Sugar-lowering drug composition and application thereof

A composition and drug technology, applied in the directions of drug combination, active ingredients of heterocyclic compounds, and pharmaceutical formulations, can solve problems such as uncontrollable type 2 diabetes, reduce plasma homocysteine ​​elevation, and reduce diabetes complications The effect of preventing diabetes complications

Active Publication Date: 2014-06-18
深圳市奥萨制药有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a hypoglycemic pharmaceutical composition and its use, which can effectively solve the defect that type 2 diabetes cannot be controlled by taking commonly used hypoglycemic drugs or vildagliptin alone in the prior art, and adding B vitamins can effectively control blood sugar , synergistically protect endothelial cell function, reduce diabetic complications and other effects

Method used

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  • Sugar-lowering drug composition and application thereof
  • Sugar-lowering drug composition and application thereof
  • Sugar-lowering drug composition and application thereof

Examples

Experimental program
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Effect test

no. 1 example

[0025] The hypoglycemic pharmaceutical composition includes 25 mg vildagliptin, 2000 mg metformin and 0.1 mg folic acid.

[0026] Preparation method of compound metformin and vildagliptin folic acid tablets (1000 tablets):

[0027] Formula: Metformin 400g

[0028] Vidagliptin 5g

[0029] Folic acid 800mg

[0030] Starch 100g

[0031] Microcrystalline cellulose 100g

[0032] Sodium Carboxymethyl Starch 75g

[0033] Low-substituted hydroxypropyl cellulose 75g

[0034] Povidone ethanol solution

[0035] Magnesium stearate 0.5%

[0036] Preparation method: pulverize the auxiliary materials in the above formula through an 80-mesh sieve and dry for later use. Take 400g of metformin, 5g of vildagliptin, and 800mg of folic acid and mix them uniformly according to the equal increasing method. Add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the formula amount, and increase in eq...

no. 2 example

[0040] The hypoglycemic pharmaceutical composition includes 50 mg vildagliptin, 1000 mg metformin and 0.4 mg folic acid.

[0041] The preparation method of the compound metformin and vildagliptin folic acid tablets (1000 tablets) in this example is similar to that of the compound metformin and vildagliptin folic acid tablets (1000 tablets) in the seventeenth embodiment of a hypoglycemic pharmaceutical composition of the present invention The preparation method is the same, and the carrier or excipient can be selected or the dosage of the carrier or excipient can be adjusted according to the common technical means used in the art to prepare the pharmaceutical composition.

[0042] In this embodiment, metformin can also be any one or any combination of metformin hydrochloride, phenformin, or buformin; folic acid can also be any one or three of vitamin B12 or vitamin B6 Any combination between.

no. 3 example

[0044] The hypoglycemic pharmaceutical composition includes 100 mg vildagliptin, 500 mg metformin and 7.5 mg folic acid.

[0045] The preparation method of the compound metformin and vildagliptin folic acid tablets (1000 tablets) in this example is similar to that of the compound metformin and vildagliptin folic acid tablets (1000 tablets) in the seventeenth embodiment of a hypoglycemic pharmaceutical composition of the present invention The preparation method is the same, and the carrier or excipient can be selected or the dosage of the carrier or excipient can be adjusted according to the common technical means used in the art to prepare the pharmaceutical composition.

[0046] In this embodiment, metformin can also be any one or any combination of metformin hydrochloride, phenformin, or buformin; folic acid can also be any one or three of vitamin B12 or vitamin B6 Any combination between.

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Abstract

The invention relates to a sugar-lowering drug composition and application thereof. The composition comprises 1) medicinal dosage of vildagliptin, 2) medicinal dosage of any one or combination of thiazolidinedione sugar-lowering drugs or medicinal salt thereof, sulfonylurea sugar-lowering drugs or medicinal salt thereof or biguanide sugar-lowering drugs or medicinal salt thereof and 3) B vitamins. The invention relates to application of the sugar-lowering drug composition to preparing the drugs for treating and / or controlling diabetes or diabetic complications. The composition can effectively overcome the defect that type 2 diabetes can not be controlled by singly taking the commonly used sugar-lowering drugs or vildagliptin in the prior art and simultaneously addition of the B vitamins is conductive to enhancing the treatment effect of the drug, effectively controlling the blood sugar, protecting the endothelial cell functions in a synergic manner, slowing rising of plasma homocysteine of the diabetes patients, especially the diabetes patients associated with chronic complications and reducing the diabetic complications.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition, in particular to a hypoglycemic pharmaceutical composition with vildagliptin, other hypoglycemic drugs and B vitamins as main active ingredients and uses thereof. Background technique [0002] Diabetes (Diabetes Inellitus) is a multi-causal metabolic disease characterized by chronic hyperglycemia, accompanied by disorders of sugar, fat and protein metabolism caused by defects in insulin secretion and / or action. Diabetes can occur at any age, and as the course of the disease is prolonged, it is easy to complicate pathological damages such as systemic nerves, microvascular and macrovascular diseases, and can lead to chronic and progressive diseases of tissues and organs such as heart, brain, kidney, nerves, and eyes. Eventually, blindness, gangrene of the lower limbs, uremia, stroke or myocardial infarction occur, and even life-threatening. With the improvement of living standards, diabetes has b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61K31/155A61K45/00A61K31/519A61K31/714A61K31/4415A61K31/4439A61K31/64A61P3/10A61P9/00A61P13/12A61P25/00A61P27/02A61P17/00
Inventor 靳晴于多陈光亮徐希平
Owner 深圳市奥萨制药有限公司
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