255 results about "Biological signaling" patented technology

A motion assistance device has a biological signal detection means for detecting a biological signal from the wearer of the device; a motion assistance device installation member having a drive source for applying torque acting to the wearer by use of each joint of the wearer as a rotating shaft; a control means for controlling the drive source to generate torque corresponding to the biological signal detected by the biological signal detection mean; a drive torque estimation means for estimating the drive torque generated by the drive source; a joint angle detection means for detecting angular displacement of a joint; and a parameter identification means for substituting the drive torque estimated by the drive torque estimation means and the angular displacement detected by the joint angle detection means into an equation of motion to specify the wearer-specific dynamics parameter, the equation relating to the entire system and including wearer-specific dynamics parameter. The control means controls the drive source according to a predetermined control method, based on the equation of motion into which the dynamics parameter identified by the parameter identification means is substituted.

In a training control method using biofeedback, and an apparatus using the method, the method includes setting a target exercise zone for a user based on a bio-signal from the user, the target exercise zone including a range of indices and comparing a current index obtained from the bio-signal with the target exercise zone in time units in an exercise training mode and providing at least one of positive biofeedback information, negative biofeedback information, and a warning message to the user according to a result of the comparison.

Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

A flexible membrane of piezoelectric material sized to be supported by and to conform to the eardrum. Electrodes on the membrane allow the membrane to function as an audio transducer stimulating the eardrum with an audio signal or detecting audio signals at the eardrum. Applications may include detecting a variety of pathophysiological and biomechanical features of the tissues of the tympanic membrane and regional integrated anatomy, detecting audio, physical and biological signals, and / or delivery a variety of therapeutic modalities.

A method and apparatus for measuring the biological condition of an animal by acquiring and analyzing its biological signals are provided. The biological signals from skin temperature, a photoplenthysmogram (PPG), an electrocardiogram (ECG), electrodermal activity (EDA), an electromyogram (EMG), and an electrogastrogram (EGG) are detected using a biological signal detection unit which is attached to the animal's skin. Feature vectors, including the mean heart rate of the photoplenthysmogram and its standard deviation, the very low frequency, low frequency, and high frequency components of heart rate variability, the frequency and mean amplitude of skin conductance responses, and the mean and maximum skin temperatures, are extracted from the detected biological signals. The biological condition, including needs and emotions, of the animal as to whether or not the animal feels hunger or fear, how much the animal is stressed, or whether or not the animal needs to have a bowel movement, is determined using a pattern classifier which has learned reference vectors, which reflect the behaviors, needs, and emotions of different kinds of animals for various biological conditions and are stored in a predetermined database. Therefore, the biological condition of the animal can be determined through instrumental communication, not through human languages, and the breeding of pets can be efficiently managed.

A method and system for customizing agriculture management using biological signals and making decisions according to pre-programmed algorithms, including decisions related to irrigation, prediction of future yield, characterization of plant varieties, and administration of topical applications.

A biological signal measurement device includes: a circular or hyperbolic fitting section (101) to be worn on a part of a human body; a sensing section (103) which is provided to the fitting section (101), and senses a biological signal by being closely attached to a specific part of the human body; a measurement environment judging section for judging an environment for measuring the biological signal by using the sensing section (103); a measurement environment notifying section (104) for notifying a user of a judgment result, according to the result of judgment performed by the measurement environment judging section; and a measurement environment adjusting section (102) for adjusting the measurement environment of the sensing section (103). Thus, it is possible to provide a human-wearable biological signal measurement device that allows easier maintenance of suitable measurement conditions.

The invention discloses an upper limb rehabilitation system based on biological signals. The upper limb rehabilitation system based on the biological signals is characterized in that a brain electric cap is attached to the surface of a brain, brain electric signals can be sensed through the brain electric cap, features of the brain electric signals are extracted and classified sequentially through a CSP feature extraction algorithm and a classifier with an adaptive LDA classification algorithm after amplification, filtering and noise reduction are performed on the brain electric signals, and then the brain electric signals are translated into drive instructions used to control drive motor equipment and pneumatic tendon auxiliary equipment, a system central processing unit fuses and sorts the drive instructions and motion state data collected by a motion state collector, and then feeds the drive instructions and the motion state data, which are fused and sorted, back to the drive motor equipment, the pneumatic tendon auxiliary equipment and a mobile terminal, and therefore a mechanical arm is driven to perform rehabilitation exercise. Work personnel remotely monitor motion and rehabilitation states of patients through the mobile terminal, and the patients also can invoke rehabilitation games in a display platform through a voice input and output device so as to perform auxiliary rehabilitation training. Accordingly, the upper limb rehabilitation system based on the biological signals improves training effectiveness of the patients, and simultaneously guarantees safety and stability in the training.

In one embodiment, the present disclosure relates to an implantable sensor system for sensing biological signal of a patient comprising: an anchor for coupling the sensor to at least one patient skull base structure; a first sensor coupled to the anchor for sensing, at a first location proximate to the at least one patient skull base structure, at least one biological signal of a patient; and a transmitter coupled to the sensor and capable of transmitting data from the sensor to an external device.

The invention provides a collection system of an Internet of things for the activity-of-daily-living information of a human body, which relates to a medical detecting technology. A detecting node for the activity-of-daily-living (ADL) information of a human body, which is based on an ZIGBEE wireless sensor network, a routing node for the information processing of the wireless sensor network, a monitoring server for the ADL information of the human body and a third-party terminal are arranged; and the collected ADL information of the human body is processed by the detecting node and is also transmitted to the routing node, the jam of the detecting node is treated, the information is also forwarded to the monitoring server for the ADL information of the human body, the received information is stored, classified and displayed by the monitoring server for the ADL information of the human body, and the monitoring server for the ADL information of the human body is also in information interaction with the third-party terminal by an INTERNET. The collection and the real-time monitoring of the activity-of-daily-living information of a human body and the quick reflection to an accident are realized, and the quantitative analysis of a doctor to the activity of the human body and the change trend of a biological signal are convenient.

A health care system using a mobile phone includes the mobile phone which has sensors attached thereto, stores a biological signal measured by the sensors, and transmits the stored biological signal during a phone call; and a health care server which receives the biological signals from the mobile phone, analyzes the received biological signal to extract a characteristic value, generates health condition information of a user based on the extracted characteristic value, and transmits the generated information to the mobile phone. Further, a health care method using a mobile phone includes determining whether a physical body comes into contact with the sensors; measuring the biological signal with the sensors when the physical body comes into contact with the sensors; extracting a characteristic value from the biological signal; transmitting the characteristic value to the server; and generating the health condition information to transmit it to the mobile phone.

Disclosed is a method and apparatus for detecting a state of a vehicle occupant, wherein a bio-signal of an occupant riding in a vehicle may be acquired by executing an artificial intelligence (AI) algorithm or a machine learning algorithm, and a physical change of the occupant may be measured by a movement signal, a respiratory signal, and a heart rate signal from the acquired bio-signal of the vehicle occupant, such that it is possible to control an operation of an internal vehicle device or to control operation of the vehicle so as to correspond to the physical change of the occupant estimated by communicating with the internal vehicle device in a 5G communication environment. According to the present disclosure, the movement signal, respiratory signal, and heart rate signal of the occupant in the vehicle may be extracted via an RF sensor mounted in the vehicle, and the physical state of the occupant may be estimated based on the extracted bio-signal of the occupant, and when the physical state is estimated to be abnormal, the occupant may be informed of the abnormal physical state.

The invention provides a system for synchronously detecting multi-modal biological signals. The system comprises a signal collecting module and a signal processing module, wherein the signal collecting module is used for synchronously collecting multi-source signals in real time, and the signal processing module is connected with the signal collecting module and used for fusing and analyzing the multi-source signals. The signal collecting module comprises an ultrasonic image collecting unit for collecting ultrasonic images, a physiological signal collecting unit for collecting physiology signals and a kinematics signal collecting unit for collecting kinematics signals. The signal processing module is used for controlling the signal collecting module to synchronously collect the ultrasonic images, the physiological signals and the kinematics signals in real time through a multithreading communication method and a timestamp method. The signal processing module processes the signals through a feature extraction and statistical learning method and establishes a motion model. According to the system, the advantages that the ultrasonic imaging technology is noninvasive, convenient to apply and cheap in application are utilized, the comprehensive ultrasonic imaging technology and the motion and electric physiology technologies are integrated, and human motion multi-information can be synchronously detected in real time. The invention further provides a method for synchronously detecting the multi-modal biological signals.

The invention relates to a chip of a surface plasmon resonance instrument which is based on polyethylene glycol and a preparation method. The chip comprises a glass film base and a gold plating film on the glass film base; wherein the gold plating film is provided with an initiator layer which is introduced in the way of self-assembly and a functionalized polyethylene glycol layer which is combined with the initiator layer. The invention uses a quartz crystal microbalance to monitor the growth of the film at the surface of the chip at real time and the chip of the invention effectively solves the problem of non-specific absorption of protein. As the surface ornament of the chip is not limited to traditional carboxylic dextran, the density and types of the functional groups at the chip surface are no longer strictly restricted. Furthermore, the chip of the invention also has good performance in terms of the specificity maintenance and quality control of biological signaling molecule and so on. The preparation method of the chip of the invention has few steps and the low manufacturing cost and is more suitable for industrial production. The chip has more potential of deep development and more superior generality.

The invention relates to an intelligent biological signal anomaly detection method and a system capable of carrying out efficient, accurate and low-cost automatic analysis on biological signals. The system comprises a model training stage and a model application stage, wherein the model training stage comprises the following steps: acquiring a biological signal; preprocessing the acquired signal;sending the preprocessed data to a CNN-BilSTM-Attention combination model to extract features, wherein the signal firstly enters a CNN convolution neural network to extract the spatial features, thenenters a two-way long-short time memory network to extract time features, then passes through each network connection layer and finally passes through a SoftMax layer to calculate the final result, each link of the network is established, and the emphasis degree of different sequence points of signals are optimized by setting an Attention mechanism; calculating loss of the network module until themodule loss is less than the threshold, then the model training is completed, and otherwise Adam is used to optimize model parameters. The invention effectively improves the analysis effect of biomedical signals.

The invention relates to a preparation method and application of an electrochemical sensor for heavy metal lead ion detection and belongs to the technical field of electrochemical detection. The biosensor is characterized in that firstly, an NG-PTCA nanomaterial is synthesized, then, HAuCl4 is reduced to gold nanoparticles (AuNPs) through Thi and modified on the NG-PTCA nanomaterial to obtain an NG-PTCA-Thi-Au nanocomposite, and a hairpin-like DNA signal probe is mixed with the composite to prepare a biological signal probe; before construction of the sensor, 8-17 DNAzyme is cut in vitro in the presence of Pb<2+>; then, the hairpin-like capture probe is fixed by a gold deposition electrode; after introduction of a cut fragment S1, a catalytic hairpin assembly process is started and the biological signal probe is fixed, so that double-signal detection of heavy metal lead ions is realized. The sensor is successfully applied to detection of lead ions in the environment. The biosensor hasthe advantages of high sensitivity, high specificity and convenience in detection. The biosensor provides experiment basis for research and development of the lead ion detection technology and provides a new thought and a new technical platform for monitoring of lead ions in the environment.

The invention relates to a preparation method and application of an electrochemical sensor for detecting a blood concentration level of an insulin sensitivity reduction early diagnosis biomarker, namely galectin-3 (Gal-3), causing type II diabetes, and belongs to the technical field of electrochemical detection. The preparation method is characterized by comprising the following steps: respectively synthesizing an N-GNRs-Fe-MOFs@AuPNs sensor substrate modified nano composite material and an AuPt-MB nano composite signal material, enabling a detection antibody capable of being in specific binding to the Gal-3 to be mixed with the AuPt-MB composite material so as to prepare a biological signal probe; conjugating a Gal-3 specific capture antibody on a substrate platform modified by the N-GNRs-Fe-MOFs@AuPNs composite material so as to conveniently and specifically capture a target Gal-3; finally, performing specific binding on the Gal-3 as well as the detection antibody and the capture antibody, thereby obtaining the electrochemical sensor for detecting the blood concentration level of the Gal-3. The sensor is successfully used for detecting the Gal-3 in serum. The electrochemical sensor disclosed by the invention has the advantages of being high in sensitivity, high in specificity, rapid in detection and convenient. An early diagnostic basis is provided for insulin resistance causing the type II diabetes.

This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity 2 / 3 times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer.

The invention discloses an electronic informatics measuring method for human meridians and collaterals and a measuring device. The measuring method comprises steps as follows: choosing a first acupuncturing electrode and a second acupuncturing electrode with two conductive tips; inserting the first acupuncturing electrode and the second acupuncturing electrode into the skin; exerting actuating signals on a first interface between the first acupuncturing electrode and the ground, and collecting signals from a second interface between the second acupuncturing electrode and the ground. The electronic informatics measuring method for human meridians and collaterals can find out the specific positions and traces of the human meridians and collaterals mainly by adjusting the inserted positions and depths of the acupuncturing electrodes and observing the changes of output signals from the second acupuncturing electrode. Moreover, the measuring method can show the actual transmission features of biological signals of the meridians and collaterals by exerting actuating signals on the actual traces. Compared with the prior art, the electronic informatics measuring method for human meridians and collaterals can be simply operated and the measured results have high value in scientific research.

The invention relates to a preparation method and application of an electrochemical sensor for achondroplasia prenatal diagnosis gene-fibroblast growth factor receptor 3 (FGFR3) gene polymorphism detection, belonging to the technical field of electrochemical detection. The preparation method is characterized by comprising the following steps: synthesizing a Hemin-MOFs composite material, reducing platinum nanoparticles onto the Hemin-MOFs composite material, and mixing a single-strand DNA signal probe with the composite material to obtain a biological signal probe; and carrying out layer-by-layer self-assembly by using reducible graphene oxide tetraethylenepentamine, nano gold and avidin to fix the biotinylated DNA capture probe, thereby preparing the electrochemical sensor for FGFR3-1138G>A gene polymorphism detection. The sensor is successfully used for detecting FGFR3-gene single base mutation. The sensor has the advantages of high sensitivity and high specificity, and is quick and convenient for detection. The invention provides a new detection method for prenatal noninvasive diagnosis of achondroplasia.

Disclosed is a sleep stage determination apparatus which comprises respiratory-signal detection means for detecting a variation of a respiratory signal from the body of a human subject, and sleep-stage determination means for determining a plurality of sleep stages using only the respiratory-signal variation. The sleep stage determination apparatus of the present invention can eliminate the need for detecting a plurality of biological signals and have simplified sensor and circuit configurations designed to detect only the respiratory signal variation which is relatively easily detectable. This makes it possible to reduce a detection error and achieve enhanced determination accuracy or creditability.

The invention discloses a personal safety protection mode which comprises the steps of logging into an information platform to input information of a safety equipment carrier, collecting fingerprint and / or sound information of a guardian, periodically obtaining the location information of the safety equipment carrier, sending the location information to the information platform, and monitoring the location information of the safety equipment carrier and alarm information through an intelligent terminal. The invention further provides a personal safety protection system. The personal safety protection mode and system have the advantages that a locating module periodically receives location information sent by a navigational satellite, and the guardian logs in to the information platform through the intelligent terminal and observes location information of safety equipment every time received by the information platform to judge the movement locus of the safety equipment carrier; it is guaranteed that only the guardian can control the normal starting and closing of the safety equipment through collection of biological signals of the guardian; the safety equipment can give an alarm when a closed loop structure is destroyed, important information and precious rescuing time are provided for the guardian and police.

A system and method for assessing treatment effects on obstructive sleep apnea are provided. The apparatus includes a bio-signal measurement unit, a combined index calculation unit, and a treatment response assessment unit. The bio-signal measurement unit measures each of the electrocardiogram and respiratory rhythm of a patient. The combined index calculation unit calculates a combined cardiac and respiratory index by combining the heart rate variability and respiratory rhythm signals measured by the bio-signal measurement unit. The treatment response assessment unit assesses a response of the patient to the treatment of obstructive sleep apnea.

A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.

The present invention provides a light-weight wearable sensor that can capture electroencephalogram (EEG or brain signals), electromyography (EMG or muscle signal), and electrooculography (EOG or eye movement signal) using a pair of modified off-the-shelf earplugs. The present invention further provides a supervised non-negative matrix factorization learning algorithm to analyze and extract these signals from the mixed signal collected by the sensor. The present invention further provides an autonomous and whole-night sleep staging system utilizing the sensor's outputs.

An electronic device is disclosed. The electronic device identifies a user on the basis of: a biological signal input unit for receiving the input of a user's biological signal detected through an electrode; a voice input unit for receiving the input of a voice signal; a biological signal inputted through the biological signal input unit; and a voice signal inputted through a microphone.

This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity 2 / 3 times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer.

The invention provides wristband-type biological signal acquisition equipment and a manufacturing method thereof. The equipment comprises a wrist strap, a micro-needle array formed on a micro-needle array substrate and a biological signal output interface, the micro-needle array is fixed on the wrist strap and is in contact with the wrist skin of a wearer, and the biological signal output interface is connected with electrodes of the micro-needle array to output acquired biological signals. The wristband-type biological signal acquisition equipment provided by the invention is low in cost, simple to use, convenient to carry, safe and comfortable, and a user can continuously and stably record static and moving biological signals after wearing the equipment for a long time.

The invention discloses a signal amplification immunodetection method. According to the method, signal amplification immunity quantitative detection is conducted through a filter, and the method comprises the step of adopting the filter for sequentially filtering a to-be-detected sample solution A containing objects to be detected, a detected object solution B labeled through avidin and an indicator solution C labeled through biotin, wherein a filter element of a filter layer of the filter is a solid phase material coupled to a specific binder of the objects to be detected, detected objects labeled through the avidin can be specifically bound to the objects to be detected, and thereby the quantity of the objects to be detected in the solution A is calculated according to the color or light quantity variation of an indicator. It is proved through experiments that compared with a conventional biotin-avidin amplification reaction sequence, the avidin-biotin amplification reaction sequence has a greater biological signal amplification effect. The method can be used for detecting samples which are from human bodies and animal bodies and can be subjected to disease diagnosis and health detection and applied to development of products for sample quantitative immunodetection in the fields of environment, pharmaceutical analysis, food and industrial analysis.