835 results about "Lipophilicity" patented technology

The invention provides water-in-oil type emulsion gel loaded with probiotics and a preparation method of the water-in-oil type emulsion gel, and belongs to the technical field of probiotic products, the water-in-oil type emulsion gel loaded with the probiotics comprises a water phase and an oil phase, and the internal water phase is composed of gel and probiotic suspension; and the external oil phase consists of edible oil, a lipophilic emulsifier and at least one oil gelator. According to the water-in-oil emulsion gel, the stability of entrapped probiotics can be remarkably improved, meanwhile, the activity of the entrapped probiotics in the processing, storage and digestion processes is improved, particularly, the normal-temperature storage time is prolonged by 3 months, and a scientific basis is provided for normal-temperature food development.

The present invention relates to a slide system (1) comprising a first slide member (10) having a slide surface (14) at least partly coated with a lipophilic composition coating (18) to provide a slide layer (19) with lowered friction, and a second slide member (20) arranged in sliding contact with the slide layer (19) at an interface to provide a slide system (1). The interface between the slide layer (19) and the second slide member (20) forms a plain bearing to allow for sliding movement of the second slide member (20) relative to the first slide member (10). At least the slide surface (14) of the first slide member (10) is made of a first plastic, and at least a part of said second slide member (20) being in sliding contact with the slide layer (19) is made of a second plastic. The first and the second plastics are different plastics. The invention further relates to a method for providing said slide system (1).

The present invention provides a method of preparing a lipid nanoparticle dispersion using a twin screw extruder. The inventive DNLF fluids are isotropic fluids which include greater than 25% lipophilic content in the form of lipidic nanoparticles dispersed in a continuous aqueous matrix with turbidity less than 375 nephelometric turbidity units (NTU).

The present disclosure relates to stick compositions including 2,4-bis-{[4-(2-ethyl hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine, at least one solvent for solubilizing the bemotrizinol, and at least one lipophilic gelling agent, as well as to methods of making and using such compositions.

The invention discloses a lipophilic liposome containing polydeoxyribonucleotide as well as a preparation method and application of the lipophilic liposome. The lipophilic liposome comprises the following components in parts by weight: 0.001-3 parts of polydeoxyribonucleotide; 0.5 to 3 parts of phospholipid; 0.1-2 parts of a cationic emulsifier; 0.1-3 parts of an anionic emulsifier; 40 to 70 parts of polyol; the total amount is 100 parts. According to the invention, an emulsifier system formed by combining lecithin with anionic and cationic compound surfactants is adopted, so that the transdermal absorption of PDRN is facilitated. The lipophilic liposome containing polydeoxyribonucleotide prepared by the invention can effectively resist nuclease degradation, prolong the acting time of PDRN in skin, and improve the skin anti-aging and repairing effects of the liposome. The anti-aging effect of the active ingredients is improved, and the bioavailability of the active ingredients is improved. The cosmetic composition can be widely applied to cosmetic formulas of various dosage forms.

The invention relates to the technical field of materials, in particular to preparation of an amphiphilic tungsten disulfide nano material and application of the amphiphilic tungsten disulfide nano material in preparation of an oil displacement agent. The oil-displacing agent prepared from the amphiphilic tungsten disulfide nano material can reduce the interfacial tension of an oil-water interface, and can be quickly adsorbed to the oil-water interface to layer oil and water; the surface wettability of the rock is changed, the lipophilicity of the rock is changed into weak hydrophilicity, and the pore throat cannot be blocked due to excessive hydrophilicity while the oil phase is stripped. The nano oil-displacing agent disclosed by the invention can still have an enough stable use effect after being frozen at a low temperature and then unfrozen.

The invention discloses a method for auxiliary screening of grease antioxidant peptides based on artificial intelligence, and belongs to the technical field of bioinformatics. According to the invention, deep learning and virtual enzymolysis are combined, so that a novel method for preparing the antioxidant peptide by rapidly and efficiently screening protein enzymolysis is researched and developed. According to the method, an antioxidant peptide is obtained as a target, an antioxidant peptide data set and a test set are constructed, a Bi-LSTM high-precision deep learning strategy is provided based on the data set, and the Bi-LSTM high-precision deep learning strategy is trained to recognize the antioxidant peptide. And then, predicting the antioxidant activity of the polypeptide obtained through virtual enzymolysis by utilizing Bi-LSTM (Bidirectional Long Short Term Memory). Taking black bean protein as an example, the strategy of the invention discovers that the antioxidant peptide can be better obtained by enzymolysis of the black bean protein through trypsin. After ABTS and DPPH activity verification, the antioxidant peptide is used for lipophilicity determination, the peptide with lipophilicity can play a better grease antioxidant effect, and a research basis is provided for safety control of a grease hot working process.

The invention relates to the technical field of nano material preparation, in particular to a hydrophobing agent and a method for preparing hydrophobic white carbon black at low temperature by adopting the hydrophobing agent. Comprising the following steps that 1, 3-divinyl-1, 1, 3, 3-tetramethyldisilazane and 1, 1, 1, 3, 5, 5, 5-heptamethyltrisiloxane are mixed, a Pt catalyst is added, the mixture enters a micro-channel reactor, a heating reaction is carried out, the mixture enters a reaction kettle to continue a stirring reaction, reaction heat in the micro-channel reactor is used for heating the reaction kettle, and unreacted components are removed; distilling to obtain a water repellent agent, and recycling a kettle substrate as a catalyst; the preparation method comprises the following steps: mixing white carbon black and a hydrophobic agent under the protection of nitrogen or inert gas, and heating and stirring to obtain the hydrophobic white carbon black. The hydrophobic agent disclosed by the invention contains a silicon-nitrogen bond with good reaction activity and is rich in lipophilic trimethylsiloxy. The silicon-nitrogen bonds can be effectively reacted and grafted with the surface of the white carbon black to form stable chemical bonding.

An oral suspension pharmaceutical composition is disclosed for water soluble salts of arylalkanoic acid (NSAID) drugs such as ibuprofen and naproxen. When mixed with glyceryl esters such as glyceryl caprate / caprylate and water, the resulting combination forms a “liquid scaffold” structure that reliably enables the suspension of significant quantities of said arylalkanoic acid drugs. For example, suspensions containing 25% w / w arylalkanoic acid may be obtained using the aforementioned combination. Suspensions comprising further pharmaceutically active agents, in addition to said arylalkanoic acids, may also be prepared. Also disclosed is a binary blend of glyceryl caprate / caprylate and the sodium salt of ibuprofen and a ternary blend of glyceryl caprate / caprylate and the potassium salt of ibuprofen.

The invention belongs to the technical field of organic synthesis, and particularly relates to an asymmetric phenanthroline compound as well as a preparation method and application thereof. Compared with the original symmetric ligand compound, the asymmetric phenanthroline compound provided by the invention has the advantage that the extraction performance and selectivity of americium are improved. In addition, the asymmetric phenanthroline compound provided by the invention is stable in structure, has good acid resistance and radiation resistance, can be suitable for high-acidity post-treatment waste liquid, improves the fat solubility of the phenanthroline ligand, is easy to split phases, does not need to use 2-bromohexanoic acid and other synergistic extractants, and reduces the introduction of secondary wastes in the post-treatment process.

The invention discloses modified calcium carbonate powder applied to silicone adhesive and a preparation method of the modified calcium carbonate powder, and relates to the technical field of calcium carbonate powder modification, the modified calcium carbonate powder comprises heavy calcium carbonate powder and an additive for modifying the heavy calcium carbonate powder; the additives comprise N, N '-ethylene bis stearamide, glycerol, an aluminate coupling agent, a castor oil derivative, a dispersing agent and a rheological agent; the calcium carbonate filler has the characteristics of high whiteness, low cost, strong lipophilicity, small stacking density, low oil absorption value and the like, and the silicone adhesive produced by using the calcium carbonate filler has the advantages of good fluidity, good thixotropy, good extrudability of the finished product adhesive and outstanding mechanical properties, and is a high-quality calcium carbonate filling filler for producing the silicone adhesive.

The invention belongs to the technical field of new organic polymer materials and products, and discloses special modified calcium carbonate for a polypropylene composite material as well as a preparation method and application of the special modified calcium carbonate. Through the mediation effect of glutaraldehyde, chemical bonding is promoted to be formed between hydroxyl on the surface of calcium carbonate and hydroxyl of glucan, and the chemical crosslinking effect not only enhances the adhesive force of glucan on the surface of calcium carbonate, but also remarkably improves the compatibility of calcium carbonate and a polypropylene matrix. The calcium carbonate modification method is suitable for different conditions and occasions, can be suitable for dry modification, and can also be suitable for wet modification, so that the compatibility of calcium carbonate and polypropylene is remarkably improved. By adjusting the experimental conditions, the surface hydrophilicity and lipophilicity of the calcium carbonate can be regulated and controlled, and the calcium carbonate with different contact angle characteristics is prepared so as to meet different functions and application requirements.

The invention belongs to the technical field of emulsion gel, and particularly relates to a double-gel composition, a high-temperature-resistant and high-moisture-resistant gel bead capable of protecting lipophilic active ingredients and probiotics as well as a preparation method and application of the double-gel composition and the high-temperature-resistant and high-moisture-resistant gel bead. The double-gel composition provided by the invention consists of the low-temperature response gel and the high-temperature response gel, and the gel prepared from the double-gel composition has good tolerance to high temperature and high moisture and can be used for preparing high-temperature-resistant and high-moisture-resistant gel products. The high-temperature-resistant and high-moisture-resistant gel bead provided by the invention is prepared from the double-gel composition and an oil phase containing active ingredients through the steps of shear mixing, dropping pill cooling, crosslinking and the like, the structure of the gel bead is a network gel skeleton structure, and the active ingredients are uniformly distributed in the gel bead. The gel bead has excellent heat resistance, can tolerate heat treatment in a high-moisture environment and under a high-moisture condition, and plays an effective role in protecting active ingredients distributed in a network gel skeleton.

The invention discloses a surface lipophilic modified barite weighting material as well as a preparation method and application thereof, and belongs to the technical field of drilling fluids. The surface lipophilic modified barite weighting material comprises barite and a surface modifier, and the surface modifier comprises a copolymer formed by polymerizing a monomer A, a monomer B, a monomer C and a monomer D. According to the invention, the lipophilicity of the barite is chemically modified by the surface modifier, and all monomers have a synergistic effect, so that when the grafted and modified barite weighting material is used as the weighting agent of the oil-based drilling fluid, the dispersity and the stability of particles in the oil-based drilling fluid can be improved, and the rheological property, the plugging property and the high-temperature resistance of the drilling fluid can be adjusted.

The invention relates to the technical field of carbon fiber sizing agents, in particular to a preparation method and application of a self-emulsifying cationic waterborne polyurethane emulsion sizing agent. The preparation method comprises the following steps: firstly, preparing the cationic waterborne polyurethane emulsion by adopting a self-emulsifying method, then mixing the cationic waterborne polyurethane emulsion with the lubricant, the surfactant and the coupling agent, adding distilled water, and stirring and diluting to prepare the sizing agent. According to the cationic waterborne polyurethane emulsion prepared by the method disclosed by the invention, the performance of the emulsion is improved, and the cationic waterborne polyurethane emulsion can be prepared by changing different synthesis raw materials, the ratio of the raw materials and the content of a solid intermediate and introducing a nano SiO2 structure. The emulsion has different hydrophilicity and lipophilicity, different particle sizes and different heat resistance degrees, is applied to fiber production with different requirements, and has the properties of improving the chemical bonding property and wettability of a resin and fiber interface, improving the tensile strength of fibers, enhancing the interlaminar shear strength of composite materials and the like.

The invention relates to the technical field of packaging materials, in particular to a manufacturing method of an industrial byproduct semi-hydrated gypsum hollow plastic plate. The plastic plate is prepared from the following components in parts by weight: 60 to 70 parts of superfine modified semi-hydrated phosphogypsum powder, 28 to 35 parts of polypropylene resin, 0.5 to 1.5 parts of slipping agent, 0.5 to 1.5 parts of dispersing agent, 0.5 to 1.5 parts of antistatic agent, 0.3 to 0.8 part of antioxidant, 5 to 10 parts of calcium oxide and 3 to 6 parts of polyolefin elastomer. The gypsum powder subjected to purification, calcination and quaternary ammonium / stearic acid surface treatment has oleophylic and hydrophobic properties, and 65% high-proportion filling can be realized; the light moisture-proof plate with the density of 0.75-0.95 g / cm < 3 > and the thickness of 3-6 mm is obtained by matching with a double-screw granulation process and a single-screw hollow plate extrusion process, the use amount of resin is reduced, the mechanical property and the heat resistance are obviously superior to those of a single surface modifier, and high-value utilization of ardealite resources is realized.

The invention discloses double gel loaded with active substances as well as a preparation method and application of the double gel, and belongs to the technical field of medical dressings. The double gel is composed of a water phase and an oil phase, the water phase comprises oxidized sodium alginate and carboxymethyl chitosan, and the oil phase comprises glycerol monolaurate and camellia oil. Through the synergistic effect of a water phase and an oil phase, a stable double-gel system is formed, hydrophilic epigallocatechin gallate and lipophilic curcumin are loaded, and primary encapsulation of active substances is achieved. According to the double gel loaded with the active substance and the preparation method and application thereof, the double gel has excellent mechanical stability and gel performance, can achieve efficient delivery of the active substance, and has good biocompatibility and application prospects; effective treatment is expected to be achieved in acute burn and scald wound repair, theoretical basis and technical support are provided for application of the double gel in the fields of wound repair and medical cosmetology, and the double gel has the potential of replacing a traditional dressing and becoming a new generation of functional medical dressing.

The invention relates to a decarboxylated carnosine derivative as well as a preparation method and application thereof. The structural formula of the decarboxylated carnosine derivative is shown as a formula (I), wherein R is selected from C5-C21 alkyl and C5-C21 unsaturated chain alkyl. Compared with decarboxylated carnosine, the decarboxylated carnosine derivative disclosed by the invention has a more excellent anti-saccharification effect; meanwhile, a relatively good anti-oxidation effect is achieved; moreover, the decarboxylated carnosine derivative disclosed by the invention has certain lipophilicity, is relatively easy to penetrate through a skin cuticle, is good in skin permeability and relatively good in stability, can be used for preparing cosmetics for resisting saccharification, resisting oxidation, resisting skin aging and the like, and has an important market value. # imgabs0 #

The invention discloses a red fluorescent silicon nanodot as well as a preparation method and application thereof. The method comprises the following steps: S1, weighing sulforhodamine 101, adding ultrapure water for dissolving, then adding N-(2-aminoethyl)-3-aminopropyltrimethoxysilane, uniformly stirring, transferring the obtained mixture into a reaction kettle, and heating for reaction; and S2, after the reaction is finished, cooling to room temperature, purifying the obtained product by using a silica gel chromatographic column, eluting by using an eluent, collecting the eluent, and finally, freeze-drying to obtain the red fluorescent silicon nanodots. Compared with common blue-green fluorescence, red fluorescence emission has deeper tissue penetrability and background fluorescence interference resistance; the silicon nanodot provided by the invention not only has excellent light stability and high quantum yield, but also has characteristics similar to lipophilic cations, and can specifically target mitochondria in living cells; in addition, the silicon nanodots also show excellent imaging ability in zebrafish embryos and juvenile fish bodies.

Disclosed in the present disclosure are a bio-based organic silicon surfactant, and a preparation method therefor and the use thereof. The surfactant has the following structure: Si(CH3)3-O-[Si(CH3)2-O]a-[Si(CH3)R1-O]b-[Si(CH3)R2-O]c-Si(CH3)3. By using a comb-shaped structure with a hydrophobic siloxane as a main chain and a hydrophilic polyether as a side chain, a bio-based substance is grafted and introduced to the polyether at the side chain thereof by means of an epoxide ring-opening reaction, thereby adjusting the hydrophilicity and lipophilicity of the organic silicon surfactant to a certain extent and improving the surface activity of the organic silicon surfactant. The introduction of the bio-based substance can reduce the heat conductivity coefficient of polyurethane foam, increase the flow index of the polyurethane foam and improve the heat insulation performance and flowing performance of the foam. In addition, the synthesis of the organic silicon surfactant provides a new synthesis route for the development of a bio-based foam stabilizer; and the preparation method is simple, easily operated and suitable for industrial production.

The present invention relates to a cationic carrier and application thereof of a loadable cosmetic lipophilic active substance. The raw material of the cationic carrier includes an aqueous solution of a nonionic emulsifier, silk fibroin nanofiber and cocamidopropyl PG-dimethyl ammonium chloride phosphate, wherein the mass ratio of the nonionic emulsifier, the aqueous solution and the cocamidopropyl PG-dimethyl ammonium chloride phosphate is 1:(1.5~5):(0.7~2), and the content of β-folding in the silk fibroin nanofiber is 25%~45%. The cationic carrier provided by the present invention has a stronger lipophilic active substance loading capacity, and the cationic inclusion containing the cationic carrier has better permeability, stability and mildness simultaneously, and has broad application prospects.

The invention relates to the technical field of skin care product preparation, in particular to traditional Chinese medicine skin care cream for repairing skin and a preparation method thereof. The preparation method comprises the following steps: preparing acylated alkyl glucoside; preparing a turpinia arguta extract; preparing a suspension of the naringin and the turpinia arguta extract; and preparing the traditional Chinese medicine skin cream for repairing the skin. According to the method, myristic acid and alkyl glycoside are used for preparing acylated alkyl glycoside, myristic acid and alkyl glycoside are subjected to acylation reaction through lipase Lipozyme435 enzyme, damage to a flavone structure in the microwave extraction process is avoided, after alkyl glycoside acylation, the lipophilicity is remarkably enhanced, and the lipophilicity of alkyl glycoside is remarkably reduced. Due to the enhanced lipophilicity, the alkyl glycoside can more effectively interact with fat-soluble flavonoid compounds, so that the solubility and dispersity of the alkyl glycoside in a fat phase are improved, the oxidation loss of flavonoid substances in the extraction process of the turpinia arguta leaves is reduced, and the content of the flavonoid substances in the turpinia arguta leaf extract is increased.

The invention provides a benzene azepine derivative, a radioactive probe and application thereof, and belongs to the technical field of biological medicine. According to the present invention, the benzazepine derivative is modified, and the hydrophilic or lipophilic side chain is introduced, such that the prepared benzazepine derivative can be used as the V2R targeting precursor for application, the specific V2R targeting can be achieved, and the new molecular tool is provided for the subsequent V2R positive tumor diagnosis and treatment. The radioactive probe combined with the 68Ga marker shows a good tumor imaging effect, can realize PET imaging of V2R positive tumors, is helpful for improving the accuracy of tumor diagnosis, can also be used for evaluating the treatment effect, has a relatively high target / non-target ratio, can better display the distribution of whole body V2R receptors, and has a good application prospect. The invention has various applications in cancer diagnosis and treatment.

The present application provides biodegradable microcapsules, based on specific poly ß-amino ester shells that can encapsulate and retain cargoes such as, lipophilic, or hydrophobic core materials comprising fragrances, butters, essential or other oils; or oil solubilized ingredients, process of making said biodegradable microcapsules and their applications in various industries. Present application further provides biodegradable shell materials that show evidence of biodegradation or non-persistence in aquatic based and / or soil or compost based environments, and which are stable on storage before use.

Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

A multi-fluid blending system employing low-energy static mixing provides efficient mechanical blending process for mass-producing thermodynamically stable hydro-fuels, eliminating the need of high-energy mixing equipment, and maintaining a compact, cost-effective design. Suitable for small to large-scale production, the system produces microemulsions following Hydrophilic-Lipophilic Difference (HLD) surfactant formulations. Modular design allows for scalable applications, from equipment installations to trailer-mounted units and onboard ships. The system ensures the production of hydro-fuel microemulsions using precise metering, dosing systems and low-energy static mixing. Hydro-fuels produced reduce engine combustion emissions and harmful pollutants, hydrocarbons, particulate matter, black carbon and smoke opacity, benefiting the environment and human health.

A capacitor includes a capacitor element having a predetermined liquid preparation held between a pair of electrodes facing each other across a separator, a body case for housing the capacitor element, and a sealing member made of rubber for sealing seals the body case. A supplying portion is provided in contact with the sealing member to supply the liquid preparation held in the capacitor element to the sealing member. The liquid preparation has a lipid-soluble sealing member deterioration preventing agent dissolved in a lipophilic solvent. The sealing member deterioration preventing agent supplied by the supplying portion to the sealing member permeates the sealing member. The ratio by weight of the sealing member deterioration preventing agent in the sealing member to the sealing member is 0.1% by weight to 25% by weight.

The present invention relates to new salt forms of sabcomeline. The new salt forms are lipophilic acid salts of sabcomeline wherein the lipophilic acids used to prepare the new salts may have a Hansen solubility parameter distance from water of at least 20.7. The present invention also relates to new crystalline forms of sabocomeline salts.

This disclosure relates to quaternary phosphonium compounds having lipophilic groups. In certain embodiments, this disclosure relates to quaternary phosphonium compounds having chemical formula as reported herein. In certain embodiments, this disclosure relates to compositions and devices comprising or coated with quaternary phosphonium compounds disclosed herein. In certain embodiments, this disclosure relates to preventing or treating a microbial infection or cancer using quaternary phosphonium compounds disclosed herein.

The present invention is referred to a method for production of a pharmaceutical composition, said composition comprises: A) naturally secreted exosomes from normal human embryonic lung fibroblast cells (MRC-5 cell line), wherein said exosomes comprise a lipophilic and / or hydrophilic active substance, said method comprises the following steps in the following order: a) separation of exosomes by ultrafiltration, b) collection of exosomes by membrane-based affinity binding method, c) loading of exosomes with active substance, or B) artificial exosomes, wherein said exosomes comprise a lipophilic and / or hydrophilic active substance, said method is a microfluidic method and said method comprises the following steps in the following order: a) extraction of lipids from a cell line of normal human embryonic lung fibroblast cells (MRC-5 cell line) to obtain a lipid film, b) resuspending of the lipid film in an organic solvent and mixing with the aqueous phase in a microfluidics device to obtain exosomes, wherein the aqueous phase comprises Tween 20 and wherein in the microfluidics device I) the flow rate ratio of the organic phase to the flow rate of the aqueous phase (flow rate ratio, FRR) is set from 1:5 to 1:3, ii) the organic phase flow rate (OPFR) is preferably set at 200 pL / min or 400 pL / min and ill) the aqueous phase flow rate (APFR) is preferably set at 100 pL / min or 1000 pL / min, c) purification of the obtained exosomes using size exclusion chromatography, d) loading of the exosomes with active substance, e) purification of the obtained exosomes using size exclusion chromatography to remove the unloaded drug.