10 results about "Polyphagia" patented technology

The application discloses application of Xintong preparation in preparation of a medicine for treating diabetes and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The Xintong preparation is prepared from 13 raw medicinal materials of Huangqi, Gegen, Danshen, Dangshen, Maidong, Heshouwu, Yinyanghuo, Dangui, Zaokesheng, Haizao, Kelp, Muli and Zhishi, has the effects of benefiting qi and activating blood, reducing phlegm and dredging collaterals. Pharmacodynamic experiments show that the Xintong preparation has the effect of reducing blood sugar, can effectively improve the physical conditions of polydipsia, polyphagia, polyuria and emaciation and lack of strength of an animal model of diabetes, significantly reduces the fasting blood sugar and serum insulin level, improves the oral glucose tolerance, has a definite treatment effect on type II diabetes, and expands the clinical application range of the Xintong preparation, and has a wide market application prospect.

The present disclosure is directed to the treatment of diseases or conditions characterized by the buildup of fatty tissue, or hyperphagia, such as Prader-Willi syndrome, obesity, metabolic syndrome, type II diabetes, etc. A composition containing a monoclonal antibody directed against gastric inhibitory polypeptide is administered. This results in a reduced rate of weight gain, weight loss, and / or reduction in fatty tissue, and a marked decrease in lipid synthesis and accumulation.

Methods of treating a subject having a metabolic syndrome or disease, diabetes, obesity, overweight, eating disorders, polyphagia, hyperlipidemia, insulin resistance, or methods of reducing body weight in a subject are provided. The methods involve administering to the subject a composition comprising a compound of formula I, including, for example, GAL475 (l-(2, 6-dimethylamino-8-propylamino-pyrimido [5, 4-d] pyrimidin-4-ylamino)-2-methyl-propan-2-ol), e.g., GAL475 (l-(2, 6-dimethylamino-8-propylamino-pyrimido [5, 4-d] pyrimidin-4-ylamino)-2-methyl-propan-2-ol), e.g., GAL475 (l-(2, 6- or a pharmaceutically acceptable salt, solvate, hydrate, enantiomer, stereoisomer, tautomer or isotope variant thereof, and a pharmaceutically acceptable carrier or excipient.

The invention provides application of antifebrile dichroa extract and derivatives thereof in preparation of drugs for diabetes, and relates to the technical field of biological medicines. In the application, the antifebrile dichroa extract is specifically antifebrile B, and a derivative of the antifebrile dichroa extract is halofuginone. Experiments prove that the antifebrile dichroa extract and derivatives thereof (halofuginone and febrile B) can effectively regulate blood sugar, reduce polydipsia and polyphagia symptoms of experimental animals, reduce body weight, increase sugar tolerance of the experimental animals, improve insulin resistance of the experimental animals, prevent complications such as cardiovascular diseases, neuropathy and nephropathy caused by diabetes, improve the life quality of patients, and prevent diabetes mellitus from being damaged by diabetes mellitus. And the long-term health risk is reduced.

The invention provides a composition containing medicinal and edible astragalus polysaccharide and application of the composition in reducing blood sugar. The composition provided by the invention consists of astragalus polysaccharide, tremella polysaccharide, lycium barbarum polysaccharide and angelica polysaccharide. The mass ratio of the raw materials is (1-3): (1-3): (1-3): (1-3). The hypoglycemic effect of the plant polysaccharide and the composition thereof is proved through a hyperglycemia mouse model, it is shown that the four plant polysaccharides can reduce the blood sugar of mice, after the four plant polysaccharides are compounded, the obvious synergistic interaction effect is shown, and the effect is obviously better than that of other schemes that every two plant polysaccharides are combined or combined in a stacked mode. Clinical medical manifestations of polydipsia, polyphagia, diuresis and weight loss of diabetes mellitus are slowed down and improved after polysaccharide combination treatment, a positive effect on reduction of hyperglycemia is achieved, the adopted plant polysaccharide is safe and non-toxic, blood sugar can be effectively reduced, and the diabetes mellitus health-care product has a good health-care effect on diabetes mellitus. The traditional Chinese medicine composition can also prevent acute complications caused by hyperglycemia, such as diabetic ketoacidosis, hyperglycemia syndrome and the like.

The utility model discloses a treasure basin ornament assembling structure which comprises a bottom support, a bottom plate and a lower flower belt are arranged on the bottom support, the bottom plate is placed on the upper portion of the interior of the bottom support, the lower flower belt is placed on the top of the bottom support, and the top of the lower flower belt is connected with an upper-layer auspicious cloud belt in a penetrating mode. The top of the upper-layer auspicious cloud belt is connected with a flowerpot outer container in a penetrating mode, the bottom of the flowerpot outer container is fixedly connected with the bottom plate through bolts, an upper flower belt and a dragon-shaped pattern decorating part are arranged on the flowerpot outer container, and the upper flower belt is connected to the top of the flowerpot outer container in a penetrating mode. The dragon-shaped pattern decorating parts are annularly distributed and connected to the outer side of the outer container of the treasure basin in a penetrating mode, and the dragon bead decorating parts are connected to the outer side of the outer container of the treasure basin between the adjacent dragon-shaped pattern decorating parts in a penetrating mode. According to the utility model, the decorating part can be easily replaced, and the assembling convenience is effectively improved.

The invention relates to the technical field of dietary therapy sugar control or sugar reduction, in particular to natural camellia oil with a blood sugar reducing effect, and provides application of the camellia oil in preparation of drugs, functional foods or health care products for reducing blood sugar. The camellia oil is taken as a research object, and the research finds that the camellia oil can effectively reduce the fasting blood-glucose level of diabetic mice and relieve polydipsia and polyphagia symptoms, can be used for preventing or treating the type 2 diabetes and provides an important scientific basis for diet intervention prevention and treatment of the type 2 diabetes.

The invention discloses a traditional Chinese medicine composition for diabetes reversal and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. Diabetes is a metabolic disease characterized by chronic hyperglycemia, is often caused by insufficiency of insulin secretion or dysfunction, and is classified into the category of diabetes in traditional Chinese medicine, and the etiology and pathogenesis are mostly closely related to deficiency of both qi and yin, dryness-heat accumulation, phlegm and blood stasis, spleen and kidney deficiency and the like. The invention provides a traditional Chinese medicine composition for reversing diabetes and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 20g of codonopsis pilosula, 20g of rhizoma smilacis glabrae, 15g of rhizoma acori graminei, 15g of polygala tenuifolia, 9g of rhizoma cimicifugae, 20g of radix rehmanniae recen, 12g of radix paeoniae alba, 12g of angelica sinensis, 12g of ligusticum wallichii, 12g of dens draconis, 6g of radix gentianae, 9g of scutellaria baicalensis, 12g of coptis chinensis, 15g of gypsum, 12g of immature bitter orange, 12g of trichosanthes kirilowii maxim, 12g of cortex lycii radicis, 12g of radix ophiopogonis, 9g of radix polygonati officinalis, 12g of ramulus euonymi and 9g of raw liquorice. The blood sugar level can be effectively reduced, and the symptoms of polydipsia, polyphagia, hypodynamia, frequent urination and the like of diabetic patients can be improved.

The invention discloses an FGF21 (Fibroblast Growth Factor 21), GLP-1 (Glucagon) and Glucagon three-receptor agonist protein. The amino acid sequence of the three-receptor agonist protein is shown as SEQ ID NO: 1 or SEQ ID NO: 2. The invention also provides nucleic acid for coding the tri-receptor stimulant protein, a recombinant vector, a host cell and a method for producing the tri-receptor stimulant protein, and also provides application of the tri-receptor stimulant protein in preparation of drugs for treating NAFLD, lipid-lowering drugs, drugs for treating lipid metabolism disorder, weight-reducing drugs and drugs for reducing blood sugar. After db / db mice are administered for a long time, the hypoglycemic activity is higher, the sugar tolerance is improved, weight gain can be inhibited, polydipsia and polyphagia are improved, the liver is protected, liver cell fat vacuoles are reduced, hepatic fibrosis is inhibited, the contents of TG, TC and LDL in blood fat can be reduced, lipid metabolism disorder can be regulated, and the overall efficacy is superior to that of FGF21.

This invention discloses a traditional Chinese medicine composition for improving blood sugar, its preparation method, and its application, belonging to the field of traditional Chinese medicine compound technology. The composition is prepared by combining scorpion, centipede, jujube seed, dandelion, cardamom, and platycodon in specific weight proportions. Based on the pathological mechanism of integrated traditional Chinese and Western medicine, this invention establishes liver phlegm obstruction, abnormal liver qi rising, and liver stagnation with internal heat disturbing the hypothalamus as the core pathogenesis of type 2 diabetes. Phlegm and dampness stagnation in the liver collaterals leads to impaired liver glycogen synthesis, and compensatory hyperactivity of the hypothalamus causes elevated blood sugar, polyphagia, and polydipsia. Deficiency of peripheral fluids and blood induces muscle atrophy and prediabetic foot lesions. This invention abandons the drawbacks of traditional yin-nourishing drugs that are greasy and promote dampness, using insect-derived drugs to clear phlegm and dampness from the liver collaterals, combined with herbs that clear the liver, nourish the liver, strengthen the spleen, and promote lung function. It regulates glucose metabolism at multiple targets, calms hypothalamic central hyperactivity, and nourishes the extremities. This formula can be prepared at home. It has a mild medicinal effect, stabilizes blood sugar, improves dry mouth and excessive appetite, numbness and atrophy of limbs, and slows the progression of diabetic foot. It has clinical application and industrial transformation value.