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Medicine composition for preventing and/or treating diabetes and complication of diabetes

A composition and technology for diabetes, applied in the fields of drug combination, urinary system diseases, food science, etc., can solve the problems of unsatisfactory hypoglycemic effect, unsatisfactory hypoglycemic effect, and insignificant effect of islet cell repair.

Inactive Publication Date: 2015-02-11
颜明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ren Wenhui et al. (The protective and repairing effects of paeoniflorin on INS-1 cells damaged by STZ, Chinese Journal of Gerontology, January 2011, volume 31, pages 230-232) have disclosed that in islet cell culture experiments, Paeoniflorin Glycoside monomers have a strong protective effect on islet cells damaged by STZ, and can greatly improve the degree of reduction in cell viability and insulin secretion caused by STZ; however, the repair effect on islet cells is not obvious, suggesting that paeoniflorin can effectively prevent diabetes
[0013] Although it has been disclosed in the prior art that the peony extract or paeoniflorin monomer has a certain hypoglycemic effect, the disclosed hypoglycemic effect is not ideal, mainly because of some researches on the mechanism
There are also some researchers who try to improve the unsatisfactory hypoglycemic effect of Paeoniae officinalis extract or Paeoniflorin monomer by combining methods. For example, CN1857293A discloses a medicinal composition of scutellarin and paeoniflorin, which can Treatment and prevention of diabetic coronary heart disease, but the composition must be injected to be effective, and there is no experimental data to prove whether the composition has a direct control effect on blood sugar
CN101780155A discloses that the composition of Radix Paeoniae Alba and Radix Glycyrrhizae can synergize the hypoglycemic effect of acarbose, but there is no experimental data to prove whether the composition alone can directly control blood sugar
CN1303671A has disclosed the use of cinnamic acid in the preparation of medicines for treating diabetes; CN1313085A has disclosed the use of cinnamic acid in the preparation of medicines for controlling the incidence of type 1 diabetes; CN1303672A has disclosed the potassium or sodium salts of cinnamic acid in Use in the preparation of medicines for treating diabetes, but the effect of cinnamic acid on lowering blood sugar is not ideal
[0020] At present, prior art At present, there is no bibliographical report that the composition of peony and cinnamon is used for the treatment of diabetes, and the composition of pinane monoterpene glycosides and cinnamic acid / aldehyde compounds in peony is not used for diabetes literature reports on treatment

Method used

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  • Medicine composition for preventing and/or treating diabetes and complication of diabetes
  • Medicine composition for preventing and/or treating diabetes and complication of diabetes
  • Medicine composition for preventing and/or treating diabetes and complication of diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Weigh 100g of white peony root and 10g of cassia twig according to the mass ratio, mix the white peony and cinnamon twig, add 60% ethanol (the ratio of material to liquid is 1:15), soak for 24 hours at room temperature; extract by reflux method (temperature 65 ℃, extract 2 times, 4 hours each time); vacuum filtration; combine the filtrate, evaporate the water on a rotary evaporator, and concentrate to make an extract.

Embodiment 2

[0096] Weigh 100g of white peony root and 30g of cinnamon according to the mass ratio.

[0097] The red peony extract is prepared as follows: take clean and dry red peony, crush it, add 8-12 times the weight of 60%-80% (v / v) ethanol, and extract 1-3 at 65-75°C. Times, 2-4h each time, combine the extracts, filter, the filtrate is decompressed to recover the solvent, and concentrated in vacuo to a crude red peony extract; add 18-25 times the weight of 60%-80% ( v / v) Dissolve in ethanol, adjust the pH to 5.5-6.5 with sodium hydroxide solution, use the HPD-300 macroporous adsorption resin with polystyrene framework to adsorb the solution, after the adsorption is saturated, first absorb the impurities with water to the Molish reaction If negative, use 8-13 times the amount of resin in 60%-80% (v / v) ethanol, eluting at a flow rate of 1-5 times the amount of resin per hour, recover the eluate, concentrate, and dry to obtain red peony extract Things, spare.

[0098] The cinnamon extract ...

Embodiment 3

[0101] 100 grams of white peony, 50 grams of cassia twig,

[0102] Take the white peony smash into coarse powder, add 75% ethanol and reflux for extraction three times, the first and second times are 2 hours each, and the third time is 1 hour. Combine the extracts, concentrate under reduced pressure at 50°C to about 400ml, and extract three times with n-butanol , 300ml each time, combine the n-butanol extracts, concentrate under reduced pressure until there is no n-butanol flavor, add 200ml of water, heat to dissolve, filter, and spray dry the filtrate to obtain the white peony extract.

[0103] Take the cinnamon sticks and crush them into coarse powder, and then boil it with 5 times the weight of the raw material for 3 hours to filter out the boiling liquid; add 4 times the weight of the raw material to continue boiling the filter residue for 2 hours; filter the boiling liquid, and then Add water three times the weight of the raw material, and continue to boil the filter residue f...

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Abstract

The invention discloses a medicine composition for preventing and / or treating diabetes and complication of diabetes. The medicine composition is prepared from Chinese herbaceous peony and cassia bark in a weight ratio of (10-1) to 1. The medicine composition comprises the following effective components in parts by weight: 50-150 parts of a pinane monoterpene glycoside compound in Chinese herbaceous peony, and 1-5 parts of a cinnamic acid / aldehyde compound. The medicine composition not only has a good and stable blood sugar reduction and weight loss function, but also can effectively prevent and treat multiple diabetes complications, such as fatty liver, diabetic cardiomyopathy, diabetes peripheral neuritis, diabetes eye diseases and diabetic nephropathy. The composition is low in toxicity, small in side effect, low in cost and safe to use.

Description

Technical field [0001] The invention relates to the field of natural medicines, in particular to a pharmaceutical composition for preventing and / or treating diabetes and its complications. Background technique [0002] Modern medicine believes that diabetes is a group of systemic diseases caused by absolute or relative shortage of insulin and decreased sensitivity of target cells to insulin. In the early clinical stage, it may be asymptomatic. Typical patients have symptoms such as polydipsia, polyphagia, polyuria, fatigue, weight loss, etc. The peak prevalence is 50 to 70 years old. Diabetes is generally divided into two types: insulin-dependent (type I, IDDM) and non-insulin-dependent (type II, NIDDM). Type II diabetes accounts for more than 80%. With the improvement of people's living standards, the prevalence of diabetes is increasing rapidly, and it has become one of the main diseases affecting human health. It was reported in 1997 that there were 125 million diabetic pati...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K31/7048A61P3/10A61P13/12A61P27/02A61P25/02A61P9/00A61P3/06A61P1/16A61K31/192
CPCA61K36/71A23L2/02A23L2/52A23V2002/00A61K8/06A61K8/97A61K9/205A61K9/2054A61K9/4866A61K9/4875A61K31/11A61K31/192A61K31/7048A61K36/54A61K2236/331A61K2236/333A61K2236/51A61K2300/00A23V2250/21A23V2200/328
Inventor 颜明刘畅周毅曹林陆洋
Owner 颜明
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