30 results about "Skin rashes" patented technology

The invention belongs to the field of wash supplies, and provides a composition with functions of controlling oil, inhibiting bacteria, relieving itching and repairing ultraviolet damage and a facial cleanser. The composition is prepared from hydrolyzed keratin, recombinant collagen, zinc acetate, a rhizoma atractylodis macrocephalae extract, zingiber officinale roscoe essential oil and a fructus cnidii extract, and the mass ratio of the hydrolyzed keratin to the recombinant collagen to the zinc acetate to the rhizoma atractylodis macrocephalae extract to the zingiber officinale roscoe essential oil to the fructus cnidii extract is (3-3.2): (3-3.2): (1-1.2): (2-2.2): (2-2.2): (2-2.2). The facial cleanser contains the composition, and the mass fraction of the composition in the facial cleanser is 0.1%-5.0%. Experiments prove that the composition and the facial cleanser have good effects in the aspects of inhibiting skin sebum secretion, inhibiting bacteria, inhibiting eczema, inhibiting allergic rash, relieving itching, repairing ultraviolet damage and the like, and the problem that the comprehensive performance of the existing composition for facial skin and the related facial cleanser is not satisfactory can be solved.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

A multi-purpose medicinal cream comprising shea butter, wild opium lettus powder, Orange Blood, Frankincense, Lavender, Rosemary, Copaiba Balsam, Birch Sweet, Lemon Grass, Marjoram, Basil, Eucalyptus, Peppermint, Cinnamon, Cedarwood, Thyme, Clove, Vetiver, Geranium, Cinnamon Leaf, and Ylang Ylang. The multi-purpose cream is an aid in pain management of disorders including lupus, arthritis, rheumatoid arthritis, knee and joint pain, neck pain, inflammation, migraines, and neuropathic disorders, as well the treatment of skin conditions including eczema, dry skin, psoriasis, swelling, heat rash, rashes, and rashes of dogs.

The invention discloses a traditional Chinese medicine composition for treating a warm disease clinically belonging to the same disease of defensive qi and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 5-35 parts of bupleurum chinense, 9-50 parts of scutellaria baicalensis, 9-50 parts of artemisia apiacea, 5-35 parts of radix paeoniae rubra, 5-35 parts of moutan bark and 4-26 parts of folia perillae acutae. According to the traditional Chinese medicine composition, the effects of all the medicines are utilized to generate a synergistic effect, and the effects of relieving fever, eliminating evil and detoxifying are achieved together. The traditional Chinese medicine composition is used for treating fever or hyperpyrexia, slight aversion to wind-cold, headache, sweating, thirst, cough and pharyngalgia caused by cold, viral cold and upper respiratory tract infection febrile disease defensive qi, and can be accompanied by nausea, vomiting, neck stiffness, rash appearance, red eye swelling and pain and the like, so that the febrile disease is effectively treated.

The invention provides a pharmaceutical composition for treating herpes zoster as well as a preparation method and application thereof, and belongs to the technical field of medicines. Comprising the following components in parts by weight: 8-15 parts of sticky rice, 8-15 parts of mung beans, 1-3 parts of snake slough, 8-15 parts of flying centipedes, 1-3 parts of realgar and 1-5 parts of borneol. By adding the basic components including the sticky rice, the mung bean, the snake slough, the centipede, the realgar and the borneol, the traditional Chinese medicine composition can achieve the synergistic effects of resisting viruses, relieving pain, diminishing inflammation and the like, effectively relieves the symptoms of rash, pain and the like of herpes zoster, plays a role in neuroinflammation caused by viruses, is relatively mild in medicine property, and is free of toxic and side effects. The medicine is suitable for being used by herpes zoster patients with sensitive skin.

The invention provides a traditional Chinese medicine composition for treating rash, a medicinal preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises the following components: radix rehmanniae, radix ophiopogonis, radix scutellariae, fried tribulus terrestris, fructus kochiae, cortex lycii radicis, radix scrophulariae, radix puerariae, rhizoma cimicifugae, radix paeoniae alba, radix saposhnikoviae and liquorice. The traditional Chinese medicine composition and the medicinal preparation provided by the invention have the effects of removing heat to cool blood and nourishing yin to dispel wind, and can be used for treating rash, especially yin deficiency and internal heat type chronic rash with symptoms of dry and erythema of skin, severe itching at night and red tongue with little tongue fur.

This invention belongs to the field of rehabilitation medicine technology and discloses a targeted assessment and intervention system and method for refractory rashes based on fascial guidance. The system includes: a multimodal targeted data acquisition module for acquiring rash characteristics, body structure, fascial biomechanical properties of the target location, surface projection area of ​​the target viscera, and craniosacral rhythm indicators; a target localization module for matching rash characteristics with a viscera-skin association model to obtain the target viscera and association rules; a sunshade model for determining the fascial mechanical conduction path and attenuation degree between the target viscera and the rash area; an assessment module for matching misalignment chain information, fascial biomechanical properties, attenuation degree, and rhythm indicators with association rules to obtain assessment results; and an intervention plan recommendation module for determining an intervention plan based on the assessment results. This system enables precise localization and targeted intervention of the structural root cause of the rash.

A disposable wearing article having an excellent rash preventing effect. A skin contact region in a top sheet formed of a nonwoven fabric having a basis weight of 5 to 40 g / m2 has a glycerin-containing region in which glycerin is applied in a region to which a body fluid pervious treatment agent containing a nonionic surfactant having an amide and / or amino group is applied.

A fire-retardant topical formulation comprising glycerol and urea in a ratio of 1:1 to 1:30 is provided. The formulation may further comprise polyvinyl pyrrolidone and / or ethylhexylglycerin, and / or a barrier forming agent and / or a stabilising agent. The formulation may be a moisturiser, shampoo, conditioner, hair dye, sun cream, aftersun composition, emollient or medical composition. The formulation may be for use in treating a skin condition, such as eczema, dermatitis, psoriasis, elderly dry and itchy skin, ichthyosis, rash, or infection. The composition when transferred to a fabric suppresses the flammability of the fabric and is also capable of being removed from the fabric by washing. A preferred formulation comprises 1% phenoxyethanol, 10% urea, 10% sodium lactate (60% solution), 1% lactic acid, 1% glycerol, 3% ethylhexylglycerin, 2% polyacrylate crosspolymer-6, 0.5% polyvinylpyrrolidone and 71.5% water by weight. A fire-retardant topical formulation comprising 1% glycerol, 2% polyacrylate crosspolymer-6, 10% sodium lactate solution, 1% phenoxyethanol, 1% lactic acid, 3% ethylhexylglycerin and 0.5% polyvinylpyrrolidone by weight is also disclosed. [Fig: None]

The invention relates to the technical field of medicine, in particular to application of N-ethyl maleimide in inflammatory dermatosis, by adopting an LL-37-induced mouse rosacea model, experiments prove that NEM can directly and effectively inhibit inflammatory response by inhibiting glycerophospholipid metabolism and regulating expression of related genes such as keratinocytes and T lymphocytes, so that the inflammatory response is effectively inhibited, and the inflammatory response is inhibited. The compound can improve mouse rosacea-like rash, has no obvious cytotoxicity, can be used as a candidate compound, is used for developing a glycerophospholipid metabolism inhibitor, and is used for treating skin inflammatory diseases related to glycerophospholipid metabolism, such as rosacea and psoriasis. By utilizing multiple experimental means such as transcriptomics sequencing, histopathologic examination, reverse transcription real-time fluorescent quantitative PCR (RT-qPCR) and the like, it is proved for the first time that N-ethyl maleimide improves mouse rosacea by inhibiting glycerophospholipid metabolism.

The present invention is a bio-electrode including: a substrate having anti-reflective structure for light on at least one side; and (A) an electro-conductive layer having electro-conductive wiring on the opposite side from the side having the anti-reflective structure of the substrate. This provides: a bio-electrode that allows thin, highly transparent, highly sensitive to biological signals, excellent in biocompatibility, light-weight, manufacturable at low cost, capable of preventing significant reduction in sensitivity to biological signals even when attached on the skin for a long time and when wetted with water or dried, and comfortable without itching, reddening, nor rash of the skin.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an external traditional Chinese medicine composition for atopic dermatitis and chronic rash, a traditional Chinese medicine preparation based on the composition and a preparation method and application thereof. The external traditional Chinese medicine composition for atopic dermatitis and chronic rash is prepared from the following raw materials in parts by weight: 3 to 15 parts of rhizoma atractylodis, 3 to 15 parts of radix sanguisorbae, 3 to 15 parts of rhizoma coptidis, 3 to 15 parts of gallnut, 3 to 15 parts of fructus cnidii, 3 to 15 parts of frankincense, 3 to 15 parts of myrrh and 3 to 8 parts of borneol. The external traditional Chinese medicine composition for treating chronic rash of atopic dermatitis conforms to the pathogenesis of chronic disease course of atopic dermatitis, repeated attack, difficulty in removing damp evil due to root deficiency and blood stasis due to long illness, has the effects of consolidating root, clearing damp, dispersing blood stasis and healing sore, and is used for treating chronic rash.

The invention provides a traditional Chinese medicine external composition for treating AIDS (acquired immune deficiency syndrome) cutaneous pruritus. The external traditional Chinese medicine composition for treating AIDS cutaneous pruritus is prepared from, by weight, 1 part of radix saposhnikoviae, 1 part of radix cynanchi paniculati, 1 part of radix sophorae flavescentis, 1 part of cortex dictamni, 1 part of radix et rhizoma rhei, 1 part of cortex phellodendri, 1 part of radix scutellariae, 1 part of radix angelicae sinensis, 1 part of radix arnebiae seu lithospermi, 1 part of radix ophiopogonis, 1 part of radix asparagi, 1 part of cortex pseudolaricis, 1 part of fructus cnidii, 1 part of pericarpium zanthoxyli, 1 part of radix astragali, 1 part of radix glycyrrhizae, 1 part of rhizoma bletillae and 1 part of radix ampelopsis. The external traditional Chinese medicine composition for treating AIDS skin itch provided by the invention has the advantages of effectively relieving itch, shortening the disease course, promoting rash fading and improving the immune function.

The utility model refers to a cosmetic cream containing extract of Hypericum perforatum (St. John's wort) and finds application in the cosmetic industry, skin care. The cream possesses the beneficial properties of Hypericum perforatum, such as anti-inflammatory, antibacterial, antimicrobial, antioxidant action, moisturizes and softens the skin, resulting in an exceptionally good nourishing, regenerating and protective effect on the skin, without causing irritation or skin rashes.

The invention discloses an antioxidant-free kanamycin injection and a preparation method thereof.The injection is composed of kanamycin sulfate, a pH regulator and water for injection, the pH is 4.5-7.0, headspace oxygen is controlled to be smaller than or equal to 1% through nitrogen charging, and the injection is completely free of sodium hydrogen sulfite, cysteine hydrochloride and other antioxidants and can be used for intravenous drip and intramuscular injection; the invention further provides a preparation process and an ion chromatography verification method which are compatible with an existing production line, and the product quality meets the requirements of Chinese Pharmacopoeia 2020 through high temperature, strong light and long-term stability test verification; clinical retrospective analysis shows that the rash occurrence rate is reduced to 3.1% from 27.3%, the safety is remarkably improved while the medicine quality is ensured, and the method has a good industrial application prospect.

This disclosure describes a cannabinoid-based nanoplatform for treating shingles, designed to enhance bioavailability and controlled release of active ingredients. The composition includes cannabinoids like cannabidiol (CBD) and cannabigerol (CBG), alongside flavonoids, polyphenols, and alkaloids, in oral and topical formulations. The oral capsule combines cannabinoids with polyphenols and flavonoids to provide systemic anti-inflammatory, antiviral, and neuroprotective effects, particularly for nerve pain and inflammation, including postherpetic neuralgia. The topical cream includes cannabinoids, capsaicin, and aloe vera, offering localized relief from pain, itching, and rash. The method targets both systemic and localized symptoms during the acute phase of shingles, aiming to inhibit varicella-zoster virus replication, disrupt viral assembly, and prevent viral release, while also providing immune modulation and anti-inflammatory benefits. The nanoplatform uses nano-emulsification techniques, producing particles smaller than 200 nm to ensure optimal delivery and therapeutic efficacy, offering comprehensive relief for shingles symptoms.

The invention discloses a patient-based tumor drug adverse reaction remote monitoring system and a protection method. According to the invention, through the algorithm design in the patient dynamic interaction and symptom intelligent capture module, the accuracy and integrity of symptom information acquisition are firstly improved. A natural language processing algorithm in the module can automatically extract key information, such as core elements such as symptom appearance time, duration and pain level, from character description or voice transliteration text of a patient, and omission or misjudgment during manual recording is avoided; meanwhile, an image recognition algorithm can perform feature analysis on uploaded body surface symptom pictures such as rash and swelling, an abnormal area is quickly positioned, morphological features are marked, and doctors are assisted in visually judging symptom types. According to the algorithms, the complexity of manual input of the patient is reduced, scattered symptom description is converted into structured data, and the reliability of subsequent analysis is improved.

The utility model discloses a nursing vest for an arm fracture patient, which relates to the technical field of rehabilitation treatment and comprises a wearing vest main body. A placement groove is formed in the surface of the front end of the wearing vest body, a ventilation net is arranged on the surface of the bottom of the placement groove, a sweat absorption pad is installed in the placement groove and is made of a sponge material, a bonding layer is arranged at the bottom of the lower surface of the placement groove, and a protective layer is connected to the surface of the bonding layer in a bonding mode. Compared with an existing common nursing vest for the patients with the arm fractures, the nursing vest for the patients with the arm fractures has the advantages that through the arrangement of the sweat absorption pad, when the nursing vest for the patients with the arm fractures is worn on the nursing vest body, the nursing vest can be used for nursing the patients with the arm fractures; according to the wearable vest, sweat generated by the skin can be absorbed, the sweat is prevented from adhering to the interior of the wearable vest body, and uncomfortable symptoms such as skin itch and rash easily caused by the fact that the skin of a patient is in a stuffy and humid environment can be avoided.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention relates to the technical field of health-care products, in particular to skin-soothing health-care emulsifiable paste and a preparation method thereof.The skin-soothing health-care emulsifiable paste is prepared from tribulus terrestris, radix sophorae flavescentis, mint, Chinese magnoliavine roots, senecio scandens, pine needles, perfoliote knotweed herb and chlorhexidine. The cream is prepared from tribulus terrestris, radix sophorae flavescentis, mint, berberis poiretii schneid, senecio scandens, pine needle, perfoliote knotweed herb, chlorhexidine and the like according to a specific proportion, and has the beneficial effects that the skin-soothing health-care cream is scientific and reasonable in formula, adopts the compatibility principle of monarch, minister, assistant and guide, has a good effect of improving skin problems due to the synergistic effect of the components, and is high in safety; the traditional Chinese medicine composition is suitable for improving sub-health crowds caused by whelks, rash, acne, psoriasis, skin itch, redness, skin pimples, skin keratosis and dryness, hair follicle comedo, facial skin laxity and skin aging, and has the effects of promoting health and caring health by smearing uncomfortable parts with the traditional Chinese medicine composition; the preparation method is simple and feasible, is suitable for large-scale production, and has a wide application prospect.

The rapid development of tumor molecular targeted drugs and immunotherapy promotes the progress of tumor treatment field, but the treatment means of related adverse reactions is very single, the application discloses a kind of traditional Chinese medicine composition and preparation method for preventing and treating new generation of tumor targeted and immunotherapy related adverse reactions.The composition includes the following mass parts of traditional Chinese medicinal materials: 3-20 parts of radix astragali, 3-18 parts of radix rehmanniae, 3-15 parts of radix lithospermi, 3-20 parts of old snake tongue grass, 3-20 parts of white milk vetch, 3-18 parts of old heron grass, 3-12 parts of gallnut, 3-20 parts of fried elaterium, 3-10 parts of raw licorice.The traditional Chinese medicine composition has the effects of nourishing yin and benefiting qi, promoting blood circulation to expel wind, detoxifying and removing turbidity, and is good for preventing and treating skin rash, gastrointestinal inflammation and diarrhea, hypothyroidism, proteinuria, hypertension, pneumonia, myocarditis and the like.The preparation method is decoction, granules, pills and capsule preparations.The application is simple, economical and effective, has no toxic side effects, and is helpful to prolong the tolerance period of targeted and immunotherapy and improve the survival quality of patients.

The application discloses a traditional Chinese medicine composition for treating nodular erythema, which is prepared from the following raw materials in a proportion by weight: 3-15 parts of Bupleurum, 3-20 parts of Artemisia annua, 3-15 parts of Angelica sinensis, 3-15 parts of Radix Angelicae Pubescentis, 3-20 parts of Cynanchum, 3-15 parts of Notopterygium, 3-20 parts of Fructus Kochiae, 3-15 parts of Cnidium, 3-20 parts of Alnus, 3-10 parts of Glycyrrhiza, 3-20 parts of Salvia miltiorrhiza, 3-15 parts of Saposhnikovia divaricata, 3-15 parts of Paeonia suffruticosa, 3-10 parts of honeycomb, 3-12 parts of Tripterygium wilfordii, 5-30 parts of Crataegus pinnatifida, and 5-30 parts of Sorsastrum hemningsii. The composition can fade the skin rash and nodular erythema, has a low recurrence rate, and is superior to methylprednisolone which is commonly used in the clinic. The application can effectively treat the nodular erythema related to connective tissue disease, and has the clinical popularization and application value.

A topical composition for treating a skin condition on mammalian skin that contains active inorganic carbonate useful as a skin desiccant and mild abrasive for cosmetic and medical purposes. The composition includes inorganic carbonate particles and at least one additional component of an emollient, an emulsifier, a fragrance, a humectant, an occlusive, a pH adjuster, a preservative, a grain, and a solvent. The inorganic carbonate particles are precipitated calcium carbonate, CaCO,; calcium hydroxide, Ca(OH)2; magnesium hydroxide, Mg(OH)2; calcium magnesium carbonate, CaMg(COa)2; or a combination thereof obtained from a water softening process. The topical skin composition is a skin desiccant that is effective for treating skin conditions in humans and animals such as wounds, blisters, bums, insect bites, sunburns, rashes, acne, and eczema. The composition does not include silica products, but instead includes active inorganic carbonate, in some cases, from spent lime while providing additional minerals and nutrients for skin health.

To provide a safe antiperspirant / deodorant for underarms which has high antiperspirant / deodorant effect, and does not cause skin irritation and rash.SOLUTION: An antiperspirant / deodorant for underarms has lactate contained in ethanol aqueous solution.SELECTED DRAWING: None

The invention provides a traditional Chinese medicine composition for preventing rash caused by medicines as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises honeysuckle, dandelion, wild chrysanthemum flower, cornu bubali, radix sophorae flavescentis, fructus kochiae, herba violae and mint. The preparation method comprises the following steps: 1) taking the raw material medicines in parts by weight, crushing, adding a solvent, adjusting the pH value, adding an antioxidant, and heating and extracting in an ultrasonic-microwave synergistic extraction device to obtain an extracting solution; the traditional Chinese medicine composition has the advantages that inflammation pathways and skin barrier protein expression can be targeted by the traditional Chinese medicine composition, multi-pathway synergistic inflammation inhibition and skin barrier repairing can be realized, curative effects can be improved, drug resistance can be avoided, and recurrence rate can be reduced.

The present application provides a kind of mask for targeting drug skin rash and its preparation method, the mask includes mask substrate and loaded essence, and the active ingredient of essence includes anti-inflammatory component, ceramide mixture, plant extract compound and humectant.The anti-inflammatory component is compounded by astragalus seed extract and acetyl tetrapeptide-15 according to a certain proportion, the ceramide mixture is composed according to a certain proportion, and the plant extract compound contains cortex phellodendri, artemisia annua and the like.In preparation, astragalus seed is extracted by ultrasonic-assisted ethanol, and after vacuum concentration, it is compounded with other components.The mask can significantly reduce skin rash grading, improve stratum corneum water content, inhibit IL-6 and TNF-α, no adverse reaction incidence, with strong anti-inflammatory and barrier repair function, and the safety is superior to existing products.

A disposable wearing article having an excellent rash preventing effect. The above problem is solved by a disposable wearing article including a top sheet having a skin contact region in contact with a skin of a wearer, wherein the skin contact region has, in a region to which a body fluid pervious treatment agent containing a nonionic surfactant having an amide group is applied, a glycerin-containing region to which glycerin is applied, and the top sheet has a two-layer structure of an upper layer of less than 2.0 dtex and a lower layer of 2.0 to 4.0 dtex, and is formed of a nonwoven fabric having a basis weight of 5 to 40 g / m2.

The utility model discloses a gentian suede mask cloth multilayer structure which comprises a plurality of mask layers which are integrated in a spunlace mode, each mask layer is sequentially provided with a gentian fiber layer, a liquid storage layer and a breathable layer from inside to outside, and the gentian fiber layer is arranged on the inner layer and makes contact with the human body; heating film cloth is placed on the upper surface, located on the breathable layer, of the multiple mask layers, a plurality of through holes are formed in the heating film cloth, and the heating temperature of the heating film cloth ranges from 30 DEG C to 37 DEG C; the Chinese gentian fiber layer made of Chinese gentian fibers serves as the inner layer and is in direct contact with the face of the human body, so that the Chinese gentian health-care mask has the sterilization and disinfection effects, has the effects of clearing heat and decreasing internal heat and can be used for treating skin itch and the like caused by dermatitis and rash, and the heating film cloth is placed on the upper surface of the breathable layer, so that hot compress is carried out, and the heating effect is good. Therefore, the nursing effect on the face is improved, and a user does not feel uncomfortable when applying the mask in winter.

The invention discloses an artificial intelligence-based fever and rash diagnosis and decision-making integrated system and method. The system comprises a multi-source clinical data acquisition and structured input module which is used for inputting rash images, clinical context information and laboratory data of a fever and rash patient; the rash vision-time sequence depth feature analysis module is used for extracting morphological and spatial distribution features and dynamic change rules along with time of the fever with rash; the multi-modal fusion diagnosis reasoning and confidence evaluation module analyzes morphology, spatial distribution characteristics, clinical context information and laboratory data of the fever with rash by utilizing medical knowledge map reasoning, and generates a differential diagnosis list and confidence; the individualized treatment decision suggestion generation module is used for generating individualized treatment decision suggestions by utilizing treatment rules and a medicine knowledge base in combination with diagnosis results, patient characteristics and treatment environment context information; according to the method, differential diagnosis and individualized treatment decision are realized through multi-modal fusion and knowledge graph reasoning.