497 results about "Lipophilicity" patented technology

The invention discloses a lipophilic liposome containing polydeoxyribonucleotide as well as a preparation method and application of the lipophilic liposome. The lipophilic liposome comprises the following components in parts by weight: 0.001-3 parts of polydeoxyribonucleotide; 0.5 to 3 parts of phospholipid; 0.1-2 parts of a cationic emulsifier; 0.1-3 parts of an anionic emulsifier; 40 to 70 parts of polyol; the total amount is 100 parts. According to the invention, an emulsifier system formed by combining lecithin with anionic and cationic compound surfactants is adopted, so that the transdermal absorption of PDRN is facilitated. The lipophilic liposome containing polydeoxyribonucleotide prepared by the invention can effectively resist nuclease degradation, prolong the acting time of PDRN in skin, and improve the skin anti-aging and repairing effects of the liposome. The anti-aging effect of the active ingredients is improved, and the bioavailability of the active ingredients is improved. The cosmetic composition can be widely applied to cosmetic formulas of various dosage forms.

The invention relates to the technical field of materials, in particular to preparation of an amphiphilic tungsten disulfide nano material and application of the amphiphilic tungsten disulfide nano material in preparation of an oil displacement agent. The oil-displacing agent prepared from the amphiphilic tungsten disulfide nano material can reduce the interfacial tension of an oil-water interface, and can be quickly adsorbed to the oil-water interface to layer oil and water; the surface wettability of the rock is changed, the lipophilicity of the rock is changed into weak hydrophilicity, and the pore throat cannot be blocked due to excessive hydrophilicity while the oil phase is stripped. The nano oil-displacing agent disclosed by the invention can still have an enough stable use effect after being frozen at a low temperature and then unfrozen.

An oral suspension pharmaceutical composition is disclosed for water soluble salts of arylalkanoic acid (NSAID) drugs such as ibuprofen and naproxen. When mixed with glyceryl esters such as glyceryl caprate / caprylate and water, the resulting combination forms a “liquid scaffold” structure that reliably enables the suspension of significant quantities of said arylalkanoic acid drugs. For example, suspensions containing 25% w / w arylalkanoic acid may be obtained using the aforementioned combination. Suspensions comprising further pharmaceutically active agents, in addition to said arylalkanoic acids, may also be prepared. Also disclosed is a binary blend of glyceryl caprate / caprylate and the sodium salt of ibuprofen and a ternary blend of glyceryl caprate / caprylate and the potassium salt of ibuprofen.

The invention belongs to the technical field of organic synthesis, and particularly relates to an asymmetric phenanthroline compound as well as a preparation method and application thereof. Compared with the original symmetric ligand compound, the asymmetric phenanthroline compound provided by the invention has the advantage that the extraction performance and selectivity of americium are improved. In addition, the asymmetric phenanthroline compound provided by the invention is stable in structure, has good acid resistance and radiation resistance, can be suitable for high-acidity post-treatment waste liquid, improves the fat solubility of the phenanthroline ligand, is easy to split phases, does not need to use 2-bromohexanoic acid and other synergistic extractants, and reduces the introduction of secondary wastes in the post-treatment process.

The invention discloses a surface lipophilic modified barite weighting material as well as a preparation method and application thereof, and belongs to the technical field of drilling fluids. The surface lipophilic modified barite weighting material comprises barite and a surface modifier, and the surface modifier comprises a copolymer formed by polymerizing a monomer A, a monomer B, a monomer C and a monomer D. According to the invention, the lipophilicity of the barite is chemically modified by the surface modifier, and all monomers have a synergistic effect, so that when the grafted and modified barite weighting material is used as the weighting agent of the oil-based drilling fluid, the dispersity and the stability of particles in the oil-based drilling fluid can be improved, and the rheological property, the plugging property and the high-temperature resistance of the drilling fluid can be adjusted.

The invention relates to the technical field of packaging materials, in particular to a manufacturing method of an industrial byproduct semi-hydrated gypsum hollow plastic plate. The plastic plate is prepared from the following components in parts by weight: 60 to 70 parts of superfine modified semi-hydrated phosphogypsum powder, 28 to 35 parts of polypropylene resin, 0.5 to 1.5 parts of slipping agent, 0.5 to 1.5 parts of dispersing agent, 0.5 to 1.5 parts of antistatic agent, 0.3 to 0.8 part of antioxidant, 5 to 10 parts of calcium oxide and 3 to 6 parts of polyolefin elastomer. The gypsum powder subjected to purification, calcination and quaternary ammonium / stearic acid surface treatment has oleophylic and hydrophobic properties, and 65% high-proportion filling can be realized; the light moisture-proof plate with the density of 0.75-0.95 g / cm < 3 > and the thickness of 3-6 mm is obtained by matching with a double-screw granulation process and a single-screw hollow plate extrusion process, the use amount of resin is reduced, the mechanical property and the heat resistance are obviously superior to those of a single surface modifier, and high-value utilization of ardealite resources is realized.

The invention discloses double gel loaded with active substances as well as a preparation method and application of the double gel, and belongs to the technical field of medical dressings. The double gel is composed of a water phase and an oil phase, the water phase comprises oxidized sodium alginate and carboxymethyl chitosan, and the oil phase comprises glycerol monolaurate and camellia oil. Through the synergistic effect of a water phase and an oil phase, a stable double-gel system is formed, hydrophilic epigallocatechin gallate and lipophilic curcumin are loaded, and primary encapsulation of active substances is achieved. According to the double gel loaded with the active substance and the preparation method and application thereof, the double gel has excellent mechanical stability and gel performance, can achieve efficient delivery of the active substance, and has good biocompatibility and application prospects; effective treatment is expected to be achieved in acute burn and scald wound repair, theoretical basis and technical support are provided for application of the double gel in the fields of wound repair and medical cosmetology, and the double gel has the potential of replacing a traditional dressing and becoming a new generation of functional medical dressing.

Disclosed in the present disclosure are a bio-based organic silicon surfactant, and a preparation method therefor and the use thereof. The surfactant has the following structure: Si(CH3)3-O-[Si(CH3)2-O]a-[Si(CH3)R1-O]b-[Si(CH3)R2-O]c-Si(CH3)3. By using a comb-shaped structure with a hydrophobic siloxane as a main chain and a hydrophilic polyether as a side chain, a bio-based substance is grafted and introduced to the polyether at the side chain thereof by means of an epoxide ring-opening reaction, thereby adjusting the hydrophilicity and lipophilicity of the organic silicon surfactant to a certain extent and improving the surface activity of the organic silicon surfactant. The introduction of the bio-based substance can reduce the heat conductivity coefficient of polyurethane foam, increase the flow index of the polyurethane foam and improve the heat insulation performance and flowing performance of the foam. In addition, the synthesis of the organic silicon surfactant provides a new synthesis route for the development of a bio-based foam stabilizer; and the preparation method is simple, easily operated and suitable for industrial production.

The present invention relates to a cationic carrier and application thereof of a loadable cosmetic lipophilic active substance. The raw material of the cationic carrier includes an aqueous solution of a nonionic emulsifier, silk fibroin nanofiber and cocamidopropyl PG-dimethyl ammonium chloride phosphate, wherein the mass ratio of the nonionic emulsifier, the aqueous solution and the cocamidopropyl PG-dimethyl ammonium chloride phosphate is 1:(1.5~5):(0.7~2), and the content of β-folding in the silk fibroin nanofiber is 25%~45%. The cationic carrier provided by the present invention has a stronger lipophilic active substance loading capacity, and the cationic inclusion containing the cationic carrier has better permeability, stability and mildness simultaneously, and has broad application prospects.

The present application provides biodegradable microcapsules, based on specific poly ß-amino ester shells that can encapsulate and retain cargoes such as, lipophilic, or hydrophobic core materials comprising fragrances, butters, essential or other oils; or oil solubilized ingredients, process of making said biodegradable microcapsules and their applications in various industries. Present application further provides biodegradable shell materials that show evidence of biodegradation or non-persistence in aquatic based and / or soil or compost based environments, and which are stable on storage before use.

Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

A capacitor includes a capacitor element having a predetermined liquid preparation held between a pair of electrodes facing each other across a separator, a body case for housing the capacitor element, and a sealing member made of rubber for sealing seals the body case. A supplying portion is provided in contact with the sealing member to supply the liquid preparation held in the capacitor element to the sealing member. The liquid preparation has a lipid-soluble sealing member deterioration preventing agent dissolved in a lipophilic solvent. The sealing member deterioration preventing agent supplied by the supplying portion to the sealing member permeates the sealing member. The ratio by weight of the sealing member deterioration preventing agent in the sealing member to the sealing member is 0.1% by weight to 25% by weight.

The present invention relates to new salt forms of sabcomeline. The new salt forms are lipophilic acid salts of sabcomeline wherein the lipophilic acids used to prepare the new salts may have a Hansen solubility parameter distance from water of at least 20.7. The present invention also relates to new crystalline forms of sabocomeline salts.

The present invention is referred to a method for production of a pharmaceutical composition, said composition comprises: A) naturally secreted exosomes from normal human embryonic lung fibroblast cells (MRC-5 cell line), wherein said exosomes comprise a lipophilic and / or hydrophilic active substance, said method comprises the following steps in the following order: a) separation of exosomes by ultrafiltration, b) collection of exosomes by membrane-based affinity binding method, c) loading of exosomes with active substance, or B) artificial exosomes, wherein said exosomes comprise a lipophilic and / or hydrophilic active substance, said method is a microfluidic method and said method comprises the following steps in the following order: a) extraction of lipids from a cell line of normal human embryonic lung fibroblast cells (MRC-5 cell line) to obtain a lipid film, b) resuspending of the lipid film in an organic solvent and mixing with the aqueous phase in a microfluidics device to obtain exosomes, wherein the aqueous phase comprises Tween 20 and wherein in the microfluidics device I) the flow rate ratio of the organic phase to the flow rate of the aqueous phase (flow rate ratio, FRR) is set from 1:5 to 1:3, ii) the organic phase flow rate (OPFR) is preferably set at 200 pL / min or 400 pL / min and ill) the aqueous phase flow rate (APFR) is preferably set at 100 pL / min or 1000 pL / min, c) purification of the obtained exosomes using size exclusion chromatography, d) loading of the exosomes with active substance, e) purification of the obtained exosomes using size exclusion chromatography to remove the unloaded drug.

The invention relates to a rebamipide TBPH ion pair compound freeze-dried flash release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Comprising the following components in parts by weight: 80-90 parts of a rebamipide TBPH ion pair compound, 60-100 parts of a proppant, 8-20 parts of a stabilizer, 8-15 parts of an acidulant, 1-5 parts of a sweetening agent and 3-8 parts of a flavoring agent. The rebamipide TBPH ion pair compound has the advantages that in order to improve the solubility and bioavailability of rebamipide, the rebamipide is firstly prepared into the rebamipide TBPH ion pair compound, so that the hydrophilicity and lipophilicity of the rebamipide TBPH ion pair compound are effectively improved, the solubility of the rebamipide TBPH ion pair compound in water or lipid can be remarkably improved, and then quick release and dissolution are realized through a freeze-drying technology; the tablet can be rapidly disintegrated and dissolved in a short time, is good in molding, free of cracking and collapse phenomena, free of water during taking, convenient to take, instant to dissolve in the mouth, good in taste, free of grit feeling, free of peculiar smell, convenient to take by a patient, rapid in effect taking, capable of reducing waiting time after taking, and capable of improving the bioavailability of the tablet.

The invention relates to the technical field of daily chemicals, in particular to modified titanium dioxide for cosmetics and a preparation method of the modified titanium dioxide. The modified titanium dioxide is prepared from the following raw materials: sodium stearoyl glutamate, titanium isopropoxide triisostearate, silica and titanium dioxide; the mass ratio of the sodium stearoyl glutamate to the titanium isopropoxide triisostearate to the silica to the titanium dioxide is (2-4): (0.2-1): (1-3): (93-97). Through synergistic modification of sodium acyl glutamate and titanium isopropoxide triisostearate, the surface of titanium dioxide has hydrophilicity and lipophilicity at the same time, and the titanium dioxide is endowed with excellent interface wettability. The modified titanium dioxide can show good dispersibility and stability in a wax-based makeup ointment system, a silicone oil system, a synthetic ester grease system and an oil-in-water (O / W) system, and is not limited by the polarity of an oil phase, the compatibility and adaptation range of a formula are remarkably improved, and the titanium dioxide treated by the method effectively resists the problem of darkness.

The object of this invention is a lipophilic activity modifier in the form of dimethyl sulfone (MSM) for use as a transdermal penetration enhancer for high molecular weight active substances with a molecular weight (Mw) > 500 Da. Another object of this invention is a cosmetic composition for transdermal application comprising an active substance and a transdermal penetration enhancer, characterized in that the active substance is encapsulated by the transdermal penetration enhancer, which is the lipophilic activity modifier according to claim 1, and the active substance is a high molecular weight active substance with a molecular weight (Mw) > 500 Da. Another object of the present invention is a method for preparing a composition according to the invention, characterized in that the method is carried out by thermal emulsification or cold emulsification, wherein thermal emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel; b) bringing the mixture to 70-85°C; c) stirring the mixture at 70-85°C; the start of homogenization depends on the stage of phase combination; d) cooling the mixture to 20-40°C, preferably 30°C; e) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min; while cold emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel and dissolving at a temperature maintained at 20-25°C; b) bringing the mixture to a temperature of 15-35°C, preferably ambient temperature or 25°C; c) stirring the mixture at a temperature of 15-80°C, preferably 25°C; the start of homogenization depends on the stage of phase combination; d) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min.

A topical neurocosmetic composition comprising a first component including one or more of bakuchiol, allantoin, squalane, or Morinda citrifolia extract; a second component including one or more of hyaluronic acid, vitamin E, Zanthoxylum alatum fruit extract, Coriandrum sativum seed oil, Vitex agnus-castus extract, Helianthus annuus sprout extract, niacinamide, resveratrol, or an ascorbyl ester; and a cosmetically acceptable oil-in-water vehicle configured to deliver both lipophilic and hydrophilic actives through the skin to dermal neurons. The composition improves measurable skin parameters such as hydration and elasticity and supports psychophysiological comfort. Methods of manufacture and use are also described

A lipophilic derivative of an aminopolycarboxylic acid may be used as an extractant to extract at least one rare earth from an acidic aqueous solution. Such a lipophilic derivative may be applied to the production of rare earths from concentrates derived from urban ores and, in particular, from concentrates from waste electrical and electronic equipment such as used or discarded NdFeB permanent magnets. Such a lipophilic derivative may be used in producing rare earths from concentrates derived from natural ores or from concentrates derived from residues of natural ores.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

The invention discloses a solution immersion type fingerprint detection method based on AIEgens, which comprises the step of carrying out immersion type fluorescent fingerprint detection based on the aggregation-induced emission effect of an organic fluorescent compound TPP-APBP-P. TPP is used as a luminous substrate, a long chain is connected to the luminous substrate to improve the lipophilicity of the luminous substrate, TPP-APBP-P is obtained, meanwhile, the PH of a solution is adjusted to improve the hydrophilicity of the luminous substrate, and finally the detection effect of the luminous substrate on potential fingerprints is improved; the fingerprint detector has very excellent detection effects on fingerprints in a high-temperature environment and aged fingerprints, and has high contrast, high sensitivity and high precision on fingerprint development.

COMPOSITION COMPRISING INORGANIC UV FILTERS The present invention relates to a composition comprising: (a) at least one first inorganic UV filter selected from hydrophilic inorganic UV filters; and (b) at least one second inorganic UV filter selected from (b1) amphiphilic inorganic UV filters, (b2) lipophilic inorganic UV filters, and mixtures thereof, the weight ratio of the quantity of (a) first inorganic UV filter(s) / the quantity of (b1) amphiphilic inorganic UV filter(s) in the composition being from 10:1 to 1:10, and the weight ratio of the quantity of (a) first inorganic UV filter(s) / the quantity of (b2) lipophilic inorganic UV filter(s) in the composition being from 10:1 to 1:8.The composition according to the present invention can offer at least an acceptable user experience, preferably in terms of a pulling sensation, a sticky sensation, a fresh sensation and a greasy sensation. Figure for the abstract: none.

The invention discloses a liquid-liquid coalescence filter element material for oil dehydration, which takes glass fiber paper as a substrate and is coated with the following modified materials in percentage by mass: 1 to 5 percent of nano silicon dioxide, 2 to 10 percent of gamma-aminopropyltriethoxysilane, 2 to 10 percent of octadecyltriethoxysilane and the balance of absolute ethyl alcohol. The water contact angle of the liquid-liquid coalescence filter element material is larger than 150 degrees, and the oil contact angle is smaller than 10 degrees; the invention also discloses a preparation method which comprises the following steps: uniformly mixing the raw materials to form a modified solution, spraying the modified solution on the surface of the cured glass fiber paper, and drying to obtain the liquid-liquid coalescence filter element material. According to the invention, the nano silicon dioxide is modified by gamma-aminopropyltriethoxysilane and octadecyltriethoxysilane, so that the super-hydrophobicity and super-lipophilicity of the glass fiber paper are improved; the prepared liquid-liquid coalescence filter element material is uniform and firm in coating adhesion and suitable for the fields of oil product production, storage, transportation and the like.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

The present disclosure relates to compositions of microemulsion formulations for the delivery of lipophilic pharmacologically active agents or combinations of lipophilic pharmacologically active agents. The microemulsion formulations may be supplied as soft gel capsules for oral delivery or as solutions suitable for intravenous administration. The compositions find use in reducing inflammation and / or pain.

The present invention relates to a cosmetic composition in the form of a water-in-oil (W / O) emulsion, comprising a continuous fatty phase comprising at least one hydrocarbon oil with a refractive index greater than equal to 1.4, an aqueous phase dispersed in the continuous fatty phase, at least one emulsifying surfactant with an HLB less than or equal to 8, at least one lipophilic filmforming polymer, at least one ester-terminated polyester polyamide, and at least one coloring material.

A photoluminescent nanocomposite material according to one aspect of the present invention includes a carrier matrix, a plurality of photoluminescence nanostructures distributed in the carrier matrix, and an additive including one or more coordination complexes having thiol and lipophilic properties.

A method for selectively removing sodium or potassium from an alkaline lithium-containing aqueous solution, the method comprising: (i) contacting the alkaline lithium-containing aqueous solution with a hydrophobic solution comprising: (a) an aqueous-insoluble hydrophobic solvent, (b) a protic ionic liquid of the formula X-Y+, wherein X- is a conjugate base of a superacid and Y+ is a protonated cation, and (c) at least one of lipophilic sodium-selective and potassium-selective complexing ligands, wherein the contacting step results in selective complexation with and removal of sodium and / or potassium ions from the lithium-containing aqueous solution into the hydrophobic solution along with simultaneous abstraction of a proton from Y+ to form Y; and (ii) separating the aqueous solution from the hydrophobic solution, wherein, in some embodiments, X- is a bis(sulfonyl)imide and Y+ is a protic ammonium species. The method may further include stripping sodium and potassium ions from the hydrophobic solution and regenerating Y+.

The application discloses a preparation method of soybean oil body with antioxidant effect, and relates to the field of food processing and storage. The inner core of natural soybean oil body is hydrophobic triglyceride, which is lipophilic, and the outer part is covered by a phospholipid-oil body protein film, which is hydrophilic. The application utilizes the structural characteristics of natural soybean oil body with amphiphilicity, couples small-molecule compounds with antioxidant effect with soybean oil body protein, and wraps the antioxidant active substances into the inner part of the soybean oil body to prepare soybean oil body composite particles with antioxidant effect. The application improves the antioxidant capacity and storage stability of the soybean oil body.

The present invention relates to a solid composition comprising a lipophilic drug (such as a cannabinoid or Vitamin E) and a cyclodextrin wherein the lipophilic drug and the cyclodextrin are in the form of a combined complexation, and the lipophilic drug and the cyclodextrin in the combined complexation are either at a molar ratio of about 1:2; and methods of obtaining the same.