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Application of composition in preparation of medicine for treating diabetic gastroparesis

A composition and drug technology, applied in the field of medicine, can solve the undisclosed problems such as the application of Huanghou Zhixie dripping pills

Active Publication Date: 2022-03-18
安徽雷允上药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The application of Huanghou Zhixie Dropping Pills in the treatment of diabetic gastroparesis has not been disclosed in the prior art

Method used

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  • Application of composition in preparation of medicine for treating diabetic gastroparesis
  • Application of composition in preparation of medicine for treating diabetic gastroparesis
  • Application of composition in preparation of medicine for treating diabetic gastroparesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Huanghou Zhixie Dropping Pills Treating Drug Effects of Diabetic Gastroparesis (DGP) Rats

[0030] (1) Construction of DGP rat model

[0031] 100 5-6 week-old clean healthy male SD rats (provided by Shanghai Jihui Experimental Animal Breeding Co., Ltd., license number SCXK (Shanghai) 2017-0012), were raised in Suzhou Xishan Zhongke Pharmaceutical Research and Development Co., Ltd., After 1 week of adaptive feeding, 10 rats were randomly selected as blank control rats, and the rest were model rats; after all rats were fasted for 12 hours, 10 blank control rats were intraperitoneally injected with 0.1mol / L citric acid buffer ( pH=4.5), the model rats were injected intraperitoneally with 1% streptozotocin (STZ, dissolved in the above-mentioned citric acid buffer), and the dosage was 60mg / kg; the tail vein blood sampling of the model rats after 72h measured the blood glucose value, and screening Rats with blood glucose ≥ 16.7mmol / L. Qualified rats use high-fat a...

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Abstract

The invention provides application of a composition in preparation of a medicine for treating diabetic gastroparesis. The composition comprises coptis chinensis, mangnolia officinalis, radix aucklandiae and rhizoma zingiberis. The composition can be prepared into anti-diarrheal dropping pills for application. For a DGP rat model, the curative effect of single use of the Huang-Thick antidiarrheal dropping pill is obviously superior to that of dry ginger, scutellaria baicalensis, coptis chinensis and ginseng soup, and is not inferior to that of single use of mosapride; and the improvement degree of the combination of the yellow and thick mosapride on the model animal is obviously higher than that of the combination of the berberine hydrochloride and the mosapride.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a composition in the preparation of medicines for treating diabetic gastroparesis. Background technique [0002] Gastroparesis is a chronic disorder in which solid-liquid gastric emptying is delayed but not obstructed. The diagnostic criteria are: (1) presence of gastroparesis symptoms such as postprandial abdominal distention, nausea, vomiting, and epigastric pain; (2) exclusion of pyloric organs. Outlet obstruction caused by qualitative lesions; (3) Delayed gastric emptying confirmed. Diabetic gastroparesis (DGP) is a common complication of diabetes, characterized by decreased gastric motility, delayed gastric emptying, and gastric rhythm disturbance. [0003] Studies have shown that controlling blood sugar can reduce the degree of gastroparesis, and gastroparesis prolongs gastric emptying time, which leads to blood sugar fluctuations, and the two influen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K31/5375A61P1/00A61P1/14
CPCA61K36/718A61K36/575A61K36/285A61K36/9068A61P1/00A61P1/14A61K31/5375A61K2300/00
Inventor 夏扬胡洋叶潘耀宗王恒斌张邦国
Owner 安徽雷允上药业有限公司
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