Eye patch plaster as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an eye patch plaster as well as a preparation method and application thereof. The eye patch plaster is prepared from the following raw materials in parts by weight: 8-12 parts of chrysanthemum morifolium, 8-12 parts of centipeda minima, 8-12 parts of angelica sinensis, 8-12 parts of glossy privet fruit, 8-12 parts of fructus lycii, 8-12 parts of cicada slough, 8-12 parts of feather cockscomb seed, 8-12 parts of mulberry, 8-12 parts of gastrodia elata, 8-12 parts of codonopsis pilosula, 8-12 parts of bighead atractylodes rhizome, 8-12 parts of long-noded pit viper, 8-12 parts of scorpion and 8-12 parts of dried ginger. Under the synergistic effect of all the raw material components, the eye patch plaster has the effects of nourishing the liver, tonifying the spleen, promoting blood circulation, dispelling wind, clearing the liver, improving eyesight and promoting aging to make new; the traditional Chinese medicine composition has a remarkable effect on vision problems of myopia, astigmatism and the like of children, and has a better conditioning effect on eye problems of myopia, hyperopia, cataract, muscae volitantes and the like of adults.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an eye plaster and a preparation method and application thereof. Background Art

[0004] In recent years, TCM treatment of myopia has developed rapidly, and there are indeed many treatment methods, such as granules, acupuncture, eye drops, and acupressure. However, these methods have the disadvantages of slow onset, unsatisfactory treatment effects, and easy rebound.

[0005] In view of this, the present invention is proposed. Summary of the invention

[0006] The purpose of the present invention is to provide an eye plaster and a preparation method and application thereof; the eye plaster has the effects of nourishing the liver and spleen, promoting blood circulation and dispelling wind, clearing the liver and improving eyesight, and promoting the old and bringing forth the new under the synergistic effect of various raw material components; it has a significant effect on vision problems such as myopia and astigmatism in children, and has a good conditioning effect on eye problems such as myopia, hyperopia, cataracts, floaters, etc. in adults.

[0007] In order to overcome the deficiencies of the prior art, the present invention provides the following technical solutions:

[0008] An eye plaster comprises the following raw materials in parts by weight: 8-12 parts of chrysanthemum, 8-12 parts of celery, 8-12 parts of angelica, 8-12 parts of glossy privet fruit, 8-12 parts of wolfberry, 8-12 parts of cicada shell, 8-12 parts of amaranth fruit, 8-12 parts of mulberry, 8-12 parts of gastrodia, 8-12 parts of codonopsis, 8-12 parts of atractylodes, 8-12 parts of white flower snake, 8-12 parts of scorpion, and 8-12 parts of dried ginger.

[0009] Furthermore, the following raw materials are included by weight: 10 parts of chrysanthemum, 10 parts of goose not eating grass, 10 parts of angelica, 10 parts of glossy privet fruit, 10 parts of wolfberry, 10 parts of cicada shell, 10 parts of amaranth fruit, 10 parts of mulberry, 10 parts of gastrodia, 10 parts of codonopsis, 10 parts of atractylodes, 10 parts of white flower snake, 10 parts of scorpion, and 10 parts of dried ginger.

[0010] Furthermore, auxiliary materials are included; the auxiliary materials include 1 to 3 parts of cinnamon oil, 1 to 3 parts of borneol, 1 to 3 parts of menthol and 1 to 3 parts of camphor.

[0011] In addition, the present invention also provides a method for preparing the above-mentioned eye patch, comprising the following steps:

[0012] S1. Weigh each Chinese medicinal material by weight, grind it into fine powder, sieve it, and mix it evenly to obtain Chinese medicinal powder;

[0013] S2, heating the medical hot melt adhesive until it is completely melted to obtain a hot melt adhesive matrix;

[0014] S3, adding the Chinese medicine powder obtained in step S1 into the hot melt adhesive matrix, stirring thoroughly to obtain a paste;

[0015] S4, applying the paste obtained in step S3 on the base liner by a coating machine to form a drug layer, thereby obtaining a plaster base material;

[0016] S5, cutting the plaster base material obtained in step S4 to obtain the eye patch.

[0017] Furthermore, in step S1, the product is sieved through a 100-200 mesh sieve.

[0018] Furthermore, in step S2, the heating time of the hot melt adhesive is 3 to 4 hours, and the heating temperature is 160 to 180 degrees Celsius.

[0019] Furthermore, in step S3, when the temperature of the hot melt adhesive matrix drops to 130 degrees Celsius, the Chinese medicine powder obtained in step S1 is added into the hot melt adhesive matrix.

[0020] Furthermore, in step S3, the Chinese medicine powder obtained in step S1 is added into the hot melt adhesive matrix, and then the auxiliary materials are added and stirred thoroughly to obtain a paste.

[0021] Furthermore, in step S4, the material of the base lining includes cotton cloth and non-woven fabric.

[0022] In addition, the present invention also provides the use of the above-mentioned eye plaster in medicine for treating myopia, hyperopia, cataract and floaters.

[0023] Compared with the prior art, the technical solution of the present invention has at least the following technical effects:

[0024] The eye patch of the present invention has the effects of nourishing the liver and spleen, promoting blood circulation and dispelling wind, clearing the liver and improving eyesight, and promoting the old and bringing forth the new under the synergistic effect of various raw material components; it has a remarkable effect on vision problems such as myopia and astigmatism in children, and has a good conditioning effect on eye problems such as myopia, hyperopia, cataracts, and floaters in adults. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical scheme and advantages of the present invention clearer, the technical scheme in the embodiment of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present invention. The process parameters of the following embodiments that do not specify specific conditions are usually based on conventional conditions.

[0026] The endpoints and any values ​​of the ranges disclosed in the present invention are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be regarded as specifically disclosed in the present invention.

[0027] According to a first aspect of the present invention, an eye plaster is provided, which is made of the following raw materials, by weight: 8-12 parts of chrysanthemum (for example, 8, 9, 10, 11, 12 parts), 8-12 parts of goose grass (for example, 8, 9, 10, 11, 12 parts), 8-12 parts of angelica (for example, 8, 9, 10, 11, 12 parts), 8-12 parts of Ligustrum lucidum (for example, 8, 9, 10, 11, 12 parts), 8-12 parts of wolfberry (for example, 8, 9, 10, 11, 12 parts), 8-12 parts of cicada shell (for example, 8, 9, 10, 11, 12 parts), 8-12 parts of green amaranth (for example, 8, 9, 10, 11, 12 parts), For example, 8, 9, 10, 11, 12 portions), mulberry 8-12 portions (for example, 8, 9, 10, 11, 12 portions), Gastrodia elata 8-12 portions (for example, 8, 9, 10, 11, 12 portions), Codonopsis pilosula 8-12 portions (for example, 8, 9, 10, 11, 12 portions), Atractylodes macrocephala 8-12 portions (for example, 8, 9, 10, 11, 12 portions), White flower snake 8-12 portions (for example, 8, 9, 10, 11, 12 portions), scorpion 8-12 portions (for example, 8, 9, 10, 11, 12 portions), dried ginger 8-12 portions (for example, 8, 9, 10, 11, 12 portions).

[0028] The eye patch of the present invention has the effects of nourishing the liver and spleen, promoting blood circulation and dispelling wind, clearing the liver and improving eyesight, and promoting the old and bringing forth the new under the synergistic effect of various raw material components; it has a remarkable effect on vision problems such as myopia and astigmatism in children, and has a good conditioning effect on eye problems such as myopia, hyperopia, cataracts, and floaters in adults.

[0029] The weight parts of the present invention mainly include the disclosed numerical range, any numerical value (including integer and decimal) or any interval of two numerical values ​​in the disclosed range, or multiple discontinuous intervals, and also include numerical values ​​or numerical ranges close to the end value of the numerical range whose effects can be expected to be similar, such as 5-10 parts, not only including 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and any interval of two parts, for other numerical ranges, not exemplified one by one, all are included in the present invention. Therefore, the present invention also includes the sub-range of any numerical range that has been directly disclosed or any specific numerical value therein.

[0030] In order to further optimize the effect of the eye patch, the present invention studies the influence of different proportions of various raw medicinal materials on the efficacy thereof, and obtains a better proportion of raw medicinal materials, wherein the better proportion of raw medicinal materials is: 10 parts of chrysanthemum, 10 parts of goose not eating grass, 10 parts of angelica, 10 parts of glossy privet fruit, 10 parts of wolfberry, 10 parts of cicada shell, 10 parts of amaranth fruit, 10 parts of mulberry, 10 parts of gastrodia, 10 parts of codonopsis, 10 parts of atractylodes, 10 parts of white flower snake, 10 parts of scorpion, and 10 parts of dried ginger.

[0031] In the above-mentioned eye patch, as a preferred embodiment, it also includes auxiliary materials; the auxiliary materials include 1-3 parts of cinnamon oil, 1-3 parts of borneol, 1-3 parts of menthol and 1-3 parts of camphor. Cinnamon oil has sedative, analgesic, anti-inflammatory, antibacterial, antioxidant and other effects and functions; borneol has the effects of refreshing the mind, clearing away heat and relieving pain; camphor has the effect of promoting local blood circulation and can have analgesic effect; menthol has anti-inflammatory effect and can reduce swelling and itching.

[0032] According to a second aspect of the present invention, there is also provided a method for preparing the above-mentioned eye patch, comprising the following steps:

[0033] S1. Weigh each Chinese medicinal material by weight, grind it into fine powder, sieve it, and mix it evenly to obtain Chinese medicinal powder;

[0034] S2, heating the medical hot melt adhesive until it is completely melted to obtain a hot melt adhesive matrix;

[0035] S3, adding the Chinese medicine powder obtained in step S1 into the hot melt adhesive matrix, stirring thoroughly to obtain a paste;

[0036] S4, applying the paste obtained in step S3 on the base liner by a coating machine to form a drug layer, thereby obtaining a plaster base material;

[0037] S5, cutting the plaster base material obtained in step S4 to obtain the eye patch.

[0038] It should be noted that the medical hot melt adhesive in the present invention is a medical hot melt adhesive commonly used in the prior art. Its use in plaster matrix is ​​common knowledge to those skilled in the art and will not be described in detail here.

[0039] In the above preparation method, as a preferred embodiment, in step S1, the product is sieved through a 100-200 mesh sieve.

[0040] In the above preparation method, as a preferred embodiment, in step S2, the heating time of the hot melt adhesive is 3 to 4 hours, and the heating temperature is 160 to 180 degrees Celsius.

[0041] In the above preparation method, as a preferred embodiment, in step S3, when the temperature of the hot melt adhesive matrix drops to 130 degrees Celsius, the Chinese medicine powder obtained in step S1 is added into the hot melt adhesive matrix.

[0042] In the above preparation method, as a preferred embodiment, in step S3, the Chinese medicine powder obtained in step S1 is added to the hot melt adhesive matrix, and then the auxiliary materials are added and stirred evenly to obtain a paste.

[0043] In the above preparation method, as a preferred embodiment, in step S4, the material of the base liner includes cotton cloth and non-woven fabric.

[0044] According to the third aspect of the present invention, there is also provided the use of the above-mentioned eye patch in the treatment of myopia, hyperopia, cataracts and floaters.

[0045] The method for using the eye patch of the present invention is to apply the patch to both eyes at the same time, twice a day, each time for about 30 minutes. The application position of the patch is mainly the brow bone under the eyebrows. According to the different causes of myopia, the plasters can be applied to auxiliary acupoints such as the bilateral head linqi point, the Yanglao point, the Guangming point, etc.

[0046] Combined with massage techniques (press the eye acupoints with one finger or a massage tool, do not loosen the force when the patient feels soreness, numbness, swelling or pain, massage nine times in a clockwise direction and nine times in a counterclockwise direction, one clockwise and one counterclockwise is one time, and massage a group of acupoints four times at a time) and then apply the patch. Normally, there will be an obvious response after continuous treatment for about a week. Patients with 500-degree myopia will generally have an ideal effect of restoring 100 points of vision within a month.

[0047] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0048] Example 1

[0049] The present embodiment provides an eye patch, and the weight proportions of the raw medicinal materials are as follows: 10 parts of chrysanthemum, 10 parts of herba angelicae sinensis, 10 parts of fructus ligustris, 10 parts of fructus wolfberrye, 10 parts of pericarp of cicada, 10 parts of fructus amarantii, 10 parts of mulberry, 10 parts of elata, 10 parts of codonopsis pilosula, 10 parts of atractylodes macrocephala, 10 parts of snakehead, 10 parts of whole scorpion, and 10 parts of dried ginger; auxiliary materials: 2 parts of cinnamon oil, 2 parts of borneol, 2 parts of menthol, and 2 parts of camphor.

[0050] The preparation method of the eye patch of the present embodiment is as follows:

[0051] 1. Weigh each Chinese medicinal material by weight, grind it into fine powder, pass it through a 150-mesh sieve, and mix it evenly to obtain Chinese medicinal powder;

[0052] 2. Heat the medical hot melt adhesive until it is completely melted to obtain a hot melt adhesive matrix; wherein the heating time is 3.5 hours and the heating temperature is 170 degrees Celsius;

[0053] 3. When the temperature of the hot melt adhesive matrix drops to 130 degrees Celsius, add the Chinese medicine powder into the hot melt adhesive matrix, then add the auxiliary materials, stir well to obtain a paste;

[0054] 4. The paste is coated on the base liner by a coating machine to form a drug layer to obtain a plaster base material;

[0055] 5. Cut the plaster base material to obtain the eye patch of this embodiment.

[0056] Example 2

[0057] The present embodiment provides an eye patch, and the weight proportions of the raw medicinal materials are as follows: 8 parts of chrysanthemum, 8 parts of herba angelicae, 8 parts of fructus ligustris, 8 parts of fructus wolfberries, 8 parts of pericarp of cicada, 8 parts of fructus amarantii, 8 parts of mulberry, 8 parts of gastrodia, 8 parts of codonopsis, 8 parts of atractylodes, 8 parts of snakehead, 8 parts of scorpion, and 8 parts of dried ginger; auxiliary materials: 1 part of cinnamon oil, 1 part of borneol, 1 part of menthol, and 1 part of camphor.

[0058] The preparation method of the eye patch of the present embodiment is as follows:

[0059] 1. Weigh each Chinese medicinal material by weight, grind it into fine powder, pass it through a 100-mesh sieve, and mix it evenly to obtain Chinese medicinal powder;

[0060] 2. Heat the medical hot melt adhesive until it is completely melted to obtain a hot melt adhesive matrix; wherein the heating time is 3 hours and the heating temperature is 160 degrees Celsius;

[0061] 3. When the temperature of the hot melt adhesive matrix drops to 130 degrees Celsius, add the Chinese medicine powder into the hot melt adhesive matrix, then add the auxiliary materials, stir well to obtain a paste;

[0062] 4. The paste is coated on the base liner by a coating machine to form a drug layer to obtain a plaster base material;

[0063] 5. Cut the plaster base material to obtain the eye patch of this embodiment.

[0064] Example 3

[0065] The present embodiment provides an eye patch, and the weight proportions of the raw medicinal materials are as follows: 12 parts of chrysanthemum, 12 parts of herba angelicae, 12 parts of fructus ligustris, 12 parts of fructus lycii, 12 parts of pericarp of cicada, 12 parts of fructus amarantii, 12 parts of mulberry, 12 parts of gastrodia, 12 parts of codonopsis, 12 parts of atractylodes, 12 parts of snakehead, 12 parts of whole scorpion, and 12 parts of dried ginger; auxiliary materials: 3 parts of cinnamon oil, 3 parts of borneol, 3 parts of menthol, and 3 parts of camphor.

[0066] The preparation method of the eye patch of the present embodiment is as follows:

[0067] 1. Weigh each Chinese medicinal material by weight, grind it into fine powder, pass it through a 200-mesh sieve, and mix it evenly to obtain Chinese medicinal powder;

[0068] 2. Heat the medical hot melt adhesive until it is completely melted to obtain a hot melt adhesive matrix; wherein the heating time is 4 hours and the heating temperature is 180 degrees Celsius;

[0069] 3. When the temperature of the hot melt adhesive matrix drops to 130 degrees Celsius, add the Chinese medicine powder into the hot melt adhesive matrix, then add the auxiliary materials, stir well to obtain a paste;

[0070] 4. The paste is coated on the base liner by a coating machine to form a drug layer to obtain a plaster base material;

[0071] 5. Cut the plaster base material to obtain the eye patch of this embodiment.

[0072] Clinical observation of eye patch of the present invention:

[0073] Observation method:

[0074] All participants in the trial were myopic patients. 30 myopic patients from March 2021 to April 2022 were selected, and 20 patients formed the treatment group: 10 males and 20 females, aged 8-18 years old.

[0075] Diagnostic criteria: According to the standard test criteria of the "Visual Acuity Chart".

[0076] Exclusion criteria: visual impairment caused by other diseases.

[0077] Treatment method: Massage the eye acupoints and then apply plaster.

[0078] Treatment group: The eye patch of the present invention was applied to both eyes at the same time, twice a day, each time for about 30 minutes, and the plaster was applied mainly to the brow bone under the eyebrows, and it was used continuously for 90 days.

[0079] Efficacy evaluation criteria:

[0080] Cured: visual acuity reached 1.5 and no recurrence within 1 year; a total of 21 cases.

[0081] Markedly effective: Symptoms were significantly improved compared with before, and visual acuity recovered to above 1.0; 4 cases in total.

[0082] Improvement: Symptoms have improved compared to before; 4 cases.

[0083] Ineffective: No significant improvement in symptoms in 1 case.

[0084] Results: The total effective rate was 96.6%.

[0085] In order to show the effect of the eye patch of the present invention, the following typical cases are selected for illustration:

[0086] Case 1: Yuan, female, 18 years old, a senior in high school, had myopia due to excessive use of eyes, 250° for the left eye, 225° for the right eye, and 70° astigmatism. After massage (press the acupoints of the eyes with one finger or a massage tool, massage nine times in a clockwise direction and then nine times in a counterclockwise direction, one time for a clockwise and one time for a group of acupoints, and massage four times at a time), she used the eye patch of the present invention for three months, did not wear glasses during use, fasted all iced and cold foods, especially cold foods such as duck meat, seafood, duck eggs, bananas, pitaya, etc., and combined with correct scientific use of eyes, the naked eye vision of both eyes reached 1.5, and there was no rebound in vision after stopping the application of the plaster for half a year.

[0087] Case 2: Mr. Hu, male, 17 years old, myopia of 325° in the right eye and 350° in the left eye. After massage (press the acupoints of the eyes with one finger or a massage tool, massage nine times in a clockwise direction and then nine times in a counterclockwise direction, one clockwise and one counterclockwise is one time, and a group of acupoints are massaged four times at a time), after using the eye patch of the present invention for two and a half months, the naked eye vision of both eyes recovered to 1.5. During the use of the plaster, glasses were not worn, and all iced and cold foods were forbidden, especially cold foods, such as duck meat, seafood, duck eggs, bananas, dragon fruit, etc.), and combined with correct scientific use of the eyes, no rebound phenomenon occurred after stopping the medication for half a year.

[0088] Case 3: Li, female, 42 years old, had a naked eye vision of 0.4. After massage (press the eye acupoints with one finger or a massage tool, massage nine times in a clockwise direction and then nine times in a counterclockwise direction, one clockwise and one counterclockwise is one time, and a group of acupoints are massaged four times at a time), after using the eye patch of the present invention, she did not wear glasses during the use of the plaster, fasted all iced and cold foods, especially cold foods such as duck meat, seafood, duck eggs, bananas, pitaya, etc., and combined with correct scientific use of the eyes, her naked eye vision recovered to 0.8, showing obvious improvement. After stopping the medication for half a year, there was no rebound phenomenon.

[0089] The above describes and evaluates the efficacy of some embodiments of the present invention. It should be understood that the present invention is not limited to the above specific implementations. Any technician familiar with the art can use the above disclosed methods and technical contents to make many possible changes and modifications to the technical solutions of the present invention without departing from the scope of the technical solutions of the present invention, or modify them into equivalent embodiments of equivalent changes, which does not affect the essential content of the present invention. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solutions of the present invention still falls within the scope of protection of the technical solutions of the present invention.

Claims

1. An eye plaster, characterized in that: The invention comprises the following raw materials by weight: 8-12 parts of chrysanthemum, 8-12 parts of goose not eating grass, 8-12 parts of angelica, 8-12 parts of glossy privet fruit, 8-12 parts of wolfberry, 8-12 parts of cicada shell, 8-12 parts of amaranth fruit, 8-12 parts of mulberry, 8-12 parts of gastrodia, 8-12 parts of codonopsis, 8-12 parts of atractylodes, 8-12 parts of white flower snake, 8-12 parts of whole scorpion and 8-12 parts of dried ginger.

2. The eye patch according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 10 parts of chrysanthemum, 10 parts of herba goosefoot, 10 parts of angelica, 10 parts of glossy privet fruit, 10 parts of wolfberry, 10 parts of cicada shell, 10 parts of amaranth fruit, 10 parts of mulberry, 10 parts of gastrodia, 10 parts of codonopsis pilosula, 10 parts of atractylodes macrocephala, 10 parts of white flower snake, 10 parts of whole scorpion and 10 parts of dried ginger.

3. The eye patch according to claim 1 or 2, characterized in that: The invention also comprises auxiliary materials, which include 1 to 3 parts of cinnamon oil, 1 to 3 parts of borneol, 1 to 3 parts of menthol and 1 to 3 parts of camphor.

4. A method for preparing the eye patch according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Weigh each Chinese medicinal material by weight, grind it into fine powder, sieve it, and mix it evenly to obtain Chinese medicinal powder; S2, heating the medical hot melt adhesive until it is completely melted to obtain a hot melt adhesive matrix; S3, adding the Chinese medicine powder obtained in step S1 into the hot melt adhesive matrix, stirring thoroughly to obtain a paste; S4, applying the paste obtained in step S3 on the base liner by a coating machine to form a drug layer, thereby obtaining a plaster base material; S5, cutting the plaster base material obtained in step S4 to obtain the eye patch.

5. The method for preparing the eye patch according to claim 4, characterized in that: In step S1, the product is sieved through a 100-200 mesh sieve.

6. The method for preparing the eye patch according to claim 4, characterized in that: In step S2, the heating time of the hot melt adhesive is 3 to 4 hours, and the heating temperature is 160 to 180 degrees Celsius.

7. The method for preparing the eye patch according to claim 6, characterized in that: In step S3, when the temperature of the hot melt adhesive matrix drops to 130 degrees Celsius, the Chinese medicine powder obtained in step S1 is added into the hot melt adhesive matrix.

8. The method for preparing the eye patch according to claim 4, characterized in that: In step S3, the Chinese medicine powder obtained in step S1 is added into the hot melt adhesive matrix, and then the auxiliary materials are added and stirred thoroughly to obtain a paste.

9. The method for preparing the eye patch according to claim 4, characterized in that: In step S4, the material of the base lining includes cotton cloth and non-woven fabric.

10. Use of the eye patch according to any one of claims 1 to 3 in medicines for treating myopia, hyperopia, cataracts and floaters.