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Pharmaceutical preparation for treating chronic urticaria

A pharmaceutical preparation, the technology of ephedra, applied in the field of pharmaceutical preparations for the treatment of chronic urticaria, can solve the problems of easy recurrence, difficult treatment, complicated etiology of chronic urticaria, etc., and achieve the effect of reducing pain and remarkable therapeutic effect

Inactive Publication Date: 2014-08-20
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine mainly includes antihistamines, calcium agents, and corticosteroids. These drugs have certain side effects such as lethargy and obesity, which are difficult for patients to accept.
The etiology of chronic urticaria is complicated, the course of the disease is long, and the treatment is difficult. Most of the allergens cannot be identified
At present, the non-sedative H 1 Receptor antagonists are used for treatment, but the effect is satisfactory when the drug is used, and it is easy to relapse after stopping the drug, which brings great troubles to the work and life of the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The present invention also provides a preparation method of the above-mentioned pharmaceutical preparation, when the prepared dosage form is a granule, specifically,

[0028] In the first step, ephedra, goose does not eat grass, schisandra, Poria, clematis, houttuynia cordata, knotweed, dandelion, geranium, sealwort, Shouwu vine, dendrobium, dodder, gardenia, astragalus, anemarrhena, peony Peel, rhubarb and jujube were crushed separately, put into a blender and mixed evenly to obtain a mixture, and the alcohol concentration was 95% ethanol for reflux extraction twice, the first time adding ethanol in an amount 8 times the mass of the mixture, and reflux for 2 hours For the second time, add ethanol in an amount 7 times the mass of the mixture, reflux for 1 hour, and filter; combine the filtrates twice, concentrate under reduced pressure to a clear paste with a temperature of 60 ° C and a relative density of 1.30 to 1.32 for later use; simultaneously volatilize ethanol, K...

Embodiment 1

[0068] Embodiment 1 Granule 1

[0069] 40g ephedra, 25g goose grazing grass, 40g schisandra, 25g tuckahoe, 15g clematis, 25g houttuynia cordata, 40g knotweed, 35g dandelion, 20g geranium yellow, 40g sealwort, 25g shouwu vine, 30g dendrobium, 25g dodder, 30g Gardenia, 70g Astragalus, 35g Anemarrhena, 30g Cortex Moutan, 25g Rhizoma Rhizoma, and 30g Jujube were crushed separately, sent to a blender and mixed evenly to obtain a mixture, and the alcohol concentration was 95% ethanol reflux extraction twice, the first time Add ethanol in an amount 8 times the mass of the mixture, and reflux for 2 hours; add ethanol in an amount 7 times the mass of the mixture for the second time, reflux for 1 hour, and filter; combine the two filtrates, and concentrate under reduced pressure until the temperature is 60°C , relative density 1.30 clear ointment for later use; volatilize ethanol at the same time, keep the dregs of the medicine, 30g of the dregs of notopterygium, 15g of Xu Changqing, 30...

Embodiment 2

[0070] Embodiment 2 Granules 2

[0071] 45g ephedra, 30g goose grazing grass, 45g schisandra, 30g tuckahoe, 20g clematis, 30g houttuynia, 45g knotweed, 40g dandelion, 20g geranium, 40g sealwort, 25g shouwu vine, 30g dendrobium, 25g dodder, 30g Gardenia, 70g Astragalus, 35g Anemarrhena, 30g Cortex Moutan, 25g Rhizoma Rhizoma, and 30g Jujube were crushed separately, sent to a blender and mixed evenly to obtain a mixture, and the alcohol concentration was 95% ethanol reflux extraction twice, the first time Add ethanol in an amount 8 times the mass of the mixture, and reflux for 2 hours; add ethanol in an amount 7 times the mass of the mixture for the second time, reflux for 1 hour, and filter; combine the two filtrates, and concentrate under reduced pressure until the temperature is 60°C , relative density 1.30 clear ointment for later use; volatilize ethanol at the same time, keep the dregs of the medicine, 30g of the dregs of the medicine obtained above, 20g of Xu Changqing, 35...

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Abstract

The invention provides a pharmaceutical preparation for treating chronic urticaria. The pharmaceutical preparation comprises the following raw medicines: ephedra, centipeda minima, notopterygium root, cynanchum paniculatum, schisandra chinensis, rhizoma corydalis, sappanwood, poria cocos, radix clematidis, houttuynia cordata, polygonum cuspidatum, dandelion, schizonepeta, salvia miltiorrhiza, concretio silicea bambusae, sealwort, caulis polygoni multiflori, dendrobe, semen cuscutae, jasmine, folium eriobotryae, peach kernel, agastache rugosus, astragalus membranaceus, purslane, rhizoma anemarrhenae, moutan bark, conyza japonica, rhaponticum, fructus ziziphi jujubae, and honeysuckle stem. The pharmaceutical preparation shows obvious treatment effect, does not generate any side effects like dizzy giddy, drowsiness and weak caused by use of Western medicines, and is of great significance for relieving pain of a patient with chronic urticaria and preventing chronic urticaria.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical preparation for treating chronic urticaria. Background technique [0002] Urticaria is a localized edema reaction due to the expansion and increased permeability of small blood vessels in the skin and mucous membranes. It will be manifested clinically as wheals of different sizes, itching, recurrent attacks, and those that last for at least 6 weeks are called chronic urticaria. Chronic urticaria is a common and frequently-occurring disease in dermatology. The etiology is complex, and it is mostly related to infection, drugs, diet, exposure, autoimmunity, mental factors, physical factors, and systemic diseases. In large and medium-sized cities, with the increase of environmental and food pollution, the incidence of chronic urticaria is gradually on the rise. Because it does not heal for a long time, it recurs, which brings serious troubles to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P17/00
Inventor 翁婉丹江峰靳一鸣徐雷张杰古洪亮
Owner NINGBO UNIV
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