13 results about "Centipeda minima" patented technology

This invention provides a medicinal ointment for treating rhinitis based on a traditional Chinese medicine compound and its preparation method, relating to the field of traditional Chinese medicine technology. The medicinal ointment for treating rhinitis based on a traditional Chinese medicine compound comprises the following components in parts by weight: Bupleurum chinense 2-10 parts, Dictamnus dasycarpus root bark 3-7 parts, Magnolia biondii flower 8-12 parts, Xanthium sibiricum fruit 4-10 parts, Centipeda minima 2-6 parts, Liquidambar formosana fruit 6-10 parts, Chrysanthemum indicum flower 6-10 parts, Angelica dahurica root 6-12 parts, Houttuynia cordata flower 8-12 parts, Borneol 1-3 parts, Menthol 1-3 parts, Ligusticum chuanxiong rhizome 5-13 parts, Scutellaria baicalensis root 8-12 parts. The ingredients are: 5-11 parts licorice root, 9-10 parts calamus, 1-5 parts Fritillaria thunbergii, 2-6 parts Gleditsia sinensis thorns, 6-10 parts Saposhnikovia divaricata, 8-12 parts Cynanchum paniculatum, 3-9 parts Kochia scoparia, 1-2 parts artificial musk, 5-8 parts ginger, 3-4 parts myrrh, 4-6 parts Schisandra chinensis, 1-3 parts petrolatum, 1-3 parts beeswax, and 2-3 parts coconut oil. In this invention, myrrh reduces acute inflammatory reactions of the nasal mucosa through its anti-inflammatory effect, while Schisandra chinensis reduces secretions through its astringent effect. The combination of the two can effectively relieve nasal congestion and runny nose symptoms.

The application discloses a wild hundred-petal grass domestication cultivation method and particularly relates to the field of wild plant cultivation technology, and comprises the following steps: step one, wild resource investigation and conservation, resource investigation is conducted on wild populations of hundred-petal grass, accompanying plants, original habitat types, soil conditions, illumination conditions, humidity conditions and distribution characteristics are recorded, germplasm resources of different populations are synchronously collected, including seeds and rhizomes, and the collected samples are numbered, stored in different zones and registered in traits, a seedling test area and a germplasm resource basic file are established, and basis is provided for subsequent directional domestication. The application improves seed germination rate and seedling uniformity, also improves transplanting survival rate and field adaptability, realizes wild resource protection and sustainable utilization, constructs an ecological planting mode suitable for local climate, improves stability and controllability of medicinal material quality, reduces chemical input and meets green development requirements.

This invention proposes a traditional Chinese medicine preparation and its preparation method for treating olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type. Belonging to the field of traditional Chinese medicine preparations, it is made from the following raw materials: 10-15g of Rehmannia glutinosa (processed), 20-30g of Paeonia lactiflora, 10-15g of Spatholobus suberectus, 12-15g of Eclipta prostrata, 10-15g of Ligustrum lucidum, 8-10g of Centipeda minima, 10-15g of Acorus tatarinowii, and 10-15g of Angelica dahurica. The entire formula works synergistically to nourish the liver and kidneys, invigorate blood circulation, and clear the nasal passages, exhibiting good clinical therapeutic effects. This invention assesses the olfactory function of patients with olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type using the T&T olfactory test and other methods, and applies a traditional Chinese medicine nasal spray treatment, systematically exploring the therapeutic efficacy of this external application of traditional Chinese medicine for the aforementioned symptoms. This invention can provide clinical data support for the standardized diagnosis and treatment of olfactory dysfunction in Parkinson's disease and has significant clinical application value for improving patients' quality of life and optimizing the prognostic assessment system.

The invention relates to the technical field of biological medicine, in particular to centipeda minima extracellular vesicle nose drops and a preparation method and application thereof.The centipeda minima extracellular vesicle nose drops comprise active ingredients, plant extracellular vesicles (Cm-EVs) derived from centipeda minima, the concentration of the plant extracellular vesicles (Cm-EVs) is 1 * 10 < 10 >-5 * 10 < 11 > particles / ml; the key active substances are as follows: the content of the Cm-EVs naturally encapsulated sesquiterpene lactone compound centipederin is more than or equal to 50 micrograms per milliliter (detected by HPLC-MS); the pharmaceutical auxiliary materials comprise 0.05 to 0.2 percent (w / v) of sodium hyaluronate, 0.8 to 1.0 percent (w / v) of NaCl and 0.005 to 0.02 percent (v / v) of polysorbate 80; the method has the beneficial effects that the targeted enrichment capability is realized: mucous membrane adhesion is enhanced through surface pectin protein, and the nasal cavity residence time is prolonged to 6 hours (the free medicine is less than 1 hour); the nano-scale particle size (80-200nm) can efficiently penetrate through the mucous layer, and the nasal mucosa drug concentration reaches 20 times of the plasma concentration (rat pharmacokinetic data); the long-acting slow-release property is as follows: the active ingredients are protected by the lipid bilayer, the cumulative release rate of the centipederin within 72 hours reaches 82%, and the free medicine can be completely released within 24 hours.

The invention discloses a herbal nose-soothing health-care liquid and a preparation method thereof, and particularly relates to the technical field of rhinitis medicine preparation, and the herbal nose-soothing health-care liquid comprises the following components in parts by weight: 5-15 parts of angelica sinensis, 5-15 parts of salvia miltiorrhiza, 5-15 parts of ligusticum wallichii, 5-15 parts of sculellaria barbata, 5-15 parts of sambucus williamsii, 5-15 parts of pseudo-ginseng, 3-10 parts of magnolia flower, 3-10 parts of centipeda minima, 10-20 parts of astragalus membranaceus and 1-3 parts of borneol. According to the preparation method, medicinal materials with different properties are subjected to grouping treatment, graded extraction of components with different polarities is achieved through gradient variable-pressure decoction, the yield of active components is increased and the flavor of the product is improved through ultrasonic-assisted enzymolysis and solid-state segmented fermentation, accurate enrichment of target components is achieved through a membrane separation and resin adsorption combined technology, and the purity of the product is improved. The stability of volatile components is remarkably improved through a cyclodextrin inclusion technology, and the preparation is ensured to be uniformly dispersed through a high-shear emulsification technology.

The invention discloses a traditional Chinese medicine composition for treating rhinitis and a preparation method thereof. The traditional Chinese medicine composition comprises traditional Chinese medicine raw materials and functional auxiliary materials, wherein the traditional Chinese medicine raw materials comprise the following medicinal materials in percentage by weight: 12% of biond magnolia flower, 12% of small centipeda herb, 15% of dwarf lilyturf tuber, 3% of wild chrysanthemum flower, 3% of dahurian angelica root, 3% of dandelion, 3% of manchurian wildginger, 3% of cocklebur fruit, 8% of common burreed rhizome, 8% of curcuma zedoary, 10% of red-rooted salvia root, 6% of szechuan lovage rhizome and 6% of thunberg fritillary bulb; the functional auxiliary materials comprise the following raw materials in percentage by weight: 0.4% of cellulase, 0.2% of pectinase, 1.2% of carbomer, 0.8% of poloxamer, 0.1% of glycyrrhetinic acid, 0.05% of limonene, 5.24% of chitosan-sodium alginate and 0.01% of an anti-VEGF antibody. According to the application, a nasal polyp targeting component is added, so that the dual effects of dredging orifices, resisting inflammation (rhinitis) and resisting fiber (nasal polyp) are realized; the clinical value is higher than that of single rhinitis treatment; plant cell walls are destroyed by adopting composite enzymolysis, and fat-soluble, water-soluble and volatile oil active ingredients are synchronously extracted in combination with supercritical CO2 extraction; the mucous membrane stimulation risk caused by impurities is reduced.

The invention discloses a traditional Chinese medicine plugging agent for treating rhinitis, and relates to the technical field of medicines, the traditional Chinese medicine plugging agent comprises traditional Chinese medicine compound compatibility of dahurian angelica root, mint, ligusticum wallichii, magnolia flower, centipeda minima, borneol and spina gleditsiae, the traditional Chinese medicine compound compatibility is combined with a biodegradable matrix PLGA (poly (lactic-co-glycolic acid)) for forming, and stable release of the medicine is realized through a slow release technology. The preparation method comprises the steps of superfine grinding of traditional Chinese medicine powder, suspension preparation, microsphere forming, vacuum drying and the like. The plugging agent is conical, smooth in surface, soft in texture, convenient to insert into the nasal cavity, not prone to falling off and suitable for treating acute and chronic rhinitis. By adjusting the proportion of the PLGA and adding a penetration enhancer laurocapram, the drug release and permeability are optimized. The defects of existing traditional Chinese medicine preparations in dosage form adaptability, targeted delivery and drug release controllability are overcome, the treatment effect and use comfort are remarkably improved, and clinical requirements are met.

The invention discloses a traditional Chinese medicine composition for treating nasopharynx cancer and a preparation method of a nano freeze-dried tablet of the traditional Chinese medicine composition. The traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight: 25-35 parts of astragalus membranaceus, 25-35 parts of ganoderma lucidum spore powder, 25-35 parts of centipeda minima, 25-35 parts of cortex juglandis mandshuricae, 8-12 parts of dried toad skin, 2-4 parts of centipede, 1-3 parts of gecko, 10-20 parts of ligusticum wallichii, 10-20 parts of sculellaria barbata, 25-35 parts of oldenlandia diffusa, 10-20 parts of paris polyphylla, 5-10 parts of liquorice, 8-12 parts of magnolia flower and 5-10 parts of fresh ginger. The nasopharynx cancer can be treated through the traditional Chinese medicine, so that the defects of operative treatment, radiotherapy and chemical treatment are overcome, and the treatment effect is improved.

The invention belongs to the technical field of thesium chinense processing, and discloses a thesium chinense processing and smashing device which comprises a rack assembly. The crushing tank is arranged on the inner side of the rack assembly and can rotate relative to the rack assembly; the main shaft is arranged in the crushing tank; the spiral crushing blades are mounted on the outer side of the main shaft; and the auxiliary crushing assembly is arranged on the outer side of the crushing tank. The power assembly is used for distributing power and driving the internal main shaft and the external crushing tank to perform differential rotation, the internal cutting and external disturbance combined movement mechanism forces materials to be continuously separated from the tank wall and roll down towards the center, the materials are in a dynamic rolling state all the time, crushing dead angles are eliminated, and meanwhile the crushing efficiency is improved. The rotating speed difference between the main shaft and the crushing tank remarkably improves the relative linear speed between the spiral crushing blades and materials, the effective shearing frequency of the materials in unit time is increased, in addition, the design of the sealing plate effectively isolates a transmission area from a material area, and dust is prevented from invading a transmission part.

The invention relates to the technical field of Chinese herbal medicines, and particularly discloses a dropping liquid for treating rhinitis and otitis media and a production process thereof. The dropping liquid is prepared from 10-15 parts of rhizoma cimicifugae, 10-15 parts of radix astragali, 10-15 parts of herba ephedrae, 10-15 parts of flos caryophylli, 8-10 parts of radix saposhnikoviae, 8-10 parts of radix puerariae, 8-10 parts of rhizoma seu radix notopterygii, 8-10 parts of honey-fried liquorice root, 8-10 parts of herba houttuyniae, 8-10 parts of flos lonicerae and 20 parts of rhizoma coptidis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-18 parts of radix scutellariae, 15-18 parts of radix isatidis, 15-18 parts of chrysanthemum morifolium, 15-18 parts of acorus calamus, 15-18 parts of bothriospermum chinense, 15-18 parts of rhizoma phragmitis, 15-18 parts of fructus piperis longi, 15-18 parts of poria cocos, 18-20 parts of semen trichosanthis, 18-20 parts of centipeda minima, 18-20 parts of herba violae, 18-20 parts of cortex moutan, 18-20 parts of wax gourd kernels and 18-20 parts of radices stellariae dichotomae. The side effects of drug resistance, mucosal lesion, decline of immunity and the like easily caused by long-term use of antibiotics, glucocorticoid and other components in western medicines are avoided. The traditional Chinese medicine emphasizes overall conditioning, has relatively small side effects, and is more suitable for long-term use by patients with chronic and recurrent rhinitis and otitis media.

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a traditional Chinese medicine formula for treating rhinitis and a preparation method, and the traditional Chinese medicine composition is prepared from the following raw material components: cocklebur fruit, centipeda minima, radix angelicae, borneol, asarum, spina gleditsiae, cicada slough and musk delavayi. The preparation method comprises the following steps: performing oil extraction on medicinal materials such as centipeda minima and radix angelicae which are rich in lipophilic components to obtain medicinal oil; the preparation method comprises the following steps: performing water extraction on fructus xanthii, spina gleditsiae and other medicinal materials rich in water-soluble components to obtain a water-phase extract; carrying out high-speed shearing and emulsifying on the obtained medicinal oil and the water-phase extract to prepare O / W type emulsifiable paste; and finally, adding volatile components such as borneol, musk and the like at low temperature, and homogenizing. According to the invention, through reasonable compatibility of the medicinal materials and a water-oil two-phase extraction process, multi-target collaborative treatment is realized, and the obtained cream is endowed with good nasal mucosa adhesion and long-acting slow-release characteristics, so that the integrity of a pharmacodynamic material basis is ensured, and the local bioavailability and the treatment effect are improved.

This invention relates to the field of traditional Chinese medicine antibacterial liquid technology, and particularly to a traditional Chinese medicine antibacterial liquid for nasal use, made from the following raw materials: Xanthium sibiricum, Centipeda minima, Magnolia biondii, Asarum heterotropoides, Acorus tatarinowii, Akebia trifoliata, Atractylodes lancea, Indigo naturalis, Mentha haplocalyx, and polyhexamethylene biguanide. This invention combines nine traditional Chinese medicines—Xanthium sibiricum, Centipeda minima, Magnolia biondii, Asarum heterotropoides, Acorus tatarinowii, Akebia trifoliata, Atractylodes lancea, Indigo naturalis, and Mentha haplocalyx—with polyhexamethylene biguanide. The traditional Chinese medicine components are an improvement on the ancient formula of Xanthium sibiricum powder, synergistically exerting the effects of clearing the lungs and nasal passages, dispelling wind and cold, and anti-inflammatory and anti-allergic properties. Polyhexamethylene biguanide provides broad-spectrum antibacterial efficacy. By changing the traditional oral dosage form to a nasal drop, the liquid acts directly on the nasal mucosa lesion site, avoiding the first-pass effect of the liver and the metabolic burden on the kidneys associated with oral medications, significantly improving drug safety. Skin irritation, eye irritation, and allergy tests all showed no irritation or sensitization.

The invention discloses a formula for treating rhinitis and a production process thereof, relates to the technical field of traditional Chinese medicines, and solves the technical problem that products in different forms cannot be prepared to meet different treatment requirements in the existing technical scheme. Comprising plant extracts and auxiliary additives, the plant extracts comprise fructus xanthii, flos magnoliae, herba asari, radix astragali, cynanchum otophyllum, rhizoma chuanxiong and centipeda minima, and the auxiliary additives comprise radix saposhnikoviae, agastache rugosus, honeysuckle flowers, wild chrysanthemum flowers, borneol, menthol, honey and beeswax. Various dosage forms can be prepared according to different rhinitis types and patient requirements; due to the flexible dosage form selection, the product can adapt to different clinical symptoms, and the use convenience and the treatment effect of a patient are remarkably improved; the main components in the formula all come from natural plant extracts and natural auxiliary additives, have low toxic and side effects, are mild to human bodies, and are suitable for long-term use.