Compositions and methods for skin care

a skin care and composition technology, applied in the field of biomedical compositions and methods for treating diseases, disorders and conditions affecting skin, can solve the problems of physiologically untargeted compounds that generally exhibit poor bioavailability, affect the structural integrity of skin, and affect the appearance of skin, etc., to achieve the effect of enhancing skin elasticity, reducing skin aging, and reducing skin aging

Inactive Publication Date: 2009-10-15
ANTIPODEAN PHARMA
View PDF16 Cites 77 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Degradation of dermal extracellular matrix, which is composed primarily of type I collagen, impairs the structural integrity of the skin, and is largely responsible for the thin, wrinkled appearance of aged and photoaged skin.
Unfortunately, these homeostatic defenses, although highly effective, have limited capacity and can be overwhelmed, thereby leading to increased ROS in the skin that can foster the development of dermatological diseases.
CoQ10, however, is a physiologically untargeted compound that generally exhibits poor bioavailability, at least in part due to its high degree of hydrophobicity, making it difficult to achieve protective levels of CoQ10 antioxidant activity at sites of oxidative damage.
As an untargeted antioxidant, however, idebenone lacks the ability to deliver high local concentrations of antioxidant activity to tissue, cellular and subcellular sites where oxidative damage may be occurring.
Highly reactive free radicals that have the potential for damaging cells and tissues may result from altered or defective mitochondrial activity, including but not limited to failure at any step of the ETC.
These free radicals may include reactive oxygen species (ROS) such as superoxide, peroxynitrite and hydroxyl radicals, and potentially other reactive species that may be toxic to cells.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for skin care
  • Compositions and methods for skin care
  • Compositions and methods for skin care

Examples

Experimental program
Comparison scheme
Effect test

example 1

Topical Antioxidant Formulation

[0127]The indicated components are combined to prepare a topical antioxidant formulation cream for treating skin conditions that result from ROS production in the skin.

TABLE 1Topical formulation: MitoQuinol-C10-methanesulfonate(0.05% w / v) CreamQuantityComponent(g / mL)Utility[10-(4,5-dimethoxy-2-methyl-0.0025Active Antioxidant3,6-dioxo-1,4-cyclohexadien-compound,1-yl)decyl]mitochondriallytriphenylphosphoniumtargetedmethanesulfonateParaffin oil light0.159VehiclePolysorbate 600.024EmulsifierLanolin liquid0.006EmulsifierSorbitan monostearate0.016EmulsifierCetyl alcohol 95%0.004EmulsifierStearyl alcohol0.03ThickenerGlycerol monostearate0.03ThickenerGlycerine0.05SolventBenzyl alcohol0.03PreservativeWaterQS to 1 mlSolvent

TABLE 2Topical formulation: MitoQuinol-C10-methanesulfonate(0.05% w / v) CreamIngredientQuantity[10-(4,5-dimethoxy-2-methyl-3,6-0.0025 g / ml dioxo-1,4-cyclohexadien-1-yl)decyl] triphenylphosphoniummethanesulfonate with β-Cyclodextrin (20% w / wMito...

example 2

MitoQ10 Mesylate Suppresses ROS And Collagenase Production by Human Skin Fibroblasts in an In Vitro Skin Aging Model

[0128]In photoaged human skin in vivo, skin wrinkling was accompanied by elevated collagenase levels that stimulated collagen fragmentation and ROS production. This Example describes an in vitro model of skin collagen fragmentation that was created and tested for the effects of antioxidant compounds. Materials and methods for preparing three-dimensional extracellular matrix (ECM) collagen lattices, for culturing skin fibroblasts and keratinocytes thereupon, and for treating such matrices with, and characterizing the effects on them of, matrix metalloproteinases (MMPs) have been described (see, e.g., Pilcher et al., 1997 J. Cell Biol. 137:1445; Hotary et al., 2000 J. Cell Biol. 149:1309; Netzel-Arnett et al., 2002 J. Biol. Chem. 277:45154; Fisher et al., 2002 Arch Dermatol. 138:1462; Kang et al., 2003 J. Invest. Dermatol. 120:835; Xu et al., 2006 Am J Pathol. 169:823; X...

example 3

MitoQ10 Mesylate Suppresses UV Irradiation-Induced Activation Of ERK in Human Keratinocytes

[0131]Ultraviolet (UV) irradiation causes skin photoaging and has been reported to activate mitogen-activated protein (MAP) kinase signal transduction pathways. (Fisher et al., 1998 J. Clin. Invest. 101:1432; Kang et al., 2003 J. Invest. Dermatol. 120:835). The mechanism of UV activation of the epidermal growth factor receptor (EGFR) in such pathways remains unknown, although a role for ROS has been implicated (Xu et al., 2006 Am. J. Pathol. 169:823; Xu et al., 2006 J. Biol. Chem. 281:27389). This Example describes an in vitro model of UV-induced signal transduction in human keratinocytes. Publications describing exemplary materials and methods that were adapted to perform these experiments include e.g., Pilcher et al., 1997 J. Cell Biol. 137:1445; Hotary et al., 2000 J. Cell Biol. 149:1309; Netzel-Arnett et al., 2002 J. Biol. Chem. 277:45154; Fisher et al., 2002 Arch Dermatol. 138:1462; Kang ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 61 / 041,551 filed Apr. 1, 2008; which provisional application is incorporated herein by reference in its entirety.BACKGROUND[0002]1. Technical Field[0003]The present invention relates generally to biomedical compositions and methods for treating diseases, disorders and conditions affecting skin. In particular, the present invention provides compositions and methods for treating skin conditions that result from reactive oxygen species production in human skin, such as photoaging and other age-related skin damage, by highly effective delivery of antioxidants to skin fibroblasts and keratinocytes, including delivery to mitochondria in these cell types.[0004]2. Description of the Related Art[0005]In higher vertebrates including mammals and particularly in humans, skin is the largest body organ and serves as an important environmental interfac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/66A61K31/355A61P17/02
CPCA61K8/55A61K31/203A61Q19/08A61K2800/522A61K45/06A61K31/66A61K31/385A61K31/355A61K31/375A61K2300/00A61P17/00A61P17/02A61P17/04A61P17/06A61P17/08A61P17/10A61P17/18A61P31/04A61P31/10A61P31/12A61P33/00A61P35/00A61K47/40
Inventor MURPHY, MICHAEL PATRICKSMITH, ROBIN A.J.TAYLOR, KENNETH MARTIN
Owner ANTIPODEAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap