9 results about "Polymer interaction" patented technology

The invention provides a nanocrystalline composite oral ulcer film agent as well as a preparation method and application thereof. The nanocrystalline composite oral ulcer film agent comprises a waterproof backing layer and a drug-loading adhesion layer coated on the waterproof backing layer, the drug-loaded adhesion layer comprises a macromolecular hydrogen bond compound formed by a weakly acidic polymer and a nonionic proton receptor polymer, and a nanocrystalline drug. Compared with the prior art, the preparation method has the advantages that the polyacrylic acid polymer and the nonionic cellulose polymer interact to form IPC serving as an adhesion layer film-forming material, the nanocrystals are loaded into the adhesion layer film-forming material, the waterproof backing layer is coated with the adhesion layer film-forming material, and the oral ulcer film agent is prepared after drying and cutting. The obtained film agent has good comfort and adhesive power, shows good drug stability and permeation promotion performance, can be used as a carrier of an oral administration route, prolongs the drug action time and improves the curative effect. The preparation method of the film agent is simple and easy for industrial mass production.

Mechanically and piezoelectrically anisotropic polymer fibers may be formed by spinning a polymer solution or gel that includes a high molecular weight crystallizable polymer and a liquid solvent. The solvent may be configured to interact with the polymer to facilitate chain alignment and, in some examples, create a higher crystalline content within the spun fibers. The polymer solution may also include a low molecular weight additive. The high and low molecular weight polymers may each be characterized by a bimodal molecular weight distribution where the molecular weight of the additive is less than the molecular weight of the crystallizable polymer. The polymer(s) and the additive(s) may be independently selected from vinylidene fluoride, trifluoroethylene, chlorotrifluoroethylene, hexafluoropropene, vinyl fluoride, etc. The spun fibers may be oriented, annealed, poled, and woven or laminated to form a polymer thin film having a high elastic modulus and a high electromechanical coupling factor.

An optically anisotropic polymer thin film includes a crystallizable polymer and an additive configured to interact with the polymer (e.g., via π-π interactions) to facilitate chain alignment and, in some examples, create a higher crystalline content within the polymer thin film. The polymer thin film may be characterized by a bimodal molecular weight distribution where the molecular weight of the additive may be less than approximately 50% of the molecular weight of the crystallizable polymer. Example crystallizable polymers include polyethylene naphthalate, polyethylene terephthalate, polybutylene naphthalate, polybutylene terephthalate, as well as derivatives thereof. Example additives, which may occupy up to approximately 10 wt. % of the polymer thin film, include aromatic ester oligomers, aromatic amide oligomers, and polycyclic aromatic hydrocarbons, for example. The optically anisotropic polymer thin film may be characterized by a refractive index greater than approximately 1.7 and an in-plane birefringence greater than approximately 0.2.

The invention relates to a gas separation polymer composite membrane with high pressure resistance as well as a preparation method and application thereof. The method comprises the following steps: dissolving a crystalline polymer in a good solvent, uniformly coating the polymer solution on the surface of a flat substrate, immersing the flat substrate in an ionic liquid with weak interaction with the polymer, and carrying out solvent exchange treatment at a constant temperature. The polymer / ionic liquid composite membrane prepared by the method is used for gas separation. According to the gas separation polymer composite membrane, the high ionic liquid content is maintained, and meanwhile the high mechanical performance of the composite membrane is maintained. The ionic liquid can stably exist in a polymer matrix to improve the continuity of a gas transmission path, and meanwhile, the ionic liquid which weakly interacts with a macromolecular chain can effectively promote a polymer molecular chain to form a microcrystalline structure in the exchange process, so that the mechanical property of the composite membrane in the gas separation process is greatly improved, and the gas separation efficiency is improved. And during gas separation, high pressure resistance, high permeability and high selectivity are shown. The method is simple in process, convenient to operate and mild in condition.

The present application relates to a method and system for detecting macromolecules in water. The present application utilizes the interaction between particles and polymers under flow conditions, especially the high sensitivity of particle retention to macromolecular substances, to detect macromolecular information in water through the retention of particles at microchannel obstacles. The detection method of the present application has high sensitivity, short time consumption, low cost and small implementation difficulty compared with conventional chromatographic methods. In addition, due to the specificity of particle-polymer interaction, it is not easily disturbed by other small molecular substances compared with TOC, UV254, COD and other methods, and has high specificity.

A mixed matrix membrane for molecular separation includes a plurality of metal organic framework (MOF) nanosheets, the MOF comprising a square grid pillared by an inorganic building block, the square grid being Ni(pyrazine)2 and the inorganic building block selected from [NbOF5]2−, [AlF5(H2O)]2−, [FeF5(H2O)]2− and [GaF5(H2O]2−. The mixed matrix membrane further includes a polymer matrix, and the plurality of MOF nanosheets are incorporated into the polymer matrix to form a mixed matrix metal organic framework (MMMOF) membrane. The nanosheets have a high aspect ratio and when incorporated into the polymer matrix, the nanosheets are in-plane aligned with one another such that 1D channels of the nanosheets are parallel for enhancing gas diffusion. The MMMOF membrane has high nanosheet loading and strong nanosheet-polymer interaction, resulting in high separation performance.

The present invention relates to a method for removal of solid particles suspended in an aqueous medium. The method comprises adding to the aqueous medium a cationic biopolymer selected from cationic linear α-(1,3-glucan) polymers, cationic branched α-(1,3-glucan) polymers, and any of their mixtures. The solid particles suspended in the aqueous medium are allowed to interact with the cationic biopolymer to form agglomerates, and the agglomerates are separated from the aqueous medium.

Provided is a toroidal mixed nanoparticle including a first polymer and a second polymer interacting with the first polymer. Also provided is a method for preparing the toroidal mixed nanoparticle, including mixing the first polymer and the second polymer having cleavable hydrophobic groups to form a mixed nanoparticle; and removing a portion of cleavable hydrophobic groups from the second polymer to make the second polymer charged and to form the toroidal mixed nanoparticle. Further provided is a method for delivering a drug or a bioactive agent to a subject in need thereof, including administering to the subject a pharmaceutical composition that includes the toroidal mixed nanoparticle conjugated to an effective amount of the drug or the bioactive agent, and a pharmaceutically acceptable excipient thereof.

This invention discloses a method for preparing defect-free zeolite molecular sieve-based mixed matrix membranes via low-temperature crosslinking, belonging to the field of gas separation membrane preparation technology. The invention first prepares a zeolite precursor using a silicon source, a template agent, and water as raw materials. Then, it modifies the template agent-containing zeolite precursor with carboxylic acid to obtain a template-free zeolite precursor. This template-free zeolite precursor is then used as an inorganic filler to prepare a mixed matrix membrane. The layered zeolite precursor has a richer number of hydroxyl groups on its surface than conventional zeolites, facilitating its bonding with polymers. These hydroxyl groups interact with the polymer during the low-temperature heating-initiated crosslinking reaction, effectively solving the compatibility problem between the filler and the polymer, resulting in a high-performance, defect-free zeolite molecular sieve-based mixed matrix membrane.