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Hypoglycemic medicine composition

A composition and technology of hypoglycemic drugs, applied in the field of medicine, can solve the problems of no research report on B vitamins found in sulfonylurea hypoglycemic drugs, failure to reduce the harm of Hcy to diabetic patients, etc.

Inactive Publication Date: 2008-01-16
SHENZHEN AUSA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, the combination of sulfonylureas and thiazolidinediones cannot reduce the harm of Hcy to diabetic patients
In clinical practice or published scientific literature, we have not found research reports on the combined application of sulfonylureas, thiazolidinediones, and B vitamins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Example 1 Preparation of compound glimepiride rosiglitazone folic acid (0.4mg) tablets (quantity of 1000 tablets)

[0132] Formula: Glimepiride 1g

[0133] Rosiglitazone 4g

[0134] Folic acid 0.4g

[0135] Starch 20g

[0136] Microcrystalline Cellulose 40g

[0137] Sodium carboxymethyl starch 40g

[0138] Low-substituted hydroxypropyl cellulose 20g

[0139] Proper amount of povidone ethanol solution

[0140] Magnesium Stearate 0.5%

[0141] Preparation method: crush the auxiliary materials through an 80-mesh sieve, and dry for later use. Take 1g of glimepiride, 4g of rosiglitazone, and 0.4g of folic acid and mix them uniformly according to the method of equal increase, and then add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the prescription amount, Mix evenly according to equal increment method, use 5% povidone K29 / 30-95% ethanol solution to make soft material, granulate with 20 mesh...

Embodiment 2～ Embodiment 8

[0142] Embodiment 2 to Embodiment 8 Preparation of glimepiride rosiglitazone folic acid tablets containing different content ratios

[0143] The preparation method is the same as in Example 1, and the granules obtained according to the formula shown in Table 1 are made into tablets.

Embodiment 9

[0144] Example 9 Preparation of compound glimepiride rosiglitazone vitamin B12 (2mg) tablets (quantity of 1000 tablets)

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PUM

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Abstract

The invention relates to a newly-developed medicine compound for diabetes which contains sulfonylureas drug for diabetes or a bioactive metabolite of the sulfonylureas drug for diabetes or pharmaceutical salt of the sulfonylureas drug for diabetes, and thiazolidinedione drug for diabetes or pharmaceutical salt and vitamin B of the thiazolidinedione drug for diabetes. The compound contains the sulfonylureas drug for diabetes of therapy dose or the bioactive metabolite of the sulfonylureas drug for diabetes or the pharmaceutical salt of the sulfonylureas drug for diabetes, the thiazolidinedione drug for diabetes of therapy dose or the pharmaceutical salt and therapy dose of vitamin B of the thiazolidinedione drug for diabetes or compound which is related to the thiazolidinedione drug for diabetes and has similar bioactivity and pharmaceutical carrier or excipient. The invention also relates to the purpose of the compound in preparation of drug for treating diabetes or preventing diabetes complication, belonging to the pharmaceutical field.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing sulfonylurea hypoglycemic drugs, thiazolidinedione hypoglycemic drugs and B vitamins, and the use of the composition in preparing drugs for treating diabetes or preventing diabetic complications. The invention belongs to the field of medicine. Background technique [0002] Diabetes mellitus is a metabolic disease of multiple etiologies characterized by chronic hyperglycemia accompanied by disturbances in carbohydrate, fat and protein metabolism due to defects in insulin secretion and / or action. Diabetes is currently a serious epidemic. In 2003, 194 million people worldwide had diabetes, ranging in age from 20 to 79 years. By 2025, this number may increase by 72% to 333 million, and approximately 80% of cases will be distributed in poor industrial developing countries. my country is one of the three countries with the largest number of people with diabetes. On October 12, 2004, the Mini...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K31/64A61K31/4436A61K9/20A61K9/48A61K9/14A61K9/08A61K9/70A61P3/10
Inventor 戴成祥王文艳李华陈明侠王燕于多陈光亮徐希平
Owner SHENZHEN AUSA PHARMA
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