107 results about "Berberine hydrochloride" patented technology

The invention discloses a nano-drug material based on self-assembly of berberine and caffeic acid and a preparation method of the nano-drug material. The preparation method comprises the following steps: respectively dissolving berberine and caffeic acid in an organic solvent to prepare a berberine-organic solvent solution and a caffeic acid-organic solvent solution; adjusting the pH value of the caffeic acid-organic solvent solution to 7.0-7.5; adding the caffeic acid-organic solvent solution while stirring the berberine-organic solvent solution, uniformly mixing, adding the mixed solution into deionized water with the preheating temperature of 30-70 DEG C, and stirring at a constant temperature, so that the berberine and the caffeic acid are self-assembled to obtain a mixed solution; dialyzing the mixed solution to obtain a berberine and caffeic acid self-assembled solution; and performing vacuum freeze drying to obtain a target product. The nano-drug material disclosed by the invention is small in particle size, better in solubility and dissolution rate in different pH environments than berberine hydrochloride and caffeic acid eutectic, good in stability in an aqueous solution and environment-friendly in method.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

The invention discloses a synthetic method of photosensitive composite hydrogel and application of the photosensitive composite hydrogel in treatment of periodontitis. The composition expression of the photosensitive composite hydrogel is MHA-B-coated Lipo, and the photosensitive composite hydrogel is prepared by the following steps: entrapping berberine hydrochloride by lipidosome with proton gradient, and then mixing with methacrylated hyaluronic acid, a photoinitiator and a cross-linking agent; according to the liposome with the proton gradient, a citric acid buffer solution is adopted for preparing blank liposome, and then alkali liquor is used for adjusting the pH value of an external phase to be alkalescent, so that the transmembrane gradient is formed. The liposome is used as a drug delivery carrier, berberine is entrapped in the liposome and is combined with the MHA hydrogel to form a composite sustained-release drug, and the composite sustained-release drug has the advantages of strong targeting property, good responsiveness, good biocompatibility and high biological safety; and the hydrogel has injectable and photosensitive cross-linking characteristics, is suitable for clinical minimally invasive operation, has the advantages of accurate immune regulation and control, and has a wide application prospect.

The invention discloses a quality detection method of a gout clearing mixture for treating hyperuricemia, which adopts a separation analysis technology of ultra-high performance liquid chromatography to detect eight chemical components in the gout clearing mixture. Comprising the following components: 3-O-feruloylquinic acid, 5-O-caffeoylshikimic acid, paeoniflorin, polydatin, neoastilbin, astilbin, berberine hydrochloride and emodin-8-beta-D-glucopyranoside. According to the method, eight chemical components of six active components in the gout clearing mixture are quantitatively analyzed at the same time, and the method has the advantages of being easy and convenient to operate, good in stability and easy to popularize. The invention can provide a comprehensive and reliable quality control basis for the gout clearing mixture, and has important significance for ensuring the clinical curative effect of the gout clearing mixture.

The invention discloses construction and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum for integrally controlling a multi-component material basis of a traumatic injury bone-growing capsule, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and neochlorogenic acid, protocatechuic aldehyde, cryptochlorogenic acid, vanillic acid, rosmarinic acid, alkannic acid, berberine hydrochloride and salvianolic acid B are taken as reference substances; the fingerprint spectrum is successfully constructed by detecting different batches of traumatic injury bone-growing capsules. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least eight components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be carried out on a plurality of characteristic components of the traumatic injury bone-growing capsule accurately, rapidly and simultaneously, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the traumatic injury bone-growing capsule.

1. Name of the Design Product: Packaging Box (Compound Berberine Hydrochloride Tablets). 2. Use of the Design Product: For product packaging. 3. Design Key Points of the Design Product: The combination of shape and pattern. 4. Picture or Photograph that Best Illustrates the Design Key Points: Front View.

The invention discloses an intestinal microneedle anastomosis stent with an antibacterial function and a preparation method and application thereof, which can effectively and physically isolate an anastomotic stoma from intestinal contents and provide a relatively clean local environment for healing of the anastomotic stoma. The microneedle anastomotic stent is fixed at the anastomotic stoma, so that the tension at the anastomotic stoma can be further reduced, and the occurrence of anastomotic stoma leakage caused by overlarge tension is avoided; the microneedle layer on the surface of the stent can realize in-situ long-acting slow release of berberine hydrochloride (BBH) on the superficial layer of an anastomotic stoma, so that the drug utilization rate of the BBH is improved, the initial inflammation of the anastomotic stoma can be effectively reduced, and the anastomotic stoma can be regulated and controlled to be better healed. Animal experiment results prove that the implantation of the microneedle anastomosis stent can effectively reduce inflammatory cell infiltration of local tissues, reduce anastomotic stoma arrangement and regulate the anastomotic stoma to heal smoothly.

This invention belongs to the field of pharmaceutical technology, specifically relating to biomimetic nanomedicines for treating subcutaneous drug-resistant bacterial infections, their preparation methods, and applications. In this invention, dopamine hydrochloride is added during the synthesis of a metal-organic framework to prepare a dandelion-shaped carbon nanozyme precursor. This precursor is then carbonized to obtain a carbon nanozyme with targeting, photoresponsiveness, and peroxidase activity. Finally, berberine hydrochloride is loaded onto the carbon nanozyme to obtain the biomimetic nanomedicine. The biomimetic nanomedicine provided by this invention firstly possesses good biocompatibility; secondly, it has a unique dandelion-like morphology, which is beneficial for its targeting effect; and finally, it exhibits strong photoresponsiveness in the near-infrared region, enabling synergistic and efficient bactericidal action through the mechanisms of antibacterial drugs, photothermal therapy, and chemokinetics. It has significant application value in the preparation of drugs for treating subcutaneous drug-resistant bacterial infections.

1. The name of the design product: medicine box (small child berberine hydrochloride anhydrous swallow granules). 2. The use of the design product: for packaging. 3. The design points of the design product: the combination of patterns and colors. 4. The picture or photo that best indicates the design points: design 1 perspective view 1. 5. The design protected contains colors. 6. Design 1 is designated as the basic design.

This invention discloses a topical traditional Chinese medicine composition for relieving pain and its preparation method, belonging to the field of traditional Chinese medicine preparation technology. The topical traditional Chinese medicine composition for relieving pain is made from the following raw materials in parts by weight: Angelica sinensis 5-25 parts, Ligusticum striatum 5-20 parts, Lycopodium clavatum 10-35 parts, Artemisia argyi 5-25 parts, artificial Phellodendron chinense 3-18 parts, Clematis chinensis 10-40 parts, and Angelica dahurica 5-20 parts. This invention uses steam distillation to extract volatile oils and a dual-solvent gradient extraction method with the residue, which not only fully extracts the volatile fat-soluble components from Angelica sinensis, Ligusticum striatum, and Angelica dahurica, but also efficiently extracts the water-soluble components from artificial Phellodendron chinense, Lycopodium clavatum, and other medicinal materials. Experimental results show that the extraction rates of ferulic acid, ligustilide, imperatorin, and berberine hydrochloride in Example 1 of this invention reached 89.23%, 92.56%, 90.12%, and 93.45%, respectively, which are 110.7%, 223.1%, 75.8%, and 23.6% higher than those of conventional water decoction process, thus improving the utilization rate of raw materials.

The present invention provides a method for producing berberine, palmatine and jatrorrhizine hydrochloride based on Fibraurea recisa Pierre; the present invention uses specific Fibraurea recisa Pierre as raw material, after crushing, warming extraction with dilute acid, temperature-controlled filtration for clarification and membrane separation, berberine hydrochloride is separated by crystallization and recrystallization: then the crystallization mother liquor is subjected to fractional crystallization and recrystallization to separate palmatine hydrochloride; finally, jatrorrhizine hydrochloride is separated by the combined use of ion exchange resin and macroporous adsorption resin chromatography. The present invention continuously produces three high-value-added alkaloid monomers based on Fibraurea recisa Pierre containing berberine, palmatine and jatrorrhizine, all of which are heterocyclic compounds; the present invention can also solve the problems of environmental pollution by salt wastewater, alkaline browning, difficult regeneration caused by resin staining during the production process, and improve the purity of alkaloid monomers, forming a production system that can be applied industrially.

The embodiment of the invention discloses hydrogel based on self-assembled nanoparticles as well as a preparation method and application of the hydrogel. On the basis of a supramolecular self-assembly technology of the Sanhuang heart-purging decoction, the active components including berberine hydrochloride, baicalin and tannic acid are assembled into nanoparticles and prepared into the hydrogel, the preparation is simple in effective components, the residence time of the effective components in the stomach can be prolonged, the effective components can play a therapeutic effect on the surface of gastric ulcer for a long time, and the curative effect is good. The component homogeneity and the preparation stability are remarkably improved while the synergistic efficacy of the compound is reserved.

In order to improve the absorption efficiency of skin to mask liquid, the mask capable of achieving deep transdermal absorption is designed, the method for preparing the mask capable of achieving deep transdermal absorption according to the absorption efficiency factor of mask materials can achieve the purpose that traditional Chinese medicine paste is screened through transdermal agents, and the purpose of deep transdermal absorption is achieved. By adopting more than 20 materials such as propylene glycol, azone, gelatin gel, polypropylene glycol, asiaticosine, menthol, berberine hydrochloride, sodium alginate and the like, the prepared permeation and absorption mask has relatively strong effects of promoting skin permeation and absorption, healing wounds, resisting allergy and resisting inflammation.

The invention discloses a quantitative fingerprint spectrum analysis method for components in Da Yin-tonifying pills, and belongs to the field of quality control research of traditional Chinese medicines. The method comprises the following steps: preparing a reference solution and a test solution; injecting into a liquid chromatography for analysis and determination, selecting a Silversil C18 chromatographic column, carrying out gradient elution at the column temperature of 29.5-30.5 DEG C and the detection wavelength of 290 nm; and recording the chromatograms of the test solutions and the reference solutions of the Da Yin-tonifying pills in multiple batches, determining common peaks and quantitative detection indexes, and evaluating the quality of the Da Yin-tonifying pills according to the fingerprint similarity and the content of each component. The method can be used for determining 5-hydroxymethylfurfural, 3-O-feruloylquinic acid, neomangiferin and berberine hydrochloride in the Da Yin-tonifying pills, and has a wide application prospect in the field of quality control of the Da Yin-tonifying pills.

The invention provides a method for identifying and detecting a phlegm stasis and arthralgia dredging prescription. The method comprises three modules of construction of a characteristic chromatogram of a medicinal material and optional thin-layer chromatography identification and effective component content determination. The construction of the characteristic spectrum adopts a diethyl ether-ethyl acetate two-stage segmented extraction UPLC analysis strategy, so that the interference of complex components is overcome, and the overall chemical characteristics of the compound can be comprehensively represented; thin-layer chromatography identification provides a specific identification method for medicines such as coptis chinensis, curcuma wenyujin and vinegar-processed rhizoma corydalis; and the content determination adopts a high performance liquid chromatography to detect the effective components chlorogenic acid, salvianolic acid B, glycyrrhizic acid and berberine hydrochloride. According to the invention, a multi-dimensional and configurable quality control system is constructed, the comprehensive quality control of the phlegm stasis and arthralgia dredging prescription from qualitative and overall characterization to quantitative analysis is realized, the specificity is strong, and the result is reliable.

The invention discloses a pH sensitive berberine hydrochloride solid dispersion which comprises berberine hydrochloride, a pH sensitive polymer and a plasticizer, the mass ratio of the berberine hydrochloride to the pH sensitive polymer is 1: (1-9), and the pH sensitive polymer is dissolved in a solution with the pH larger than 5.5. The pH-sensitive polymer is used as a carrier material of berberine hydrochloride, the dissolution of berberine hydrochloride in gastric juice can be inhibited by forming a charge-assisted hydrogen bond between the pH-sensitive polymer and berberine hydrochloride, and the pH-sensitive polymer can be quickly dissolved in a solution with the pH being greater than 5.5, so that quick release in intestinal tracts can be realized; therefore, the absorption of the medicine in the intestinal tract is improved, and the bioavailability is further improved. Meanwhile, the flavoring agent is also added, the bitter taste is mixed through competition between the sour taste of the flavoring agent and a bitter taste receptor, the pH of oral saliva is adjusted, the dissolution of berberine hydrochloride in the oral cavity is further inhibited, and a good taste masking effect is achieved.

This invention discloses the application of plant extracts in the preparation of drugs that inhibit canine parvovirus, belonging to the field of biomedical technology. The plant extract is at least one selected from phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin. Through in-depth research on various plant extracts, this invention has found that phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin all exhibit significant inhibitory effects on canine parvovirus, with soy isoflavones showing particularly outstanding effects. This research provides a novel natural drug option for the prevention and treatment of canine parvovirus. This invention not only expands the application scope of natural plant extracts in the veterinary medicine field but also provides important technical support for the development of novel, highly effective, safe, and side-effect-free drug formulations for the prevention and treatment of canine parvovirus.

The application belongs to the field of organic chemistry and particularly relates to a synthesis method of berberine hydrochloride. The method comprises the following steps: taking 3,4-dimethoxyphenethylamine hydrochloride and 3,4-methylenedioxybenzaldehyde as starting materials, sequentially undergoing oxidative cyclization, selective reduction and quaternary ammonium ring closure through three-step reactions, and finally directly obtaining the target product berberine hydrochloride through acid treatment. The technical scheme has the characteristics of high efficiency, simplicity, and high industrial cost ratio in the synthesis of berberine hydrochloride, the overall reaction is more green and safe, the reaction condition is more mild, the reaction process has high selectivity, and the berberine hydrochloride product with higher purity can be obtained.

The application discloses a co-crystal of berberine hydrochloride and m-hydroxybenzoic acid and a preparation method thereof, wherein the co-crystal of berberine hydrochloride and m-hydroxybenzoic acid is formed by the berberine hydrochloride and the m-hydroxybenzoic acid in a molar ratio of 1:0.5-1.5, the co-crystal is a triclinic system, a P-1 space group, and the cell parameters are as follows: alpha / °=102.49+ / -0.2, beta / °=100.51+ / -0.2, gamma / °=117.81+ / -0.2, and Z=2. The co-crystal formed by the berberine hydrochloride and the m-hydroxybenzoic acid can significantly improve the dissolution rate and the dissolution speed of the berberine hydrochloride, the bioavailability of the berberine hydrochloride is significantly increased, the co-crystal has a good treatment effect, and is suitable for clinical application.

The application discloses an intestinal micro-needle anastomosis stent with an antibacterial function and a preparation method and application thereof, which can effectively physically isolate an anastomotic stoma from intestinal contents, provides a relatively clean local environment for healing of the anastomotic stoma, and further reduces tension at the anastomotic stoma by fixing the micro-needle anastomosis stent at the anastomotic stoma, so that anastomotic leakage caused by excessive tension is avoided; a micro-needle layer on a surface of the stent can realize in-situ long-acting slow release of berberine hydrochloride (BBH) on a superficial layer of the anastomotic stoma, so that drug utilization of the BBH is improved, and occurrence of initial inflammation of the anastomotic stoma is effectively reduced, and healing of the anastomotic stoma is better regulated. Animal experiment results prove that implantation of the micro-needle anastomosis stent can effectively reduce inflammatory cell infiltration of local tissues, reduce anastomotic arrangement, and regulate smooth healing of the anastomotic stoma.

The application discloses a kind of characteristic chromatogram detection methods of Qinggan Jieyu granules. After the solvent and microporous filter membrane treatment of Qinggan Jieyu granules, different batches of test solution are obtained, and the chromatogram of each is obtained by preparing the reference solution; the chromatogram of different batches of test solution and reference solution is combined to obtain the characteristic chromatogram and characteristic chromatographic peak of control, and then the relative retention time of the characteristic chromatographic peak and reference berberine hydrochloride peak solution is used to obtain the relative retention time of the control characteristic chromatogram as the specified value; the chromatogram is obtained by detecting the to-be-tested granules, and S peak correction is carried out, and the detection result is obtained by comparing the specified value of relative retention time. The characteristic chromatogram detection method of Qinggan Jieyu granules established by the application is simple in operation, reliable in result, high in stability and precision, and good in repeatability; the characteristic chromatogram of Qinggan Jieyu granules provided by the application can comprehensively and effectively control the quality of the preparation, and ensure the stability, reliability and safety of the preparation.

The application discloses a berberine hydrochloride extraction device and relates to the technical field of natural product extraction equipment. The device comprises a supporting frame, a water receiver, a cooler one and an external controller. The water receiver is fixedly connected to the top end of the supporting frame. The cooler one is fixedly connected to the top end of the water receiver. The middle part of the cooler one is provided with a cooling mechanism. The top part of the cooler one is provided with an adjusting mechanism. The cooling mechanism comprises a water inlet valve body opening fixedly communicated with the bottom end of the cooler one and a water outlet valve body opening fixedly communicated with the top end of the cooler one. The device prolongs the flow time of materials in the cooling water through the conical spiral flow guide pipe three, and increases the heat exchange contact area. Meanwhile, the combined design of the shunt pipe, the segmentation groove and the inclined plate makes the material liquid be dispersed and then gathered again, promotes the internal liquid movement of the material liquid, avoids local temperature difference, significantly improves the cooling uniformity and ensures the uniformity of berberine hydrochloride crystal particles.

The invention belongs to the technical field of feed additives, and particularly relates to a preparation method of sheep Zhuang powder, which comprises the following specific steps: preparing an astragalus extract, preparing berberine hydrochloride, and mixing for preparation. In the preparation process of the sheep strengthening powder, the feed additive is added, the feed additive effectively replaces the previous aureomycin, the antibacterial effect (MIC) of the feed additive on escherichia coli AZ1, escherichia coli 8-1 and salmonella sk77 is obviously better than that of the aureomycin, the dosage every time is smaller, animals are healthier, both pathogenic bacteria are killed, the immunity is improved, and the sheep strengthening powder is suitable for being used for preparing sheep strengthening powder. The feed is safe and compliant, has no residue and no withdrawal period, and has the effects of fattening and weight gaining and fierce eating and fierce growth.

The invention belongs to the technical field of biological medicine manufacturing, and particularly relates to a pharmaceutical preparation for improving ovarian functions and a preparation method thereof. The pharmaceutical preparation comprises the following raw materials in parts by weight: 12-25 parts of berberine hydrochloride, 8-16 parts of shionone, 5-10 parts of dicliptera chinensis polysaccharide, 10-20 parts of a diluent, 5-9 parts of an adhesive and 1-6 parts of a lubricant. According to the pharmaceutical composition, berberine hydrochloride, shionone and dicliptera chinensis polysaccharide are compounded, sexual cycle disorder caused by the polycystic ovarian syndrome is adjusted in a synergistic interaction mode, insulin resistance is improved, indexes such as luteinizing hormone (LH), follicle-stimulating hormone (FSH) and LH / FSH are remarkably improved, and the pharmaceutical composition has the application potential of treating the polycystic ovarian syndrome and has good application prospects. And the market prospect is wide.

The present invention provides a detection device and a detection method for berberine hydrochloride, which relate to the technical field of detection equipment. The device comprises a base, a chromatographic column oven and a detection box, wherein the chromatographic column oven and the detection box are electrically connected and fixedly mounted on the base, the chromatographic column oven is provided with a manual injector, and the detection box comprises a liquid storage tank tray, a degassing device, a detector and an infusion unit, which are sequentially installed from top to bottom, a control panel is installed on the side wall of the liquid storage tank tray, and a U-shaped rack is evenly and equidistantly fixedly mounted on the upper end of the liquid storage tank tray. The solvent bottle of the device can be kept in a horizontal position with the placement rack, and the static pressure of the mobile phase of the horizontally placed solvent bottle is constant. According to the principle of liquid statics, stable static pressure at the outlet means stable flow rate of the mobile phase, and the stable flow rate ensures consistent retention time of the sample in the chromatographic column, better peak separation, and more accurate quantitative results.

The application discloses a synthetic method suitable for industrial production of berberine and berberine hydrochloride, which comprises the following steps: adding berberine acetonitrile, o-veratraldehyde, an alcohol reaction solvent and a mixture of anhydrous copper sulfate-Pd / C in a reaction container in proportion, carrying out a reduction reaction by introducing hydrogen under the conditions of 50-70 DEG C and 0.3-0.8 MPa, removing the hydrogen after the system stops eating hydrogen, adding glyoxal, stirring and heating to 80-100 DEG C, reacting for 4-8 hours or more, cooling to room temperature, and then carrying out suction filtration to obtain a berberine methanol solution; the berberine methanol solution is subjected to post-treatment to obtain berberine or hydrogen chloride is introduced to obtain berberine hydrochloride by crystallization. The catalyst is matched by Pd / C and anhydrous copper sulfate, the temperature and pressure requirements in the reaction process are improved, the traditional high-temperature and high-pressure reaction is reduced to controllable reaction temperature and pressure, the reaction risk is greatly reduced, the catalyst can be recycled and reused, and the material cost and three-waste treatment are reduced.

The invention relates to the field of pharmaceutical preparations, and particularly discloses a preparation method of dihydroberberine, which comprises the following steps: S1, by taking berberine hydrochloride as a raw material and taking a catalyst complex of zinc chloride and a palladium-copper metal catalyst in a mass ratio of 1: (2-3) as a catalyst mixture, reacting in a supercritical fluid system at the supercritical pressure of 10-12MPa for 1-3 hours to obtain berberine hydrochloride; the temperature is 40-45 DEG C, and the supercritical fluid is a mixed fluid of carbon dioxide and hydrogen in a volume ratio of 1: (0.4-0.5); and S2, after the reaction is finished, depressurizing to separate out a crude product of dihydroberberine, collecting the crude product, and purifying the crude product to obtain dihydroberberine. The method has the characteristics of high efficiency, simplicity and convenience in operation, easiness in planned production, reduction of side reactions and improvement of yield.

The invention relates to the technical field of fruit and vegetable preservation, and discloses a hydrogel spray preparation method which comprises the following steps: adding berberine hydrochloride into distilled water, and stirring under the water bath condition of 70-90 DEG C until the berberine hydrochloride is completely dissolved to obtain a clear and transparent berberine solution; adding ammonium glycyrrhizinate into the berberine solution, and continuously stirring until the ammonium glycyrrhizinate is completely dissolved to form a homogeneous-phase mixed solution; and standing the mixed solution at room temperature for 8-24 hours. The fresh-keeping hydrogel disclosed by the invention has excellent antioxidant and antibacterial properties, has the capability of tracing the cleanliness degree by fluorescence, can effectively inhibit fungal rot of strawberries and maintain fresh flavor components, and does not influence the sensory quality of the strawberries.

The application belongs to the field of adsorbing material preparation, and particularly relates to a method for synthesizing a magnetic porous high-efficiency adsorbing berberine hydrochloride electrolytic manganese residue and coke composite material by a two-step ball-milling pyrolysis method, which comprises the following steps: ball-milling electrolytic manganese residue to obtain manganese residue powder; crushing coke to obtain coke and drying; soaking the manganese residue powder in sulfuric acid to generate a manganese-iron salt solution; washing and then plasma-activating the coke; washing and then plasma-activating the manganese-iron salt solution; stirring the coke product and the manganese-iron salt solution product in a water bath; mixing the obtained product with acetic acid, then adding a mixed solution of trisodium citrate and oxalic acid dihydrate, and then plasma-activating; program heating and pyrolyzing the obtained product; washing and drying the obtained product, and the target product is obtained. The composite material can efficiently treat berberine hydrochloride in wastewater containing berberine hydrochloride, has strong adsorbing capacity, ideal material functionality, and is easy to recycle.