult uniform mixing, and also has convenient use, obvious growth promotion function and low cost.

The method for extracting hypericin from hypericum perforatum includes the following steps: soaking plant hypericum perforatun in KOH and NaHCO3 solution with a specific concentration, boiling, filtering and drying to obtain its extract, dissolving said extract in propyl alcohol, filtering solute, and using water-alcohol process to refine the extract so as to obtain the invented product. It is used as main component, and matched with other component, and can be made into the hypericin medicine composite or other different dosage forms for curing depression.

Disclosed is a safe substance which can inhibit the activity of aromatase (an enzyme capable of converting androgen into estrogen) to thereby effectively treat and/or prevent a sex hormone-dependent disease such as breast cancer occurring in a female person after menopause, as well as a climacteric disorder in a male person and metabolic syndrome caused by the accumulation of a visceral fat. Specifically disclosed is a therapeutic and/or prophylactic agent for a sex hormone-dependent disease, which is characterized by comprising at least one herbal extract selected from the group consisting of “Kokeiten” (golden root), prunella spike, sweet hydrangea leaf, milk thistle, a jasmine tea, “Bokusoku” (a bark of Quercus acutissima or a closely related plant thereof), “Tencha” (sweet tea), “Karensou” (Eclipta prostrata), “Youbaihi” (a bark of Myrica rubra Sie b. et Zucc.), French maritime pine, betel palm, asparagus, “Rouro” (a root of Rhaponticum unifloru m DC. or Echinops latifolius Tausch), “Ryoukyou” (a rhizome of Alpinia officinarum Hance), rooibos tea, rhubarb, pu-erh tea, green tea, “Ougon” (a root of Scutellaria baicalensis Georgi), St. John's wort (Hypericum perforatum L.), licorice, “Senrikou” (Senecio scandens Buch.-Ham.), wintergreen, “Kashi” (a matured fruit of Terminalia chebula Retz.), “Yagotou” (a bark of Mallotus japonicus), polygnum root, barrenwort (Epimedium Herb), guarana, “Ouhi” (a bark of Prunus jamasakura Sieb. ex. Koidz. or a closely related plant thereof), Argy's wormwood, sticky rehmannia, Japanese cornel, Asiasarum root, cinnamon, peony root, pine needle and amla fruit.

The invention relates to a method for separating and purifying hypericins by adopting a macroporous resin separation technique and an alumina chromatographic technique. The method comprises the following steps of: grinding fresh hypericum perforatum L, leaching the ground hypericum perforatum L for 1 to 2 hours in saturated lime solution, adjusting a pH value to 6 to 7 by hydrochloric acid at normal temperature, and performing resin separation, segmented elution, alumina chromatography, ethanol elution and cyclohexane to obtain the finished product. The method has the advantages of simple process, little energy consumption and high-purity hypericins.

The invention relates to a Chinese medicinal preparation used as air disinfectant, more particularly to a herbal air disinfectant for controlling avian influenza and a preparation method thereof. The herbal air disinfectant for controlling avian influenza is prepared from the following materials in weight ratio: 1-10 parts of Hypericum perforatum, 1-10 parts of Scutellaria baicalensis, 1-10 parts of Isatis indigotica root, 1-10 parts of Lonicera japonica flower, 1-10 parts of Pogostemon cablin and 1-10 parts of Eupatorium fortunei. The air disinfectant is produced by the following steps: mixing the above herbal materials, decocting in water for 1-3 times (boiling for 2-3 hours for each time), collecting volatile oils and decoctions, mixing the decoctions, standing overnight, collecting supernatant, filtering, concentrating, precipitating with ethanol, removing ethanol, diluting with water, stirring, standing, collecting supernatant, filtering, adding the volatile oils, adjusting the concentration of drug liquid to 4-10% of the raw materials, stirring and packaging. According to the technical proposal mentioned above, the air disinfectant has no irritation and toxicity, can efficiently kill various pathogenic microorganisms, particularly avian influenza virus, and is used for the prevention and treatment of avian influenza.

The invention discloses a Chinese medicinal composition for treating depression. The medicine adopts lilies, semen ziziphi apinosae, curcuma longa, hypericum perforatum L., perilla, ginseng, and radix bupleuri as raw materials, which are then separate and extracted by 0-75% ethanol so as to be prepared into certain preparation form. The above six drugs used together can soothe liver and relieve depression, reconcile and activate qi, tranquilize the mind and calm the nerves, and can be used for mild and moderate depression and patients belonging to stagnation of qi due to depression of liver, as well as heart-spleen deficiency. Pharmacodynamic research indicates that: the medicinal composition has substantial antagonistic effects on reserpine induced depression models, mouse akinesia and hypothermia, and can increase the spontaneous movements of tail suspension and forced swimming induced despair animal models, as well as the immobility time of tail suspension and swimming. Clinical research results show that a HAMD (Hamilton depression scale) used for evaluating depression severity and Chinese medicinal syndromes before and after treatment are taken as main curative effect indexes, which show that the Chinese medicinal composition in the invention has substantial curative effects. The composition provided in the invention can be prepared into medically acceptable oral preparations, such as tablets, capsules (soft capsules and hard capsules), granules, and other preparation forms. Clinical effects and pharmacodynamic research prove that the Chinese medicinal composition of the invention has the functions of liver soothing and depression relieving, mind tranquilizing as well as nerve calming, and is an effective medicine special for depression treatment.

The invention discloses an externally applied Chinese herbal composition with a facial redness removing effect. The composition consists of the following active pharmaceutical ingredients in parts by weight: 20-50 of red bean, 20-40 of dark plum fruit, 20-40 of witch hazel, 10-30 of salvia miltiorrhiza and 10-30 of hypericum perforatum L. The active pharmaceutical ingredients are selected from natural Chinese herbal plant ingredients, so that the composition is safe and moderate and does not stimulate. The compound Chinese herbs are reasonable in compatibility, on the one hand, pathogenesis which causes redness inflammation is eliminated through inhibiting inflammatory factors; and on the other hand, through inhibiting platelet aggregation, facial blood circulation is promoted, the facial skin autophage is improved, and moreover, the composition also has the efficacies of radiation protecting and moisturizing. After the composition is used, facial redness and facial health problems of red, swelling, pain and the like along with the facial redness can be effectively solved, and finally, an effect of recovering the facial skin health is realized.