52 results about "Skin rashes" patented technology

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The utility model discloses a front traction bracket for orthodontics, which comprises a plurality of vertical rods, one end of each vertical rod is provided with a placing component, one end of each vertical rod is provided with an adjusting component I and an adjusting component II, and the adjusting component I is provided with an auxiliary component. The front support can be provided for counter-acting force generated by traction, so that the acting point is more reliable, the stress area is wider, the pressure of the contact surface is greatly reduced, medical breathable sponge pads are attached to the inner side of the lower jaw surrounding baffle and the inner side of the lower jaw supporting plate, lower jaw skin injury caused by stress is relieved to the maximum extent, and the safety of the lower jaw is improved. By additionally arranging the enclosure pressing plate and the jaw support pressing plate on the outer sides of the lower jaw enclosure plate and the lower jaw support plate, the medical gauze can be conveniently and quickly fixed by medical staff or patients subsequently, the medical staff or the patients can conveniently replace the medical gauze, and the problem that the skin is in contact with the front traction bracket for orthodontics for a long time, bacteria are bred, and then rash is caused can be effectively solved.

The invention discloses a pharmaceutical composition, which comprises chlorogenic acid, ferulic acid and a zeolite imidazole framework material, the mass ratio of chlorogenic acid to ferulic acid is 4: 1-1: 4, and the zeolite imidazole framework material is a Zn-based zeolite imidazole framework material. In the composition, the compatibility of chlorogenic acid and ferulic acid can synergistically regulate the proliferation, migration and apoptosis of keratinocytes, and restore the physiological function imbalance of human skin keratinocytes caused by EGFRIs. The ZIF can efficiently carry chlorogenic acid and ferulic acid together, the nanoscale particle size of the ZIF is beneficial to permeation of the medicine into the skin, and hydroxyl on the surface of the ZIF and ceramide in the skin are subjected to hydrogen-bond interaction to retain the medicine at the focus position. The composition preparation disclosed by the invention is good in moisturizing performance and simple and convenient to use, and can be used for effectively treating skin toxic reactions such as pustule type rash, skin dryness and itching, perionychomycosis, abnormal hair regeneration and the like caused by EGFRIs.

The invention belongs to the field of wash supplies, and provides a composition with functions of controlling oil, inhibiting bacteria, relieving itching and repairing ultraviolet damage and a facial cleanser. The composition is prepared from hydrolyzed keratin, recombinant collagen, zinc acetate, a rhizoma atractylodis macrocephalae extract, zingiber officinale roscoe essential oil and a fructus cnidii extract, and the mass ratio of the hydrolyzed keratin to the recombinant collagen to the zinc acetate to the rhizoma atractylodis macrocephalae extract to the zingiber officinale roscoe essential oil to the fructus cnidii extract is (3-3.2): (3-3.2): (1-1.2): (2-2.2): (2-2.2): (2-2.2). The facial cleanser contains the composition, and the mass fraction of the composition in the facial cleanser is 0.1%-5.0%. Experiments prove that the composition and the facial cleanser have good effects in the aspects of inhibiting skin sebum secretion, inhibiting bacteria, inhibiting eczema, inhibiting allergic rash, relieving itching, repairing ultraviolet damage and the like, and the problem that the comprehensive performance of the existing composition for facial skin and the related facial cleanser is not satisfactory can be solved.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

The present invention relates to disposable or wearable absorbent articles such as; but not limited to, baby diapers, pants, pull up diapers, adult incontinence articles, which provide skin irritation / rash control and antibacterial properties by an absorbent core free of bleach activator with homogeneous distributed sodium percarbonate.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

The present application relates to a kind of anti-non-small cell lung cancer for strengthening healthy qi and resolving stasis and preparation method thereof, strengthening healthy qi and resolving stasis is made from the following weight proportion of raw medicinal materials: Ficus pumila 2g~50g / portion, radix pseudostellariae 2g~50g / portion, poria cocos 2g~50g / portion, atractylodes 2g~50g / portion, radix scutellariae 2g~50g / portion, oldenlandia 2g~50g / portion, cat's paw grass 2g~50g / portion, giant knotweed 2g~50g / portion, curcuma zedoary 2g~50g / portion, oyster 2g~50g / portion, platycodon 2g~50g / portion, mountain bitterling 2g~50g / portion, half branch orchid 2g~50g / portion. By cell test and the construction NSCLC osimertin drug resistance animal model prove, strengthening healthy qi and resolving stasis of the present application can adjust tumor microenvironment (TME) and inhibit non-small cell lung cancer cell growth of osimertin drug resistance. Not only this, strengthening healthy qi and resolving stasis of the present application can also inhibit common non-small cell lung cancer cell growth. While clinical observation finds, strengthening healthy qi and resolving stasis of the present application can improve insomnia, skin rash, diarrhea and other symptoms of lung accumulation (lung cancer, lung nodule) patient, improve its quality of life.

To provide a surface material for absorbent articles which has a sufficient antibacterial effect and is unlikely to cause skin rashes. [Solution] The surface material 10 of the absorbent article has a skin side 10a and a non-skin side 10b, and has a first layer 11 and a second layer 12. The first layer is made of a fiber assembly that forms the skin side. The second layer is located closer to the non-skin side than the first layer and is made of a fiber assembly. A first antibacterial agent and a second antibacterial agent are blended into the first layer. A third antibacterial agent is blended into the second layer. The first antibacterial agent and the third antibacterial agent are surfactants. The first antibacterial agent is contained in a first fiber treatment agent of fiber 2 contained in the first layer. The third antibacterial agent is contained in a second fiber treatment agent of fiber 6 contained in the second layer. The second antibacterial agent is a metal oxide antibacterial agent, and is contained in the fiber contained in the first layer. The first antibacterial agent and the third antibacterial agent are more soluble in water than the second antibacterial agent.

Systems, methods, and devices for determining the condition of a skin surface covered by an adhesive patch. An external device may be configured to be attached to the skin surface via the adhesive patch. A light source of the external device may emit light through the adhesive patch. A photodetector of the device may output a signal indicative of an amount of the light received by the photodetector after passing through the adhesive patch. A controller of the device may determine, based on the signal, a condition of the skin surface covered by the adhesive patch. In some alternative embodiments, the photodetector may instead by in an implantable device, which may convey the signal to the external device. In some other alternative embodiments, the light source may instead be in an implantable device.

A multi-purpose medicinal cream comprising shea butter, wild opium lettus powder, Orange Blood, Frankincense, Lavender, Rosemary, Copaiba Balsam, Birch Sweet, Lemon Grass, Marjoram, Basil, Eucalyptus, Peppermint, Cinnamon, Cedarwood, Thyme, Clove, Vetiver, Geranium, Cinnamon Leaf, and Ylang Ylang. The multi-purpose cream is an aid in pain management of disorders including lupus, arthritis, rheumatoid arthritis, knee and joint pain, neck pain, inflammation, migraines, and neuropathic disorders, as well the treatment of skin conditions including eczema, dry skin, psoriasis, swelling, heat rash, rashes, and rashes of dogs.

The invention discloses a traditional Chinese medicine composition for treating a warm disease clinically belonging to the same disease of defensive qi and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 5-35 parts of bupleurum chinense, 9-50 parts of scutellaria baicalensis, 9-50 parts of artemisia apiacea, 5-35 parts of radix paeoniae rubra, 5-35 parts of moutan bark and 4-26 parts of folia perillae acutae. According to the traditional Chinese medicine composition, the effects of all the medicines are utilized to generate a synergistic effect, and the effects of relieving fever, eliminating evil and detoxifying are achieved together. The traditional Chinese medicine composition is used for treating fever or hyperpyrexia, slight aversion to wind-cold, headache, sweating, thirst, cough and pharyngalgia caused by cold, viral cold and upper respiratory tract infection febrile disease defensive qi, and can be accompanied by nausea, vomiting, neck stiffness, rash appearance, red eye swelling and pain and the like, so that the febrile disease is effectively treated.

The invention provides a pharmaceutical composition for treating herpes zoster as well as a preparation method and application thereof, and belongs to the technical field of medicines. Comprising the following components in parts by weight: 8-15 parts of sticky rice, 8-15 parts of mung beans, 1-3 parts of snake slough, 8-15 parts of flying centipedes, 1-3 parts of realgar and 1-5 parts of borneol. By adding the basic components including the sticky rice, the mung bean, the snake slough, the centipede, the realgar and the borneol, the traditional Chinese medicine composition can achieve the synergistic effects of resisting viruses, relieving pain, diminishing inflammation and the like, effectively relieves the symptoms of rash, pain and the like of herpes zoster, plays a role in neuroinflammation caused by viruses, is relatively mild in medicine property, and is free of toxic and side effects. The medicine is suitable for being used by herpes zoster patients with sensitive skin.

A diaper rash prevention system includes an Internet of Things gas detection device equipped with at least one sensor that wirelessly communicates its readings to a communication device in the form of a software application running on a smartphone. The sensors inside the Internet of Things gas detection device analyze the gases in the air to determine when a child has a dirty diaper or underpants providing accurate and real-time notifications to caregivers.

The invention provides a traditional Chinese medicine composition for treating rash, a medicinal preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises the following components: radix rehmanniae, radix ophiopogonis, radix scutellariae, fried tribulus terrestris, fructus kochiae, cortex lycii radicis, radix scrophulariae, radix puerariae, rhizoma cimicifugae, radix paeoniae alba, radix saposhnikoviae and liquorice. The traditional Chinese medicine composition and the medicinal preparation provided by the invention have the effects of removing heat to cool blood and nourishing yin to dispel wind, and can be used for treating rash, especially yin deficiency and internal heat type chronic rash with symptoms of dry and erythema of skin, severe itching at night and red tongue with little tongue fur.

This disclosure provides fast acting itch relief and cooling sprays containing hydrocortisone, a cooling agent, such as sensate molecule (e.g. menthyl lactate), and a soothing agent (such as e.g., Aloe vera). The sprays of the disclosure can be used to relieve itching associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, poison ivy, oak, sumac, insect bites, detergents, jewelry, cosmetics, soaps, seborrheic dermatitis. The disclosure also provides for methods of treating skin with cooling sprays as well as containers containing the spray.

This invention belongs to the field of rehabilitation medicine technology and discloses a targeted assessment and intervention system and method for refractory rashes based on fascial guidance. The system includes: a multimodal targeted data acquisition module for acquiring rash characteristics, body structure, fascial biomechanical properties of the target location, surface projection area of ​​the target viscera, and craniosacral rhythm indicators; a target localization module for matching rash characteristics with a viscera-skin association model to obtain the target viscera and association rules; a sunshade model for determining the fascial mechanical conduction path and attenuation degree between the target viscera and the rash area; an assessment module for matching misalignment chain information, fascial biomechanical properties, attenuation degree, and rhythm indicators with association rules to obtain assessment results; and an intervention plan recommendation module for determining an intervention plan based on the assessment results. This system enables precise localization and targeted intervention of the structural root cause of the rash.

The invention discloses application of cryptotanshinone in preparation of a medicine for relieving toxic and side effects of osimertinib. In an in-vitro cell model, cryptotanshinone can reverse the keratinocyte survival rate reduced by osimertinib, inhibit keratinocyte apoptosis caused by osimertinib, down-regulate a DNA damage marker gamma-H2A. X, and reduce the levels of keratinocyte inflammatory factors TNF alpha and IL6; on an animal model, cryptotanshinone can significantly improve osimertinib-induced skin unhairing and rash symptoms, recover the thickness of mouse epidermis, reduce the nuclear fixation and shrinkage proportion and recover the number of hair follicles. Researches confirm that cryptotanshinone can significantly improve rash, unhairing and inflammatory reactions caused by osimertinib, effectively alleviate toxic and side effects of osimertinib, improve safety of osimertinib, and expand clinical application of osimertinib.

A disposable wearing article having an excellent rash preventing effect. A skin contact region in a top sheet formed of a nonwoven fabric having a basis weight of 5 to 40 g / m2 has a glycerin-containing region in which glycerin is applied in a region to which a body fluid pervious treatment agent containing a nonionic surfactant having an amide and / or amino group is applied.

A fire-retardant topical formulation comprising glycerol and urea in a ratio of 1:1 to 1:30 is provided. The formulation may further comprise polyvinyl pyrrolidone and / or ethylhexylglycerin, and / or a barrier forming agent and / or a stabilising agent. The formulation may be a moisturiser, shampoo, conditioner, hair dye, sun cream, aftersun composition, emollient or medical composition. The formulation may be for use in treating a skin condition, such as eczema, dermatitis, psoriasis, elderly dry and itchy skin, ichthyosis, rash, or infection. The composition when transferred to a fabric suppresses the flammability of the fabric and is also capable of being removed from the fabric by washing. A preferred formulation comprises 1% phenoxyethanol, 10% urea, 10% sodium lactate (60% solution), 1% lactic acid, 1% glycerol, 3% ethylhexylglycerin, 2% polyacrylate crosspolymer-6, 0.5% polyvinylpyrrolidone and 71.5% water by weight. A fire-retardant topical formulation comprising 1% glycerol, 2% polyacrylate crosspolymer-6, 10% sodium lactate solution, 1% phenoxyethanol, 1% lactic acid, 3% ethylhexylglycerin and 0.5% polyvinylpyrrolidone by weight is also disclosed. [Fig: None]

The invention relates to the technical field of medicine, in particular to application of N-ethyl maleimide in inflammatory dermatosis, by adopting an LL-37-induced mouse rosacea model, experiments prove that NEM can directly and effectively inhibit inflammatory response by inhibiting glycerophospholipid metabolism and regulating expression of related genes such as keratinocytes and T lymphocytes, so that the inflammatory response is effectively inhibited, and the inflammatory response is inhibited. The compound can improve mouse rosacea-like rash, has no obvious cytotoxicity, can be used as a candidate compound, is used for developing a glycerophospholipid metabolism inhibitor, and is used for treating skin inflammatory diseases related to glycerophospholipid metabolism, such as rosacea and psoriasis. By utilizing multiple experimental means such as transcriptomics sequencing, histopathologic examination, reverse transcription real-time fluorescent quantitative PCR (RT-qPCR) and the like, it is proved for the first time that N-ethyl maleimide improves mouse rosacea by inhibiting glycerophospholipid metabolism.

A method of treating diaper rash in a subject is provided. A method of treating athlete's foot in a subject is provided. A method of treating contact dermatitis in a subject is provided. A method of treating perspiration and body odor in a subject is provided. The method comprises administering an effective amount of a preparation comprising ammonia oxidizing microorganisms to the subject, thereby treating the diaper rash, athlete's foot, contact dermatitis, or perspiration and body odor. Related preparations, kits, and devices are also provided.

The present invention is a bio-electrode including: a substrate having anti-reflective structure for light on at least one side; and (A) an electro-conductive layer having electro-conductive wiring on the opposite side from the side having the anti-reflective structure of the substrate. This provides: a bio-electrode that allows thin, highly transparent, highly sensitive to biological signals, excellent in biocompatibility, light-weight, manufacturable at low cost, capable of preventing significant reduction in sensitivity to biological signals even when attached on the skin for a long time and when wetted with water or dried, and comfortable without itching, reddening, nor rash of the skin.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an external traditional Chinese medicine composition for atopic dermatitis and chronic rash, a traditional Chinese medicine preparation based on the composition and a preparation method and application thereof. The external traditional Chinese medicine composition for atopic dermatitis and chronic rash is prepared from the following raw materials in parts by weight: 3 to 15 parts of rhizoma atractylodis, 3 to 15 parts of radix sanguisorbae, 3 to 15 parts of rhizoma coptidis, 3 to 15 parts of gallnut, 3 to 15 parts of fructus cnidii, 3 to 15 parts of frankincense, 3 to 15 parts of myrrh and 3 to 8 parts of borneol. The external traditional Chinese medicine composition for treating chronic rash of atopic dermatitis conforms to the pathogenesis of chronic disease course of atopic dermatitis, repeated attack, difficulty in removing damp evil due to root deficiency and blood stasis due to long illness, has the effects of consolidating root, clearing damp, dispersing blood stasis and healing sore, and is used for treating chronic rash.

The invention provides a traditional Chinese medicine external composition for treating AIDS (acquired immune deficiency syndrome) cutaneous pruritus. The external traditional Chinese medicine composition for treating AIDS cutaneous pruritus is prepared from, by weight, 1 part of radix saposhnikoviae, 1 part of radix cynanchi paniculati, 1 part of radix sophorae flavescentis, 1 part of cortex dictamni, 1 part of radix et rhizoma rhei, 1 part of cortex phellodendri, 1 part of radix scutellariae, 1 part of radix angelicae sinensis, 1 part of radix arnebiae seu lithospermi, 1 part of radix ophiopogonis, 1 part of radix asparagi, 1 part of cortex pseudolaricis, 1 part of fructus cnidii, 1 part of pericarpium zanthoxyli, 1 part of radix astragali, 1 part of radix glycyrrhizae, 1 part of rhizoma bletillae and 1 part of radix ampelopsis. The external traditional Chinese medicine composition for treating AIDS skin itch provided by the invention has the advantages of effectively relieving itch, shortening the disease course, promoting rash fading and improving the immune function.

A diaper rash prevention system includes an Internet of Things gas detection device equipped with at least one sensor that wirelessly communicates its readings to a communication device in the form of a software application running on a smartphone. The sensors inside the Internet of Things gas detection device analyze the gases in the air to determine when a child has a dirty diaper or underpants providing accurate and real-time notifications to caregivers.

The utility model refers to a cosmetic cream containing extract of Hypericum perforatum (St. John's wort) and finds application in the cosmetic industry, skin care. The cream possesses the beneficial properties of Hypericum perforatum, such as anti-inflammatory, antibacterial, antimicrobial, antioxidant action, moisturizes and softens the skin, resulting in an exceptionally good nourishing, regenerating and protective effect on the skin, without causing irritation or skin rashes.

The invention discloses an antioxidant-free kanamycin injection and a preparation method thereof.The injection is composed of kanamycin sulfate, a pH regulator and water for injection, the pH is 4.5-7.0, headspace oxygen is controlled to be smaller than or equal to 1% through nitrogen charging, and the injection is completely free of sodium hydrogen sulfite, cysteine hydrochloride and other antioxidants and can be used for intravenous drip and intramuscular injection; the invention further provides a preparation process and an ion chromatography verification method which are compatible with an existing production line, and the product quality meets the requirements of Chinese Pharmacopoeia 2020 through high temperature, strong light and long-term stability test verification; clinical retrospective analysis shows that the rash occurrence rate is reduced to 3.1% from 27.3%, the safety is remarkably improved while the medicine quality is ensured, and the method has a good industrial application prospect.

This disclosure describes a cannabinoid-based nanoplatform for treating shingles, designed to enhance bioavailability and controlled release of active ingredients. The composition includes cannabinoids like cannabidiol (CBD) and cannabigerol (CBG), alongside flavonoids, polyphenols, and alkaloids, in oral and topical formulations. The oral capsule combines cannabinoids with polyphenols and flavonoids to provide systemic anti-inflammatory, antiviral, and neuroprotective effects, particularly for nerve pain and inflammation, including postherpetic neuralgia. The topical cream includes cannabinoids, capsaicin, and aloe vera, offering localized relief from pain, itching, and rash. The method targets both systemic and localized symptoms during the acute phase of shingles, aiming to inhibit varicella-zoster virus replication, disrupt viral assembly, and prevent viral release, while also providing immune modulation and anti-inflammatory benefits. The nanoplatform uses nano-emulsification techniques, producing particles smaller than 200 nm to ensure optimal delivery and therapeutic efficacy, offering comprehensive relief for shingles symptoms.

The invention discloses a patient-based tumor drug adverse reaction remote monitoring system and a protection method. According to the invention, through the algorithm design in the patient dynamic interaction and symptom intelligent capture module, the accuracy and integrity of symptom information acquisition are firstly improved. A natural language processing algorithm in the module can automatically extract key information, such as core elements such as symptom appearance time, duration and pain level, from character description or voice transliteration text of a patient, and omission or misjudgment during manual recording is avoided; meanwhile, an image recognition algorithm can perform feature analysis on uploaded body surface symptom pictures such as rash and swelling, an abnormal area is quickly positioned, morphological features are marked, and doctors are assisted in visually judging symptom types. According to the algorithms, the complexity of manual input of the patient is reduced, scattered symptom description is converted into structured data, and the reliability of subsequent analysis is improved.